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Q07066 (PXMP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal membrane protein 2
Alternative name(s):
22 kDa peroxisomal membrane protein
Gene names
Name:Pxmp2
Synonyms:Pmp22
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

Subunit structure

Interacts with PEX19 and SIVA1 By similarity.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the peroxisomal membrane protein PXMP2/4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 194193Peroxisomal membrane protein 2
PRO_0000218931

Regions

Topological domain2 – 3029Cytoplasmic Potential
Transmembrane31 – 5121Helical; Potential
Topological domain52 – 7423Peroxisomal Potential
Transmembrane75 – 9521Helical; Potential
Topological domain96 – 11318Cytoplasmic Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 17238Peroxisomal Potential
Transmembrane173 – 19321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q07066 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4BEDB2CEBE52EAAC

FASTA19422,577
        10         20         30         40         50         60 
MAPAASRLRV ESELRSLPKR ALAQYLLFLK FYPVVTKAVS SGILSALGNL LAQMIEKKQK 

        70         80         90        100        110        120 
KDSRSLEVSG LLRYLVYGLF VTGPLSHYLY LFMEYWVPPE VPWARVKRLL LDRLFFAPTF 

       130        140        150        160        170        180 
LLLFFFVMNL LEGKNISVFV AKMRSGFWPA LQMNWRMWTP LQFININYVP LQFRVLFANM 

       190 
AALFWYAYLA SLGK 

« Hide

References

[1]"Membrane topology of the 22 kDa integral peroxisomal membrane protein."
Kaldi K., Diestelkoetter P., Stenbeck G., Auerbach S., Jaekle U., Maegert H.-J., Wieland F.T., Just W.W.
FEBS Lett. 315:217-222(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-19; 31-37; 135-139 AND 145-154.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70223 mRNA. Translation: CAA49756.1.
PIRS28850.
RefSeqNP_113775.1. NM_031587.1.
UniGeneRn.10292.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248168. 1 interaction.
STRING10116.ENSRNOP00000053518.

Proteomic databases

PaxDbQ07066.
PRIDEQ07066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29533.
KEGGrno:29533.
UCSCRGD:61812. rat.

Organism-specific databases

CTD5827.
RGD61812. Pxmp2.

Phylogenomic databases

eggNOGNOG293053.
HOGENOMHOG000008014.
HOVERGENHBG052506.
InParanoidQ07066.
KOK13347.
PhylomeDBQ07066.

Gene expression databases

GenevestigatorQ07066.

Family and domain databases

InterProIPR007248. Mpv17_PMP22.
[Graphical view]
PANTHERPTHR11266. PTHR11266. 1 hit.
PfamPF04117. Mpv17_PMP22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609512.

Entry information

Entry namePXMP2_RAT
AccessionPrimary (citable) accession number: Q07066
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families