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Protein

Tumor necrosis factor receptor superfamily member 9

Gene

TNFRSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

GO - Molecular functioni

  • receptor activity Source: ProtInc
  • tumor necrosis factor-activated receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049249-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 9
Alternative name(s):
4-1BB ligand receptor
CDw137
T-cell antigen 4-1BB homolog
T-cell antigen ILA
CD_antigen: CD137
Gene namesi
Name:TNFRSF9
Synonyms:CD137, ILA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11924. TNFRSF9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 186ExtracellularSequence analysisAdd BLAST163
Transmembranei187 – 213HelicalSequence analysisAdd BLAST27
Topological domaini214 – 255CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3604.
OpenTargetsiENSG00000049249.
PharmGKBiPA36617.

Chemistry databases

GuidetoPHARMACOLOGYi1878.

Polymorphism and mutation databases

BioMutaiTNFRSF9.
DMDMi728738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003457724 – 255Tumor necrosis factor receptor superfamily member 9Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
Disulfide bondi31 ↔ 45PROSITE-ProRule annotation
Disulfide bondi48 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 78PROSITE-ProRule annotation
Disulfide bondi68 ↔ 86PROSITE-ProRule annotation
Disulfide bondi88 ↔ 94PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi121 ↔ 133PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi139 ↔ 158PROSITE-ProRule annotation
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07011.
PeptideAtlasiQ07011.
PRIDEiQ07011.

PTM databases

iPTMnetiQ07011.
PhosphoSitePlusiQ07011.

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells.

Gene expression databases

BgeeiENSG00000049249.
CleanExiHS_TNFRSF9.
ExpressionAtlasiQ07011. baseline and differential.
GenevisibleiQ07011. HS.

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.3 Publications

Protein-protein interaction databases

BioGridi109817. 13 interactors.
DIPiDIP-3021N.
STRINGi9606.ENSP00000366729.

Structurei

3D structure databases

ProteinModelPortaliQ07011.
SMRiQ07011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 45TNFR-Cys 1Add BLAST22
Repeati47 – 86TNFR-Cys 2Add BLAST40
Repeati87 – 118TNFR-Cys 3Add BLAST32
Repeati119 – 159TNFR-Cys 4Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 255Interaction with LRR-1Add BLAST42

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW3N. Eukaryota.
ENOG41129F9. LUCA.
GeneTreeiENSGT00730000111279.
HOGENOMiHOG000033708.
HOVERGENiHBG000021.
InParanoidiQ07011.
KOiK05146.
OMAiWTNCSLD.
OrthoDBiEOG091G03XW.
PhylomeDBiQ07011.
TreeFamiTF336151.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020413. TNFR_9.
[Graphical view]
PANTHERiPTHR23097:SF136. PTHR23097:SF136. 2 hits.
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01924. TNFACTORR9.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP
60 70 80 90 100
NSFSSAGGQR TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS
110 120 130 140 150
MCEQDCKQGQ ELTKKGCKDC CFGTFNDQKR GICRPWTNCS LDGKSVLVNG
160 170 180 190 200
TKERDVVCGP SPADLSPGAS SVTPPAPARE PGHSPQIISF FLALTSTALL
210 220 230 240 250
FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG CSCRFPEEEE

GGCEL
Length:255
Mass (Da):27,899
Last modified:February 1, 1995 - v1
Checksum:iF3A563FE5EF00460
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01892056A → T.1 PublicationCorresponds to variant rs9657963dbSNPEnsembl.1
Natural variantiVAR_018921115K → N.1 PublicationCorresponds to variant rs9657965dbSNPEnsembl.1
Natural variantiVAR_018922176A → D.1 PublicationCorresponds to variant rs9657979dbSNPEnsembl.1
Natural variantiVAR_035478250E → G in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs776878260dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03397 mRNA. Translation: AAA53133.1.
L12964 mRNA. Translation: AAA62478.2.
AY438976 Genomic DNA. Translation: AAR05440.1.
AL009183 Genomic DNA. Translation: CAB57398.1.
BC006196 mRNA. Translation: AAH06196.1.
CCDSiCCDS92.1.
PIRiI38426.
RefSeqiNP_001552.2. NM_001561.5.
XP_011539688.1. XM_011541386.2.
UniGeneiHs.738942.
Hs.86447.

Genome annotation databases

EnsembliENST00000377507; ENSP00000366729; ENSG00000049249.
ENST00000615230; ENSP00000478699; ENSG00000049249.
GeneIDi3604.
KEGGihsa:3604.
UCSCiuc001aot.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03397 mRNA. Translation: AAA53133.1.
L12964 mRNA. Translation: AAA62478.2.
AY438976 Genomic DNA. Translation: AAR05440.1.
AL009183 Genomic DNA. Translation: CAB57398.1.
BC006196 mRNA. Translation: AAH06196.1.
CCDSiCCDS92.1.
PIRiI38426.
RefSeqiNP_001552.2. NM_001561.5.
XP_011539688.1. XM_011541386.2.
UniGeneiHs.738942.
Hs.86447.

3D structure databases

ProteinModelPortaliQ07011.
SMRiQ07011.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109817. 13 interactors.
DIPiDIP-3021N.
STRINGi9606.ENSP00000366729.

Chemistry databases

GuidetoPHARMACOLOGYi1878.

PTM databases

iPTMnetiQ07011.
PhosphoSitePlusiQ07011.

Polymorphism and mutation databases

BioMutaiTNFRSF9.
DMDMi728738.

Proteomic databases

PaxDbiQ07011.
PeptideAtlasiQ07011.
PRIDEiQ07011.

Protocols and materials databases

DNASUi3604.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377507; ENSP00000366729; ENSG00000049249.
ENST00000615230; ENSP00000478699; ENSG00000049249.
GeneIDi3604.
KEGGihsa:3604.
UCSCiuc001aot.4. human.

Organism-specific databases

CTDi3604.
DisGeNETi3604.
GeneCardsiTNFRSF9.
HGNCiHGNC:11924. TNFRSF9.
MIMi602250. gene.
neXtProtiNX_Q07011.
OpenTargetsiENSG00000049249.
PharmGKBiPA36617.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW3N. Eukaryota.
ENOG41129F9. LUCA.
GeneTreeiENSGT00730000111279.
HOGENOMiHOG000033708.
HOVERGENiHBG000021.
InParanoidiQ07011.
KOiK05146.
OMAiWTNCSLD.
OrthoDBiEOG091G03XW.
PhylomeDBiQ07011.
TreeFamiTF336151.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049249-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

GeneWikiiCD137.
GenomeRNAii3604.
PROiQ07011.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049249.
CleanExiHS_TNFRSF9.
ExpressionAtlasiQ07011. baseline and differential.
GenevisibleiQ07011. HS.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020413. TNFR_9.
[Graphical view]
PANTHERiPTHR23097:SF136. PTHR23097:SF136. 2 hits.
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01924. TNFACTORR9.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR9_HUMAN
AccessioniPrimary (citable) accession number: Q07011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.