Q07011 (TNR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor receptor superfamily member 9

Alternative name(s):
4-1BB ligand receptor
CDw137
T-cell antigen 4-1BB homolog
T-cell antigen ILA
CD_antigen=CD137

Gene names

Name:	TNFRSF9
Synonyms:	CD137, ILA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Subunit structure	Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Ref.9 Ref.10 Ref.11
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed on the surface of activated T-cells.
Sequence similarities	Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	induction of apoptosis Traceable author statement PubMed 8639902. Source: ProtInc negative regulation of cell proliferation Traceable author statement PubMed 8639902. Source: ProtInc
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.8
	Chain	24 – 255	232	Tumor necrosis factor receptor superfamily member 9		PRO_0000034577
Regions
	Topological domain	24 – 186	163	Extracellular Potential
	Transmembrane	187 – 213	27	Helical; Potential
	Topological domain	214 – 255	42	Cytoplasmic Potential
	Repeat	24 – 45	22	TNFR-Cys 1
	Repeat	47 – 86	40	TNFR-Cys 2
	Repeat	87 – 118	32	TNFR-Cys 3
	Repeat	119 – 159	41	TNFR-Cys 4
	Region	214 – 255	42	Interaction with LRR-1
Amino acid modifications
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
	Disulfide bond	28 ↔ 37		By similarity
	Disulfide bond	31 ↔ 45		By similarity
	Disulfide bond	48 ↔ 62		By similarity
	Disulfide bond	65 ↔ 78		By similarity
	Disulfide bond	68 ↔ 86		By similarity
	Disulfide bond	88 ↔ 94		By similarity
	Disulfide bond	99 ↔ 106		By similarity
	Disulfide bond	102 ↔ 117		By similarity
	Disulfide bond	121 ↔ 133		By similarity
	Disulfide bond	139 ↔ 158		By similarity
Natural variations
	Natural variant	56	1	A → T. Ref.5 Corresponds to variant rs9657963 [ dbSNP | Ensembl ].		VAR_018920
	Natural variant	115	1	K → N. Ref.5 Corresponds to variant rs9657965 [ dbSNP | Ensembl ].		VAR_018921
	Natural variant	176	1	A → D. Ref.5 Corresponds to variant rs9657979 [ dbSNP | Ensembl ].		VAR_018922
	Natural variant	250	1	E → G in a colorectal cancer sample; somatic mutation. Ref.12		VAR_035478

Sequences

	Sequence		Length	Mass (Da)
	Q07011 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: F3A563FE5EF00460	FASTA	255	27,899
	10 20 30 40 50 60 MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP NSFSSAGGQR 70 80 90 100 110 120 TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS MCEQDCKQGQ ELTKKGCKDC 130 140 150 160 170 180 CFGTFNDQKR GICRPWTNCS LDGKSVLVNG TKERDVVCGP SPADLSPGAS SVTPPAPARE 190 200 210 220 230 240 PGHSPQIISF FLALTSTALL FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG 250 CSCRFPEEEE GGCEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and biological characterization of human 4-1BB and its ligand." Alderson M.R., Smith C.A., Tough T.W., Davis-Smith T., Armitage R.J., Falk B., Roux E., Baker E., Sutherland G.R., Din W.S., Goodwin R.G. Eur. J. Immunol. 24:2219-2227(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[2]	"A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family." Schwarz H., Tuckwell J., Lotz M. Gene 134:295-298(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[3]	Schwarz H. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 107.
[4]	"Characterization of human homologue of 4-1BB and its ligand." Zhou Z., Kim S., Hurtado J., Lee Z.H., Kim K.K., Pollok K.E., Kwon B.S. Immunol. Lett. 45:67-73(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[5]	NIEHS SNPs program Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-56; ASN-115 AND ASP-176.
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[8]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
[9]	"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB." Arch R.H., Thompson C.B. Mol. Cell. Biol. 18:558-565(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TRAF1; TRAF2 AND TRAF3.
[10]	"CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand." Saoulli K., Lee S.Y., Cannons J.L., Yeh W.C., Santana A., Goldstein M.D., Bangia N., DeBenedette M.A., Mak T.W., Choi Y., Watts T.H. J. Exp. Med. 187:1849-1862(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TRAF1 AND TRAF2.
[11]	"A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction." Jang I.-K., Lee Z.-H., Kim H.-H., Hill J.M., Kim J.-D., Kwon B.S. Mol. Cells 12:304-312(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH LRR-REPEAT PROTEIN 1/LRR-1.
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-250.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	U03397 mRNA. Translation: AAA53133.1. L12964 mRNA. Translation: AAA62478.2. AY438976 Genomic DNA. Translation: AAR05440.1. AL009183 Genomic DNA. Translation: CAB57398.1. BC006196 mRNA. Translation: AAH06196.1.
IPI	IPI00014211.
PIR	I38426.
RefSeq	NP_001552.2. NM_001561.5.
UniGene	Hs.738942. Hs.86447.
3D structure databases
ProteinModelPortal	Q07011.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3021N.
STRING	9606.ENSP00000366729.
PTM databases
PhosphoSite	Q07011.
Polymorphism databases
DMDM	728738.
Proteomic databases
PaxDb	Q07011.
PRIDE	Q07011.
Protocols and materials databases
DNASU	3604.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377507; ENSP00000366729; ENSG00000049249.
GeneID	3604.
KEGG	hsa:3604.
UCSC	uc001aot.3. human.
Organism-specific databases
CTD	3604.
GeneCards	GC01M007980.
HGNC	HGNC:11924. TNFRSF9.
HPA	CAB002423.
MIM	602250. gene.
neXtProt	NX_Q07011.
PharmGKB	PA36617.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44848.
HOGENOM	HOG000033708.
HOVERGEN	HBG000021.
InParanoid	Q07011.
KO	K05146.
OMA	TNCSLDG.
OrthoDB	EOG4KH2VT.
PhylomeDB	Q07011.
Enzyme and pathway databases
Pathway_Interaction_DB	cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
Gene expression databases
Bgee	Q07011.
CleanEx	HS_TNFRSF9.
Genevestigator	Q07011.
GermOnline	ENSG00000049249. Homo sapiens.
Family and domain databases
InterPro	IPR001368. TNFR/NGFR_Cys_rich_reg. IPR020413. TNFR_9. [Graphical view]
Pfam	PF00020. TNFR_c6. 1 hit. [Graphical view]
PRINTS	PR01924. TNFACTORR9.
SMART	SM00208. TNFR. 2 hits. [Graphical view]
PROSITE	PS00652. TNFR_NGFR_1. 1 hit. PS50050. TNFR_NGFR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3604.
NextBio	14085.
SOURCE	Search...

Entry information

Entry name

TNR9_HUMAN

Accession

Primary (citable) accession number: Q07011

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.