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Q07020

- RL18_HUMAN

UniProt

Q07020 - RL18_HUMAN

Protein

60S ribosomal protein L18

Gene

RPL18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA binding Source: ProtInc
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L18
    Gene namesi
    Name:RPL18
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10310. RPL18.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic large ribosomal subunit Source: UniProtKB
    4. membrane Source: UniProtKB
    5. nucleolus Source: HPA
    6. nucleus Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34679.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 18818760S ribosomal protein L18PRO_0000132769Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301Phosphoserine5 Publications
    Modified residuei158 – 1581Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ07020.
    PaxDbiQ07020.
    PeptideAtlasiQ07020.
    PRIDEiQ07020.

    2D gel databases

    SWISS-2DPAGEQ07020.

    PTM databases

    PhosphoSiteiQ07020.

    Expressioni

    Gene expression databases

    ArrayExpressiQ07020.
    BgeeiQ07020.
    CleanExiHS_RPL18.
    GenevestigatoriQ07020.

    Organism-specific databases

    HPAiHPA046572.

    Interactioni

    Protein-protein interaction databases

    BioGridi112061. 132 interactions.
    IntActiQ07020. 21 interactions.
    MINTiMINT-5000047.
    STRINGi9606.ENSP00000084795.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00Q1-188[»]
    ProteinModelPortaliQ07020.
    SMRiQ07020. Positions 1-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L18e family.Curated

    Phylogenomic databases

    eggNOGiCOG1727.
    HOGENOMiHOG000213425.
    HOVERGENiHBG000875.
    InParanoidiQ07020.
    KOiK02883.
    OrthoDBiEOG7PS1GP.
    PhylomeDBiQ07020.
    TreeFamiTF300202.

    Family and domain databases

    InterProiIPR000039. Ribosomal_L18e.
    IPR021131. Ribosomal_L18e/L15P.
    IPR021132. Ribosomal_L18e_CS.
    [Graphical view]
    PANTHERiPTHR10934. PTHR10934. 1 hit.
    PfamiPF00828. Ribosomal_L18e. 1 hit.
    [Graphical view]
    SUPFAMiSSF52080. SSF52080. 1 hit.
    PROSITEiPS01106. RIBOSOMAL_L18E. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q07020-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR    50
    LFMSRTNRPP LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV 100
    CALRVTSRAR SRILRAGGKI LTFDQLALDS PKGCGTVLLS GPRKGREVYR 150
    HFGKAPGTPH SHTKPYVRSK GRKFERARGR RASRGYKN 188
    Length:188
    Mass (Da):21,634
    Last modified:January 23, 2007 - v2
    Checksum:iC4E416E7A5329B7C
    GO
    Isoform 2 (identifier: Q07020-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-30: MGVDIRHNKDRKVRRKEPKSQDIYLRLLVK → M

    Note: No experimental confirmation available. Based on EST data.

    Show »
    Length:159
    Mass (Da):18,091
    Checksum:i1F622F3CD8BABC8E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621S → C in AAH21743. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3030MGVDI…RLLVK → M in isoform 2. CuratedVSP_055170Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11566 mRNA. Translation: AAA16329.1.
    AB061825 Genomic DNA. Translation: BAB79463.1.
    AC022154 Genomic DNA. No translation available.
    BC000374 mRNA. Translation: AAH00374.1.
    BC009708 mRNA. Translation: AAH09708.1.
    BC021743 mRNA. Translation: AAH21743.1.
    CCDSiCCDS12726.1. [Q07020-1]
    CCDS58669.1. [Q07020-2]
    PIRiS38352.
    RefSeqiNP_000970.1. NM_000979.3.
    NP_001257419.1. NM_001270490.1.
    UniGeneiHs.515517.

    Genome annotation databases

    EnsembliENST00000549920; ENSP00000447001; ENSG00000063177. [Q07020-1]
    ENST00000552588; ENSP00000449204; ENSG00000063177. [Q07020-2]
    GeneIDi6141.
    KEGGihsa:6141.
    UCSCiuc002pjq.2. human. [Q07020-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11566 mRNA. Translation: AAA16329.1 .
    AB061825 Genomic DNA. Translation: BAB79463.1 .
    AC022154 Genomic DNA. No translation available.
    BC000374 mRNA. Translation: AAH00374.1 .
    BC009708 mRNA. Translation: AAH09708.1 .
    BC021743 mRNA. Translation: AAH21743.1 .
    CCDSi CCDS12726.1. [Q07020-1 ]
    CCDS58669.1. [Q07020-2 ]
    PIRi S38352.
    RefSeqi NP_000970.1. NM_000979.3.
    NP_001257419.1. NM_001270490.1.
    UniGenei Hs.515517.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 Q 1-188 [» ]
    ProteinModelPortali Q07020.
    SMRi Q07020. Positions 1-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112061. 132 interactions.
    IntActi Q07020. 21 interactions.
    MINTi MINT-5000047.
    STRINGi 9606.ENSP00000084795.

    PTM databases

    PhosphoSitei Q07020.

    2D gel databases

    SWISS-2DPAGE Q07020.

    Proteomic databases

    MaxQBi Q07020.
    PaxDbi Q07020.
    PeptideAtlasi Q07020.
    PRIDEi Q07020.

    Protocols and materials databases

    DNASUi 6141.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000549920 ; ENSP00000447001 ; ENSG00000063177 . [Q07020-1 ]
    ENST00000552588 ; ENSP00000449204 ; ENSG00000063177 . [Q07020-2 ]
    GeneIDi 6141.
    KEGGi hsa:6141.
    UCSCi uc002pjq.2. human. [Q07020-1 ]

    Organism-specific databases

    CTDi 6141.
    GeneCardsi GC19M049118.
    H-InvDB HIX0018528.
    HGNCi HGNC:10310. RPL18.
    HPAi HPA046572.
    MIMi 604179. gene.
    neXtProti NX_Q07020.
    PharmGKBi PA34679.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1727.
    HOGENOMi HOG000213425.
    HOVERGENi HBG000875.
    InParanoidi Q07020.
    KOi K02883.
    OrthoDBi EOG7PS1GP.
    PhylomeDBi Q07020.
    TreeFami TF300202.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL18. human.
    GeneWikii RPL18.
    GenomeRNAii 6141.
    NextBioi 23857.
    PROi Q07020.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07020.
    Bgeei Q07020.
    CleanExi HS_RPL18.
    Genevestigatori Q07020.

    Family and domain databases

    InterProi IPR000039. Ribosomal_L18e.
    IPR021131. Ribosomal_L18e/L15P.
    IPR021132. Ribosomal_L18e_CS.
    [Graphical view ]
    PANTHERi PTHR10934. PTHR10934. 1 hit.
    Pfami PF00828. Ribosomal_L18e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52080. SSF52080. 1 hit.
    PROSITEi PS01106. RIBOSOMAL_L18E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide and deduced amino acid sequence of human ribosomal protein L18."
      Puder M., Barnard G.F., Staniunas R.J., Steele G.D. Jr., Chen L.B.
      Biochim. Biophys. Acta 1216:134-136(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Colon.
    2. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Lung.
    5. "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
      Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
      J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-14, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND THR-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL18_HUMAN
    AccessioniPrimary (citable) accession number: Q07020
    Secondary accession number(s): F8VWC5, Q8WTZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3