Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase Lyn

Gene

Lyn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B (By similarity). Phosphorylates LPXN on 'Tyr-72' (By similarity). Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation1 Publication

Enzyme regulationi

Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by PTPRC/CD45.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei275 – 2751ATPPROSITE-ProRule annotation
Active sitei367 – 3671Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi253 – 2619ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • enzyme binding Source: RGD
  • gamma-tubulin binding Source: RGD
  • glycosphingolipid binding Source: RGD
  • integrin binding Source: RGD
  • kinase activity Source: RGD
  • non-membrane spanning protein tyrosine kinase activity Source: GO_Central
  • phosphoprotein binding Source: RGD
  • platelet-derived growth factor receptor binding Source: RGD
  • protein complex binding Source: RGD
  • protein tyrosine kinase activity Source: RGD
  • receptor binding Source: RGD
  • ubiquitin protein ligase binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Adaptive immunity, Immunity, Inflammatory response, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.
ReactomeiREACT_277188. EPHB-mediated forward signaling.
REACT_278187. FCERI mediated NF-kB activation.
REACT_286909. Platelet Adhesion to exposed collagen.
REACT_289444. CD28 co-stimulation.
REACT_292219. FCGR activation.
REACT_296697. Fc epsilon receptor (FCERI) signaling.
REACT_297589. GPVI-mediated activation cascade.
REACT_302394. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_305922. CTLA4 inhibitory signaling.
REACT_313117. EPH-ephrin mediated repulsion of cells.
REACT_313573. Regulation of KIT signaling.
REACT_314415. Growth hormone receptor signaling.
REACT_320606. Regulation of signaling by CBL.
REACT_335137. Signaling by SCF-KIT.
REACT_335402. EPHA-mediated growth cone collapse.
REACT_340722. FCERI mediated Ca+2 mobilization.
REACT_341785. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_343260. Cell surface interactions at the vascular wall.
REACT_348379. EPH-Ephrin signaling.
REACT_353315. FCERI mediated MAPK activation.
REACT_359326. Dectin-2 family.
REACT_359478. CD209 (DC-SIGN) signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Lyn (EC:2.7.10.2)
Alternative name(s):
V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
p53Lyn
p56Lyn
Gene namesi
Name:Lyn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621017. Lyn.

Subcellular locationi

  • Cell membrane By similarity
  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cytoplasmperinuclear region By similarity
  • Golgi apparatus By similarity

  • Note: Accumulates in the nucleus by inhibition of Crm1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the cell membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport (By similarity).By similarity

GO - Cellular componenti

  • cell-cell adherens junction Source: RGD
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: Ensembl
  • extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
  • Golgi apparatus Source: UniProtKB-SubCell
  • integrin alpha2-beta1 complex Source: RGD
  • mast cell granule Source: GOC
  • membrane Source: RGD
  • membrane raft Source: RGD
  • mitochondrial crista Source: RGD
  • mitochondrial intermembrane space Source: RGD
  • mitochondrial membrane Source: RGD
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: RGD
  • plasma membrane Source: RGD
  • postsynaptic density Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 512511Tyrosine-protein kinase LynPRO_0000088131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Lipidationi3 – 31S-palmitoyl cysteineBy similarity
Modified residuei193 – 1931PhosphotyrosineBy similarity
Modified residuei228 – 2281PhosphoserineBy similarity
Modified residuei265 – 2651PhosphotyrosineBy similarity
Modified residuei306 – 3061PhosphotyrosineBy similarity
Modified residuei316 – 3161PhosphotyrosineBy similarity
Modified residuei397 – 3971Phosphotyrosine; by autocatalysis1 Publication
Modified residuei460 – 4601PhosphotyrosineBy similarity
Modified residuei473 – 4731PhosphotyrosineBy similarity
Modified residuei508 – 5081Phosphotyrosine; by autocatalysis, CSK and MATK1 Publication

Post-translational modificationi

Ubiquitinated. Ubiquitination is SH3-dependent (By similarity).By similarity
Phosphorylated on tyrosine residues in response to KIT signaling (By similarity). Autophosphorylated. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylation at Tyr-508 inhibits kinase activity. Phosphorylated at Tyr-508 by CSK. Dephosphorylated by PTPRC/CD45. Becomes rapidly phosphorylated upon activation of the B-cell receptor and the immunoglobulin receptor FCGR1A (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ07014.
PRIDEiQ07014.

