Q07066 (PXMP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal membrane protein 2

Alternative name(s):
22 kDa peroxisomal membrane protein

Gene names

Name:	Pxmp2
Synonyms:	Pmp22

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
Subunit structure	Interacts with PEX19 and SIVA1 By similarity.
Subcellular location	Peroxisome membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the peroxisomal membrane protein PXMP2/4 family.

Ontologies

Keywords
Cellular component	Membrane Peroxisome
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to peroxisomal membrane Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 194	193	Peroxisomal membrane protein 2		PRO_0000218931
Regions
	Topological domain	2 – 30	29	Cytoplasmic Potential
	Transmembrane	31 – 51	21	Helical; Potential
	Topological domain	52 – 74	23	Peroxisomal Potential
	Transmembrane	75 – 95	21	Helical; Potential
	Topological domain	96 – 113	18	Cytoplasmic Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Topological domain	135 – 172	38	Peroxisomal Potential
	Transmembrane	173 – 193	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q07066 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 4BEDB2CEBE52EAAC	FASTA	194	22,577
	10 20 30 40 50 60 MAPAASRLRV ESELRSLPKR ALAQYLLFLK FYPVVTKAVS SGILSALGNL LAQMIEKKQK 70 80 90 100 110 120 KDSRSLEVSG LLRYLVYGLF VTGPLSHYLY LFMEYWVPPE VPWARVKRLL LDRLFFAPTF 130 140 150 160 170 180 LLLFFFVMNL LEGKNISVFV AKMRSGFWPA LQMNWRMWTP LQFININYVP LQFRVLFANM 190 AALFWYAYLA SLGK

References

[1]

"Membrane topology of the 22 kDa integral peroxisomal membrane protein." Kaldi K., Diestelkoetter P., Stenbeck G., Auerbach S., Jaekle U., Maegert H.-J., Wieland F.T., Just W.W. FEBS Lett. 315:217-222(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-19; 31-37; 135-139 AND 145-154. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70223 mRNA. Translation: CAA49756.1.
IPI	IPI00231204.
PIR	S28850.
RefSeq	NP_113775.1. NM_031587.1.
UniGene	Rn.10292.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000053518.
Proteomic databases
PaxDb	Q07066.
PRIDE	Q07066.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	29533.
KEGG	rno:29533.
UCSC	RGD:61812. rat.
Organism-specific databases
CTD	5827.
RGD	61812. Pxmp2.
Phylogenomic databases
eggNOG	NOG293053.
HOGENOM	HOG000008014.
HOVERGEN	HBG052506.
InParanoid	Q07066.
KO	K13347.
OrthoDB	EOG4STS5T.
Gene expression databases
ArrayExpress	Q07066.
Genevestigator	Q07066.
GermOnline	ENSRNOG00000037446. Rattus norvegicus.
Family and domain databases
InterPro	IPR007248. Mpv17_PMP22. [Graphical view]
PANTHER	PTHR11266. PTHR11266. 1 hit.
Pfam	PF04117. Mpv17_PMP22. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	609512.

Entry information

Entry name

PXMP2_RAT

Accession

Primary (citable) accession number: Q07066

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program