Q07079 (IBP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Insulin-like growth factor-binding protein 5
Short name=IBP-5
Short name=IGF-binding protein 5
Short name=IGFBP-5

Gene names

Name:	Igfbp5
Synonyms:	Igfbp-5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular location	Secreted.
Tissue specificity	Most abundant in kidney, uterus and gastrocnemius muscle.
Sequence similarities	Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Growth factor binding
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to cAMP Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from mutant phenotype PubMed 19897600. Source: MGI glucose metabolic process Inferred from mutant phenotype PubMed 19897600. Source: MGI hair follicle morphogenesis Inferred from mutant phenotype PubMed 16024235. Source: MGI intracellular signal transduction Inferred from electronic annotation. Source: Compara mammary gland involution Inferred from mutant phenotype PubMed 17255210. Source: MGI negative regulation of insulin-like growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 16024235. Source: MGI negative regulation of osteoblast differentiation Inferred from genetic interaction PubMed 19208758. Source: MGI negative regulation of smooth muscle cell migration Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of translation Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from expression pattern PubMed 16311053. Source: BHF-UCL positive regulation of insulin-like growth factor receptor signaling pathway Inferred from genetic interaction PubMed 16675541. Source: MGI positive regulation of protein kinase B signaling cascade Inferred from mutant phenotype PubMed 18762576. Source: MGI regulation of cell growth Inferred from genetic interaction PubMed 16675541. Source: MGI regulation of glucose metabolic process Inferred from genetic interaction PubMed 16675541. Source: MGI skeletal muscle tissue growth Inferred from electronic annotation. Source: Compara striated muscle cell differentiation Inferred from mutant phenotype PubMed 18762576. Source: MGI type B pancreatic cell proliferation Inferred from genetic interaction PubMed 16675541. Source: MGI
Cellular_component	insulin-like growth factor binding protein complex Inferred by curator PubMed 14680841. Source: MGI
Molecular_function	fibronectin binding Inferred from direct assay PubMed 19236847. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 271	252	Insulin-like growth factor-binding protein 5		PRO_0000014386
Regions
	Domain	22 – 102	81	IGFBP N-terminal
	Domain	188 – 262	75	Thyroglobulin type-1
Amino acid modifications
	Disulfide bond	44 ↔ 58		By similarity
	Disulfide bond	66 ↔ 79		By similarity
	Disulfide bond	191 ↔ 218		By similarity
	Disulfide bond	229 ↔ 240		By similarity
	Disulfide bond	242 ↔ 262		By similarity
Experimental info
	Sequence conflict	112	1	Missing in AAC01750. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q07079 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: F55A58729861F6F0	FASTA	271	30,372
	10 20 30 40 50 60 MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP GCGCCMTCAL 70 80 90 100 110 120 AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL NEKSYGEQTK IERDSREHEE 130 140 150 160 170 180 PTTSEMAEET YSPKVFRPKH TRISELKAEA VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP 190 200 210 220 230 240 EMRQESEQGP CRRHMEASLQ EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC 250 260 270 WCVDKYGMKL PGMEYVDGDF QCHAFDSSNV E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation." James P.L., Jones S.B., Busby W.H. Jr., Clemmons D.R., Rotwein P. J. Biol. Chem. 268:22305-22312(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Myoblast.
[2]	"Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene." Kou K., Jenkins N.A., Gilbert D.J., Copeland N.G., Rotwein P. Genomics 20:412-418(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Spleen.
[3]	"cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins." Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S. Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and FVB/N. Tissue: Brain and Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L12447 mRNA. Translation: AAC37636.1. U02025 , U02023, U02027, U02024 Genomic DNA. Translation: AAC01750.1. X81583 mRNA. Translation: CAA57273.1. BC054812 mRNA. Translation: AAH54812.1. BC057447 mRNA. Translation: AAH57447.1.
IPI	IPI00114022.
PIR	I48604.
RefSeq	NP_034648.2. NM_010518.2.
UniGene	Mm.405761.
3D structure databases
ProteinModelPortal	Q07079.
SMR	Q07079. Positions 24-104, 189-263.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q07079. 1 interaction.
Protein family/group databases
MEROPS	I31.952.
PTM databases
PhosphoSite	Q07079.
Proteomic databases
PaxDb	Q07079.
PRIDE	Q07079.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185.
GeneID	16011.
KEGG	mmu:16011.
Organism-specific databases
CTD	3488.
MGI	MGI:96440. Igfbp5.
Phylogenomic databases
eggNOG	NOG42882.
HOGENOM	HOG000253012.
HOVERGEN	HBG002631.
InParanoid	Q07079.
OMA	HEPEFGP.
OrthoDB	EOG4RV2RZ.
Gene expression databases
ArrayExpress	Q07079.
Bgee	Q07079.
CleanEx	MM_IGFBP5.
Genevestigator	Q07079.
GermOnline	ENSMUSG00000026185. Mus musculus.
Family and domain databases
Gene3D	4.10.800.10. 1 hit.
InterPro	IPR009030. Growth_fac_rcpt. IPR012213. IGFBP-5. IPR000867. IGFBP-like. IPR009168. IGFBP1-6. IPR022321. IGFBP_1-6_chordata. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000716. Thyroglobulin_1. [Graphical view]
PANTHER	PTHR11551. PTHR11551. 1 hit. PTHR11551:SF4. PTHR11551:SF4. 1 hit.
Pfam	PF00219. IGFBP. 1 hit. PF00086. Thyroglobulin_1. 1 hit. [Graphical view]
PRINTS	PR01976. IGFBPFAMILY. PR01981. IGFBPFAMILY5.
SMART	SM00121. IB. 1 hit. SM00211. TY. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 1 hit. SSF57610. Thyroglobulin_1. 1 hit.
PROSITE	PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS00484. THYROGLOBULIN_1_1. 1 hit. PS51162. THYROGLOBULIN_1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IGFBP5. mouse.
NextBio	288826.
PMAP-CutDB	Q07079.
SOURCE	Search...

Entry information

Entry name

IBP5_MOUSE

Accession

Primary (citable) accession number: Q07079

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 1, 2013
This is version 126 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program