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Protein

Peroxisomal membrane protein 2

Gene

Pxmp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 2
Alternative name(s):
22 kDa peroxisomal membrane protein
Gene namesi
Name:Pxmp2
Synonyms:Pmp22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi61812. Pxmp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3029CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Topological domaini52 – 7423PeroxisomalSequence AnalysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Topological domaini96 – 11318CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 17238PeroxisomalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: RGD
  2. peroxisomal membrane Source: UniProtKB
  3. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 194193Peroxisomal membrane protein 2PRO_0000218931Add
BLAST

Proteomic databases

PaxDbiQ07066.
PRIDEiQ07066.

Expressioni

Gene expression databases

GenevestigatoriQ07066.

Interactioni

Subunit structurei

Interacts with PEX19 and SIVA1.By similarity

Protein-protein interaction databases

BioGridi248168. 1 interaction.
STRINGi10116.ENSRNOP00000053518.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293053.
HOGENOMiHOG000008014.
HOVERGENiHBG052506.
InParanoidiQ07066.
KOiK13347.
PhylomeDBiQ07066.

Family and domain databases

InterProiIPR007248. Mpv17_PMP22.
[Graphical view]
PANTHERiPTHR11266. PTHR11266. 1 hit.
PfamiPF04117. Mpv17_PMP22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07066-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPAASRLRV ESELRSLPKR ALAQYLLFLK FYPVVTKAVS SGILSALGNL
60 70 80 90 100
LAQMIEKKQK KDSRSLEVSG LLRYLVYGLF VTGPLSHYLY LFMEYWVPPE
110 120 130 140 150
VPWARVKRLL LDRLFFAPTF LLLFFFVMNL LEGKNISVFV AKMRSGFWPA
160 170 180 190
LQMNWRMWTP LQFININYVP LQFRVLFANM AALFWYAYLA SLGK
Length:194
Mass (Da):22,577
Last modified:January 23, 2007 - v2
Checksum:i4BEDB2CEBE52EAAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70223 mRNA. Translation: CAA49756.1.
PIRiS28850.
RefSeqiNP_113775.1. NM_031587.1.
UniGeneiRn.10292.

Genome annotation databases

GeneIDi29533.
KEGGirno:29533.
UCSCiRGD:61812. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70223 mRNA. Translation: CAA49756.1.
PIRiS28850.
RefSeqiNP_113775.1. NM_031587.1.
UniGeneiRn.10292.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248168. 1 interaction.
STRINGi10116.ENSRNOP00000053518.

Proteomic databases

PaxDbiQ07066.
PRIDEiQ07066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29533.
KEGGirno:29533.
UCSCiRGD:61812. rat.

Organism-specific databases

CTDi5827.
RGDi61812. Pxmp2.

Phylogenomic databases

eggNOGiNOG293053.
HOGENOMiHOG000008014.
HOVERGENiHBG052506.
InParanoidiQ07066.
KOiK13347.
PhylomeDBiQ07066.

Miscellaneous databases

NextBioi609512.

Gene expression databases

GenevestigatoriQ07066.

Family and domain databases

InterProiIPR007248. Mpv17_PMP22.
[Graphical view]
PANTHERiPTHR11266. PTHR11266. 1 hit.
PfamiPF04117. Mpv17_PMP22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Membrane topology of the 22 kDa integral peroxisomal membrane protein."
    Kaldi K., Diestelkoetter P., Stenbeck G., Auerbach S., Jaekle U., Maegert H.-J., Wieland F.T., Just W.W.
    FEBS Lett. 315:217-222(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-19; 31-37; 135-139 AND 145-154.
    Tissue: Liver.

Entry informationi

Entry nameiPXMP2_RAT
AccessioniPrimary (citable) accession number: Q07066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.