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Q07079 (IBP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein 5

Short name=IBP-5
Short name=IGF-binding protein 5
Short name=IGFBP-5
Gene names
Name:Igfbp5
Synonyms:Igfbp-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subcellular location

Secreted.

Tissue specificity

Most abundant in kidney, uterus and gastrocnemius muscle.

Sequence similarities

Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandGrowth factor binding
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to cAMP

Inferred from electronic annotation. Source: Ensembl

glucose homeostasis

Inferred from mutant phenotype PubMed 19897600. Source: MGI

glucose metabolic process

Inferred from mutant phenotype PubMed 19897600. Source: MGI

hair follicle morphogenesis

Inferred from mutant phenotype PubMed 16024235. Source: MGI

intracellular signal transduction

Inferred from electronic annotation. Source: Ensembl

mammary gland involution

Inferred from mutant phenotype PubMed 17255210. Source: MGI

negative regulation of insulin-like growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 16024235. Source: MGI

negative regulation of osteoblast differentiation

Inferred from genetic interaction PubMed 19208758. Source: MGI

negative regulation of smooth muscle cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of translation

Inferred from electronic annotation. Source: Ensembl

osteoblast differentiation

Inferred from expression pattern PubMed 16311053. Source: BHF-UCL

positive regulation of insulin-like growth factor receptor signaling pathway

Inferred from genetic interaction PubMed 16675541. Source: MGI

positive regulation of protein kinase B signaling

Inferred from mutant phenotype PubMed 18762576. Source: MGI

regulation of cell growth

Inferred from genetic interaction PubMed 16675541. Source: MGI

regulation of glucose metabolic process

Inferred from genetic interaction PubMed 16675541. Source: MGI

regulation of growth

Inferred from genetic interaction PubMed 16675541. Source: MGI

skeletal muscle tissue growth

Inferred from electronic annotation. Source: Ensembl

striated muscle cell differentiation

Inferred from mutant phenotype PubMed 18762576. Source: MGI

type B pancreatic cell proliferation

Inferred from genetic interaction PubMed 16675541. Source: MGI

   Cellular_componentinsulin-like growth factor binding protein complex

Inferred by curator PubMed 14680841. Source: MGI

   Molecular_functionfibronectin binding

Inferred from direct assay PubMed 19236847. Source: MGI

insulin-like growth factor binding

Inferred from physical interaction PubMed 14566968. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 271252Insulin-like growth factor-binding protein 5
PRO_0000014386

Regions

Domain22 – 10281IGFBP N-terminal
Domain188 – 26275Thyroglobulin type-1

Amino acid modifications

Disulfide bond44 ↔ 58 By similarity
Disulfide bond66 ↔ 79 By similarity
Disulfide bond191 ↔ 218 By similarity
Disulfide bond229 ↔ 240 By similarity
Disulfide bond242 ↔ 262 By similarity

Experimental info

Sequence conflict1121Missing in AAC01750. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q07079 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: F55A58729861F6F0

FASTA27130,372
        10         20         30         40         50         60 
MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP GCGCCMTCAL 

        70         80         90        100        110        120 
AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL NEKSYGEQTK IERDSREHEE 

       130        140        150        160        170        180 
PTTSEMAEET YSPKVFRPKH TRISELKAEA VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP 

       190        200        210        220        230        240 
EMRQESEQGP CRRHMEASLQ EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC 

       250        260        270 
WCVDKYGMKL PGMEYVDGDF QCHAFDSSNV E 

« Hide

References

« Hide 'large scale' references
[1]"A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation."
James P.L., Jones S.B., Busby W.H. Jr., Clemmons D.R., Rotwein P.
J. Biol. Chem. 268:22305-22312(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Myoblast.
[2]"Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene."
Kou K., Jenkins N.A., Gilbert D.J., Copeland N.G., Rotwein P.
Genomics 20:412-418(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Spleen.
[3]"cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Brain and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12447 mRNA. Translation: AAC37636.1.
U02025 expand/collapse EMBL AC list , U02023, U02027, U02024 Genomic DNA. Translation: AAC01750.1.
X81583 mRNA. Translation: CAA57273.1.
BC054812 mRNA. Translation: AAH54812.1.
BC057447 mRNA. Translation: AAH57447.1.
CCDSCCDS15037.1.
PIRI48604.
RefSeqNP_034648.2. NM_010518.2.
UniGeneMm.405761.

3D structure databases

ProteinModelPortalQ07079.
SMRQ07079. Positions 24-104, 189-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ07079. 1 interaction.

Protein family/group databases

MEROPSI31.952.

PTM databases

PhosphoSiteQ07079.

Proteomic databases

PaxDbQ07079.
PRIDEQ07079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185.
GeneID16011.
KEGGmmu:16011.
UCSCuc007bkx.1. mouse.

Organism-specific databases

CTD3488.
MGIMGI:96440. Igfbp5.

Phylogenomic databases

eggNOGNOG42882.
HOGENOMHOG000253012.
HOVERGENHBG002631.
InParanoidQ07079.
OMAYREQAKI.
OrthoDBEOG74N5HG.
PhylomeDBQ07079.
TreeFamTF331211.

Gene expression databases

ArrayExpressQ07079.
BgeeQ07079.
CleanExMM_IGFBP5.
GenevestigatorQ07079.

Family and domain databases

Gene3D4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIGFBP5. mouse.
NextBio288826.
PMAP-CutDBQ07079.
PROQ07079.
SOURCESearch...

Entry information

Entry nameIBP5_MOUSE
AccessionPrimary (citable) accession number: Q07079
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot