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Q07011

- TNR9_HUMAN

UniProt

Q07011 - TNR9_HUMAN

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Protein

Tumor necrosis factor receptor superfamily member 9

Gene

TNFRSF9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

GO - Molecular functioni

  1. receptor activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: ProtInc
  2. negative regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 9
Alternative name(s):
4-1BB ligand receptor
CDw137
T-cell antigen 4-1BB homolog
T-cell antigen ILA
CD_antigen: CD137
Gene namesi
Name:TNFRSF9
Synonyms:CD137, ILA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11924. TNFRSF9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 186163ExtracellularSequence AnalysisAdd
BLAST
Transmembranei187 – 21327HelicalSequence AnalysisAdd
BLAST
Topological domaini214 – 25542CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 255232Tumor necrosis factor receptor superfamily member 9PRO_0000034577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
Disulfide bondi31 ↔ 45PROSITE-ProRule annotation
Disulfide bondi48 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 78PROSITE-ProRule annotation
Disulfide bondi68 ↔ 86PROSITE-ProRule annotation
Disulfide bondi88 ↔ 94PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi121 ↔ 133PROSITE-ProRule annotation
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi139 ↔ 158PROSITE-ProRule annotation
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07011.
PRIDEiQ07011.

PTM databases

PhosphoSiteiQ07011.

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells.

Gene expression databases

BgeeiQ07011.
CleanExiHS_TNFRSF9.
ExpressionAtlasiQ07011. baseline and differential.
GenevestigatoriQ07011.

Organism-specific databases

HPAiCAB002423.

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.3 Publications

Protein-protein interaction databases

BioGridi109817. 13 interactions.
DIPiDIP-3021N.
STRINGi9606.ENSP00000366729.

Structurei

3D structure databases

ProteinModelPortaliQ07011.
SMRiQ07011. Positions 28-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 4522TNFR-Cys 1Add
BLAST
Repeati47 – 8640TNFR-Cys 2Add
BLAST
Repeati87 – 11832TNFR-Cys 3Add
BLAST
Repeati119 – 15941TNFR-Cys 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 25542Interaction with LRR-1Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44848.
GeneTreeiENSGT00730000111279.
HOGENOMiHOG000033708.
HOVERGENiHBG000021.
InParanoidiQ07011.
KOiK05146.
OMAiTNCSLDG.
OrthoDBiEOG786H2Q.
PhylomeDBiQ07011.
TreeFamiTF336151.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020413. TNFR_9.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01924. TNFACTORR9.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07011-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP
60 70 80 90 100
NSFSSAGGQR TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS
110 120 130 140 150
MCEQDCKQGQ ELTKKGCKDC CFGTFNDQKR GICRPWTNCS LDGKSVLVNG
160 170 180 190 200
TKERDVVCGP SPADLSPGAS SVTPPAPARE PGHSPQIISF FLALTSTALL
210 220 230 240 250
FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG CSCRFPEEEE

GGCEL
Length:255
Mass (Da):27,899
Last modified:February 1, 1995 - v1
Checksum:iF3A563FE5EF00460
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561A → T.1 Publication
Corresponds to variant rs9657963 [ dbSNP | Ensembl ].
VAR_018920
Natural varianti115 – 1151K → N.1 Publication
Corresponds to variant rs9657965 [ dbSNP | Ensembl ].
VAR_018921
Natural varianti176 – 1761A → D.1 Publication
Corresponds to variant rs9657979 [ dbSNP | Ensembl ].
VAR_018922
Natural varianti250 – 2501E → G in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035478

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03397 mRNA. Translation: AAA53133.1.
L12964 mRNA. Translation: AAA62478.2.
AY438976 Genomic DNA. Translation: AAR05440.1.
AL009183 Genomic DNA. Translation: CAB57398.1.
BC006196 mRNA. Translation: AAH06196.1.
CCDSiCCDS92.1.
PIRiI38426.
RefSeqiNP_001552.2. NM_001561.5.
UniGeneiHs.738942.
Hs.86447.

