Q06VW2 (Q06VW2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glucocorticoid receptor EMBL ABF57998.1

Gene names

Name:

Nr3c1 MGI 95824

Organism

Mus musculus (Mouse) EMBL ABF57998.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	791 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334 SAAS SAAS000536
Cellular component	Nucleus RuleBase RU004334 SAAS SAAS000536
Domain	Zinc-finger RuleBase RU004334 SAAS SAAS000536
Ligand	DNA-binding RuleBase RU004334 SAAS SAAS000536 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL ABF57998.1
Gene Ontology (GO)
Biological_process	adrenal gland development Inferred from mutant phenotype PubMed 7628695. Source: MGI glucocorticoid metabolic process Inferred from mutant phenotype PubMed 10509797. Source: MGI mammary gland duct morphogenesis Inferred from mutant phenotype PubMed 12198239. Source: MGI positive regulation of neuron apoptotic process Inferred from genetic interaction PubMed 10744634. Source: MGI regulation of glucocorticoid biosynthetic process Inferred from mutant phenotype PubMed 7628695. Source: MGI regulation of gluconeogenesis Inferred from mutant phenotype PubMed 7628695. Source: MGI regulation of transcription, DNA-dependent Inferred from direct assay PubMed 10224232. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytosol Inferred from direct assay PubMed 7914432. Source: MGI membrane Inferred from direct assay PubMed 9237103. Source: MGI nucleus Inferred from direct assay PubMed 11555636PubMed 15870285PubMed 7914432. Source: MGI
Molecular_function	glucocorticoid receptor activity Inferred from direct assay PubMed 15199138PubMed 7914432PubMed 9237103. Source: MGI protein dimerization activity Inferred from direct assay PubMed 7883868. Source: MGI sequence-specific DNA binding Inferred from direct assay PubMed 7883868. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q06VW2 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: A2D621E74B53D062	FASTA	791	87,036
	10 20 30 40 50 60 MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA AASQADSKQQ 70 80 90 100 110 120 RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ PQPDLSKAVS LSMGLYMGET ETKVMGNDLG 130 140 150 160 170 180 YPQQGQLGLS SGETDFRLLE ESIANLNRST SRPENPKSST PAAGCATPTE KEFPQTHSDP 190 200 210 220 230 240 SSEQQNRKSQ PGTNGGSVKL YTTDQSTFDI LQDLEFSAGS PGKETNESPW RSDLLIDENL 250 260 270 280 290 300 LSPLAGEDDP FLLEGDVNED CKPLILPDTK PKIQDTGDTI LSSPSSVALP QVKTEKDDFI 310 320 330 340 350 360 ELCTPGVIKQ EKLGPVYCQA SFSGTNIIGN KMSAISVHGV STSGGQMYHY DMNTASLSQQ 370 380 390 400 410 420 QDQKPVFNVI PPIPVGSENW NRCQGSGEDN LTSLGAMNFA GRSVFSNGYS SPGMRPDVSS 430 440 450 460 470 480 PPSSSSTATG PPPKLCLVCS DEASGCHYGV LTCGSCKVFF KRAVEGQHNY LCAGRNDCII 490 500 510 520 530 540 DKIRRKNCPA CRYRKCLQAG MNLEARKTKK KIKGIQQATA GVSQDTSENA NKTIVPAALP 550 560 570 580 590 600 QLTPTLVSLL EVIEPEVLYA GYDSSVPDSA WRIMTTLNML GGRQVIAAVK WAKAIPGFRN 610 620 630 640 650 660 LHLDDQMTLL QYSWMFLMAF ALGWRSYRQA SGNLLCFAPD LIINEQRMTL PCMYDQCKHM 670 680 690 700 710 720 LFISTELQRL QVSYEEYLCM KTLLLLSSVP KEGLKSQELF DEIRMTYIKE LGKAIVKREG 730 740 750 760 770 780 NSSQNWQRFY QLTKLLDSMH DVVENLLSYC FQTFLDKSMS IEFPEMLAEI ITNQIPKYSN 790 GNIKKLLFHQ K

References

[1]	"A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors." Xu D., Buehner A., Xu J., Lambert T., Nekl C., Nielsen M.K., Zhou Y. FASEB J. 20:2414-2416(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Outbred cross EMBL ABF57998.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ504162 mRNA. Translation: ABF57998.1.
IPI	IPI00856360.
UniGene	Mm.129481.
3D structure databases
ProteinModelPortal	Q06VW2.
SMR	Q06VW2. Positions 435-506, 537-791.
ModBase	Search...
Protein-protein interaction databases
STRING	Q06VW2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:95824. Nr3c1.
Phylogenomic databases
HOGENOM	HOG000037950.
HOVERGEN	HBG007583.
Gene expression databases
ArrayExpress	Q06VW2.
Bgee	Q06VW2.
Genevestigator	Q06VW2.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR001409. Glcrtcd_rcpt. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF02155. GCR. 1 hit. PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00528. GLCORTICOIDR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NR3C1. mouse.
SOURCE	Search...

Entry information

Entry name

Q06VW2_MOUSE

Accession

Primary (citable) accession number: Q06VW2

Entry history

Integrated into UniProtKB/TrEMBL:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)