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Q07092 (COGA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(XVI) chain
Gene names
Name:COL16A1
ORF Names:FP1572
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1604 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. Ref.11

Subunit structure

Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3. Ref.3 Ref.4 Ref.9 Ref.11

Subcellular location

Secretedextracellular spaceextracellular matrix Ref.9.

Tissue specificity

In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at protein level). In the placenta, where it is found in the amnion, a membranous tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers. Also located to a fibroblast layer beneath this dense layer. Exists in tissues in association with other types of collagen. Ref.10

Developmental stage

Transiently elevated expression during gestation, and decrease at term.

Domain

This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Glycosylated. Ref.3 Ref.4

Sequence similarities

Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.

Contains 8 collagen-like domains.

Contains 1 laminin G-like domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q07092-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q07092-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1052-1052: Missing.
     1161-1161: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.3 Ref.4
Chain22 – 16041583Collagen alpha-1(XVI) chain
PRO_0000005792

Regions

Domain50 – 231182Laminin G-like
Domain375 – 42349Collagen-like 1
Domain573 – 63361Collagen-like 2
Domain667 – 72155Collagen-like 3
Domain788 – 84053Collagen-like 4
Domain888 – 93851Collagen-like 5
Domain1018 – 107558Collagen-like 6
Domain1472 – 152453Collagen-like 7
Domain1528 – 157649Collagen-like 8
Region232 – 374143Nonhelical region 10 (NC10)
Region375 – 506132Triple-helical region 9 (COL9) with 3 imperfections
Region507 – 52115Nonhelical region 9 (NC9)
Region522 – 55534Triple-helical region 8 (COL8) with 1 imperfection
Region556 – 57217Nonhelical region 8 (NC8)
Region573 – 63159Triple-helical region 7 (COL7) with 1 imperfection
Region632 – 65221Nonhelical region 7 (NC7)
Region653 – 72371Triple-helical region 6 (COL6) with 1 imperfection
Region724 – 73815Nonhelical region 6 (NC6)
Region739 – 876138Triple-helical region 5 (COL5) with 3 imperfections
Region877 – 88711Nonhelical region 5 (NC5)
Region888 – 93952Triple-helical region 4 (COL4) with 2 imperfections
Region940 – 97334Nonhelical region 4 (NC4)
Region974 – 98815Triple-helical region 3 (COL3)
Region989 – 101123Nonhelical region 3 (NC3)
Region1012 – 1433422Triple-helical region 2 (COL2) with 2 imperfections
Region1434 – 147239Nonhelical region 2 (NC2)
Region1473 – 1578106Triple-helical region 1 (COL1) with 2 imperfections
Region1579 – 160426Nonhelical region 1 (NC1)
Motif540 – 5423Cell attachment site Potential
Motif1006 – 10083Cell attachment site Potential
Motif1227 – 12293Cell attachment site Potential

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation3271N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence10521Missing in isoform 2.
VSP_024259
Alternative sequence11611Missing in isoform 2.
VSP_024260
Natural variant271Q → H.
Corresponds to variant rs2229802 [ dbSNP | Ensembl ].
VAR_048777
Natural variant621T → K. Ref.1
Corresponds to variant rs2228552 [ dbSNP | Ensembl ].
VAR_031440
Natural variant4181R → Q.
Corresponds to variant rs6699645 [ dbSNP | Ensembl ].
VAR_048778
Natural variant7451G → S.
Corresponds to variant rs34770879 [ dbSNP | Ensembl ].
VAR_048779
Natural variant9091P → L.
Corresponds to variant rs2229804 [ dbSNP | Ensembl ].
VAR_048780

Experimental info

Sequence conflict4191D → G in AAB25797. Ref.7
Sequence conflict420 – 4212GR → A in AAA58427. Ref.1
Sequence conflict5381P → R in AAA58427. Ref.1
Sequence conflict848 – 8492RD → VM in CAA33142. Ref.6
Sequence conflict848 – 8492RD → VM in CAA33085. Ref.6
Sequence conflict11611P → T in AAA58427. Ref.1
Sequence conflict11641P → T in AAA58427. Ref.1
Sequence conflict11661P → S in AAA58427. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 5FAA1950DFC6CA3C

FASTA1,604157,751
        10         20         30         40         50         60 
MWVSWAPGLW LLGLWATFGH GANTGAQCPP SQQEGLKLEH SSSLPANVTG FNLIHRLSLM 

        70         80         90        100        110        120 
KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF ALVLTLLLKK HTHQKTWYLF 

       130        140        150        160        170        180 
QVTDANGYPQ ISLEVNSQER SLELRAQGQD GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA 

