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Protein

Oleandomycin polyketide synthase, modules 5 and 6

Gene

orfB

Organism
Streptomyces antibioticus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in the biosynthesis of the oleandomycin lactone ring.

Cofactori

pantetheine 4'-phosphateNote: Binds 2 phosphopantetheines covalently.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210For beta-ketoacyl synthase 1 activity1
Active sitei660Acyl-ester intermediate1
Active sitei1859For beta-ketoacyl synthase 2 activity1
Active sitei2311Acyl-ester intermediate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1203 – 1249NADPAdd BLAST47
Nucleotide bindingi2859 – 2905NADPAdd BLAST47

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17052.

Protein family/group databases

ESTHERistrat-ol56. Thioesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Oleandomycin polyketide synthase, modules 5 and 6
Gene namesi
Name:orfB
OrganismiStreptomyces antibioticus
Taxonomic identifieri1890 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001802971 – 3519Oleandomycin polyketide synthase, modules 5 and 6Add BLAST3519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1524O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3178O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRIDEiQ07017.

Structurei

3D structure databases

ProteinModelPortaliQ07017.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1487 – 1561Acyl carrier 1PROSITE-ProRule annotationAdd BLAST75
Domaini3141 – 3215Acyl carrier 2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni? – 3519Module 6
Regioni1 – ?Module 5
Regioni32 – 501Beta-ketoacyl synthase 1Add BLAST470
Regioni569 – 890Acyltransferase (AT) 1Add BLAST322
Regioni1200 – 1382Beta-ketoacyl reductase 1Add BLAST183
Regioni1686 – 2156Beta-ketoacyl synthase 2Add BLAST471
Regioni2220 – 2541Acyltransferase (AT) 2Add BLAST322
Regioni2856 – 3038Beta-ketoacyl reductase 2Add BLAST183
Regioni3270 – 3519ThioesteraseAdd BLAST250

Sequence similaritiesi

Contains 2 acyl carrier domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK16007.

