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Q06VW2

- Q06VW2_MOUSE

UniProt

Q06VW2 - Q06VW2_MOUSE

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Protein
Submitted name: Glucocorticoid receptor
Gene
Nr3c1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. glucocorticoid receptor activity Source: MGI
  3. protein binding Source: MGI
  4. protein dimerization activity Source: MGI
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding transcription factor activity Source: InterPro
  7. steroid binding Source: InterPro
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. glucocorticoid metabolic process Source: MGI
  3. glucocorticoid receptor signaling pathway Source: MGI
  4. mammary gland duct morphogenesis Source: MGI
  5. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  6. positive regulation of neuron apoptotic process Source: MGI
  7. regulation of glucocorticoid biosynthetic process Source: MGI
  8. regulation of gluconeogenesis Source: MGI
  9. regulation of transcription, DNA-templated Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. intracellular Source: MGI
  4. membrane Source: MGI
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiQ06VW2.
BgeeiQ06VW2.
GenevestigatoriQ06VW2.

Structurei

3D structure databases

ProteinModelPortaliQ06VW2.
SMRiQ06VW2. Positions 435-506, 537-791.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotations

Phylogenomic databases

HOGENOMiHOG000037950.
HOVERGENiHBG007583.
PhylomeDBiQ06VW2.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06VW2-1 [UniParc]FASTAAdd to Basket

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MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA    50
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ PQPDLSKAVS 100
LSMGLYMGET ETKVMGNDLG YPQQGQLGLS SGETDFRLLE ESIANLNRST 150
SRPENPKSST PAAGCATPTE KEFPQTHSDP SSEQQNRKSQ PGTNGGSVKL 200
YTTDQSTFDI LQDLEFSAGS PGKETNESPW RSDLLIDENL LSPLAGEDDP 250
FLLEGDVNED CKPLILPDTK PKIQDTGDTI LSSPSSVALP QVKTEKDDFI 300
ELCTPGVIKQ EKLGPVYCQA SFSGTNIIGN KMSAISVHGV STSGGQMYHY 350
DMNTASLSQQ QDQKPVFNVI PPIPVGSENW NRCQGSGEDN LTSLGAMNFA 400
GRSVFSNGYS SPGMRPDVSS PPSSSSTATG PPPKLCLVCS DEASGCHYGV 450
LTCGSCKVFF KRAVEGQHNY LCAGRNDCII DKIRRKNCPA CRYRKCLQAG 500
MNLEARKTKK KIKGIQQATA GVSQDTSENA NKTIVPAALP QLTPTLVSLL 550
EVIEPEVLYA GYDSSVPDSA WRIMTTLNML GGRQVIAAVK WAKAIPGFRN 600
LHLDDQMTLL QYSWMFLMAF ALGWRSYRQA SGNLLCFAPD LIINEQRMTL 650
PCMYDQCKHM LFISTELQRL QVSYEEYLCM KTLLLLSSVP KEGLKSQELF 700
DEIRMTYIKE LGKAIVKREG NSSQNWQRFY QLTKLLDSMH DVVENLLSYC 750
FQTFLDKSMS IEFPEMLAEI ITNQIPKYSN GNIKKLLFHQ K 791
Length:791
Mass (Da):87,036
Last modified:October 31, 2006 - v1
Checksum:iA2D621E74B53D062
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ504162 mRNA. Translation: ABF57998.1.
UniGeneiMm.129481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ504162 mRNA. Translation: ABF57998.1 .
UniGenei Mm.129481.

3D structure databases

ProteinModelPortali Q06VW2.
SMRi Q06VW2. Positions 435-506, 537-791.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:95824. Nr3c1.

Phylogenomic databases

HOGENOMi HOG000037950.
HOVERGENi HBG007583.
PhylomeDBi Q06VW2.

Miscellaneous databases

ChiTaRSi NR3C1. mouse.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q06VW2.
Bgeei Q06VW2.
Genevestigatori Q06VW2.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors."
    Xu D., Buehner A., Xu J., Lambert T., Nekl C., Nielsen M.K., Zhou Y.
    FASEB J. 20:2414-2416(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Outbred crossImported.

Entry informationi

Entry nameiQ06VW2_MOUSE
AccessioniPrimary (citable) accession number: Q06VW2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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