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Q07092

- COGA1_HUMAN

UniProt

Q07092 - COGA1_HUMAN

Protein

Collagen alpha-1(XVI) chain

Gene

COL16A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.1 Publication

    GO - Molecular functioni

    1. integrin binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. cellular response to amino acid stimulus Source: Ensembl
    3. collagen catabolic process Source: Reactome
    4. extracellular matrix disassembly Source: Reactome
    5. extracellular matrix organization Source: Reactome
    6. female pregnancy Source: ProtInc
    7. integrin-mediated signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_13552. Integrin cell surface interactions.
    REACT_150401. Collagen degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XVI) chain
    Gene namesi
    Name:COL16A1
    ORF Names:FP1572
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2193. COL16A1.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix 1 Publication

    GO - Cellular componenti

    1. collagen type XVI trimer Source: ProtInc
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular region Source: Reactome
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26709.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21212 PublicationsAdd
    BLAST
    Chaini22 – 16041583Collagen alpha-1(XVI) chainPRO_0000005792Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    Glycosylated.2 Publications

    Keywords - PTMi

    Glycoprotein, Hydroxylation

    Proteomic databases

    MaxQBiQ07092.
    PaxDbiQ07092.
    PRIDEiQ07092.

    PTM databases

    PhosphoSiteiQ07092.

    Expressioni

    Tissue specificityi

    In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at protein level). In the placenta, where it is found in the amnion, a membranous tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers. Also located to a fibroblast layer beneath this dense layer. Exists in tissues in association with other types of collagen.1 Publication

    Developmental stagei

    Transiently elevated expression during gestation, and decrease at term.

    Gene expression databases

    ArrayExpressiQ07092.
    BgeeiQ07092.
    CleanExiHS_COL16A1.
    GenevestigatoriQ07092.

    Organism-specific databases

    HPAiHPA027235.
    HPA027237.

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3.4 Publications

    Protein-protein interaction databases

    BioGridi107703. 1 interaction.
    IntActiQ07092. 3 interactions.
    MINTiMINT-6743139.
    STRINGi9606.ENSP00000362776.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07092.
    SMRiQ07092. Positions 47-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 231182Laminin G-likeAdd
    BLAST
    Domaini375 – 42349Collagen-like 1Add
    BLAST
    Domaini573 – 63361Collagen-like 2Add
    BLAST
    Domaini667 – 72155Collagen-like 3Add
    BLAST
    Domaini788 – 84053Collagen-like 4Add
    BLAST
    Domaini888 – 93851Collagen-like 5Add
    BLAST
    Domaini1018 – 107558Collagen-like 6Add
    BLAST
    Domaini1472 – 152453Collagen-like 7Add
    BLAST
    Domaini1528 – 157649Collagen-like 8Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni232 – 374143Nonhelical region 10 (NC10)Add
    BLAST
    Regioni375 – 506132Triple-helical region 9 (COL9) with 3 imperfectionsAdd
    BLAST
    Regioni507 – 52115Nonhelical region 9 (NC9)Add
    BLAST
    Regioni522 – 55534Triple-helical region 8 (COL8) with 1 imperfectionAdd
    BLAST
    Regioni556 – 57217Nonhelical region 8 (NC8)Add
    BLAST
    Regioni573 – 63159Triple-helical region 7 (COL7) with 1 imperfectionAdd
    BLAST
    Regioni632 – 65221Nonhelical region 7 (NC7)Add
    BLAST
    Regioni653 – 72371Triple-helical region 6 (COL6) with 1 imperfectionAdd
    BLAST
    Regioni724 – 73815Nonhelical region 6 (NC6)Add
    BLAST
    Regioni739 – 876138Triple-helical region 5 (COL5) with 3 imperfectionsAdd
    BLAST
    Regioni877 – 88711Nonhelical region 5 (NC5)Add
    BLAST
    Regioni888 – 93952Triple-helical region 4 (COL4) with 2 imperfectionsAdd
    BLAST
    Regioni940 – 97334Nonhelical region 4 (NC4)Add
    BLAST
    Regioni974 – 98815Triple-helical region 3 (COL3)Add
    BLAST
    Regioni989 – 101123Nonhelical region 3 (NC3)Add
    BLAST
    Regioni1012 – 1433422Triple-helical region 2 (COL2) with 2 imperfectionsAdd
    BLAST
    Regioni1434 – 147239Nonhelical region 2 (NC2)Add
    BLAST
    Regioni1473 – 1578106Triple-helical region 1 (COL1) with 2 imperfectionsAdd
    BLAST
    Regioni1579 – 160426Nonhelical region 1 (NC1)Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi540 – 5423Cell attachment siteSequence Analysis
    Motifi1006 – 10083Cell attachment siteSequence Analysis
    Motifi1227 – 12293Cell attachment siteSequence Analysis

    Domaini

    This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.

