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Protein

HLA class I histocompatibility antigen, Cw-15 alpha chain

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, Cw-15 alpha chain
Alternative name(s):
MHC class I antigen Cw*15
Gene namesi
Name:HLA-C
Synonyms:HLAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4933 HLA-C
MIMi142840 gene
neXtProtiNX_Q07000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 333HelicalSequence analysisAdd BLAST25
Topological domaini334 – 366CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3107
MalaCardsiHLA-C

Polymorphism and mutation databases

DMDMi543713

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001887825 – 366HLA class I histocompatibility antigen, Cw-15 alpha chainAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiQ07000
MaxQBiQ07000
PeptideAtlasiQ07000
PRIDEiQ07000

PTM databases

iPTMnetiQ07000
SwissPalmiQ07000

Expressioni

Gene expression databases

CleanExiHS_HLA-C

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KIR2DL1P436262EBI-1058803,EBI-8684277

Protein-protein interaction databases

IntActiQ07000, 7 interactors

Structurei

3D structure databases

ProteinModelPortaliQ07000
SMRiQ07000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMAPRTLL LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPHFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQTDRV
110 120 130 140 150
NLRKLRGYYN QSEAGSHIIQ RMYGCDLGPD GRLLRGHDQL AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS
360
SNSAQGSDES LIACKA
Length:366
Mass (Da):40,863
Last modified:June 1, 1994 - v1
Checksum:iFDF703B7AFB05FDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → T in BAA32614 (Ref. 2) Curated1

Polymorphismi

The following alleles of Cw-15 are known: Cw*15:02, Cw*15:03, Cw*15:04, Cw*15:05, Cw*15:10 and Cw*15:11. The sequence shown is that of Cw*15:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01663940G → S in allele Cw*15:11. 1
Natural variantiVAR_01664045H → R in allele Cw*15:10. 1
Natural variantiVAR_05650073A → E. Corresponds to variant dbSNP:rs1050409Ensembl.1
Natural variantiVAR_05650176V → M. Corresponds to variant dbSNP:rs1065382Ensembl.1
Natural variantiVAR_01664190N → K in allele Cw*15:11. Combined sources1
Natural variantiVAR_01664297T → A in allele Cw*15:03. 1
Natural variantiVAR_016643137H → Y in allele Cw*15:04. 1
Natural variantiVAR_016644140L → F in allele Cw*15:05. 1
Natural variantiVAR_016645140L → S in allele Cw*15:04. 1
Natural variantiVAR_056503201E → K. Corresponds to variant dbSNP:rs1131103Ensembl.1
Natural variantiVAR_056504272V → MCombined sourcesCorresponds to variant dbSNP:rs1050276Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67818 mRNA Translation: CAA48029.1
D83031 mRNA Translation: BAA32614.1
AJ420250 Genomic DNA Translation: CAD12435.1
AJ272049 Genomic DNA Translation: CAB75584.1
M99388 mRNA Translation: AAA88087.1
X73518 mRNA Translation: CAA51917.1
X78343 mRNA Translation: CAA55138.1
X87841 mRNA Translation: CAA61110.1
AF302134, AF302133 Genomic DNA Translation: AAG33823.1
AH010335 Genomic DNA Translation: AAK07656.1
PIRiI37523
I37527
I37544
UniGeneiHs.656020
Hs.743218

Genome annotation databases

EnsembliENST00000400341; ENSP00000383195; ENSG00000206435
ENST00000400394; ENSP00000383244; ENSG00000206452

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1C15_HUMAN
AccessioniPrimary (citable) accession number: Q07000
Secondary accession number(s): O78165
, Q29864, Q29991, Q31605, Q9BD28, Q9GJ33, Q9MY49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health