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Q07064 (FTHS_CLOCY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
OrganismClostridium cylindrosporum
Taxonomic identifier1495 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199339

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07064 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 44C16B0A957890FB

FASTA55659,096
        10         20         30         40         50         60 
MKTDVQIAQE AQMKPITEVA NYLGIQDDEL ELYGKYKAKV SLDVLERQKD KEDAKLVLVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTTNVGLSM GLNKIGKRTI TALREPSLGP CFGVKGGAAG GGYAQVVPMD 

       130        140        150        160        170        180 
DINLHFTGDF HAITSAHNLL AALLDNHLHQ GNALNINPKK IVWKRVIDMN DRSLRNVIIG 

       190        200        210        220        230        240 
LGGNGDGFVR QAQFDITVAS EIMAILCLAT SMSDLKERLS KMIVAYAKDG SAVTAGQLEA 

       250        260        270        280        290        300 
TGAMALLLKD AVKPNLVQTL ENTPAFIHGG PFANIAHGCN SVLATKVALK LADYVVTEGG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKSRFAGL KPNCDVSVAT VRALKMNGGV PKTELAAENV EAVKKGVANL 

       370        380        390        400        410        420 
ERHIENVAKF GVPAVVAINK FPLDTEAELK AVEDACNAKG ADVVLSDVWA NGGEGGVEMA 

       430        440        450        460        470        480 
KKVVEICEKN EANFAPLYDV NLSIPEKIEK IATTIYRADG VDFTSDCKKQ IAELEKLGLD 

       490        500        510        520        530        540 
KMPICMAKTQ YSFSDDPTLL GAPTGFRITV REVRVSAGAG FIVALTGNMM TMPGLPKVPA 

       550 
ANGMDILESG EIIGLS 

« Hide

References

[1]"Sequence and expression of the gene for N10-formyltetrahydrofolate synthetase from Clostridium cylindrosporum."
Rankin C.A., Haslam G.C., Himes R.H.
Protein Sci. 2:197-205(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12465 Genomic DNA. Translation: AAA23239.1.
PIRI40808.

3D structure databases

ProteinModelPortalQ07064.
SMRQ07064. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-13114.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CLOCY
AccessionPrimary (citable) accession number: Q07064
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways