Reviewed,
UniProtKB/Swiss-Prot Q07011 (TNR9_HUMAN)
Last modified
November 4, 2008.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tumor necrosis factor receptor superfamily member 9 Alternative name(s): 4-1BB ligand receptor T-cell antigen 4-1BB homolog T-cell antigen ILA CDw137 CD_antigen=CD137 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 255 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for TNFSF14/4-1BBL. Possibly active during T cell activation. |
| Subunit structure | Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. |
| Subcellular location | |
| Tissue specificity | Expressed on the surface of activated T-cells. |
| Sequence similarities | Contains 4 TNFR-Cys repeats. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal Transmembrane |
| Molecular function | Receptor |
| PTM | Glycoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | induction of apoptosis Traceable author statement. Source: ProtInc negative regulation of cell proliferationTraceable author statement. Source: ProtInc |
| Cellular component | integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc |
| Molecular function | receptor activity Ref.2 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | |||||||||
| Chain | 24 – 255 | 232 | Tumor necrosis factor receptor superfamily member 9 | PRO_0000034577 | |||||||
Regions | |||||||||||
| Topological domain | 24 – 186 | 163 | Extracellular Potential | ||||||||
| Transmembrane | 187 – 213 | 27 | Potential | ||||||||
| Topological domain | 214 – 255 | 42 | Cytoplasmic Potential | ||||||||
| Repeat | 24 – 45 | 22 | TNFR-Cys 1 | ||||||||
| Repeat | 47 – 86 | 40 | TNFR-Cys 2 | ||||||||
| Repeat | 87 – 118 | 32 | TNFR-Cys 3 | ||||||||
| Repeat | 119 – 159 | 41 | TNFR-Cys 4 | ||||||||
| Region | 214 – 255 | 42 | Interaction with LRR-1 | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 138 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 149 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 28 ↔ 37 | By similarity | |||||||||
| Disulfide bond | 31 ↔ 45 | By similarity | |||||||||
| Disulfide bond | 48 ↔ 62 | By similarity | |||||||||
| Disulfide bond | 65 ↔ 78 | By similarity | |||||||||
| Disulfide bond | 68 ↔ 86 | By similarity | |||||||||
| Disulfide bond | 88 ↔ 94 | By similarity | |||||||||
| Disulfide bond | 99 ↔ 106 | By similarity | |||||||||
| Disulfide bond | 102 ↔ 117 | By similarity | |||||||||
| Disulfide bond | 121 ↔ 133 | By similarity | |||||||||
| Disulfide bond | 139 ↔ 158 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 56 | 1 | A → T: dbSNP rs9657963. | VAR_018920 | |||||||
| Natural variant | 115 | 1 | K → N: dbSNP rs9657965. | VAR_018921 | |||||||
| Natural variant | 176 | 1 | A → D: dbSNP rs9657979. | VAR_018922 | |||||||
| Natural variant | 250 | 1 | E → G in a colorectal cancer sample; somatic mutation. | VAR_035478 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular and biological characterization of human 4-1BB and its ligand." Alderson M.R., Smith C.A., Tough T.W., Davis-Smith T., Armitage R.J., Falk B., Roux E., Baker E., Sutherland G.R., Din W.S., Goodwin R.G. Eur. J. Immunol. 24:2219-2227(1994) [PubMed: 8088337] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood. |
| [2] | "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family." Schwarz H., Tuckwell J., Lotz M. Gene 134:295-298(1993) [PubMed: 8262389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood. |
| [3] | Schwarz H. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 107. |
| [4] | "Characterization of human homologue of 4-1BB and its ligand." Zhou Z., Kim S., Hurtado J., Lee Z.H., Kim K.K., Pollok K.E., Kwon B.S. Immunol. Lett. 45:67-73(1995) [PubMed: 7622190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Blood. |
| [5] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Rieder M.J., Livingston R.J., Daniels M.R., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-56; ASN-115 AND ASP-176. |
| [6] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [8] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38. |
| [9] | "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB." Arch R.H., Thompson C.B. Mol. Cell. Biol. 18:558-565(1998) [PubMed: 9418902] [Abstract] Cited for: INTERACTION WITH TRAF1; TRAF2 AND TRAF3. |
| [10] | "CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand." Saoulli K., Lee S.Y., Cannons J.L., Yeh W.C., Santana A., Goldstein M.D., Bangia N., DeBenedette M.A., Mak T.W., Choi Y., Watts T.H. J. Exp. Med. 187:1849-1862(1998) [PubMed: 9607925] [Abstract] Cited for: INTERACTION WITH TRAF1 AND TRAF2. |
| [11] | "A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction." Jang I.-K., Lee Z.-H., Kim H.-H., Hill J.M., Kim J.-D., Kwon B.S. Mol. Cells 12:304-312(2001) [PubMed: 11804328] [Abstract] Cited for: INTERACTION WITH LRR-REPEAT PROTEIN 1/LRR-1. |
| [12] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-250. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U03397 mRNA. Translation: AAA53133.1. L12964 mRNA. Translation: AAA62478.2. AY438976 Genomic DNA. Translation: AAR05440.1. AL009183 Genomic DNA. Translation: CAB57398.1. BC006196 mRNA. Translation: AAH06196.1. | |
| PIR | I38426. |
| RefSeq | NP_001552.2. |
| UniGene | Hs.654459 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JMA based on UniProtKB Q92956. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:3021N. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000049249. Homo sapiens. [Contig view] |
| GeneID | 3604. |
| KEGG | hsa:3604. |
Organism-specific databases | |
| H-InvDB | HIX0000096. |
| HGNC | HGNC:11924. TNFRSF9. |
| HPA | CAB002423. |
| MIM | 602250. gene. |
| PharmGKB | PA36617. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q07011. |
| HOVERGEN | Q07011. |
Gene expression databases | |
| ArrayExpress | Q07011. |
| CleanEx | HS_TNFRSF9. |
| GermOnline | ENSG00000049249. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001368. TNFR_c6. [Graphical view] |
| Pfam | PF00020. TNFR_c6. 1 hit. [Graphical view] |
| SMART | SM00208. TNFR. 2 hits. [Graphical view] |
| PROSITE | PS00652. TNFR_NGFR_1. 1 hit. PS50050. TNFR_NGFR_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 14085. |
| SOURCE | Search... |
Entry information
| Entry name | TNR9_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q07011 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