Family and domain databases

Gene3Di1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.1820. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR020802. PKS_thioesterase.
IPR015083. Polyketide_synth_docking.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR001031. Thioesterase.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 2 hits.
PF16197. KAsynt_C_assoc. 2 hits.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 2 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
SM00824. PKS_TE. 1 hit.
[Graphical view]
SUPFAMiSSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 1 hit.
SSF51735. SSF51735. 4 hits.
SSF52151. SSF52151. 4 hits.
SSF53474. SSF53474. 2 hits.
SSF53901. SSF53901. 2 hits.
SSF55048. SSF55048. 2 hits.
PROSITEiPS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAEKLREY LWRATTELKE VSDRLRETEE RAREPIAIVG MSCRFPGGGD
60 70 80 90 100
ATVNTPEQFW DLLNSGGDGI AGLPEDRGWD LGRLYDPDPD RAGTSYVREG
110 120 130 140 150
GFLYDSGEFD AAFFGISPRE ALAMDPQQRL LLETSWEAFE SAGIKRAALR
160 170 180 190 200
GSDTGVYIGA WSTGYAGSPY RLVEGLEGQL AIGTTLGAAS GRVAYTFGLE
210 220 230 240 250
GPAVTVDTAC SSSLVALHLA VQGLRRGECS LALVGGVTVM SSPVTLTTFS
260 270 280 290 300
RQRGLSVDGR CKAFPASADG FGAAEGVGVL LVERLSDARR LGHRVLAVVR
310 320 330 340 350
GSAVNQDGAS NGLTAPNGPS QQRVIRAALA DAGLAPADVD VVEAHGTGTR
360 370 380 390 400
LGDPIEAQAL LATYGQGRAG GRPVWLGSVK SNIGHTQAAA GVAGVMKMVL
410 420 430 440 450
ALGRGVVPKT LHVDEPSPHV DWSAGAVELL TEERPWEPEA ERLRRAGISA
460 470 480 490 500
FGVSGTNAHV IVEEAPAEPE PEPGTRVVAA GDLVVPWVVS GRDARALRAQ
510 520 530 540 550
AARLAAHVSG VSAVDVGWSL VATRSVFEHR AVAIGSELDS MAGSLAGFAA
560 570 580 590 600
GGVVPGVVSG VAPAEGRRVV FVFPGQGSQW VGMAAGLLDA CPVFAEAVAE
610 620 630 640 650
CAAVLDPVTG WSLVEVLQGR DATVLGRVDV VQPALWAVMV SLARTWRYYG
660 670 680 690 700
VEPAAVVGHS QGEIAAACVA GGLSLADGAR VVVLRSRAIA RIAGGGGMVS
710 720 730 740 750
VSLPAGRVRT MLEEFDGRLS VAAVNGPSST VVSGDVQALD ELLAGCEREG
760 770 780 790 800
VRARRVPVDY ASHSAQMDQL RDELLEALAD ITPQDSSVPF FSTVTADWLG
810 820 830 840 850
TTALGAGYWF TNLRETVRFQ EAVEGLVAQG MGAFVECSPH PVLVPGIEQT
860 870 880 890 900
LDALDQNAAV FGSLRRDEGG LDRFLTSLAE AFVQGVPVDW SRAFEGVTPR
910 920 930 940 950
TVDLPTYPFQ RQHYWLMAEE APVSQPPHSE NSFWSVVADA DAEAAAELLG
960 970 980 990 1000
VDVEAVEAVM PALSSWHRQS QLRAEVNQWR YDVAWKRLTT GALPEKPGNW
1010 1020 1030 1040 1050
LVVTPAGTDT TFAESLARTA AAELGVSVSF AQVDTAHPDR SQYAHALRQA
1060 1070 1080 1090 1100
LTGPENVDHL VSLLALDQAT DDLAAAPSCL AASLVLAQAL VDLGRVGEGP
1110 1120 1130 1140 1150
RLWLVTRGAV VAGPSDAGAV IDPVQAQVWG FGRVLGLEHP ELWGGLIDLP
1160 1170 1180 1190 1200
VGVDEEVCRR FVGVVASAGF EDQVAVRGSG VWVRRLVRAV VDGGGGGWRP
1210 1220 1230 1240 1250
RGTVLVTGGL GGLGAHTARW LVGGGADHVV LVSRRGGSAP GAGDLVRELE
1260 1270 1280 1290 1300
GLGGARVSVR ACDVADRVAL RALLSDLGEP VTAVFHAAGV PQSTPLAEIS
1310 1320 1330 1340 1350
VQEAADVMAA KVAGAVNLGE LVDPCGLEAF VLFSSNAGVW GSGGQAVYAA
1360 1370 1380 1390 1400
ANAFLDALAV RRRGVGLPAT SVAWGMWAGE GMASVGGAAR ELSRRGVRAM
1410 1420 1430 1440 1450
DPERAVAVMA DAVGRGEAFV AVADVDWERF VTGFASARPR PLISDLPEVR
1460 1470 1480 1490 1500
AVVEGQVQGR GQGLGLVGEE ESSGWLKRLS GLSRVRQEEE LVELVRAQAA
1510 1520 1530 1540 1550
VVLGHGSAQD VPAERAFKEL GFDSLTAVEL RNGLAAATGI RLPATMAFDH
1560 1570 1580 1590 1600
PNATAIARFL QSQLLPDAES ESAVPSSPED EVRQALASLS LDQLKGAGLL
1610 1620 1630 1640 1650
DPLLALTRLR EINSTVQNPE PTTESIDEMD GETCCAWRSA KSTAEPLTTG
1660 1670 1680 1690 1700
ADMPDPTAKY VEALRASLKE NERLRQQNHS LLAASREAIA ITAMSCRFGG
1710 1720 1730 1740 1750
GIDSPEDLWR FLAEGRDAVA GLPEDRGWDL DALYHPDPEN PGTTYVREGA
1760 1770 1780 1790 1800
FRYDAAQFDA GFFGISPREA LAMDPQQRLL LETSWELFER ADIDPYTVRG
1810 1820 1830 1840 1850
TATGIFIGAG HQGYGPDPKR APESVAGYLL TGTASAVLSG RISYTFGLEG
1860 1870 1880 1890 1900
PAVTVDTACS SSLVALHLAV QALRRGECSL AIAGGVAVMS TPDAFVEFSR
1910 1920 1930 1940 1950
QQGMARDGRC KAFAAAADGM GWGEGVSLLL LERLSDARRL GHRVLAVVRG
1960 1970 1980 1990 2000
SAVNQDGASN GLAAPNGPSQ QRVIRAALAD AGLAPADVDV VEAHGTGTRL
2010 2020 2030 2040 2050
GDPIEAQALL ATYGQGRAGG RPVWLGSVKS NIGHTQAAAG VAGVMKMVLA
