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Q07064

- FTHS_CLOCY

UniProt

Q07064 - FTHS_CLOCY

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium cylindrosporum
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-13114.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    OrganismiClostridium cylindrosporum
    Taxonomic identifieri1495 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000199339Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ07064.
    SMRiQ07064. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q07064-1 [UniParc]FASTAAdd to Basket

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    MKTDVQIAQE AQMKPITEVA NYLGIQDDEL ELYGKYKAKV SLDVLERQKD    50
    KEDAKLVLVT AINPTPAGEG KTTTNVGLSM GLNKIGKRTI TALREPSLGP 100
    CFGVKGGAAG GGYAQVVPMD DINLHFTGDF HAITSAHNLL AALLDNHLHQ 150
    GNALNINPKK IVWKRVIDMN DRSLRNVIIG LGGNGDGFVR QAQFDITVAS 200
    EIMAILCLAT SMSDLKERLS KMIVAYAKDG SAVTAGQLEA TGAMALLLKD 250
    AVKPNLVQTL ENTPAFIHGG PFANIAHGCN SVLATKVALK LADYVVTEGG 300
    FGADLGAEKF FDIKSRFAGL KPNCDVSVAT VRALKMNGGV PKTELAAENV 350
    EAVKKGVANL ERHIENVAKF GVPAVVAINK FPLDTEAELK AVEDACNAKG 400
    ADVVLSDVWA NGGEGGVEMA KKVVEICEKN EANFAPLYDV NLSIPEKIEK 450
    IATTIYRADG VDFTSDCKKQ IAELEKLGLD KMPICMAKTQ YSFSDDPTLL 500
    GAPTGFRITV REVRVSAGAG FIVALTGNMM TMPGLPKVPA ANGMDILESG 550
    EIIGLS 556
    Length:556
    Mass (Da):59,096
    Last modified:October 1, 1994 - v1
    Checksum:i44C16B0A957890FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12465 Genomic DNA. Translation: AAA23239.1.
    PIRiI40808.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12465 Genomic DNA. Translation: AAA23239.1 .
    PIRi I40808.

    3D structure databases

    ProteinModelPortali Q07064.
    SMRi Q07064. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MetaCyc:MONOMER-13114.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and expression of the gene for N10-formyltetrahydrofolate synthetase from Clostridium cylindrosporum."
      Rankin C.A., Haslam G.C., Himes R.H.
      Protein Sci. 2:197-205(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiFTHS_CLOCY
    AccessioniPrimary (citable) accession number: Q07064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3