    Sequence similaritiesi

    Contains 8 collagen-like domains.Curated
    Contains 1 laminin G-like domain.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000085653.
    HOVERGENiHBG071631.
    InParanoidiQ07092.
    OMAiSTWYLFQ.
    OrthoDBiEOG779NXQ.
    PhylomeDBiQ07092.
    TreeFamiTF332900.

    Family and domain databases

    InterProiIPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF01391. Collagen. 8 hits.
    [Graphical view]
    SMARTiSM00210. TSPN. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q07092-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWVSWAPGLW LLGLWATFGH GANTGAQCPP SQQEGLKLEH SSSLPANVTG     50
    FNLIHRLSLM KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF 100
    ALVLTLLLKK HTHQKTWYLF QVTDANGYPQ ISLEVNSQER SLELRAQGQD 150
    GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA SVHVDCSSAS SQPLGPRRPM 200
    RPVGHVFLGL DAEQGKPVSF DLQQVHIYCD PELVLEEGCC EILPAGCPPE 250
    TSKARRDTQS NELIEINPQS EGKVYTRCFC LEEPQNSEVD AQLTGRISQK 300
    AERGAKVHQE TAADECPPCV HGARDSNVTL APSGPKGGKG ERGLPGPPGS 350
    KGEKGARGND CVRISPDAPL QCAEGPKGEK GESGALGPSG LPGSTGEKGQ 400
    KGEKGDGGIK GVPGKPGRDG RPGEICVIGP KGQKGDPGFV GPEGLAGEPG 450
    PPGLPGPPGI GLPGTPGDPG GPPGPKGDKG SSGIPGKEGP GGKPGKPGVK 500
    GEKGDPCEVC PTLPEGFQNF VGLPGKPGPK GEPGDPVPAR GDPGIQGIKG 550
    EKGEPCLSCS SVVGAQHLVS STGASGDVGS PGFGLPGLPG RAGVPGLKGE 600
    KGNFGEAGPA GSPGPPGPVG PAGIKGAKGE PCEPCPALSN LQDGDVRVVA 650
    LPGPSGEKGE PGPPGFGLPG KQGKAGERGL KGQKGDAGNP GDPGTPGTTG 700
    RPGLSGEPGV QGPAGPKGEK GDGCTACPSL QGTVTDMAGR PGQPGPKGEQ 750
    GPEGVGRPGK PGQPGLPGVQ GPPGLKGVQG EPGPPGRGVQ GPQGEPGAPG 800
    LPGIQGLPGP RGPPGPTGEK GAQGSPGVKG ATGPVGPPGA SVSGPPGRDG 850
    QQGQTGLRGT PGEKGPRGEK GEPGECSCPS QGDLIFSGMP GAPGLWMGSS 900
    WQPGPQGPPG IPGPPGPPGV PGLQGVPGNN GLPGQPGLTA ELGSLPIEQH 950
    LLKSICGDCV QGQRAHPGYL VEKGEKGDQG IPGVPGLDNC AQCFLSLERP 1000
    RAEEARGDNS EGDPGCVGSP GLPGPPGLPG QRGEEGPPGM RGSPGPPGPI 1050
    GPPGFPGAVG SPGLPGLQGE RGLTGLTGDK GEPGPPGQPG YPGATGPPGL 1100
    PGIKGERGYT GSAGEKGEPG PPGSEGLPGP PGPAGPRGER GPQGNSGEKG 1150
    DQGFQGQPGF PGPPGPPGFP GKVGSPGPPG PQAEKGSEGI RGPSGLPGSP 1200
    GPPGPPGIQG PAGLDGLDGK DGKPGLRGDP GPAGPPGLMG PPGFKGKTGH 1250
    PGLPGPKGDC GKPGPPGSTG RPGAEGEPGA MGPQGRPGPP GHVGPPGPPG 1300
    QPGPAGISAV GLKGDRGATG ERGLAGLPGQ PGPPGHPGPP GEPGTDGAAG 1350
    KEGPPGKQGF YGPPGPKGDP GAAGQKGQAG EKGRAGMPGG PGKSGSMGPV 1400
    GPPGPAGERG HPGAPGPSGS PGLPGVPGSM GDMVNYDEIK RFIRQEIIKM 1450
    FDERMAYYTS RMQFPMEMAA APGRPGPPGK DGAPGRPGAP GSPGLPGQIG 1500
    REGRQGLPGV RGLPGTKGEK GDIGIGIAGE NGLPGPPGPQ GPPGYGKMGA 1550
    TGPMGQQGIP GIPGPPGPMG QPGKAGHCNP SDCFGAMPME QQYPPMKTMK 1600
    GPFG 1604
    Length:1,604
    Mass (Da):157,751
    Last modified:April 3, 2007 - v2
    Checksum:i5FAA1950DFC6CA3C
    GO
    Isoform 2 (identifier: Q07092-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1052-1052: Missing.
         1161-1161: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,602
    Mass (Da):157,557
    Checksum:iC0F8388B57BBA080
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti419 – 4191D → G in AAB25797. (PubMed:1284248)Curated
    Sequence conflicti420 – 4212GR → A in AAA58427. (PubMed:1631157)Curated
    Sequence conflicti538 – 5381P → R in AAA58427. (PubMed:1631157)Curated
    Sequence conflicti848 – 8492RD → VM in CAA33142. 1 PublicationCurated
    Sequence conflicti848 – 8492RD → VM in CAA33085. 1 PublicationCurated
    Sequence conflicti1161 – 11611P → T in AAA58427. (PubMed:1631157)Curated
    Sequence conflicti1164 – 11641P → T in AAA58427. (PubMed:1631157)Curated
    Sequence conflicti1166 – 11661P → S in AAA58427. (PubMed:1631157)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271Q → H.
    Corresponds to variant rs2229802 [ dbSNP | Ensembl ].
    VAR_048777
    Natural varianti62 – 621T → K.1 Publication
    Corresponds to variant rs2228552 [ dbSNP | Ensembl ].
    VAR_031440
    Natural varianti418 – 4181R → Q.
    Corresponds to variant rs6699645 [ dbSNP | Ensembl ].
    VAR_048778
    Natural varianti745 – 7451G → S.
    Corresponds to variant rs34770879 [ dbSNP | Ensembl ].
    VAR_048779
    Natural varianti909 – 9091P → L.
    Corresponds to variant rs2229804 [ dbSNP | Ensembl ].
    VAR_048780