2060 2070 2080 2090 2100
LGRGVVPKTL HVDEPSPHVD WSAGAVELLT EERPWEPEAE RLRRAGISAF
2110 2120 2130 2140 2150
GVSGTNAHVI VEEAPAEPEP EPGTRVVAAG DLVVPWVVSG RDVGALREQA
2160 2170 2180 2190 2200
ARLAAHVSST GAGVVDVGWS LVATRSVFEH RAVMVGTDLD SMAGSLAGFA
2210 2220 2230 2240 2250
AGGVVPGVVS GVAPAEGRRV VFVFPGQGSQ WVGMAAGLLD ACPVFAEAVA
2260 2270 2280 2290 2300
ECAAVLDPVT GWSLVEVLQG RDATVLGRVD VVQPALWAVM VSLARTWRYY
2310 2320 2330 2340 2350
GVEPAAVVGH SQGEIAAACV AGGLSLADGA RVVVLRSRAI ARIAGGGGMV
2360 2370 2380 2390 2400
SVSLPAGRVR TMLDTYGGRV SVAAVNGPSS TVVSGDVQAL DELLAGCERE
2410 2420 2430 2440 2450
GVRARRVPVD YASHSAQMDQ LRDELLEALA DITPQDSSVP FFSTVTADWL
2460 2470 2480 2490 2500
DTTALDAGYW FTNLRETVRF QEAVEGLVAQ GMGAFVECSP HPVLVPGIEQ
2510 2520 2530 2540 2550
TLDALDQNAA VLGSLRRDEG GLDRLLTSLA EAFVQGVPVD WTHAFEGVTP
2560 2570 2580 2590 2600
RTVDLPTYPF QRQRFWLDGS PASSANGVDG EADAMIWDAV EREDSVAVAE
2610 2620 2630 2640 2650
ELGIDAEALH TVLPALSSWR RRRVEHRRLQ DWRYRVEWKP FPAALDEVLG
2660 2670 2680 2690 2700
GGWLFVVPRG LADDGVVARV VAAVTARGGE VSVVELDPTR PDRRAYAEAV
2710 2720 2730 2740 2750
AGRGVSGVVS FLSWDDRRHS EHPVVPAGLA ASLVLAQALV DLGRVGEGPR
2760 2770 2780 2790 2800
LWLVTRDAVV AGPSDAGAVI DPVQAQVWGF GRVLGLEHPE LWGGLIDLPV
2810 2820 2830 2840 2850
EAPEPGSTCD HTYADLLATV VASAGFEDQV AVRGSGVWVR RLVRAVVDGG
2860 2870 2880 2890 2900
GGGWRPRGTV LVTGGLGGLG AHTARWLVGG GADHVVLVSR RGGSAPGAGD
2910 2920 2930 2940 2950
LVRELEGLGG ARVSVRACDV ADRVALRALL SDLGEPVTAV FHAAGVPQST
2960 2970 2980 2990 3000
PLAEISVQEA ADVMAAKVAG AVNLGELVDP CGLEAFVLFS SNAGVWGSGG
3010 3020 3030 3040 3050
QAVYAAANAF LDALAVRRRG VGLPATSVAW GMWAGEGMAS VGGAARELSR
3060 3070 3080 3090 3100
RGVRAMDPER AVAVMADAVG RGEAFVAVAD VDWERFVTGF ASARPRPLIS
3110 3120 3130 3140 3150
DLPEVRTALR NQEQEQLHAP VPEDRSAQLL RRLSMLSPAG REAELVKLVR
3160 3170 3180 3190 3200
TEAAAVLGHG SAQDVPAERA FKELGFDSLT AVQLRNRLAA ATGTRLPASA
3210 3220 3230 3240 3250
VFDHPHAAAL ARWLLAGMRH ADGGHGGGHA GGPGPDADEG RSAGAGHSGM
3260 3270 3280 3290 3300
LADLYRRSAE LGRSREFIGL LADTAAFRPV FHGPADLDAP LEAVPLADGV
3310 3320 3330 3340 3350
RKPQLICCSG TAPVGGPHEF ARLASFFRGT RAVSALPLPG YLPGEQLPAD
3360 3370 3380 3390 3400
LDAVLAAQAE AVEKQTGGAP FVLVGYSAGG LMAHALACHL AGRGTPPSGE
3410 3420 3430 3440 3450
VLVDVYPPGR QEPVFGWQKE LTEGMFAQDF VPMDDTRLTA LGTYDRLMGE
3460 3470 3480 3490 3500
WRPAPSGLPT LLIRATEPMA EWTGAIDWRA SWEYDHTAVD MPGNHFTIMR
3510
EHAEDAARHI DVWLKGLTP
Length:3,519
Mass (Da):368,567
Last modified:November 1, 1997 - v1
Checksum:i41AE78AAAEB61F86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09654 Unassigned DNA. Translation: AAA19695.1.
PIRiS43048.

Genome annotation databases

KEGGiag:AAA19695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09654 Unassigned DNA. Translation: AAA19695.1.
PIRiS43048.

3D structure databases

ProteinModelPortaliQ07017.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERistrat-ol56. Thioesterase.

Proteomic databases

PRIDEiQ07017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAA19695.

Phylogenomic databases

KOiK16007.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17052.

Family and domain databases

Gene3Di1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.1820. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR020802. PKS_thioesterase.
IPR015083. Polyketide_synth_docking.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR001031. Thioesterase.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 2 hits.
PF16197. KAsynt_C_assoc. 2 hits.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 2 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
SM00824. PKS_TE. 1 hit.
[Graphical view]
SUPFAMiSSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 1 hit.
SSF51735. SSF51735. 4 hits.
SSF52151. SSF52151. 4 hits.
SSF53474. SSF53474. 2 hits.
SSF53901. SSF53901. 2 hits.
SSF55048. SSF55048. 2 hits.
PROSITEiPS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOL56_STRAT
AccessioniPrimary (citable) accession number: Q07017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.