Reviewed, UniProtKB/Swiss-Prot Q06AV1 (NNMT_PIG)

Names and origin

Protein names

Recommended name:
    Nicotinamide N-methyltransferase
    EC=2.1.1.1

Gene names

Name:

NNMT

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNMT/PNMT/TEMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Nicotinamide N-methyltransferase		PRO_0000262881
Regions
	Region	63 – 64	2	S-adenosyl-L-methionine binding By similarity
	Region	142 – 143	2	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	20	1	S-adenosyl-L-methionine By similarity
	Binding site	25	1	S-adenosyl-L-methionine By similarity
	Binding site	69	1	S-adenosyl-L-methionine By similarity
	Binding site	85	1	S-adenosyl-L-methionine By similarity
	Binding site	90	1	S-adenosyl-L-methionine By similarity
	Binding site	163	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q06AV1-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: A9EC0A3A152E2BB4	FASTA	264	29,479
	10 20 30 40 50 60 MESGFTSKDA YLSHFNPQDY LEKYYNFGAK HSAEDQILRH LLKILFKIFC LDGVKGDLLI 70 80 90 100 110 120 DIGSGPTIYQ LLSACESFKE IIATDYTDQN LQELEKWLKK EPGAFDWSPV VTYVCELEGN 130 140 150 160 170 180 RVKGTEKEEK LRRAVKRVLK CDVTQSWPLG AVPLPPADCL LSTLCLHAAC PDLPTYRTAL 190 200 210 220 230 240 GNLRSLLKPG GFLVLVDALK SSYYMIGEQR FSSLCLGQEA VEAAVREAGY TIEHFEVISQ 250 260 SYSSTMANNE GLFSLVGRKL SPCV

References

[1]	Liu G.Y. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ917624 mRNA. Translation: ABI97169.1.
UniGene	Ssc.71079
3D structure databases
SMR	Q06AV1. Positions 1-260.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q06AV1.
Enzyme and pathway databases
BRENDA	2.1.1.1. 249.
Family and domain databases
InterPro	IPR000940. NNMT_TEMT_trans. [Graphical view]
PANTHER	PTHR10867. NNMT_TEMT_trans. 1 hit.
Pfam	PF01234. NNMT_PNMT_TEMT. 1 hit. [Graphical view]
PIRSF	PIRSF000384. PNMTase. 1 hit.
PROSITE	PS01100. NNMT_PNMT_TEMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNMT_PIG

Accession

Primary (citable) accession number: Q06AV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	October 31, 2006
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)