Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q07011 (TNR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 9
Alternative name(s):
4-1BB ligand receptor
CDw137
T-cell antigen 4-1BB homolog
T-cell antigen ILA
CD_antigen=CD137
Gene names
Name:TNFRSF9
Synonyms:CD137, ILA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subunit structure

Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Ref.9 Ref.10 Ref.11

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed on the surface of activated T-cells.

Sequence similarities

Contains 4 TNFR-Cys repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.8
Chain24 – 255232Tumor necrosis factor receptor superfamily member 9
PRO_0000034577

Regions

Topological domain24 – 186163Extracellular Potential
Transmembrane187 – 21327Helical; Potential
Topological domain214 – 25542Cytoplasmic Potential
Repeat24 – 4522TNFR-Cys 1
Repeat47 – 8640TNFR-Cys 2
Repeat87 – 11832TNFR-Cys 3
Repeat119 – 15941TNFR-Cys 4
Region214 – 25542Interaction with LRR-1

Amino acid modifications

Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential
Disulfide bond28 ↔ 37 By similarity
Disulfide bond31 ↔ 45 By similarity
Disulfide bond48 ↔ 62 By similarity
Disulfide bond65 ↔ 78 By similarity
Disulfide bond68 ↔ 86 By similarity
Disulfide bond88 ↔ 94 By similarity
Disulfide bond99 ↔ 106 By similarity
Disulfide bond102 ↔ 117 By similarity
Disulfide bond121 ↔ 133 By similarity
Disulfide bond139 ↔ 158 By similarity

Natural variations

Natural variant561A → T. Ref.5
Corresponds to variant rs9657963 [ dbSNP | Ensembl ].
VAR_018920
Natural variant1151K → N. Ref.5
Corresponds to variant rs9657965 [ dbSNP | Ensembl ].
VAR_018921
Natural variant1761A → D. Ref.5
Corresponds to variant rs9657979 [ dbSNP | Ensembl ].
VAR_018922
Natural variant2501E → G in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035478

Sequences

Sequence LengthMass (Da)Tools
Q07011 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: F3A563FE5EF00460

FASTA25527,899
        10         20         30         40         50         60 
MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP NSFSSAGGQR 

        70         80         90        100        110        120 
TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS MCEQDCKQGQ ELTKKGCKDC 

       130        140        150        160        170        180 
CFGTFNDQKR GICRPWTNCS LDGKSVLVNG TKERDVVCGP SPADLSPGAS SVTPPAPARE 

       190        200        210        220        230        240 
PGHSPQIISF FLALTSTALL FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG 

       250 
CSCRFPEEEE GGCEL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular and biological characterization of human 4-1BB and its ligand."
Alderson M.R., Smith C.A., Tough T.W., Davis-Smith T., Armitage R.J., Falk B., Roux E., Baker E., Sutherland G.R., Din W.S., Goodwin R.G.
Eur. J. Immunol. 24:2219-2227(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[2]"A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family."
Schwarz H., Tuckwell J., Lotz M.
Gene 134:295-298(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[3]Schwarz H.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 107.
[4]"Characterization of human homologue of 4-1BB and its ligand."
Zhou Z., Kim S., Hurtado J., Lee Z.H., Kim K.K., Pollok K.E., Kwon B.S.
Immunol. Lett. 45:67-73(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[5]NIEHS SNPs program
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-56; ASN-115 AND ASP-176.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.
[9]"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB."
Arch R.H., Thompson C.B.
Mol. Cell. Biol. 18:558-565(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRAF1; TRAF2 AND TRAF3.
[10]"CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand."
Saoulli K., Lee S.Y., Cannons J.L., Yeh W.C., Santana A., Goldstein M.D., Bangia N., DeBenedette M.A., Mak T.W., Choi Y., Watts T.H.
J. Exp. Med. 187:1849-1862(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRAF1 AND TRAF2.
[11]"A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction."
Jang I.-K., Lee Z.-H., Kim H.-H., Hill J.M., Kim J.-D., Kwon B.S.
Mol. Cells 12:304-312(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LRR-REPEAT PROTEIN 1/LRR-1.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-250.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03397 mRNA. Translation: AAA53133.1.
L12964 mRNA. Translation: AAA62478.2.
AY438976 Genomic DNA. Translation: AAR05440.1.
AL009183 Genomic DNA. Translation: CAB57398.1.
BC006196 mRNA. Translation: AAH06196.1.
PIRI38426.
RefSeqNP_001552.2. NM_001561.5.
UniGeneHs.738942.
Hs.86447.

3D structure databases

ProteinModelPortalQ07011.
SMRQ07011. Positions 28-159.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109817. 9 interactions.
DIPDIP-3021N.
STRING9606.ENSP00000366729.

Chemistry

GuidetoPHARMACOLOGY1878.

PTM databases

PhosphoSiteQ07011.

Polymorphism databases

DMDM728738.

Proteomic databases

PaxDbQ07011.
PRIDEQ07011.

Protocols and materials databases

DNASU3604.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377507; ENSP00000366729; ENSG00000049249.
GeneID3604.
KEGGhsa:3604.
UCSCuc001aot.3. human.

Organism-specific databases

CTD3604.
GeneCardsGC01M007980.
HGNCHGNC:11924. TNFRSF9.
HPACAB002423.
MIM602250. gene.
neXtProtNX_Q07011.
PharmGKBPA36617.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44848.
HOGENOMHOG000033708.
HOVERGENHBG000021.
InParanoidQ07011.
KOK05146.
OMATNCSLDG.
OrthoDBEOG786H2Q.
PhylomeDBQ07011.
TreeFamTF336151.

Gene expression databases

ArrayExpressQ07011.
BgeeQ07011.
CleanExHS_TNFRSF9.
GenevestigatorQ07011.

Family and domain databases

InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020413. TNFR_9.
[Graphical view]
PfamPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSPR01924. TNFACTORR9.
SMARTSM00208. TNFR. 2 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
PROSITEPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCD137.
GenomeRNAi3604.
NextBio14085.
PROQ07011.
SOURCESearch...

Entry information

Entry nameTNR9_HUMAN
AccessionPrimary (citable) accession number: Q07011
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries