Q07000 (1C15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, Cw-15 alpha chain

Alternative name(s):
MHC class I antigen Cw*15

Gene names

Name:	HLA-C
Synonyms:	HLAC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of Cw-15 are known: Cw*15:02, Cw*15:03, Cw*15:04, Cw*15:05, Cw*15:10 and Cw*15:11. The sequence shown is that of Cw*15:02.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome regulation of immune response Traceable author statement. Source: Reactome type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW early endosome membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome phagocytic vesicle membrane Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 366	342	HLA class I histocompatibility antigen, Cw-15 alpha chain		PRO_0000018878
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 333	25	Helical; Potential
	Topological domain	334 – 366	33	Cytoplasmic Potential
	Domain	209 – 297	89	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) Ref.11
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	40	1	G → S in allele Cw*15:11.		VAR_016639
	Natural variant	45	1	H → R in allele Cw*15:10.		VAR_016640
	Natural variant	73	1	A → E. Corresponds to variant rs1050409 [ dbSNP | Ensembl ].		VAR_056500
	Natural variant	76	1	V → M. Corresponds to variant rs1065382 [ dbSNP | Ensembl ].		VAR_056501
	Natural variant	90	1	N → K in allele Cw*15:11.		VAR_016641
	Natural variant	97	1	T → A in allele Cw*15:03.		VAR_016642
	Natural variant	137	1	H → Y in allele Cw*15:04.		VAR_016643
	Natural variant	140	1	L → F in allele Cw*15:05.		VAR_016644
	Natural variant	140	1	L → S in allele Cw*15:04.		VAR_016645
	Natural variant	182	1	A → V. Corresponds to variant rs1059539 [ dbSNP | Ensembl ].		VAR_056502
	Natural variant	201	1	E → K. Corresponds to variant rs1131103 [ dbSNP | Ensembl ].		VAR_056503
	Natural variant	272	1	V → M. Corresponds to variant rs1050276 [ dbSNP | Ensembl ].		VAR_056504
Experimental info
	Sequence conflict	5	1	A → T in BAA32614. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q07000 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: FDF703B7AFB05FDD	FASTA	366	40,863
	10 20 30 40 50 60 MRVMAPRTLL LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQTDRV NLRKLRGYYN QSEAGSHIIQ 130 140 150 160 170 180 RMYGCDLGPD GRLLRGHDQL AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP 310 320 330 340 350 360 SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and polymerase chain reaction-sequence-specific oligonucleotide detection of the allele encoding the novel allospecificity HLA-Cw6.2 (Cw*1502) in Spanish gypsies." Vilches C., de Pablo R., Herrero M.J., Moreno M.E., Kreisler M. Hum. Immunol. 37:259-263(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:02).
[2]	"HLA-C locus polymorphisms in Japanese." Wang H., Tokunaga K. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:02). Tissue: Peripheral blood.
[3]	"Cloning and sequencing full-length HLA-B and -C genes." Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M. Tissue Antigens 61:20-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE CW*15:02).
[4]	"Group specific amplification and sequencing of HLA-C locus." Witter K., Zahn R., Scholz S., Albert E. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-275 (ALLELE CW*15:02).
[5]	Domena J.D. Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE CW*15:03).
[6]	"A novel HLA-C allele (Cw*1504) related to the Cw6.2 phenotype." Pablo R., Vilches C., Moreno M.E., Kreisler M. Immunogenetics 39:79-79(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:04).
[7]	"Cw*1505: a novel HLA-C allele isolated from a B*7301 haplotype." Vilches C., de Pablo R., Herrero M.J., Moreno M.E., Kreisler M. Immunogenetics 40:313-313(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:05).
[8]	"Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles." Sanz L., Vilches C., de Pablo R., Bunce M., Moreno M.E., Kreisler M. Tissue Antigens 47:329-332(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*15:05).
[9]	"New HLA-Cw*15 sequence." Tamouza R., Schaeffer V., Marzais F., Poirier J.C., Fortier C., Charron D. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*15:10).
[10]	"Novel HLA-Cw allele detected by PCR-SSO." Greville W.D., Chapman G., Le T., Dodd R., Taverniti A., Dunckley H. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*15:11).
[11]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X67818 mRNA. Translation: CAA48029.1. D83031 mRNA. Translation: BAA32614.1. AJ420250 Genomic DNA. Translation: CAD12435.1. AJ272049 Genomic DNA. Translation: CAB75584.1. M99388 mRNA. Translation: AAA88087.1. X73518 mRNA. Translation: CAA51917.1. X78343 mRNA. Translation: CAA55138.1. X87841 mRNA. Translation: CAA61110.1. AF302134, AF302133 Genomic DNA. Translation: AAG33823.1. AH010335 Genomic DNA. Translation: AAK07656.1.
IPI	IPI00471951.
PIR	I37523. I37527. I37544.
3D structure databases
ProteinModelPortal	Q07000.
ModBase	Search...
Polymorphism databases
DMDM	543713.
Proteomic databases
PRIDE	Q07000.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000400341; ENSP00000383195; ENSG00000206435. ENST00000400394; ENSP00000383244; ENSG00000206452.
Organism-specific databases
GeneCards	GC06M031236. GC06Mn31226. GC06Mo31229.
H-InvDB	HIX0167430.
HGNC	HGNC:4933. HLA-C.
MIM	142840. gene.
neXtProt	NX_Q07000.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q07000.
CleanEx	HS_HLA-C.
Genevestigator	Q07000.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-C. human.
NextBio	35537844.
SOURCE	Search...

Entry information

Entry name

1C15_HUMAN

Accession

Primary (citable) accession number: Q07000
Secondary accession number(s): O78165 , Q29864, Q29991, Q31605, Q9BD28, Q9GJ33, Q9MY49

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.