       190        200        210        220        230        240 
SVHVDCSSAS SQPLGPRRPM RPVGHVFLGL DAEQGKPVSF DLQQVHIYCD PELVLEEGCC 

       250        260        270        280        290        300 
EILPAGCPPE TSKARRDTQS NELIEINPQS EGKVYTRCFC LEEPQNSEVD AQLTGRISQK 

       310        320        330        340        350        360 
AERGAKVHQE TAADECPPCV HGARDSNVTL APSGPKGGKG ERGLPGPPGS KGEKGARGND 

       370        380        390        400        410        420 
CVRISPDAPL QCAEGPKGEK GESGALGPSG LPGSTGEKGQ KGEKGDGGIK GVPGKPGRDG 

       430        440        450        460        470        480 
RPGEICVIGP KGQKGDPGFV GPEGLAGEPG PPGLPGPPGI GLPGTPGDPG GPPGPKGDKG 

       490        500        510        520        530        540 
SSGIPGKEGP GGKPGKPGVK GEKGDPCEVC PTLPEGFQNF VGLPGKPGPK GEPGDPVPAR 

       550        560        570        580        590        600 
GDPGIQGIKG EKGEPCLSCS SVVGAQHLVS STGASGDVGS PGFGLPGLPG RAGVPGLKGE 

       610        620        630        640        650        660 
KGNFGEAGPA GSPGPPGPVG PAGIKGAKGE PCEPCPALSN LQDGDVRVVA LPGPSGEKGE 

       670        680        690        700        710        720 
PGPPGFGLPG KQGKAGERGL KGQKGDAGNP GDPGTPGTTG RPGLSGEPGV QGPAGPKGEK 

       730        740        750        760        770        780 
GDGCTACPSL QGTVTDMAGR PGQPGPKGEQ GPEGVGRPGK PGQPGLPGVQ GPPGLKGVQG 

       790        800        810        820        830        840 
EPGPPGRGVQ GPQGEPGAPG LPGIQGLPGP RGPPGPTGEK GAQGSPGVKG ATGPVGPPGA 

       850        860        870        880        890        900 
SVSGPPGRDG QQGQTGLRGT PGEKGPRGEK GEPGECSCPS QGDLIFSGMP GAPGLWMGSS 

       910        920        930        940        950        960 
WQPGPQGPPG IPGPPGPPGV PGLQGVPGNN GLPGQPGLTA ELGSLPIEQH LLKSICGDCV 

       970        980        990       1000       1010       1020 
QGQRAHPGYL VEKGEKGDQG IPGVPGLDNC AQCFLSLERP RAEEARGDNS EGDPGCVGSP 

      1030       1040       1050       1060       1070       1080 
GLPGPPGLPG QRGEEGPPGM RGSPGPPGPI GPPGFPGAVG SPGLPGLQGE RGLTGLTGDK 

      1090       1100       1110       1120       1130       1140 
GEPGPPGQPG YPGATGPPGL PGIKGERGYT GSAGEKGEPG PPGSEGLPGP PGPAGPRGER 

      1150       1160       1170       1180       1190       1200 
GPQGNSGEKG DQGFQGQPGF PGPPGPPGFP GKVGSPGPPG PQAEKGSEGI RGPSGLPGSP 

      1210       1220       1230       1240       1250       1260 
GPPGPPGIQG PAGLDGLDGK DGKPGLRGDP GPAGPPGLMG PPGFKGKTGH PGLPGPKGDC 

      1270       1280       1290       1300       1310       1320 
GKPGPPGSTG RPGAEGEPGA MGPQGRPGPP GHVGPPGPPG QPGPAGISAV GLKGDRGATG 

      1330       1340       1350       1360       1370       1380 
ERGLAGLPGQ PGPPGHPGPP GEPGTDGAAG KEGPPGKQGF YGPPGPKGDP GAAGQKGQAG 

      1390       1400       1410       1420       1430       1440 
EKGRAGMPGG PGKSGSMGPV GPPGPAGERG HPGAPGPSGS PGLPGVPGSM GDMVNYDEIK 

      1450       1460       1470       1480       1490       1500 
RFIRQEIIKM FDERMAYYTS RMQFPMEMAA APGRPGPPGK DGAPGRPGAP GSPGLPGQIG 

      1510       1520       1530       1540       1550       1560 
REGRQGLPGV RGLPGTKGEK GDIGIGIAGE NGLPGPPGPQ GPPGYGKMGA TGPMGQQGIP 

      1570       1580       1590       1600 
GIPGPPGPMG QPGKAGHCNP SDCFGAMPME QQYPPMKTMK GPFG 

« Hide

Isoform 2 [UniParc].

