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Protein

Integrin beta

Gene

itgb3

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported
Biological processCell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:itgb3Imported
Synonyms:fgd3Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1009967. itgb3.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei717 – 739HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500416549025 – 788Integrin betaSequence analysisAdd BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 459UniRule annotation
Disulfide bondi36 ↔ 46UniRule annotation
Disulfide bondi39 ↔ 72UniRule annotation
Disulfide bondi49 ↔ 61UniRule annotation
Disulfide bondi201 ↔ 208UniRule annotation
Disulfide bondi256 ↔ 297UniRule annotation
Disulfide bondi398 ↔ 410UniRule annotation
Disulfide bondi430 ↔ 679UniRule annotation
Disulfide bondi457 ↔ 461UniRule annotation
Disulfide bondi472 ↔ 484UniRule annotation
Disulfide bondi481 ↔ 519UniRule annotation
Disulfide bondi486 ↔ 495UniRule annotation
Disulfide bondi497 ↔ 510UniRule annotation
Disulfide bondi525 ↔ 530UniRule annotation
Disulfide bondi527 ↔ 560UniRule annotation
Disulfide bondi532 ↔ 545UniRule annotation
Disulfide bondi547 ↔ 552UniRule annotation
Disulfide bondi566 ↔ 571UniRule annotation
Disulfide bondi568 ↔ 599UniRule annotation
Disulfide bondi573 ↔ 582UniRule annotation
Disulfide bondi584 ↔ 591UniRule annotation
Disulfide bondi605 ↔ 610UniRule annotation
Disulfide bondi607 ↔ 655UniRule annotation
Disulfide bondi612 ↔ 622UniRule annotation
Disulfide bondi625 ↔ 628UniRule annotation
Disulfide bondi632 ↔ 641UniRule annotation
Disulfide bondi638 ↔ 711UniRule annotation
Disulfide bondi659 ↔ 687UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ07012.
SMRiQ07012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 73PSIInterPro annotationAdd BLAST47
Domaini35 – 459INBInterPro annotationAdd BLAST425
Domaini632 – 716Integrin_B_tailInterPro annotationAdd BLAST85
Domaini740 – 786Integrin_b_cytInterPro annotationAdd BLAST47

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG006190.
KOiK06493.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
InterProiView protein in InterPro
IPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF52. PTHR10082:SF52. 1 hit.
PfamiView protein in Pfam
PF07974. EGF_2. 2 hits.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiView protein in SMART
SM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiView protein in PROSITE
PS00243. INTEGRIN_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPDVYIVYT CIVQLLLLTA GTWGASICAT RGVSSCQKCL SVSPQCAWCS
60 70 80 90 100
QEVFGKGAPR CDLKSELLSN GCELKNIEFP VSTVLVAENR PLSVKGSEGD
110 120 130 140 150
TREITQMSPQ KIDLFLRPDD TKVFNLQVRQ VEDYPVDIYY LMDLSYSMKD
160 170 180 190 200
DLIKIQTLGT SLSERMRRLT SNLRIGFGAF VDKPMSPYMF MSPPEVIKNP
210 220 230 240 250
CYEFNTECMP TFGYKHVLTL TEEVLRFNEE VQKQKVSRNR DSPEGGFDAV
260 270 280 290 300
LQAAVCDEKI GWRNESSHLL VFTTDARTHI ALDGRLAGIV QPNDGKCHLD
310 320 330 340 350
LNNDYAASTT LDYPSIGLMT EKLSDKNINL VFAVTNEVLS LYTKYSELIP
360 370 380 390 400
GTTVGVLSQD SGNVIQLIEN SYEKIRSKVE LEVRDLPEEL SLSFSASCQN
410 420 430 440 450
DELTPGLKSC TGLKIGDTVS FSIEAKVREC PSVRQKTFTI KPVGFKDSLT
460 470 480 490 500
VTVHFQCNCA CQENDQPNST LCNHGNGTLS CGICQCNPGW LGPYCECSEE
510 520 530 540 550
EYNPSQQDRC SSKEGAPVCS RRGECVCGQC VCRASDLGKV WGKYCECDDF
560 570 580 590 600
SCLRYKGEMC SGHGQCNCGD CICESDWTGD YCNCTTRTDT CMSSSGLLCS
610 620 630 640 650
GRGQCVCGKC ECTQPGSYGD TCEKCPTCPD ACTFKKGCVE CKKFERGPWF
660 670 680 690 700
EDSSCKQICR DEIESVTELV DNGKNAVNCT YKDENDCVIR FQYHEDASGK
710 720 730 740 750
SVLYVINEAE CPHGPDILVV LMSVMGAILL IGLVALLIWK LLITIHDRRE
760 770 780
FAKFEEERAK AKWDTAHNPL YKGATSTFTN ITYRGNTE
Length:788
Mass (Da):87,490
Last modified:January 1, 1999 - v2
Checksum:iE0902510E24A6109
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13591 mRNA. Translation: AAA17427.1.
PIRiI51530.
RefSeqiNP_001081183.1. NM_001087714.1.
UniGeneiXl.29245.

Genome annotation databases

GeneIDi397699.
KEGGixla:397699.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ07012_XENLA
AccessioniPrimary (citable) accession number: Q07012
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1999
Last modified: July 5, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)