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Q07014

- LYN_RAT

UniProt

Q07014 - LYN_RAT

Protein

Tyrosine-protein kinase Lyn

Gene

Lyn

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B By similarity. Phosphorylates LPXN on 'Tyr-72' By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.1 PublicationPROSITE-ProRule annotation

    Enzyme regulationi

    Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by PTPRC/CD45.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei275 – 2751ATPPROSITE-ProRule annotation
    Active sitei367 – 3671Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi253 – 2619ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. enzyme binding Source: RGD
    3. glycosphingolipid binding Source: RGD
    4. integrin binding Source: RGD
    5. kinase activity Source: RGD
    6. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    7. phosphoprotein binding Source: RGD
    8. platelet-derived growth factor receptor binding Source: RGD
    9. protein binding Source: UniProtKB
    10. protein complex binding Source: RGD
    11. protein tyrosine kinase activity Source: RGD
    12. receptor binding Source: RGD
    13. ubiquitin protein ligase binding Source: RGD

    GO - Biological processi

    1. apoptotic nuclear changes Source: Ensembl
    2. B cell homeostasis Source: UniProtKB
    3. B cell receptor signaling pathway Source: Ensembl
    4. cellular response to DNA damage stimulus Source: Ensembl
    5. cellular response to extracellular stimulus Source: RGD
    6. cellular response to heat Source: RGD
    7. cellular response to retinoic acid Source: Ensembl
    8. cytokine secretion Source: RGD
    9. dendritic cell differentiation Source: UniProtKB
    10. erythrocyte differentiation Source: UniProtKB
    11. Fc receptor mediated inhibitory signaling pathway Source: UniProtKB
    12. Fc receptor mediated stimulatory signaling pathway Source: UniProtKB
    13. histamine secretion by mast cell Source: RGD
    14. immune response-regulating cell surface receptor signaling pathway Source: UniProtKB
    15. innate immune response Source: UniProtKB-KW
    16. intracellular signal transduction Source: Ensembl
    17. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
    18. negative regulation of B cell proliferation Source: Ensembl
    19. negative regulation of cell proliferation Source: UniProtKB
    20. negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
    21. negative regulation of intracellular signal transduction Source: UniProtKB
    22. negative regulation of MAP kinase activity Source: UniProtKB
    23. negative regulation of mast cell proliferation Source: UniProtKB
    24. negative regulation of myeloid leukocyte differentiation Source: Ensembl
    25. negative regulation of protein phosphorylation Source: UniProtKB
    26. negative regulation of toll-like receptor 2 signaling pathway Source: UniProtKB
    27. negative regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
    28. neuron projection development Source: Ensembl
    29. oligodendrocyte development Source: RGD
    30. platelet degranulation Source: UniProtKB
    31. positive regulation of cell migration Source: Ensembl
    32. positive regulation of cell proliferation Source: UniProtKB
    33. positive regulation of dendritic cell apoptotic process Source: UniProtKB
    34. positive regulation of Fc receptor mediated stimulatory signaling pathway Source: RGD
    35. positive regulation of glial cell proliferation Source: RGD
    36. positive regulation of mast cell proliferation Source: Ensembl
    37. positive regulation of neuron projection development Source: Ensembl
    38. positive regulation of oligodendrocyte progenitor proliferation Source: RGD
    39. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
    40. positive regulation of phosphorylation Source: RGD
    41. positive regulation of stress-activated protein kinase signaling cascade Source: Ensembl
    42. positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
    43. protein autophosphorylation Source: Ensembl
    44. regulation of B cell apoptotic process Source: Ensembl
    45. regulation of B cell receptor signaling pathway Source: UniProtKB
    46. regulation of cell adhesion mediated by integrin Source: Ensembl
    47. regulation of cytokine production Source: UniProtKB
    48. regulation of cytokine secretion Source: Ensembl
    49. regulation of ERK1 and ERK2 cascade Source: UniProtKB
    50. regulation of erythrocyte differentiation Source: UniProtKB
    51. regulation of inflammatory response Source: Ensembl
    52. regulation of mast cell activation Source: UniProtKB
    53. regulation of mast cell degranulation Source: UniProtKB
    54. regulation of monocyte chemotaxis Source: Ensembl
    55. regulation of platelet aggregation Source: UniProtKB
    56. regulation of release of sequestered calcium ion into cytosol Source: RGD
    57. response to amino acid Source: RGD
    58. response to axon injury Source: RGD
    59. response to carbohydrate Source: RGD
    60. response to drug Source: RGD
    61. response to hormone Source: UniProtKB
    62. response to insulin Source: RGD
    63. response to organic cyclic compound Source: RGD
    64. response to peptide hormone Source: RGD
    65. response to sterol depletion Source: RGD
    66. response to toxic substance Source: RGD
    67. tolerance induction to self antigen Source: UniProtKB
    68. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Adaptive immunity, Immunity, Inflammatory response, Innate immunity