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1052 – 10521Missing in isoform 2. 1 PublicationVSP_024259
    Alternative sequencei1161 – 11611Missing in isoform 2. 1 PublicationVSP_024260

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92642 mRNA. Translation: AAA58427.1.
    AC114488 Genomic DNA. No translation available.
    AB209571 mRNA. Translation: BAD92808.1.
    X14963 mRNA. Translation: CAA33085.1.
    X15038 mRNA. Translation: CAA33142.1.
    S57132 mRNA. Translation: AAB25797.1.
    AF370368 mRNA. Translation: AAQ15204.1.
    CCDSiCCDS41297.1. [Q07092-1]
    PIRiS23810.
    RefSeqiNP_001847.3. NM_001856.3. [Q07092-1]
    UniGeneiHs.368921.

    Genome annotation databases

    EnsembliENST00000373672; ENSP00000362776; ENSG00000084636. [Q07092-1]
    GeneIDi1307.
    KEGGihsa:1307.
    UCSCiuc001btj.1. human. [Q07092-2]
    uc001btk.1. human. [Q07092-1]

    Polymorphism databases

    DMDMi143811380.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92642 mRNA. Translation: AAA58427.1 .
    AC114488 Genomic DNA. No translation available.
    AB209571 mRNA. Translation: BAD92808.1 .
    X14963 mRNA. Translation: CAA33085.1 .
    X15038 mRNA. Translation: CAA33142.1 .
    S57132 mRNA. Translation: AAB25797.1 .
    AF370368 mRNA. Translation: AAQ15204.1 .
    CCDSi CCDS41297.1. [Q07092-1 ]
    PIRi S23810.
    RefSeqi NP_001847.3. NM_001856.3. [Q07092-1 ]
    UniGenei Hs.368921.

