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Q07079

- IBP5_MOUSE

UniProt

Q07079 - IBP5_MOUSE

Protein

Insulin-like growth factor-binding protein 5

Gene

Igfbp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

    GO - Molecular functioni

    1. fibronectin binding Source: MGI
    2. insulin-like growth factor binding Source: MGI

    GO - Biological processi

    1. cellular response to cAMP Source: Ensembl
    2. glucose homeostasis Source: MGI
    3. glucose metabolic process Source: MGI
    4. hair follicle morphogenesis Source: MGI
    5. intracellular signal transduction Source: Ensembl
    6. mammary gland involution Source: MGI
    7. negative regulation of insulin-like growth factor receptor signaling pathway Source: MGI
    8. negative regulation of osteoblast differentiation Source: MGI
    9. negative regulation of smooth muscle cell migration Source: Ensembl
    10. negative regulation of smooth muscle cell proliferation Source: Ensembl
    11. negative regulation of translation Source: Ensembl
    12. osteoblast differentiation Source: BHF-UCL
    13. positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI
    14. positive regulation of protein kinase B signaling Source: MGI
    15. regulation of cell growth Source: MGI
    16. regulation of glucose metabolic process Source: MGI
    17. regulation of growth Source: MGI
    18. skeletal muscle tissue growth Source: Ensembl
    19. striated muscle cell differentiation Source: MGI
    20. type B pancreatic cell proliferation Source: MGI

    Keywords - Ligandi

    Growth factor binding

    Protein family/group databases

    MEROPSiI31.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 5
    Short name:
    IBP-5
    Short name:
    IGF-binding protein 5
    Short name:
    IGFBP-5
    Gene namesi
    Name:Igfbp5
    Synonyms:Igfbp-5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:96440. Igfbp5.

    Subcellular locationi

    GO - Cellular componenti

    1. insulin-like growth factor binding protein complex Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 271252Insulin-like growth factor-binding protein 5PRO_0000014386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
    Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
    Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
    Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
    Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ07079.
    PRIDEiQ07079.

    PTM databases

    PhosphoSiteiQ07079.

    Miscellaneous databases

    PMAP-CutDBQ07079.

    Expressioni

    Tissue specificityi

    Most abundant in kidney, uterus and gastrocnemius muscle.

    Gene expression databases

    ArrayExpressiQ07079.
    BgeeiQ07079.
    CleanExiMM_IGFBP5.
    GenevestigatoriQ07079.

    Interactioni

    Protein-protein interaction databases

    IntActiQ07079. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07079.
    SMRiQ07079. Positions 24-104, 189-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 10281IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini188 – 26275Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42882.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiQ07079.
    OMAiYREQAKI.
    OrthoDBiEOG74N5HG.
    PhylomeDBiQ07079.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012213. IGFBP-5.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF4. PTHR11551:SF4. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01981. IGFBPFAMILY5.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07079-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP    50
    GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL 100
    NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA 150
    VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESEQGP CRRHMEASLQ 200
    EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL 250
    PGMEYVDGDF QCHAFDSSNV E 271
    Length:271
    Mass (Da):30,372
    Last modified:October 1, 1994 - v1
    Checksum:iF55A58729861F6F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti112 – 1121Missing in AAC01750. (PubMed:7518410)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12447 mRNA. Translation: AAC37636.1.
    U02025
    , U02023, U02027, U02024 Genomic DNA. Translation: AAC01750.1.
    X81583 mRNA. Translation: CAA57273.1.
    BC054812 mRNA. Translation: AAH54812.1.
    BC057447 mRNA. Translation: AAH57447.1.
    CCDSiCCDS15037.1.
    PIRiI48604.
    RefSeqiNP_034648.2. NM_010518.2.
    UniGeneiMm.405761.

    Genome annotation databases

    EnsembliENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185.
    GeneIDi16011.
    KEGGimmu:16011.
    UCSCiuc007bkx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12447 mRNA. Translation: AAC37636.1 .
    U02025
    , U02023 , U02027 , U02024 Genomic DNA. Translation: AAC01750.1 .
    X81583 mRNA. Translation: CAA57273.1 .
    BC054812 mRNA. Translation: AAH54812.1 .
    BC057447 mRNA. Translation: AAH57447.1 .
    CCDSi CCDS15037.1.
    PIRi I48604.
    RefSeqi NP_034648.2. NM_010518.2.
    UniGenei Mm.405761.

    3D structure databases

    ProteinModelPortali Q07079.
    SMRi Q07079. Positions 24-104, 189-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q07079. 1 interaction.

    Protein family/group databases

    MEROPSi I31.952.

    PTM databases

    PhosphoSitei Q07079.

    Proteomic databases

    PaxDbi Q07079.
    PRIDEi Q07079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027377 ; ENSMUSP00000027377 ; ENSMUSG00000026185 .
    GeneIDi 16011.
    KEGGi mmu:16011.
    UCSCi uc007bkx.1. mouse.

    Organism-specific databases

    CTDi 3488.
    MGIi MGI:96440. Igfbp5.

    Phylogenomic databases

    eggNOGi NOG42882.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi Q07079.
    OMAi YREQAKI.
    OrthoDBi EOG74N5HG.
    PhylomeDBi Q07079.
    TreeFami TF331211.

    Miscellaneous databases

    ChiTaRSi IGFBP5. mouse.
    NextBioi 288826.
    PMAP-CutDB Q07079.
    PROi Q07079.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07079.
    Bgeei Q07079.
    CleanExi MM_IGFBP5.
    Genevestigatori Q07079.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012213. IGFBP-5.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF4. PTHR11551:SF4. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01981. IGFBPFAMILY5.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation."
      James P.L., Jones S.B., Busby W.H. Jr., Clemmons D.R., Rotwein P.
      J. Biol. Chem. 268:22305-22312(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Myoblast.
    2. "Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene."
      Kou K., Jenkins N.A., Gilbert D.J., Copeland N.G., Rotwein P.
      Genomics 20:412-418(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Spleen.
    3. "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
      Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
      Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Mammary gland.

    Entry informationi

    Entry nameiIBP5_MOUSE
    AccessioniPrimary (citable) accession number: Q07079
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3