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 5301.
    ReactomeiREACT_195025. Signaling by SCF-KIT.
    REACT_195202. FCERI mediated MAPK activation.
    REACT_196225. Regulation of signaling by CBL.
    REACT_196425. Growth hormone receptor signaling.
    REACT_197451. Regulation of KIT signaling.
    REACT_197513. FCERI mediated NF-kB activation.
    REACT_197531. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_198646. FCGR activation.
    REACT_203734. FCERI mediated Ca+2 mobilization.
    REACT_211910. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_213009. Fc epsilon receptor (FCERI) signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Lyn (EC:2.7.10.2)
    Alternative name(s):
    V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    p53Lyn
    p56Lyn
    Gene namesi
    Name:Lyn
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi621017. Lyn.

    Subcellular locationi

    Cell membrane By similarity. Nucleus By similarity. Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Golgi apparatus By similarity
    Note: Accumulates in the nucleus by inhibition of Crm1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the cell membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. integrin alpha2-beta1 complex Source: RGD
    4. mast cell granule Source: GOC
    5. membrane Source: RGD
    6. membrane raft Source: RGD
    7. mitochondrial crista Source: RGD
    8. mitochondrial intermembrane space Source: RGD
    9. mitochondrial membrane Source: RGD
    10. nucleus Source: UniProtKB
    11. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    12. plasma membrane Source: RGD
    13. postsynaptic density Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 512511Tyrosine-protein kinase LynPRO_0000088131Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity
    Modified residuei6 – 61PhosphoserineBy similarity
    Modified residuei30 – 301PhosphothreonineBy similarity
    Modified residuei32 – 321PhosphotyrosineBy similarity
    Modified residuei37 – 371PhosphothreonineBy similarity
    Modified residuei193 – 1931PhosphotyrosineBy similarity
    Modified residuei194 – 1941PhosphotyrosineBy similarity
    Modified residuei228 – 2281PhosphoserineBy similarity
    Modified residuei265 – 2651PhosphotyrosineBy similarity
    Modified residuei306 – 3061PhosphotyrosineBy similarity
    Modified residuei316 – 3161PhosphotyrosineBy similarity
    Modified residuei397 – 3971Phosphotyrosine; by autocatalysis1 Publication
    Modified residuei460 – 4601PhosphotyrosineBy similarity
    Modified residuei473 – 4731PhosphotyrosineBy similarity
    Modified residuei489 – 4891PhosphothreonineBy similarity
    Modified residuei502 – 5021PhosphothreonineBy similarity
    Modified residuei508 – 5081Phosphotyrosine; by autocatalysis, CSK and MATK1 Publication

    Post-translational modificationi

    Ubiquitinated. Ubiquitination is SH3-dependent By similarity.By similarity
    Phosphorylated on tyrosine residues in response to KIT signaling By similarity. Autophosphorylated. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylation at Tyr-508 inhibits kinase activity. Phosphorylated at Tyr-508 by CSK. Dephosphorylated by PTPRC/CD45. Becomes rapidly phosphorylated upon activation of the B-cell receptor and the immunoglobulin receptor FCGR1A By similarity.By similarity

    Keywords - PTMi

    Lipoprotein, Myristate, Palmitate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ07014.
    PRIDEiQ07014.

