Complement component 1 Q subcomponent-binding protein, mitochondrial precursor

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Reviewed, UniProtKB/Swiss-Prot Q07021 (C1QBP_HUMAN)

Last modified July 7, 2009. Version 95. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Complement component 1 Q subcomponent-binding protein, mitochondrial
Alternative name(s):
    Glycoprotein gC1qBP
      Short name=C1qBP
    GC1q-R protein
    Hyaluronan-binding protein 1
    Mitochondrial matrix protein p32
    p33

Gene names

Name:	C1QBP
Synonyms:	GC1QBP, HABP1, SF2P32

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Not known. Binds to the globular "heads" of C1Q thus inhibiting C1 activation.
Subunit structure	Interacts with Rubella virus capsid protein. Ref.9
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the MAM33 family.
Caution	Was originally (Ref.7 and Ref.1) thought to be a pre-mRNA splicing factor SF2 p32 subunit and to play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.

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Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Mitochondrion
Domain	Transit peptide
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	immune response Ref.2 Traceable author statement. Source: ProtInc interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAT2	P48634	1	EBI-347528,EBI-347545
HNRNPD	Q14103-3	1	EBI-347528,EBI-432539

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 73

Mitochondrion Ref.7

Chain

74 – 282

209

Complement component 1 Q subcomponent-binding protein, mitochondrial

PRO_0000018590

Amino acid modifications

Modified residue

188

Phosphotyrosine Ref.10

Modified residue

201

Phosphoserine Ref.11

Secondary structure

282

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q07021-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 2F747FA73BB1314B
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FASTA

282

31,362

        10         20         30         40         50         60 
MLPLLRCVPR VLGSSVAGLR AAAPASPFRQ LLQPAPRLCT RPFGLLSVRA GSERRPGLLR 

        70         80         90        100        110        120 
PRGPCACGCG CGSLHTDGDK AFVDFLSDEI KEERKIQKHK TLPKMSGGWE LELNGTEAKL 

       130        140        150        160        170        180 
VRKVAGEKIT VTFNINNSIP PTFDGEEEPS QGQKVEEQEP ELTSTPNFVV EVIKNDDGKK 

       190        200        210        220        230        240 
ALVLDCHYPE DEVGQEDEAE SDIFSIREVS FQSTGESEWK DTNYTLNTDS LDWALYDHLM 

       250        260        270        280 
DFLADRGVDN TFADELVELS TALEHQEYIT FLEDLKSFVK SQ

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a cDNA covering the complete coding region of the P32 subunit of human pre-mRNA splicing factor SF2." Honore B., Madsen P., Rasmussen H.H., Vandekerckhove J., Celis J.E., Leffers H. Gene 134:283-287(1993) [PubMed: 8262387] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 74; 76-93 AND 208-216. Tissue: Fibroblast.
[2]	"Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular 'heads' of C1q." Ghebrehiwet B., Lim B.L., Peerschke E.I., Willis A.C., Reid K.B. J. Exp. Med. 179:1809-1821(1994) [PubMed: 8195709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]	"The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis." Tye A.J., Ghebrehiwet B., Guo N., Sastry K.N., Chow B.K.C., Peerschke E.I.B., Lim B.L. J. Biol. Chem. 276:17069-17075(2001) [PubMed: 11278463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	SeattleSNPs variation discovery resource Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Ovary.
[7]	"Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators." Krainer A.R., Mayeda A., Kozak D., Binns G. Cell 66:383-394(1991) [PubMed: 1830244] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-282, PROTEIN SEQUENCE OF 74-114.
[8]	"Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2." Deb T.B., Datta K. J. Biol. Chem. 271:2206-2212(1996) [PubMed: 8567680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 86-282.
[9]	"Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria." Beatch M.D., Hobman T.C. J. Virol. 74:5569-5576(2000) [PubMed: 10823864] [Abstract] Cited for: INTERACTION WITH RUBELLA VIRUS CAPSID PROTEIN.
[10]	"Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction." Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R. Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed: 17693683] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-188, MASS SPECTROMETRY.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, MASS SPECTROMETRY.
[12]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[13]	"Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein." Jiang J., Zhang Y., Krainer A.R., Xu R.-M. Proc. Natl. Acad. Sci. U.S.A. 96:3572-3577(1999) [PubMed: 10097078] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
+	Additional computationally mapped references.

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Web resources

SeattleSNPs

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Cross-references

Sequence databases

L04636 mRNA. Translation: AAA16315.1.
X75913 mRNA. Translation: CAA53512.1.
AF338439 Genomic DNA. Translation: AAK26580.1.
BT019898 mRNA. Translation: AAV38701.1.
BT019899 mRNA. Translation: AAV38702.1.
DQ372108 Genomic DNA. Translation: ABC79624.1.
BC000435 mRNA. Translation: AAH00435.1.
BC013731 mRNA. Translation: AAH13731.1.
M69039 mRNA. Translation: AAA73055.1.
AF275902 mRNA. Translation: AAF78763.1.

IPI

IPI00014230.

PIR

JT0762.

RefSeq

NP_001203.1.

UniGene

Hs.555866

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1P32	X-ray	2.25	A/B/C	75-282	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q07021. 20 interactions.

PTM databases

PhosphoSite

Q07021.

2-D gel databases

DOSAC-COBS-2DPAGE

Q07021.

OGP

Q07021.

Proteomic databases

PRIDE

Q07021.

Genome annotation databases

Ensembl

ENSG00000108561. Homo sapiens. [Contig view]

GeneID

708.

KEGG

hsa:708.

NMPDR

fig|9606.3.peg.12956.

UCSC

uc002gby.1. human.

Organism-specific databases

GeneCards

GC17M005276.

H-InvDB

HIX0013469.

HGNC

HGNC:1243. C1QBP.

MIM

601269. gene.

PharmGKB

PA25624.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q07021.

HOVERGEN

Q07021.

OMA

Q07021. GLHTEGD.

Enzyme and pathway databases

Reactome

REACT_604. Hemostasis.

Gene expression databases

ArrayExpress

Q07021.

Bgee

Q07021.

CleanEx

HS_C1QBP.

GermOnline

ENSG00000108561. Homo sapiens.

Family and domain databases

InterPro

IPR003428. MAM33.
[Graphical view]

Gene3D

G3DSA:3.10.280.10. MAM33. 1 hit.

Pfam

PF02330. MAM33. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

2880.

PMAP-CutDB

Q07021.

SOURCE

Search...

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Entry information

Entry name

C1QBP_HUMAN

Accession

Primary (citable) accession number: Q07021
Secondary accession number(s): Q2HXR8, Q9NNY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	July 7, 2009
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2-D gel databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents