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Protein

Tumor necrosis factor receptor superfamily member 9

Gene

TNFRSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

GO - Molecular functioni

  • cytokine binding Source: Ensembl
  • receptor activity Source: ProtInc
  • tumor necrosis factor-activated receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 9
Alternative name(s):
4-1BB ligand receptor
CDw137
T-cell antigen 4-1BB homolog
T-cell antigen ILA
CD_antigen: CD137
Gene namesi
Name:TNFRSF9
Synonyms:CD137, ILA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000049249.8.
HGNCiHGNC:11924. TNFRSF9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 186ExtracellularSequence analysisAdd BLAST163
Transmembranei187 – 213HelicalSequence analysisAdd BLAST27
Topological domaini214 – 255CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3604.
OpenTargetsiENSG00000049249.
PharmGKBiPA36617.

Chemistry databases

ChEMBLiCHEMBL3712857.
GuidetoPHARMACOLOGYi1878.

Polymorphism and mutation databases

BioMutaiTNFRSF9.
DMDMi728738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003457724 – 255Tumor necrosis factor receptor superfamily member 9Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
Disulfide bondi31 ↔ 45PROSITE-ProRule annotation
Disulfide bondi48 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 78PROSITE-ProRule annotation
Disulfide bondi68 ↔ 86PROSITE-ProRule annotation
Disulfide bondi88 ↔ 94PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi121 ↔ 133PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi139 ↔ 158PROSITE-ProRule annotation
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07011.
PRIDEiQ07011.

PTM databases

iPTMnetiQ07011.
PhosphoSitePlusiQ07011.

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells.

Gene expression databases

BgeeiENSG00000049249.
CleanExiHS_TNFRSF9.
ExpressionAtlasiQ07011. baseline and differential.
GenevisibleiQ07011. HS.

Organism-specific databases

HPAiHPA071425.

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109817. 13 interactors.
DIPiDIP-3021N.
ELMiQ07011.
IntActiQ07011. 1 interactor.
STRINGi9606.ENSP00000366729.

Structurei

3D structure databases

ProteinModelPortaliQ07011.
SMRiQ07011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 45TNFR-Cys 1Add BLAST22
Repeati47 – 86TNFR-Cys 2Add BLAST40
Repeati87 – 118TNFR-Cys 3Add BLAST32
Repeati119 – 159TNFR-Cys 4Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 255Interaction with LRR-1Add BLAST42

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW3N. Eukaryota.
ENOG41129F9. LUCA.
GeneTreeiENSGT00730000111279.
HOGENOMiHOG000033708.
HOVERGENiHBG000021.
InParanoidiQ07011.
KOiK05146.
OMAiFKQPFMR.
OrthoDBiEOG091G03XW.
PhylomeDBiQ07011.
TreeFamiTF336151.

Family and domain databases

CDDicd13410. TNFRSF9. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020413. TNFR_9.
IPR034020. TNFRSF9_N.
PANTHERiPTHR23097:SF156. PTHR23097:SF156. 1 hit.
PfamiView protein in Pfam
PF00020. TNFR_c6. 1 hit.
PRINTSiPR01924. TNFACTORR9.
SMARTiView protein in SMART
SM00208. TNFR. 2 hits.
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP
60 70 80 90 100
NSFSSAGGQR TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS
110 120 130 140 150
MCEQDCKQGQ ELTKKGCKDC CFGTFNDQKR GICRPWTNCS LDGKSVLVNG
160 170 180 190 200
TKERDVVCGP SPADLSPGAS SVTPPAPARE PGHSPQIISF FLALTSTALL
210 220 230 240 250
FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG CSCRFPEEEE

GGCEL
Length:255
Mass (Da):27,899
Last modified:February 1, 1995 - v1
Checksum:iF3A563FE5EF00460
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01892056A → T1 PublicationCorresponds to variant dbSNP:rs9657963Ensembl.1
Natural variantiVAR_018921115K → N1 PublicationCorresponds to variant dbSNP:rs9657965Ensembl.1
Natural variantiVAR_018922176A → D1 PublicationCorresponds to variant dbSNP:rs9657979Ensembl.1
Natural variantiVAR_035478250E → G in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs776878260Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03397 mRNA. Translation: AAA53133.1.
L12964 mRNA. Translation: AAA62478.2.
AY438976 Genomic DNA. Translation: AAR05440.1.
AL009183 Genomic DNA. No translation available.
BC006196 mRNA. Translation: AAH06196.1.
CCDSiCCDS92.1.
PIRiI38426.
RefSeqiNP_001552.2. NM_001561.5.
XP_011539688.1. XM_011541386.2.
UniGeneiHs.738942.
Hs.86447.

Genome annotation databases

EnsembliENST00000377507; ENSP00000366729; ENSG00000049249.
ENST00000615230; ENSP00000478699; ENSG00000049249.
GeneIDi3604.
KEGGihsa:3604.
UCSCiuc001aot.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTNR9_HUMAN
AccessioniPrimary (citable) accession number: Q07011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 27, 2017
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot