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Q06VW2 (Q06VW2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Nr3c1 MGI 95824
OrganismMus musculus (Mouse) EMBL ABF57998.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length791 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377

Contains nuclear receptor DNA-binding domain. SAAS SAAS008946

Ontologies

Keywords
   Biological processTranscription
Transcription regulation RuleBase RU004334 SAAS SAAS008946
   Cellular componentNucleus RuleBase RU004334 SAAS SAAS008946
   DomainZinc-finger RuleBase RU004334 SAAS SAAS008946
   LigandDNA-binding RuleBase RU004334 SAAS SAAS008946
Metal-binding
Zinc
   Molecular functionReceptor RuleBase RU004334 EMBL ABF57998.1
Gene Ontology (GO)
   Biological_processadrenal gland development

Inferred from mutant phenotype PubMed 7628695. Source: MGI

glucocorticoid metabolic process

Inferred from mutant phenotype PubMed 10509797. Source: MGI

glucocorticoid receptor signaling pathway

Inferred from direct assay PubMed 15199138. Source: MGI

mammary gland duct morphogenesis

Inferred from mutant phenotype PubMed 12198239. Source: MGI

positive regulation of neuron apoptotic process

Inferred from genetic interaction PubMed 10744634. Source: MGI

regulation of glucocorticoid biosynthetic process

Inferred from mutant phenotype PubMed 7628695. Source: MGI

regulation of gluconeogenesis

Inferred from mutant phenotype PubMed 7628695. Source: MGI

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 10224232. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytosol

Inferred from direct assay PubMed 7914432. Source: MGI

intracellular

Inferred from direct assay PubMed 9237103. Source: MGI

membrane

Inferred from direct assay PubMed 9237103. Source: MGI

nucleus

Inferred from direct assay PubMed 11555636PubMed 15870285PubMed 7914432. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15870285. Source: MGI

glucocorticoid receptor activity

Inferred from direct assay PubMed 15199138PubMed 7914432PubMed 9237103. Source: MGI

protein dimerization activity

Inferred from direct assay PubMed 7883868. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 7883868. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

steroid binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q06VW2 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: A2D621E74B53D062

FASTA79187,036
        10         20         30         40         50         60 
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA AASQADSKQQ 

        70         80         90        100        110        120 
RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ PQPDLSKAVS LSMGLYMGET ETKVMGNDLG 

       130        140        150        160        170        180 
YPQQGQLGLS SGETDFRLLE ESIANLNRST SRPENPKSST PAAGCATPTE KEFPQTHSDP 

       190        200        210        220        230        240 
SSEQQNRKSQ PGTNGGSVKL YTTDQSTFDI LQDLEFSAGS PGKETNESPW RSDLLIDENL 

       250        260        270        280        290        300 
LSPLAGEDDP FLLEGDVNED CKPLILPDTK PKIQDTGDTI LSSPSSVALP QVKTEKDDFI 

       310        320        330        340        350        360 
ELCTPGVIKQ EKLGPVYCQA SFSGTNIIGN KMSAISVHGV STSGGQMYHY DMNTASLSQQ 

       370        380        390        400        410        420 
QDQKPVFNVI PPIPVGSENW NRCQGSGEDN LTSLGAMNFA GRSVFSNGYS SPGMRPDVSS 

       430        440        450        460        470        480 
PPSSSSTATG PPPKLCLVCS DEASGCHYGV LTCGSCKVFF KRAVEGQHNY LCAGRNDCII 

       490        500        510        520        530        540 
DKIRRKNCPA CRYRKCLQAG MNLEARKTKK KIKGIQQATA GVSQDTSENA NKTIVPAALP 

       550        560        570        580        590        600 
QLTPTLVSLL EVIEPEVLYA GYDSSVPDSA WRIMTTLNML GGRQVIAAVK WAKAIPGFRN 

       610        620        630        640        650        660 
LHLDDQMTLL QYSWMFLMAF ALGWRSYRQA SGNLLCFAPD LIINEQRMTL PCMYDQCKHM 

       670        680        690        700        710        720 
LFISTELQRL QVSYEEYLCM KTLLLLSSVP KEGLKSQELF DEIRMTYIKE LGKAIVKREG 

       730        740        750        760        770        780 
NSSQNWQRFY QLTKLLDSMH DVVENLLSYC FQTFLDKSMS IEFPEMLAEI ITNQIPKYSN 

       790 
GNIKKLLFHQ K 

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References

[1]"A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors."
Xu D., Buehner A., Xu J., Lambert T., Nekl C., Nielsen M.K., Zhou Y.
FASEB J. 20:2414-2416(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Outbred cross EMBL ABF57998.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ504162 mRNA. Translation: ABF57998.1.
UniGeneMm.129481.

3D structure databases

ProteinModelPortalQ06VW2.
SMRQ06VW2. Positions 435-506, 537-791.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95824. Nr3c1.

Phylogenomic databases

HOGENOMHOG000037950.
HOVERGENHBG007583.
PhylomeDBQ06VW2.

Gene expression databases

ArrayExpressQ06VW2.
BgeeQ06VW2.
GenevestigatorQ06VW2.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNR3C1. mouse.
SOURCESearch...

Entry information

Entry nameQ06VW2_MOUSE
AccessionPrimary (citable) accession number: Q06VW2
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)