PTM databases

PhosphoSiteiQ07014.

Expressioni

Tissue specificityi

Detected in spleen (at protein level). Expressed predominantly in B-lymphoid and myeloid cells.1 Publication

Gene expression databases

GenevisibleiQ07014. RN.

Interactioni

Subunit structurei

Interacts with TEC. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with LIME1 and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex. Interacts with phosphorylated THEMIS2. Interacts with EPOR. Interacts with MS4A2/FCER1B. Interaction (via the SH2 and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with CBLC, PPP1R15A and PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with CSF2RB, the common subunit of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with PAG1 and STAT3. Interacts with ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via proline-rich region). Interacts with LPXN (via LD motif 3) and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via SH3-domain) with ANKRD54 (via ankyrin repeat region) in an activation-independent status of LYN. Forms a multiprotein complex with ANKRD54 and HCLS1 (By similarity). Interacts (via SH2 and SH3 domains) with UNC119; leading to LYN activation (By similarity). Interacts with CD36.By similarity

Protein-protein interaction databases

BioGridi249512. 7 interactions.
IntActiQ07014. 3 interactions.
MINTiMINT-4564766.
STRINGi10116.ENSRNOP00000011130.

Structurei

3D structure databases

ProteinModelPortaliQ07014.
SMRiQ07014. Positions 67-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 12361SH3PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 22698SH2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 501255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain plays an important role in its localization in the cell membrane.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ07014.
KOiK05854.
OMAiWWRAKSL.
OrthoDBiEOG7GTT2V.
PhylomeDBiQ07014.
TreeFamiTF351634.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform LYN A (identifier: Q07014-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCIKSKRKD NLNDDGVDMK TQPVRNTDRT IYVRDPTSNK QQRPVPESQL
60 70 80 90 100
LPGQRFQAKD PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW
110 120 130 140 150
KAKSLSSKRE GFIPSNYVAK VNTLETEEWF FKDITRKDAE RQLLAPGNSA
160 170 180 190 200
GAFLIRESET LKGSFSLSVR DYDPMHGDVI KHYKIRSLDN GGYYISPRIT
210 220 230 240 250
FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW EIPRESIKLV
260 270 280 290 300
KKLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSAQAFLEE ANLMKTLQHD
310 320 330 340 350
KLVRLYAVVT KEEPIYIITE FMAKGSLLDF LKSDEGSKVL LPKLIDFSAQ
360 370 380 390 400
IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR
410 420 430 440 450
EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA
460 470 480 490 500
DVMTALSQGY RMPRMENCPD ELYDIMKMCW KESAEERPTF DYLQSVLDDF
510
YTATEGQYQQ QP
Length:512
Mass (Da):58,660
Last modified:January 23, 2007 - v3
Checksum:iE03615E229CD43F1
GO
Isoform LYN B (identifier: Q07014-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-45: Missing.

Show »
Length:491
Mass (Da):56,133
Checksum:i6FFFB1609E015180
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2311P → L in AAA20944 (PubMed:8125304).Curated
Sequence conflicti231 – 2311P → L in AAA20945 (PubMed:8125304).Curated
Sequence conflicti308 – 3081V → A in AAA20944 (PubMed:8125304).Curated
Sequence conflicti308 – 3081V → A in AAA20945 (PubMed:8125304).Curated
Sequence conflicti419 – 4191C → Y in AAA20944 (PubMed:8125304).Curated
Sequence conflicti419 – 4191C → Y in AAA20945 (PubMed:8125304).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 4521Missing in isoform LYN B. CuratedVSP_005004Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14951 mRNA. Translation: AAA41549.1.
L14782 mRNA. Translation: AAA20944.1.
L14823 mRNA. Translation: AAA20945.1.
AF000300 mRNA. Translation: AAB71344.1.
AF000301 mRNA. Translation: AAB71345.1.
AF000302 mRNA. Translation: AAB71346.1.
PIRiI56160.
PT0198.
RefSeqiNP_001104568.1. NM_001111098.1. [Q07014-2]
NP_110484.1. NM_030857.2. [Q07014-1]
XP_006237896.1. XM_006237834.2. [Q07014-1]
UniGeneiRn.4338.

