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Protein

Insulin-like growth factor-binding protein 5

Gene

Igfbp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  1. fibronectin binding Source: MGI
  2. insulin-like growth factor I binding Source: MGI
  3. insulin-like growth factor II binding Source: GO_Central

GO - Biological processi

  1. cellular response to cAMP Source: MGI
  2. cellular response to organic cyclic compound Source: MGI
  3. glucose homeostasis Source: MGI
  4. glucose metabolic process Source: MGI
  5. hair follicle morphogenesis Source: MGI
  6. intracellular signal transduction Source: Ensembl
  7. mammary gland involution Source: MGI
  8. negative regulation of cell migration Source: MGI
  9. negative regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  10. negative regulation of osteoblast differentiation Source: MGI
  11. negative regulation of smooth muscle cell migration Source: MGI
  12. negative regulation of smooth muscle cell proliferation Source: MGI
  13. negative regulation of translation Source: MGI
  14. osteoblast differentiation Source: BHF-UCL
  15. positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  16. positive regulation of protein kinase B signaling Source: MGI
  17. regulation of cell growth Source: MGI
  18. regulation of glucose metabolic process Source: MGI
  19. regulation of growth Source: MGI
  20. skeletal muscle tissue growth Source: Ensembl
  21. striated muscle cell differentiation Source: MGI
  22. type B pancreatic cell proliferation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiREACT_235886. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:Igfbp5
Synonyms:Igfbp-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:96440. Igfbp5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: GO_Central
  2. insulin-like growth factor binding protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 271252Insulin-like growth factor-binding protein 5PRO_0000014386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ07079.
PaxDbiQ07079.
PRIDEiQ07079.

PTM databases

PhosphoSiteiQ07079.

Miscellaneous databases

PMAP-CutDBQ07079.

Expressioni

Tissue specificityi

Most abundant in kidney, uterus and gastrocnemius muscle.

Gene expression databases

BgeeiQ07079.
CleanExiMM_IGFBP5.
ExpressionAtlasiQ07079. baseline and differential.
GenevestigatoriQ07079.

Interactioni

Protein-protein interaction databases

IntActiQ07079. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ07079.
SMRiQ07079. Positions 24-104, 189-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10281IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini188 – 26275Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42882.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiQ07079.
OMAiYREQAKI.
OrthoDBiEOG74N5HG.
PhylomeDBiQ07079.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07079-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESEQGP CRRHMEASLQ
210 220 230 240 250
EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHAFDSSNV E
Length:271
Mass (Da):30,372
Last modified:October 1, 1994 - v1
Checksum:iF55A58729861F6F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121Missing in AAC01750. (PubMed:7518410)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12447 mRNA. Translation: AAC37636.1.
U02025
, U02023, U02027, U02024 Genomic DNA. Translation: AAC01750.1.
X81583 mRNA. Translation: CAA57273.1.
BC054812 mRNA. Translation: AAH54812.1.
BC057447 mRNA. Translation: AAH57447.1.
CCDSiCCDS15037.1.
PIRiI48604.
RefSeqiNP_034648.2. NM_010518.2.
UniGeneiMm.405761.

Genome annotation databases

EnsembliENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185.
GeneIDi16011.
KEGGimmu:16011.
UCSCiuc007bkx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12447 mRNA. Translation: AAC37636.1.
U02025
, U02023, U02027, U02024 Genomic DNA. Translation: AAC01750.1.
X81583 mRNA. Translation: CAA57273.1.
BC054812 mRNA. Translation: AAH54812.1.
BC057447 mRNA. Translation: AAH57447.1.
CCDSiCCDS15037.1.
PIRiI48604.
RefSeqiNP_034648.2. NM_010518.2.
UniGeneiMm.405761.

3D structure databases

ProteinModelPortaliQ07079.
SMRiQ07079. Positions 24-104, 189-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ07079. 1 interaction.

Protein family/group databases

MEROPSiI31.952.

PTM databases

PhosphoSiteiQ07079.

Proteomic databases

MaxQBiQ07079.
PaxDbiQ07079.
PRIDEiQ07079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185.
GeneIDi16011.
KEGGimmu:16011.
UCSCiuc007bkx.1. mouse.

Organism-specific databases

CTDi3488.
MGIiMGI:96440. Igfbp5.

Phylogenomic databases

eggNOGiNOG42882.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiQ07079.
OMAiYREQAKI.
OrthoDBiEOG74N5HG.
PhylomeDBiQ07079.
TreeFamiTF331211.

Enzyme and pathway databases

ReactomeiREACT_235886. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

ChiTaRSiIgfbp5. mouse.
NextBioi288826.
PMAP-CutDBQ07079.
PROiQ07079.
SOURCEiSearch...

Gene expression databases

BgeeiQ07079.
CleanExiMM_IGFBP5.
ExpressionAtlasiQ07079. baseline and differential.
GenevestigatoriQ07079.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation."
    James P.L., Jones S.B., Busby W.H. Jr., Clemmons D.R., Rotwein P.
    J. Biol. Chem. 268:22305-22312(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Myoblast.
  2. "Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene."
    Kou K., Jenkins N.A., Gilbert D.J., Copeland N.G., Rotwein P.
    Genomics 20:412-418(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Spleen.
  3. "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
    Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
    Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiIBP5_MOUSE
AccessioniPrimary (citable) accession number: Q07079
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 4, 2015
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.