    PTM databases

    PhosphoSiteiQ07014.

    Expressioni

    Tissue specificityi

    Detected in spleen (at protein level). Expressed predominantly in B-lymphoid and myeloid cells.1 Publication

    Gene expression databases

    GenevestigatoriQ07014.

    Interactioni

    Subunit structurei

    Interacts with TEC. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with LIME1 and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex. Interacts with phosphorylated THEMIS2. Interacts with EPOR. Interacts with MS4A2/FCER1B. Interaction (via the SH2 and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with CBLC, PPP1R15A and PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with CSF2RB, the common subunit of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with PAG1 and STAT3. Interacts with ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via proline-rich region). Interacts with LPXN (via LD motif 3) and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via SH3-domain) with ANKRD54 (via ankyrin repeat region) in an activation-independent status of LYN. Forms a multiprotein complex with ANKRD54 and HCLS1 By similarity. Interacts (via SH2 and SH3 domains) with UNC119; leading to LYN activation By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249512. 7 interactions.
    IntActiQ07014. 3 interactions.
    MINTiMINT-4564766.
    STRINGi10116.ENSRNOP00000011130.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07014.
    SMRiQ07014. Positions 67-512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 12361SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini129 – 22698SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 501255Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain plays an important role in its localization in the cell membrane.By similarity

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00620000087866.
    HOGENOMiHOG000233858.
    HOVERGENiHBG008761.
    InParanoidiQ07014.
    KOiK05854.
    OMAiWWRAKSL.
    OrthoDBiEOG7GTT2V.
    PhylomeDBiQ07014.
    TreeFamiTF351634.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform LYN A (identifier: Q07014-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGCIKSKRKD NLNDDGVDMK TQPVRNTDRT IYVRDPTSNK QQRPVPESQL    50
    LPGQRFQAKD PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW 100
    KAKSLSSKRE GFIPSNYVAK VNTLETEEWF FKDITRKDAE RQLLAPGNSA 150
    GAFLIRESET LKGSFSLSVR DYDPMHGDVI KHYKIRSLDN GGYYISPRIT 200
    FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW EIPRESIKLV 250
    KKLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSAQAFLEE ANLMKTLQHD 300
    KLVRLYAVVT KEEPIYIITE FMAKGSLLDF LKSDEGSKVL LPKLIDFSAQ 350
    IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR 400
    EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA 450
    DVMTALSQGY RMPRMENCPD ELYDIMKMCW KESAEERPTF DYLQSVLDDF 500
    YTATEGQYQQ QP 512
    Length:512
    Mass (Da):58,660
    Last modified:January 23, 2007 - v3
    Checksum:iE03615E229CD43F1
    GO
    Isoform LYN B (identifier: Q07014-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         25-45: Missing.

    Show »
    Length:491
    Mass (Da):56,133
    Checksum:i6FFFB1609E015180
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti231 – 2311P → L in AAA20944. (PubMed:8125304)Curated
    Sequence conflicti231 – 2311P → L in AAA20945. (PubMed:8125304)Curated
    Sequence conflicti308 – 3081V → A in AAA20944. (PubMed:8125304)Curated
    Sequence conflicti308 – 3081V → A in AAA20945. (PubMed:8125304)Curated
    Sequence conflicti419 – 4191C → Y in AAA20944. (PubMed:8125304)Curated
    Sequence conflicti419 – 4191C → Y in AAA20945. (PubMed:8125304)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei25 – 4521Missing in isoform LYN B. CuratedVSP_005004Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14951 mRNA. Translation: AAA41549.1.
    L14782 mRNA. Translation: AAA20944.1.
    L14823 mRNA. Translation: AAA20945.1.
    AF000300 mRNA. Translation: AAB71344.1.
    AF000301 mRNA. Translation: AAB71345.1.
    AF000302 mRNA. Translation: AAB71346.1.
    PIRiI56160.
    PT0198.
    RefSeqiNP_001104568.1. NM_001111098.1. [Q07014-2]
    NP_110484.1. NM_030857.2. [Q07014-1]
    XP_006237896.1. XM_006237834.1. [Q07014-1]
    UniGeneiRn.4338.