Genome annotation databases

EnsembliENSRNOT00000011130; ENSRNOP00000011130; ENSRNOG00000008180. [Q07014-1]
GeneIDi81515.
KEGGirno:81515.
UCSCiRGD:621017. rat. [Q07014-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14951 mRNA. Translation: AAA41549.1.
L14782 mRNA. Translation: AAA20944.1.
L14823 mRNA. Translation: AAA20945.1.
AF000300 mRNA. Translation: AAB71344.1.
AF000301 mRNA. Translation: AAB71345.1.
AF000302 mRNA. Translation: AAB71346.1.
PIRiI56160.
PT0198.
RefSeqiNP_001104568.1. NM_001111098.1. [Q07014-2]
NP_110484.1. NM_030857.2. [Q07014-1]
XP_006237896.1. XM_006237834.2. [Q07014-1]
UniGeneiRn.4338.

3D structure databases

ProteinModelPortaliQ07014.
SMRiQ07014. Positions 67-512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249512. 7 interactions.
IntActiQ07014. 3 interactions.
MINTiMINT-4564766.
STRINGi10116.ENSRNOP00000011130.

Chemistry

BindingDBiQ07014.
ChEMBLiCHEMBL4363.

PTM databases

PhosphoSiteiQ07014.

Proteomic databases

PaxDbiQ07014.
PRIDEiQ07014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011130; ENSRNOP00000011130; ENSRNOG00000008180. [Q07014-1]
GeneIDi81515.
KEGGirno:81515.
UCSCiRGD:621017. rat. [Q07014-1]

Organism-specific databases

CTDi4067.
RGDi621017. Lyn.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ07014.
KOiK05854.
OMAiWWRAKSL.
OrthoDBiEOG7GTT2V.
PhylomeDBiQ07014.
TreeFamiTF351634.

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.
ReactomeiREACT_277188. EPHB-mediated forward signaling.
REACT_278187. FCERI mediated NF-kB activation.
REACT_286909. Platelet Adhesion to exposed collagen.
REACT_289444. CD28 co-stimulation.
REACT_292219. FCGR activation.
REACT_296697. Fc epsilon receptor (FCERI) signaling.
REACT_297589. GPVI-mediated activation cascade.
REACT_302394. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_305922. CTLA4 inhibitory signaling.
REACT_313117. EPH-ephrin mediated repulsion of cells.
REACT_313573. Regulation of KIT signaling.
REACT_314415. Growth hormone receptor signaling.
REACT_320606. Regulation of signaling by CBL.
REACT_335137. Signaling by SCF-KIT.
REACT_335402. EPHA-mediated growth cone collapse.
REACT_340722. FCERI mediated Ca+2 mobilization.
REACT_341785. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_343260. Cell surface interactions at the vascular wall.
REACT_348379. EPH-Ephrin signaling.
REACT_353315. FCERI mediated MAPK activation.
REACT_359326. Dectin-2 family.
REACT_359478. CD209 (DC-SIGN) signaling.

Miscellaneous databases

NextBioi615007.
PROiQ07014.

Gene expression databases

GenevisibleiQ07014. RN.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Bacterially expressed rat p56lyn binds several proteins in rat basophilic leukemia cells including pp72, a tyrosine phosphorylated protein prominent in activated cells."
    Minoguchi K., Nishikata H., Siraganian R.P.
    J. Immunol. 150:222-222(1993)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells."
    Rider L.G., Raben N., Miller L., Jelsema C.
    Gene 138:219-222(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE."
    Vonakis B.M., Chen H., Haleem-Smith H., Metzger H.
    J. Biol. Chem. 272:24072-24080(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity."
    Donella-Deana A., Cesaro L., Ruzzene M., Brunati A.M., Marin O., Pinna L.A.
    Biochemistry 37:1438-1446(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-397 AND TYR-508, CATALYTIC ACTIVITY, AUTOPHOSPHORYLATION, ENZYME REGULATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLYN_RAT
AccessioniPrimary (citable) accession number: Q07014
Secondary accession number(s): Q63320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.