Genome annotation databases

EnsembliENST00000377507; ENSP00000366729; ENSG00000049249.
ENST00000615230; ENSP00000478699; ENSG00000049249.
GeneIDi3604.
KEGGihsa:3604.
UCSCiuc001aot.3. human.

Polymorphism databases

DMDMi728738.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03397 mRNA. Translation: AAA53133.1 .
L12964 mRNA. Translation: AAA62478.2 .
AY438976 Genomic DNA. Translation: AAR05440.1 .
AL009183 Genomic DNA. Translation: CAB57398.1 .
BC006196 mRNA. Translation: AAH06196.1 .
CCDSi CCDS92.1.
PIRi I38426.
RefSeqi NP_001552.2. NM_001561.5.
UniGenei Hs.738942.
Hs.86447.

3D structure databases

ProteinModelPortali Q07011.
SMRi Q07011. Positions 28-159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109817. 13 interactions.
DIPi DIP-3021N.
STRINGi 9606.ENSP00000366729.

Chemistry

GuidetoPHARMACOLOGYi 1878.

PTM databases

PhosphoSitei Q07011.

Polymorphism databases

DMDMi 728738.

Proteomic databases

PaxDbi Q07011.
PRIDEi Q07011.

Protocols and materials databases

DNASUi 3604.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377507 ; ENSP00000366729 ; ENSG00000049249 .
ENST00000615230 ; ENSP00000478699 ; ENSG00000049249 .
GeneIDi 3604.
KEGGi hsa:3604.
UCSCi uc001aot.3. human.

Organism-specific databases

CTDi 3604.
GeneCardsi GC01M007980.
HGNCi HGNC:11924. TNFRSF9.
HPAi CAB002423.
MIMi 602250. gene.
neXtProti NX_Q07011.
PharmGKBi PA36617.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44848.
GeneTreei ENSGT00730000111279.
HOGENOMi HOG000033708.
HOVERGENi HBG000021.
InParanoidi Q07011.
KOi K05146.
OMAi TNCSLDG.
OrthoDBi EOG786H2Q.
PhylomeDBi Q07011.
TreeFami TF336151.

Miscellaneous databases

GeneWikii CD137.
GenomeRNAii 3604.
NextBioi 14085.
PROi Q07011.
SOURCEi Search...

Gene expression databases

Bgeei Q07011.
CleanExi HS_TNFRSF9.
ExpressionAtlasi Q07011. baseline and differential.
Genevestigatori Q07011.

Family and domain databases

InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020413. TNFR_9.
[Graphical view ]
Pfami PF00020. TNFR_c6. 1 hit.
[Graphical view ]
PRINTSi PR01924. TNFACTORR9.
SMARTi SM00208. TNFR. 2 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family."
    Schwarz H., Tuckwell J., Lotz M.
    Gene 134:295-298(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  3. Schwarz H.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 107.
  4. "Characterization of human homologue of 4-1BB and its ligand."
    Zhou Z., Kim S., Hurtado J., Lee Z.H., Kim K.K., Pollok K.E., Kwon B.S.
    Immunol. Lett. 45:67-73(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  5. NIEHS SNPs program
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-56; ASN-115 AND ASP-176.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38.
  9. "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB."
    Arch R.H., Thompson C.B.
    Mol. Cell. Biol. 18:558-565(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF1; TRAF2 AND TRAF3.
  10. "CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand."
    Saoulli K., Lee S.Y., Cannons J.L., Yeh W.C., Santana A., Goldstein M.D., Bangia N., DeBenedette M.A., Mak T.W., Choi Y., Watts T.H.
    J. Exp. Med. 187:1849-1862(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF1 AND TRAF2.
  11. "A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction."
    Jang I.-K., Lee Z.-H., Kim H.-H., Hill J.M., Kim J.-D., Kwon B.S.
    Mol. Cells 12:304-312(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LRR-REPEAT PROTEIN 1/LRR-1.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-250.

Entry informationi

Entry nameiTNR9_HUMAN
AccessioniPrimary (citable) accession number: Q07011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3