Checksum: C0F8388B57BBA080
Show »

FASTA1,602157,557

References

« Hide 'large scale' references
[1]"Cloning and chromosomal location of human alpha 1(XVI) collagen."
Pan T.-C., Zhang R.-Z., Mattei M.-G., Timpl R., Chu M.-L.
Proc. Natl. Acad. Sci. U.S.A. 89:6565-6569(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-62.
Tissue: Fibroblast.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain."
Tillet E., Mann K., Nischt R., Pan T.-C., Chu M.-L., Timpl R.
Eur. J. Biochem. 228:160-168(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-33, SUBUNIT, GLYCOSYLATION.
[4]"Molecular structure and interaction of recombinant human type XVI collagen."
Kassner A., Tiedemann K., Notbohm H., Ludwig T., Morgelin M., Reinhardt D.P., Chu M.-L., Bruckner P., Grassel S.
J. Mol. Biol. 339:835-853(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-30; 257-265 AND 941-950, SUBUNIT, INTERACTION WITH FBN1 AND FN1, GLYCOSYLATION.
[5]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-1604 (ISOFORM 2).
Tissue: Spleen.
[6]Kimura S.
Submitted (APR-1989) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 403-849.
Tissue: Placenta.
[7]"Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments."
Yamaguchi N., Kimura S., McBride O.W., Hori H., Yamada Y., Kanamori T., Yamakoshi H., Nagai Y.
J. Biochem. 112:856-863(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 418-1604 (ISOFORM 1).
Tissue: Placenta.
[8]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1387-1604.
[9]"Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells."
Grassel S., Timpl R., Tan E.M.L., Chu M.-L.
Eur. J. Biochem. 242:576-584(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, SUBCELLULAR LOCATION.
[10]"Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils."
Kassner A., Hansen U., Miosge N., Reinhardt D.P., Aigner T., Bruckner-Tuderman L., Bruckner P., Grassel S.
Matrix Biol. 22:131-143(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[11]"Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains."
Eble J.A., Kassner A., Niland S., Morgelin M., Grifka J., Grassel S.
J. Biol. Chem. 281:25745-25756(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, INTERACTION WITH INTEGRIN ALPHA-1/BETA-1 AND INTEGRIN ALPHA-2/BETA-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92642 mRNA. Translation: AAA58427.1.
AC114488 Genomic DNA. No translation available.
AB209571 mRNA. Translation: BAD92808.1.
X14963 mRNA. Translation: CAA33085.1.
X15038 mRNA. Translation: CAA33142.1.
S57132 mRNA. Translation: AAB25797.1.
AF370368 mRNA. Translation: AAQ15204.1.
PIRS23810.
RefSeqNP_001847.3. NM_001856.3.
UniGeneHs.368921.

3D structure databases

ProteinModelPortalQ07092.
SMRQ07092. Positions 47-242.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107703. 1 interaction.
IntActQ07092. 3 interactions.
MINTMINT-6743139.
STRING9606.ENSP00000362776.

PTM databases

PhosphoSiteQ07092.

Polymorphism databases

DMDM143811380.

Proteomic databases

PaxDbQ07092.
PRIDEQ07092.

Protocols and materials databases

DNASU1307.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373672; ENSP00000362776; ENSG00000084636. [Q07092-1]
GeneID1307.
KEGGhsa:1307.
UCSCuc001btj.1. human. [Q07092-2]
uc001btk.1. human. [Q07092-1]

Organism-specific databases

CTD1307.
GeneCardsGC01M032117.
H-InvDBHIX0028602.
HGNCHGNC:2193. COL16A1.
HPAHPA027235.
HPA027237.
MIM120326. gene.
neXtProtNX_Q07092.
PharmGKBPA26709.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000085653.
HOVERGENHBG071631.
InParanoidQ07092.
OMASTWYLFQ.
OrthoDBEOG779NXQ.
TreeFamTF332900.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

ArrayExpressQ07092.
BgeeQ07092.
CleanExHS_COL16A1.
GenevestigatorQ07092.

Family and domain databases

InterProIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR001791. Laminin_G.
[Graphical view]
PfamPF01391. Collagen. 8 hits.
[Graphical view]
SMARTSM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
ProtoNetSearch...

Other

GeneWikiCollagen,_type_XVI,_alpha_1.
GenomeRNAi1307.
NextBio5349.
PROQ07092.
SOURCESearch...

Entry information

Entry nameCOGA1_HUMAN
AccessionPrimary (citable) accession number: Q07092
Secondary accession number(s): Q16593, Q59F89, Q71RG9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 3, 2007
Last modified: March 19, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM