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Q07079

- IBP5_MOUSE

UniProt

Q07079 - IBP5_MOUSE

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Protein

Insulin-like growth factor-binding protein 5

Gene

Igfbp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  1. fibronectin binding Source: MGI
  2. insulin-like growth factor binding Source: MGI

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. glucose homeostasis Source: MGI
  3. glucose metabolic process Source: MGI
  4. hair follicle morphogenesis Source: MGI
  5. intracellular signal transduction Source: Ensembl
  6. mammary gland involution Source: MGI
  7. negative regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  8. negative regulation of osteoblast differentiation Source: MGI
  9. negative regulation of smooth muscle cell migration Source: Ensembl
  10. negative regulation of smooth muscle cell proliferation Source: Ensembl
  11. negative regulation of translation Source: Ensembl
  12. osteoblast differentiation Source: BHF-UCL
  13. positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  14. positive regulation of protein kinase B signaling Source: MGI
  15. regulation of cell growth Source: MGI
  16. regulation of glucose metabolic process Source: MGI
  17. regulation of growth Source: MGI
  18. skeletal muscle tissue growth Source: Ensembl
  19. striated muscle cell differentiation Source: MGI
  20. type B pancreatic cell proliferation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiREACT_235886. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:Igfbp5
Synonyms:Igfbp-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:96440. Igfbp5.

Subcellular locationi

GO - Cellular componenti

  1. insulin-like growth factor binding protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 271252Insulin-like growth factor-binding protein 5PRO_0000014386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ07079.
PaxDbiQ07079.
PRIDEiQ07079.

PTM databases

PhosphoSiteiQ07079.

Miscellaneous databases

PMAP-CutDBQ07079.

Expressioni

Tissue specificityi

Most abundant in kidney, uterus and gastrocnemius muscle.

Gene expression databases

BgeeiQ07079.
CleanExiMM_IGFBP5.
ExpressionAtlasiQ07079. baseline and differential.
GenevestigatoriQ07079.

Interactioni

Protein-protein interaction databases

IntActiQ07079. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ07079.
SMRiQ07079. Positions 24-104, 189-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10281IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini188 – 26275Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42882.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiQ07079.
OMAiYREQAKI.
OrthoDBiEOG74N5HG.
PhylomeDBiQ07079.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07079-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESEQGP CRRHMEASLQ
210 220 230 240 250
EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHAFDSSNV E
Length:271
Mass (Da):30,372
Last modified:October 1, 1994 - v1
Checksum:iF55A58729861F6F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121Missing in AAC01750. (PubMed:7518410)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12447 mRNA. Translation: AAC37636.1.
U02025
, U02023, U02027, U02024 Genomic DNA. Translation: AAC01750.1.
X81583 mRNA. Translation: CAA57273.1.
BC054812 mRNA. Translation: AAH54812.1.
BC057447 mRNA. Translation: AAH57447.1.
CCDSiCCDS15037.1.
PIRiI48604.
RefSeqiNP_034648.2. NM_010518.2.
UniGeneiMm.405761.

Genome annotation databases

EnsembliENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185.
GeneIDi16011.
KEGGimmu:16011.
UCSCiuc007bkx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12447 mRNA. Translation: AAC37636.1 .
U02025
, U02023 , U02027 , U02024 Genomic DNA. Translation: AAC01750.1 .
X81583 mRNA. Translation: CAA57273.1 .
BC054812 mRNA. Translation: AAH54812.1 .
BC057447 mRNA. Translation: AAH57447.1 .
CCDSi CCDS15037.1.
PIRi I48604.
RefSeqi NP_034648.2. NM_010518.2.
UniGenei Mm.405761.

3D structure databases

ProteinModelPortali Q07079.
SMRi Q07079. Positions 24-104, 189-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q07079. 1 interaction.

Protein family/group databases

MEROPSi I31.952.

PTM databases

PhosphoSitei Q07079.

Proteomic databases

MaxQBi Q07079.
PaxDbi Q07079.
PRIDEi Q07079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027377 ; ENSMUSP00000027377 ; ENSMUSG00000026185 .
GeneIDi 16011.
KEGGi mmu:16011.
UCSCi uc007bkx.1. mouse.

Organism-specific databases

CTDi 3488.
MGIi MGI:96440. Igfbp5.

Phylogenomic databases

eggNOGi NOG42882.
HOGENOMi HOG000253012.
HOVERGENi HBG002631.
InParanoidi Q07079.
OMAi YREQAKI.
OrthoDBi EOG74N5HG.
PhylomeDBi Q07079.
TreeFami TF331211.

Enzyme and pathway databases

Reactomei REACT_235886. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

ChiTaRSi Igfbp5. mouse.
NextBioi 288826.
PMAP-CutDB Q07079.
PROi Q07079.
SOURCEi Search...

Gene expression databases

Bgeei Q07079.
CleanExi MM_IGFBP5.
ExpressionAtlasi Q07079. baseline and differential.
Genevestigatori Q07079.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation."
    James P.L., Jones S.B., Busby W.H. Jr., Clemmons D.R., Rotwein P.
    J. Biol. Chem. 268:22305-22312(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Myoblast.
  2. "Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene."
    Kou K., Jenkins N.A., Gilbert D.J., Copeland N.G., Rotwein P.
    Genomics 20:412-418(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Spleen.
  3. "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
    Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
    Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiIBP5_MOUSE
AccessioniPrimary (citable) accession number: Q07079
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 26, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3