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Q06VW2

- Q06VW2_MOUSE

UniProt

Q06VW2 - Q06VW2_MOUSE

Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. glucocorticoid receptor activity Source: MGI
    3. protein binding Source: MGI
    4. protein dimerization activity Source: MGI
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding transcription factor activity Source: InterPro
    7. steroid binding Source: InterPro
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adrenal gland development Source: MGI
    2. glucocorticoid metabolic process Source: MGI
    3. glucocorticoid receptor signaling pathway Source: MGI
    4. mammary gland duct morphogenesis Source: MGI
    5. maternal behavior Source: MGI
    6. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
    7. positive regulation of neuron apoptotic process Source: MGI
    8. regulation of glucocorticoid biosynthetic process Source: MGI
    9. regulation of gluconeogenesis Source: MGI
    10. regulation of transcription, DNA-templated Source: MGI
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glucocorticoid receptorImported
    Gene namesi
    Name:Nr3c1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95824. Nr3c1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. intracellular Source: MGI
    4. membrane Source: MGI
    5. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ06VW2.
    BgeeiQ06VW2.
    GenevestigatoriQ06VW2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06VW2.
    SMRiQ06VW2. Positions 435-506, 537-791.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000037950.
    HOVERGENiHBG007583.
    PhylomeDBiQ06VW2.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR001409. Glcrtcd_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF02155. GCR. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00528. GLCORTICOIDR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06VW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA    50
    AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ PQPDLSKAVS 100
    LSMGLYMGET ETKVMGNDLG YPQQGQLGLS SGETDFRLLE ESIANLNRST 150
    SRPENPKSST PAAGCATPTE KEFPQTHSDP SSEQQNRKSQ PGTNGGSVKL 200
    YTTDQSTFDI LQDLEFSAGS PGKETNESPW RSDLLIDENL LSPLAGEDDP 250
    FLLEGDVNED CKPLILPDTK PKIQDTGDTI LSSPSSVALP QVKTEKDDFI 300
    ELCTPGVIKQ EKLGPVYCQA SFSGTNIIGN KMSAISVHGV STSGGQMYHY 350
    DMNTASLSQQ QDQKPVFNVI PPIPVGSENW NRCQGSGEDN LTSLGAMNFA 400
    GRSVFSNGYS SPGMRPDVSS PPSSSSTATG PPPKLCLVCS DEASGCHYGV 450
    LTCGSCKVFF KRAVEGQHNY LCAGRNDCII DKIRRKNCPA CRYRKCLQAG 500
    MNLEARKTKK KIKGIQQATA GVSQDTSENA NKTIVPAALP QLTPTLVSLL 550
    EVIEPEVLYA GYDSSVPDSA WRIMTTLNML GGRQVIAAVK WAKAIPGFRN 600
    LHLDDQMTLL QYSWMFLMAF ALGWRSYRQA SGNLLCFAPD LIINEQRMTL 650
    PCMYDQCKHM LFISTELQRL QVSYEEYLCM KTLLLLSSVP KEGLKSQELF 700
    DEIRMTYIKE LGKAIVKREG NSSQNWQRFY QLTKLLDSMH DVVENLLSYC 750
    FQTFLDKSMS IEFPEMLAEI ITNQIPKYSN GNIKKLLFHQ K 791
    Length:791
    Mass (Da):87,036
    Last modified:October 31, 2006 - v1
    Checksum:iA2D621E74B53D062
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ504162 mRNA. Translation: ABF57998.1.
    UniGeneiMm.129481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ504162 mRNA. Translation: ABF57998.1 .
    UniGenei Mm.129481.

    3D structure databases

    ProteinModelPortali Q06VW2.
    SMRi Q06VW2. Positions 435-506, 537-791.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95824. Nr3c1.

    Phylogenomic databases

    HOGENOMi HOG000037950.
    HOVERGENi HBG007583.
    PhylomeDBi Q06VW2.

    Miscellaneous databases

    ChiTaRSi NR3C1. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06VW2.
    Bgeei Q06VW2.
    Genevestigatori Q06VW2.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR001409. Glcrtcd_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF02155. GCR. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00528. GLCORTICOIDR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors."
      Xu D., Buehner A., Xu J., Lambert T., Nekl C., Nielsen M.K., Zhou Y.
      FASEB J. 20:2414-2416(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Outbred crossImported.

    Entry informationi

    Entry nameiQ06VW2_MOUSE
    AccessioniPrimary (citable) accession number: Q06VW2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)