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Q07064

- FTHS_CLOCY

UniProt

Q07064 - FTHS_CLOCY

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs
Organism
Clostridium cylindrosporum
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13114.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
OrganismiClostridium cylindrosporum
Taxonomic identifieri1495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199339Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ07064.
SMRiQ07064. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07064-1 [UniParc]FASTAAdd to Basket

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MKTDVQIAQE AQMKPITEVA NYLGIQDDEL ELYGKYKAKV SLDVLERQKD    50
KEDAKLVLVT AINPTPAGEG KTTTNVGLSM GLNKIGKRTI TALREPSLGP 100
CFGVKGGAAG GGYAQVVPMD DINLHFTGDF HAITSAHNLL AALLDNHLHQ 150
GNALNINPKK IVWKRVIDMN DRSLRNVIIG LGGNGDGFVR QAQFDITVAS 200
EIMAILCLAT SMSDLKERLS KMIVAYAKDG SAVTAGQLEA TGAMALLLKD 250
AVKPNLVQTL ENTPAFIHGG PFANIAHGCN SVLATKVALK LADYVVTEGG 300
FGADLGAEKF FDIKSRFAGL KPNCDVSVAT VRALKMNGGV PKTELAAENV 350
EAVKKGVANL ERHIENVAKF GVPAVVAINK FPLDTEAELK AVEDACNAKG 400
ADVVLSDVWA NGGEGGVEMA KKVVEICEKN EANFAPLYDV NLSIPEKIEK 450
IATTIYRADG VDFTSDCKKQ IAELEKLGLD KMPICMAKTQ YSFSDDPTLL 500
GAPTGFRITV REVRVSAGAG FIVALTGNMM TMPGLPKVPA ANGMDILESG 550
EIIGLS 556
Length:556
Mass (Da):59,096
Last modified:October 1, 1994 - v1
Checksum:i44C16B0A957890FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12465 Genomic DNA. Translation: AAA23239.1.
PIRiI40808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12465 Genomic DNA. Translation: AAA23239.1 .
PIRi I40808.

3D structure databases

ProteinModelPortali Q07064.
SMRi Q07064. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MetaCyc:MONOMER-13114.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and expression of the gene for N10-formyltetrahydrofolate synthetase from Clostridium cylindrosporum."
    Rankin C.A., Haslam G.C., Himes R.H.
    Protein Sci. 2:197-205(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFTHS_CLOCY
AccessioniPrimary (citable) accession number: Q07064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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