    Genome annotation databases

    EnsembliENSRNOT00000011130; ENSRNOP00000011130; ENSRNOG00000008180. [Q07014-1]
    GeneIDi81515.
    KEGGirno:81515.
    UCSCiRGD:621017. rat. [Q07014-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14951 mRNA. Translation: AAA41549.1 .
    L14782 mRNA. Translation: AAA20944.1 .
    L14823 mRNA. Translation: AAA20945.1 .
    AF000300 mRNA. Translation: AAB71344.1 .
    AF000301 mRNA. Translation: AAB71345.1 .
    AF000302 mRNA. Translation: AAB71346.1 .
    PIRi I56160.
    PT0198.
    RefSeqi NP_001104568.1. NM_001111098.1. [Q07014-2 ]
    NP_110484.1. NM_030857.2. [Q07014-1 ]
    XP_006237896.1. XM_006237834.1. [Q07014-1 ]
    UniGenei Rn.4338.

    3D structure databases

    ProteinModelPortali Q07014.
    SMRi Q07014. Positions 67-512.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249512. 7 interactions.
    IntActi Q07014. 3 interactions.
    MINTi MINT-4564766.
    STRINGi 10116.ENSRNOP00000011130.

    Chemistry

    BindingDBi Q07014.
    ChEMBLi CHEMBL4363.

    PTM databases

    PhosphoSitei Q07014.

    Proteomic databases

    PaxDbi Q07014.
    PRIDEi Q07014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011130 ; ENSRNOP00000011130 ; ENSRNOG00000008180 . [Q07014-1 ]
    GeneIDi 81515.
    KEGGi rno:81515.
    UCSCi RGD:621017. rat. [Q07014-1 ]

    Organism-specific databases

    CTDi 4067.
    RGDi 621017. Lyn.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00620000087866.
    HOGENOMi HOG000233858.
    HOVERGENi HBG008761.
    InParanoidi Q07014.
    KOi K05854.
    OMAi WWRAKSL.
    OrthoDBi EOG7GTT2V.
    PhylomeDBi Q07014.
    TreeFami TF351634.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 5301.
    Reactomei REACT_195025. Signaling by SCF-KIT.
    REACT_195202. FCERI mediated MAPK activation.
    REACT_196225. Regulation of signaling by CBL.
    REACT_196425. Growth hormone receptor signaling.
    REACT_197451. Regulation of KIT signaling.
    REACT_197513. FCERI mediated NF-kB activation.
    REACT_197531. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_198646. FCGR activation.
    REACT_203734. FCERI mediated Ca+2 mobilization.
    REACT_211910. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_213009. Fc epsilon receptor (FCERI) signaling.

    Miscellaneous databases

    NextBioi 615007.
    PROi Q07014.

    Gene expression databases

    Genevestigatori Q07014.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bacterially expressed rat p56lyn binds several proteins in rat basophilic leukemia cells including pp72, a tyrosine phosphorylated protein prominent in activated cells."
      Minoguchi K., Nishikata H., Siraganian R.P.
      J. Immunol. 150:222-222(1993)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells."
      Rider L.G., Raben N., Miller L., Jelsema C.
      Gene 138:219-222(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE."
      Vonakis B.M., Chen H., Haleem-Smith H., Metzger H.
      J. Biol. Chem. 272:24072-24080(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity."
      Donella-Deana A., Cesaro L., Ruzzene M., Brunati A.M., Marin O., Pinna L.A.
      Biochemistry 37:1438-1446(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-397 AND TYR-508, CATALYTIC ACTIVITY, AUTOPHOSPHORYLATION, ENZYME REGULATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLYN_RAT
    AccessioniPrimary (citable) accession number: Q07014
    Secondary accession number(s): Q63320
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 147 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3