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Protein

Annexin A7

Gene

Anxa7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

GO - Molecular functioni

GO - Biological processi

  • autophagy Source: MGI
  • cell proliferation Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cellular water homeostasis Source: MGI
  • epithelial cell differentiation Source: Ensembl
  • hemostasis Source: MGI
  • membrane fusion Source: Ensembl
  • negative regulation of gene expression Source: MGI
  • regulation of cell shape Source: MGI
  • response to calcium ion Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • response to salt stress Source: MGI
  • social behavior Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A7
Alternative name(s):
Annexin VII
Annexin-7
Synexin
Gene namesi
Name:Anxa7
Synonyms:Anx7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:88031. Anxa7.

Subcellular locationi

GO - Cellular componenti

  • chromaffin granule membrane Source: Ensembl
  • cytosol Source: MGI
  • endoplasmic reticulum membrane Source: MGI
  • extracellular exosome Source: MGI
  • membrane Source: MGI
  • nuclear envelope Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675001 – 463Annexin A7Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ07076.
MaxQBiQ07076.
PaxDbiQ07076.
PeptideAtlasiQ07076.
PRIDEiQ07076.

2D gel databases

REPRODUCTION-2DPAGEQ07076.

PTM databases

iPTMnetiQ07076.
PhosphoSitePlusiQ07076.
SwissPalmiQ07076.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021814.
CleanExiMM_ANXA7.
GenevisibleiQ07076. MM.

Interactioni

Subunit structurei

Interacts with PDCD6.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SRIP050442EBI-10824194,EBI-10816377From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198113. 3 interactors.
IntActiQ07076. 1 interactor.
MINTiMINT-1869654.
STRINGi10090.ENSMUSP00000066035.

Structurei

3D structure databases

ProteinModelPortaliQ07076.
SMRiQ07076.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 915
Repeati10 – 1425
Repeati16 – 2035
Repeati169 – 229Annexin 1Add BLAST61
Repeati241 – 301Annexin 2Add BLAST61
Repeati324 – 384Annexin 3Add BLAST61
Repeati400 – 460Annexin 4Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 143Repeat-rich regionAdd BLAST143
Regioni5 – 203 X 5 AA tandem repeats of G-Y-P-P-XAdd BLAST16

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiQ07076.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PANTHERiPTHR10502:SF110. PTHR10502:SF110. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPGYPPTG YPPFPGYPPA GQESSFPTAG QYPYPSGFPP MGGGAYPPAP
60 70 80 90 100
SGGYPGAGGY PAPGGYPAPG GYPGALSPGG PPAYPGGQGF GAPPGGAGFS
110 120 130 140 150
GYPQPPAQSY GGGPAQVPVP GGFPGGQMPS QYPGGQAPYP SQPASMTQGT
160 170 180 190 200
QGTILPASNF DAMRDAEILR KAMKGFGTDE QAIVDVVSNR SNDQRQQIKA
210 220 230 240 250
AFKTMYGKDL IKDLKSELSG NMEELILALF MPSTYYDAWS LRKAMQGAGT
260 270 280 290 300
QERVLIEILC TRTNQEIRDI VRCYQLEFGR DLEKDIRSDT SGHFERLLVS
310 320 330 340 350
MCQGNRDERQ SVNHQMAQED AQRLYQAGEG RLGTDESCFN MILATRSFPQ
360 370 380 390 400
LKATMEAYSR MANRDLLSSV SREFSGYVES GLKTILQCAL NRPAFFAERL
410 420 430 440 450
YYSMKGAGTD DSTLVRIVVT RSEIDLVQIK QMFTQMYQKT LSTMIASDTS
460
GDYRKLLLAI VGQ
Length:463
Mass (Da):49,925
Last modified:July 27, 2011 - v2
Checksum:i73339650748B4689
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti304G → A in AAA37238 (PubMed:7916616).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13129 mRNA. Translation: AAA37238.1.
AK151438 mRNA. Translation: BAE30401.1.
AK161613 mRNA. Translation: BAE36492.1.
AK169199 mRNA. Translation: BAE40974.1.
CH466613 Genomic DNA. Translation: EDL01512.1.
CCDSiCCDS26845.1.
RefSeqiNP_001104264.1. NM_001110794.1.
NP_033804.2. NM_009674.3.
UniGeneiMm.280231.
Mm.474616.

Genome annotation databases

EnsembliENSMUST00000065504; ENSMUSP00000066035; ENSMUSG00000021814.
ENSMUST00000100844; ENSMUSP00000098405; ENSMUSG00000021814.
GeneIDi11750.
KEGGimmu:11750.
UCSCiuc007sjr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13129 mRNA. Translation: AAA37238.1.
AK151438 mRNA. Translation: BAE30401.1.
AK161613 mRNA. Translation: BAE36492.1.
AK169199 mRNA. Translation: BAE40974.1.
CH466613 Genomic DNA. Translation: EDL01512.1.
CCDSiCCDS26845.1.
RefSeqiNP_001104264.1. NM_001110794.1.
NP_033804.2. NM_009674.3.
UniGeneiMm.280231.
Mm.474616.

3D structure databases

ProteinModelPortaliQ07076.
SMRiQ07076.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198113. 3 interactors.
IntActiQ07076. 1 interactor.
MINTiMINT-1869654.
STRINGi10090.ENSMUSP00000066035.

PTM databases

iPTMnetiQ07076.
PhosphoSitePlusiQ07076.
SwissPalmiQ07076.

2D gel databases

REPRODUCTION-2DPAGEQ07076.

Proteomic databases

EPDiQ07076.
MaxQBiQ07076.
PaxDbiQ07076.
PeptideAtlasiQ07076.
PRIDEiQ07076.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065504; ENSMUSP00000066035; ENSMUSG00000021814.
ENSMUST00000100844; ENSMUSP00000098405; ENSMUSG00000021814.
GeneIDi11750.
KEGGimmu:11750.
UCSCiuc007sjr.2. mouse.

Organism-specific databases

CTDi310.
MGIiMGI:88031. Anxa7.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiQ07076.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Miscellaneous databases

PROiQ07076.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021814.
CleanExiMM_ANXA7.
GenevisibleiQ07076. MM.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PANTHERiPTHR10502:SF110. PTHR10502:SF110. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA7_MOUSE
AccessioniPrimary (citable) accession number: Q07076
Secondary accession number(s): Q3TT33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.