Q07020 (RL18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L18

Gene names

Name:

RPL18

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the ribosomal protein L18e family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay Ref.4. Source: UniProtKB
Molecular_function	RNA binding Traceable author statement Ref.1. Source: ProtInc structural constituent of ribosome Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 188	187	60S ribosomal protein L18		PRO_0000132769
Amino acid modifications
	Modified residue	130	1	Phosphoserine Ref.5 Ref.6 Ref.7 Ref.8 Ref.10
	Modified residue	158	1	Phosphothreonine Ref.7
Experimental info
	Sequence conflict	62	1	S → C in AAH21743. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q07020 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: C4E416E7A5329B7C	FASTA	188	21,634
	10 20 30 40 50 60 MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP 70 80 90 100 110 120 LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV CALRVTSRAR SRILRAGGKI 130 140 150 160 170 180 LTFDQLALDS PKGCGTVLLS GPRKGREVYR HFGKAPGTPH SHTKPYVRSK GRKFERARGR RASRGYKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide and deduced amino acid sequence of human ribosomal protein L18." Puder M., Barnard G.F., Staniunas R.J., Steele G.D. Jr., Chen L.B. Biochim. Biophys. Acta 1216:134-136(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon.
[2]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
[4]	"Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing." Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G. J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-14, MASS SPECTROMETRY.
[5]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND THR-158, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L11566 mRNA. Translation: AAA16329.1. AB061825 Genomic DNA. Translation: BAB79463.1. BC000374 mRNA. Translation: AAH00374.1. BC009708 mRNA. Translation: AAH09708.1. BC021743 mRNA. Translation: AAH21743.1.
IPI	IPI00215719.
PIR	S38352.
RefSeq	NP_000970.1. NM_000979.3.
UniGene	Hs.515517.
3D structure databases
ProteinModelPortal	Q07020.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q07020. 14 interactions.
MINT	MINT-5000047.
STRING	9606.ENSP00000084795.
PTM databases
PhosphoSite	Q07020.
Polymorphism databases
DMDM	548749.
2D gel databases
SWISS-2DPAGE	Q07020.
Proteomic databases
PaxDb	Q07020.
PeptideAtlas	Q07020.
PRIDE	Q07020.
Protocols and materials databases
DNASU	6141.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000549920; ENSP00000447001; ENSG00000063177.
GeneID	6141.
KEGG	hsa:6141.
UCSC	uc002pjq.1. human.
Organism-specific databases
CTD	6141.
GeneCards	GC19M049118.
H-InvDB	HIX0018528.
HGNC	HGNC:10310. RPL18.
HPA	HPA046572.
MIM	604179. gene.
neXtProt	NX_Q07020.
PharmGKB	PA34679.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1727.
HOGENOM	HOG000213425.
HOVERGEN	HBG000875.
InParanoid	Q07020.
KO	K02883.
OrthoDB	EOG4HHP3F.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q07020.
Bgee	Q07020.
CleanEx	HS_RPL18.
Genevestigator	Q07020.
Family and domain databases
InterPro	IPR000039. Ribosomal_L18e. IPR021131. Ribosomal_L18e/L15P. IPR021132. Ribosomal_L18e_CS. [Graphical view]
PANTHER	PTHR10934. PTHR10934. 1 hit.
Pfam	PF00828. Ribosomal_L18e. 1 hit. [Graphical view]
SUPFAM	SSF52080. Ribosomal_L18e/L15. 1 hit.
PROSITE	PS01106. RIBOSOMAL_L18E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPL18. human.
GenomeRNAi	6141.
NextBio	23857.
SOURCE	Search...

Entry information

Entry name

RL18_HUMAN

Accession

Primary (citable) accession number: Q07020
Secondary accession number(s): Q8WTZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.