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Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity Source: MGI
  3. glucocorticoid receptor activity Source: MGI
  4. protein dimerization activity Source: MGI
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  7. sequence-specific DNA binding Source: MGI
  8. sequence-specific DNA binding transcription factor activity Source: MGI
  9. steroid binding Source: MGI
  10. steroid hormone binding Source: MGI
  11. zinc ion binding Source: InterPro

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. cellular response to steroid hormone stimulus Source: MGI
  3. glucocorticoid metabolic process Source: MGI
  4. glucocorticoid receptor signaling pathway Source: MGI
  5. mammary gland duct morphogenesis Source: MGI
  6. maternal behavior Source: MGI
  7. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  8. positive regulation of neuron apoptotic process Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. regulation of glucocorticoid biosynthetic process Source: MGI
  11. regulation of gluconeogenesis Source: MGI
  12. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_234105. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. intracellular Source: MGI
  4. membrane Source: MGI
  5. nucleoplasm Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiQ06VW2.
ExpressionAtlasiQ06VW2. baseline and differential.
GenevestigatoriQ06VW2.

Structurei

3D structure databases

ProteinModelPortaliQ06VW2.
SMRiQ06VW2. Positions 435-506, 537-791.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000037950.
HOVERGENiHBG007583.
PhylomeDBiQ06VW2.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06VW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA
60 70 80 90 100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ PQPDLSKAVS
110 120 130 140 150
LSMGLYMGET ETKVMGNDLG YPQQGQLGLS SGETDFRLLE ESIANLNRST
160 170 180 190 200
SRPENPKSST PAAGCATPTE KEFPQTHSDP SSEQQNRKSQ PGTNGGSVKL
210 220 230 240 250
YTTDQSTFDI LQDLEFSAGS PGKETNESPW RSDLLIDENL LSPLAGEDDP
260 270 280 290 300
FLLEGDVNED CKPLILPDTK PKIQDTGDTI LSSPSSVALP QVKTEKDDFI
310 320 330 340 350
ELCTPGVIKQ EKLGPVYCQA SFSGTNIIGN KMSAISVHGV STSGGQMYHY
360 370 380 390 400
DMNTASLSQQ QDQKPVFNVI PPIPVGSENW NRCQGSGEDN LTSLGAMNFA
410 420 430 440 450
GRSVFSNGYS SPGMRPDVSS PPSSSSTATG PPPKLCLVCS DEASGCHYGV
460 470 480 490 500
LTCGSCKVFF KRAVEGQHNY LCAGRNDCII DKIRRKNCPA CRYRKCLQAG
510 520 530 540 550
MNLEARKTKK KIKGIQQATA GVSQDTSENA NKTIVPAALP QLTPTLVSLL
560 570 580 590 600
EVIEPEVLYA GYDSSVPDSA WRIMTTLNML GGRQVIAAVK WAKAIPGFRN
610 620 630 640 650
LHLDDQMTLL QYSWMFLMAF ALGWRSYRQA SGNLLCFAPD LIINEQRMTL
660 670 680 690 700
PCMYDQCKHM LFISTELQRL QVSYEEYLCM KTLLLLSSVP KEGLKSQELF
710 720 730 740 750
DEIRMTYIKE LGKAIVKREG NSSQNWQRFY QLTKLLDSMH DVVENLLSYC
760 770 780 790
FQTFLDKSMS IEFPEMLAEI ITNQIPKYSN GNIKKLLFHQ K
Length:791
Mass (Da):87,036
Last modified:October 31, 2006 - v1
Checksum:iA2D621E74B53D062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ504162 mRNA. Translation: ABF57998.1.
UniGeneiMm.129481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ504162 mRNA. Translation: ABF57998.1.
UniGeneiMm.129481.

3D structure databases

ProteinModelPortaliQ06VW2.
SMRiQ06VW2. Positions 435-506, 537-791.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Phylogenomic databases

HOGENOMiHOG000037950.
HOVERGENiHBG007583.
PhylomeDBiQ06VW2.

Enzyme and pathway databases

ReactomeiREACT_234105. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSiNr3c1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ06VW2.
ExpressionAtlasiQ06VW2. baseline and differential.
GenevestigatoriQ06VW2.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors."
    Xu D., Buehner A., Xu J., Lambert T., Nekl C., Nielsen M.K., Zhou Y.
    FASEB J. 20:2414-2416(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Outbred crossImported.

Entry informationi

Entry nameiQ06VW2_MOUSE
AccessioniPrimary (citable) accession number: Q06VW2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: March 4, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.