    3D structure databases

    ProteinModelPortali Q07092.
    SMRi Q07092. Positions 47-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107703. 1 interaction.
    IntActi Q07092. 3 interactions.
    MINTi MINT-6743139.
    STRINGi 9606.ENSP00000362776.

    PTM databases

    PhosphoSitei Q07092.

    Polymorphism databases

    DMDMi 143811380.

    Proteomic databases

    MaxQBi Q07092.
    PaxDbi Q07092.
    PRIDEi Q07092.

    Protocols and materials databases

    DNASUi 1307.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373672 ; ENSP00000362776 ; ENSG00000084636 . [Q07092-1 ]
    GeneIDi 1307.
    KEGGi hsa:1307.
    UCSCi uc001btj.1. human. [Q07092-2 ]
    uc001btk.1. human. [Q07092-1 ]

    Organism-specific databases

    CTDi 1307.
    GeneCardsi GC01M032117.
    H-InvDB HIX0028602.
    HGNCi HGNC:2193. COL16A1.
    HPAi HPA027235.
    HPA027237.
    MIMi 120326. gene.
    neXtProti NX_Q07092.
    PharmGKBi PA26709.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000085653.
    HOVERGENi HBG071631.
    InParanoidi Q07092.
    OMAi STWYLFQ.
    OrthoDBi EOG779NXQ.
    PhylomeDBi Q07092.
    TreeFami TF332900.

    Enzyme and pathway databases

    Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_13552. Integrin cell surface interactions.
    REACT_150401. Collagen degradation.

    Miscellaneous databases

    GeneWikii Collagen,_type_XVI,_alpha_1.
    GenomeRNAii 1307.
    NextBioi 5349.
    PROi Q07092.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07092.
    Bgeei Q07092.
    CleanExi HS_COL16A1.
    Genevestigatori Q07092.

    Family and domain databases

    InterProi IPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF01391. Collagen. 8 hits.
    [Graphical view ]
    SMARTi SM00210. TSPN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal location of human alpha 1(XVI) collagen."
      Pan T.-C., Zhang R.-Z., Mattei M.-G., Timpl R., Chu M.-L.
      Proc. Natl. Acad. Sci. U.S.A. 89:6565-6569(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-62.
      Tissue: Fibroblast.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain."
      Tillet E., Mann K., Nischt R., Pan T.-C., Chu M.-L., Timpl R.
      Eur. J. Biochem. 228:160-168(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-33, SUBUNIT, GLYCOSYLATION.
    4. "Molecular structure and interaction of recombinant human type XVI collagen."
      Kassner A., Tiedemann K., Notbohm H., Ludwig T., Morgelin M., Reinhardt D.P., Chu M.-L., Bruckner P., Grassel S.
      J. Mol. Biol. 339:835-853(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-30; 257-265 AND 941-950, SUBUNIT, INTERACTION WITH FBN1 AND FN1, GLYCOSYLATION.
    5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-1604 (ISOFORM 2).
      Tissue: Spleen.
    6. Kimura S.
      Submitted (APR-1989) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 403-849.
      Tissue: Placenta.
    7. "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments."
      Yamaguchi N., Kimura S., McBride O.W., Hori H., Yamada Y., Kanamori T., Yamakoshi H., Nagai Y.
      J. Biochem. 112:856-863(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 418-1604 (ISOFORM 1).
      Tissue: Placenta.
    8. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1387-1604.
    9. "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells."
      Grassel S., Timpl R., Tan E.M.L., Chu M.-L.
      Eur. J. Biochem. 242:576-584(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, SUBCELLULAR LOCATION.
    10. "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils."
      Kassner A., Hansen U., Miosge N., Reinhardt D.P., Aigner T., Bruckner-Tuderman L., Bruckner P., Grassel S.
      Matrix Biol. 22:131-143(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains."
      Eble J.A., Kassner A., Niland S., Morgelin M., Grifka J., Grassel S.
      J. Biol. Chem. 281:25745-25756(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, INTERACTION WITH INTEGRIN ALPHA-1/BETA-1 AND INTEGRIN ALPHA-2/BETA-1.

    Entry informationi

    Entry nameiCOGA1_HUMAN
    AccessioniPrimary (citable) accession number: Q07092
    Secondary accession number(s): Q16593, Q59F89, Q71RG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3