##gff-version 3 P06537 UniProtKB Chain 1 792 . . . ID=PRO_0000019939;Note=Glucocorticoid receptor P06537 UniProtKB Domain 539 773 . . . Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189 P06537 UniProtKB DNA binding 434 509 . . . Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 P06537 UniProtKB Zinc finger 437 457 . . . Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 P06537 UniProtKB Zinc finger 473 497 . . . Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 P06537 UniProtKB Region 1 436 . . . Note=Modulating P06537 UniProtKB Region 1 25 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06537 UniProtKB Region 67 98 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06537 UniProtKB Region 148 201 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06537 UniProtKB Region 501 792 . . . Note=Interaction with CLOCK;Ontology_term=ECO:0000250;evidence=ECO:0000250 P06537 UniProtKB Region 503 538 . . . Note=Hinge P06537 UniProtKB Region 547 712 . . . Note=Interaction with CRY1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P06537 UniProtKB Modified residue 24 24 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P06537 UniProtKB Modified residue 46 46 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Modified residue 131 131 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2019585;Dbxref=PMID:2019585 P06537 UniProtKB Modified residue 152 152 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Modified residue 159 159 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2019585;Dbxref=PMID:2019585 P06537 UniProtKB Modified residue 168 168 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2019585;Dbxref=PMID:2019585 P06537 UniProtKB Modified residue 221 221 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2019585,ECO:0000269|PubMed:21994940;Dbxref=PMID:2019585,PMID:21994940 P06537 UniProtKB Modified residue 229 229 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2019585,ECO:0000269|PubMed:21994940;Dbxref=PMID:2019585,PMID:21994940 P06537 UniProtKB Modified residue 243 243 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2019585,ECO:0000269|PubMed:21994940;Dbxref=PMID:2019585,PMID:21994940 P06537 UniProtKB Modified residue 284 284 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Modified residue 324 324 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2019585;Dbxref=PMID:2019585 P06537 UniProtKB Modified residue 421 421 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P06537 UniProtKB Modified residue 496 496 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Modified residue 508 508 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Modified residue 510 510 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Modified residue 511 511 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Cross-link 294 294 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Cross-link 294 294 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Cross-link 310 310 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Cross-link 310 310 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Cross-link 435 435 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11555652;Dbxref=PMID:11555652 P06537 UniProtKB Cross-link 718 718 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04150 P06537 UniProtKB Alternative sequence 1 27 . . . ID=VSP_018774;Note=In isoform 1-B and isoform 2-B. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06537 UniProtKB Alternative sequence 467 467 . . . ID=VSP_003704;Note=In isoform 2 and isoform 2-B. G->GR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2911477;Dbxref=PMID:2911477 P06537 UniProtKB Alternative sequence 744 757 . . . ID=VSP_058320;Note=In isoform 3. VENLLSYCFQTFLD->STKHKSKTTAKKKK P06537 UniProtKB Alternative sequence 758 792 . . . ID=VSP_058321;Note=In isoform 3. Missing P06537 UniProtKB Natural variant 78 86 . . . Note=Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16141072,ECO:0000269|PubMed:20660300,ECO:0000269|PubMed:3780669;Dbxref=PMID:15489334,PMID:16141072,PMID:20660300,PMID:3780669 P06537 UniProtKB Natural variant 91 91 . . . Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17012242;Dbxref=PMID:17012242 P06537 UniProtKB Mutagenesis 1 1 . . . Note=Abolishes expression of A-type isoforms. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11435610;Dbxref=PMID:11435610 P06537 UniProtKB Mutagenesis 28 28 . . . Note=Abolishes expression of B-type isoforms. 1-B. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11435610;Dbxref=PMID:11435610 P06537 UniProtKB Mutagenesis 435 435 . . . Note=Abolishes glucocorticoid-mediated degradation and enhances transcription trans-activation. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11555652;Dbxref=PMID:11555652 P06537 UniProtKB Mutagenesis 493 493 . . . Note=Abolishes transactivation activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25676786;Dbxref=PMID:25676786 P06537 UniProtKB Mutagenesis 493 493 . . . Note=Abolishes transcriptional activity. Does not impair ligand binding. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25676786;Dbxref=PMID:25676786 P06537 UniProtKB Mutagenesis 493 493 . . . Note=Does not change transactivation activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25676786;Dbxref=PMID:25676786 P06537 UniProtKB Sequence conflict 432 432 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06537 UniProtKB Sequence conflict 446 446 . . . Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06537 UniProtKB Sequence conflict 792 792 . . . Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06537 UniProtKB Helix 547 554 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 571 594 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 599 601 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 604 631 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Beta strand 634 639 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Beta strand 642 644 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 646 649 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Turn 652 654 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 655 671 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 675 686 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Beta strand 688 691 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 698 717 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 723 756 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 758 760 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Helix 766 780 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP P06537 UniProtKB Beta strand 784 786 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MNP