##gff-version 3
Q07050	UniProtKB	Initiator methionine	1	1	.	.	.	Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Chain	2	767	.	.	.	ID=PRO_0000145200;Note=DNA topoisomerase 1	
Q07050	UniProtKB	Domain	434	767	.	.	.	Note=Topo IB-type catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01382	
Q07050	UniProtKB	Region	1	201	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q07050	UniProtKB	Region	427	428	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Region	490	495	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Region	587	589	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Compositional bias	1	26	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q07050	UniProtKB	Compositional bias	36	201	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q07050	UniProtKB	Active site	725	725	.	.	.	Note=O-(3'-phospho-DNA)-tyrosine intermediate;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01382,ECO:0000255|PROSITE-ProRule:PRU10130	
Q07050	UniProtKB	Site	318	318	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Site	366	366	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Site	414	414	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Site	445	445	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Site	503	503	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Site	534	534	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Site	576	576	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Site	634	634	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Site	652	652	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Modified residue	2	2	.	.	.	Note=N-acetylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Modified residue	2	2	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Modified residue	10	10	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Modified residue	59	59	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Modified residue	114	114	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Modified residue	174	174	.	.	.	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04750	
Q07050	UniProtKB	Modified residue	282	282	.	.	.	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Modified residue	508	508	.	.	.	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	103	103	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	105	105	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q07050	UniProtKB	Cross-link	105	105	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	119	119	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q07050	UniProtKB	Cross-link	119	119	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	119	119	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	136	136	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	150	150	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	155	155	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q07050	UniProtKB	Cross-link	155	155	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	160	160	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	166	166	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	174	174	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	206	206	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	338	338	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	551	551	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	644	644	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	702	702	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Cross-link	714	714	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11387	
Q07050	UniProtKB	Natural variant	505	505	.	.	.	Note=In CPT-resistant cell. S->G