SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q06GJ0

- Q06GJ0_OSTFU

UniProt

Q06GJ0 - Q06GJ0_OSTFU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Beta-hexosaminidase

Gene
N/A
Organism
Ostrinia furnacalis (Asian corn borer)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321N-acetyl-D-glucosamineImported
Binding sitei164 – 1641N-acetyl-D-glucosamineImported
Active sitei368 – 3681Proton donor By similarityUniRule annotation
Binding sitei375 – 3751N-acetyl-D-glucosamineImported
Binding sitei391 – 3911N-acetyl-D-glucosamine; via carbonyl oxygenImported

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
OrganismiOstrinia furnacalis (Asian corn borer)Imported
Taxonomic identifieri93504 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPyraloideaCrambidaePyraustinaeOstrinia

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NSMX-ray2.10A23-594[»]
3NSNX-ray2.10A23-594[»]
3OZOX-ray2.00A23-594[»]
3OZPX-ray2.00A23-594[»]
3S6TX-ray2.30A20-594[»]
3VTRX-ray2.50A23-594[»]
ProteinModelPortaliQ06GJ0.

Miscellaneous databases

EvolutionaryTraceiQ06GJ0.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.UniRule annotation

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06GJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MWSRRIPLFI FGVLVLILSV AAEDVVWRWS CDNGKCVKLK NDPRSSEPAL    50
SLEACKMFCN EYGLLWPRPT GEADLGNFLS KINLNSIEVK ILKKGATDDL 100
MEAAAKRFKE QVSLAIPRGS TPKLTGKAVD VYLVNENPNE KAFSLEMDES 150
YGLRVSPSGA DRVNATITAN SFFGMRHGLE TLSQLFVFDD IRDHLLMVRD 200
VNISDKPVYP YRGILLDTAR NYYSIESIKR TIEAMAAVKL NTFHWHITDS 250
QSFPFVTTKR PNLYKFGALS PQKVYTKAAI REVVRFGLER GVRVLPEFDA 300
PAHVGEGWQD TDLTVCFKAE PWKSYCVEPP CGQLNPTKDE LYQYLEDIYS 350
DMAEVFDTTD IFHMGGDEVS EACWNSSDSI QNFMMQNRWD LDKESFLKLW 400
NYFQQKAQDK AYKAFGKKLP LILWTSTLTN YKHIDDYLNK DDYIIQVWTT 450
GVDPQIKGLL EKGYRLIMSN YDALYFDCGY GAWVGAGNNW CSPYIGWQKV 500
YDNSPAVIAL EHRDQVLGGE AALWSEQSDT STLDGRLWPR AAALAERLWA 550
EPATSWQDAE YRMLHIRERL VRMGIQAESL QPEWCYQNEG YCYS 594
Length:594
Mass (Da):67,964
Last modified:October 31, 2006 - v1
Checksum:i87E8DE2ADE107ED9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ887769 mRNA. Translation: ABI81756.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ887769 mRNA. Translation: ABI81756.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NSM X-ray 2.10 A 23-594 [» ]
3NSN X-ray 2.10 A 23-594 [» ]
3OZO X-ray 2.00 A 23-594 [» ]
3OZP X-ray 2.00 A 23-594 [» ]
3S6T X-ray 2.30 A 20-594 [» ]
3VTR X-ray 2.50 A 23-594 [» ]
ProteinModelPortali Q06GJ0.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q06GJ0.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view ]
Pfami PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view ]
PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A novel beta-N-acetyl-D-hexosaminidase from the insect Ostrinia furnacalis (Guenee)."
    Yang Q., Liu T., Liu F., Qu M., Qian X.
    FEBS J. 275:5690-5702(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT."
    Zhang H., Liu T., Liu F., Shen X., Yang Q.
    Submitted (SEP-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 23-594.
  3. "Active-pocket size differentiating insectile from bacterial chitinolytic ?-N-acetyl-D-hexosaminidases."
    Liu T., Zhang H., Liu F., Chen L., Shen X., Yang Q.
    Biochem. J. 438:467-474(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 23-594.
  4. "Structural determinants of an insect beta-N-Acetyl-D-hexosaminidase specialized as a chitinolytic enzyme."
    Liu T., Zhang H., Liu F., Wu Q., Shen X., Yang Q.
    J. Biol. Chem. 286:4049-4058(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 23-594.
  5. "Structural insights into cellulolytic and chitinolytic enzymes revealing crucial residues of insect ?-N-acetyl-D-hexosaminidase."
    Liu T., Zhou Y., Chen L., Chen W., Liu L., Shen X., Zhang W., Zhang J., Yang Q.
    PLoS ONE 7:e52225-e52225(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 23-594 IN COMPLEX WITH N-ACETYL-D-GLUCOSAMINE.

Entry informationi

Entry nameiQ06GJ0_OSTFU
AccessioniPrimary (citable) accession number: Q06GJ0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

Similar proteinsi