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Q07066

- PXMP2_RAT

UniProt

Q07066 - PXMP2_RAT

Protein

Peroxisomal membrane protein 2

Gene

Pxmp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein 2
    Alternative name(s):
    22 kDa peroxisomal membrane protein
    Gene namesi
    Name:Pxmp2
    Synonyms:Pmp22
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi61812. Pxmp2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: RGD
    2. peroxisomal membrane Source: UniProtKB
    3. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 194193Peroxisomal membrane protein 2PRO_0000218931Add
    BLAST

    Proteomic databases

    PaxDbiQ07066.
    PRIDEiQ07066.

    Expressioni

    Gene expression databases

    GenevestigatoriQ07066.

    Interactioni

    Subunit structurei

    Interacts with PEX19 and SIVA1.By similarity

    Protein-protein interaction databases

    BioGridi248168. 1 interaction.
    STRINGi10116.ENSRNOP00000053518.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 3029CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini52 – 7423PeroxisomalSequence AnalysisAdd
    BLAST
    Topological domaini96 – 11318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini135 – 17238PeroxisomalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293053.
    HOGENOMiHOG000008014.
    HOVERGENiHBG052506.
    InParanoidiQ07066.
    KOiK13347.
    PhylomeDBiQ07066.

    Family and domain databases

    InterProiIPR007248. Mpv17_PMP22.
    [Graphical view]
    PANTHERiPTHR11266. PTHR11266. 1 hit.
    PfamiPF04117. Mpv17_PMP22. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07066-1 [UniParc]FASTAAdd to Basket

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    MAPAASRLRV ESELRSLPKR ALAQYLLFLK FYPVVTKAVS SGILSALGNL    50
    LAQMIEKKQK KDSRSLEVSG LLRYLVYGLF VTGPLSHYLY LFMEYWVPPE 100
    VPWARVKRLL LDRLFFAPTF LLLFFFVMNL LEGKNISVFV AKMRSGFWPA 150
    LQMNWRMWTP LQFININYVP LQFRVLFANM AALFWYAYLA SLGK 194
    Length:194
    Mass (Da):22,577
    Last modified:January 23, 2007 - v2
    Checksum:i4BEDB2CEBE52EAAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70223 mRNA. Translation: CAA49756.1.
    PIRiS28850.
    RefSeqiNP_113775.1. NM_031587.1.
    UniGeneiRn.10292.

    Genome annotation databases

    GeneIDi29533.
    KEGGirno:29533.
    UCSCiRGD:61812. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70223 mRNA. Translation: CAA49756.1 .
    PIRi S28850.
    RefSeqi NP_113775.1. NM_031587.1.
    UniGenei Rn.10292.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248168. 1 interaction.
    STRINGi 10116.ENSRNOP00000053518.

    Proteomic databases

    PaxDbi Q07066.
    PRIDEi Q07066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29533.
    KEGGi rno:29533.
    UCSCi RGD:61812. rat.

    Organism-specific databases

    CTDi 5827.
    RGDi 61812. Pxmp2.

    Phylogenomic databases

    eggNOGi NOG293053.
    HOGENOMi HOG000008014.
    HOVERGENi HBG052506.
    InParanoidi Q07066.
    KOi K13347.
    PhylomeDBi Q07066.

    Miscellaneous databases

    NextBioi 609512.

    Gene expression databases

    Genevestigatori Q07066.

    Family and domain databases

    InterProi IPR007248. Mpv17_PMP22.
    [Graphical view ]
    PANTHERi PTHR11266. PTHR11266. 1 hit.
    Pfami PF04117. Mpv17_PMP22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Membrane topology of the 22 kDa integral peroxisomal membrane protein."
      Kaldi K., Diestelkoetter P., Stenbeck G., Auerbach S., Jaekle U., Maegert H.-J., Wieland F.T., Just W.W.
      FEBS Lett. 315:217-222(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-19; 31-37; 135-139 AND 145-154.
      Tissue: Liver.

    Entry informationi

    Entry nameiPXMP2_RAT
    AccessioniPrimary (citable) accession number: Q07066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3