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Q06AV0 (NTF3_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Neurotrophin-3
Short name=NT-3
Gene names
Name:NTF3
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to promote the survival of visceral and proprioceptive sensory neurons.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the NGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 138120 By similarity
PRO_0000321575
Chain139 – 257119Neurotrophin-3
PRO_0000321576

Amino acid modifications

Glycosylation1311N-linked (GlcNAc...) Potential
Disulfide bond152 ↔ 217 By similarity
Disulfide bond195 ↔ 246 By similarity
Disulfide bond205 ↔ 248 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q06AV0 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: A71DCD1269EA0755

FASTA25729,607
        10         20         30         40         50         60 
MSILFYMIFL AYLRGIQGNS MDQRRLPEDS LNSLIIKLIQ ADILKNKLSK QMVDLQENYQ 

        70         80         90        100        110        120 
STLPKAEAPR EPERGEPAKS EFQPVTAVGP EWLRHHRRYN SPRVLLSDST PLEPPPLYLV 

       130        140        150        160        170        180 
EDYVGNPSVA NRTARRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK 

       190        200        210        220        230        240 
TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYFRALTSY NNKLVGWRWI 

       250 
RIDTSCVCAL SRKIGRT

« Hide

References

[1]Liu G.Y.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ917625 mRNA. Translation: ABI97170.1.
RefSeqNP_001116624.1. NM_001123152.1.
UniGeneSsc.1916.

3D structure databases

ProteinModelPortalQ06AV0.
SMRQ06AV0. Positions 143-253.
ModBaseSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000000761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100144493.
KEGGssc:100144493.

Organism-specific databases

CTD4908.

Phylogenomic databases

eggNOGNOG39844.
HOGENOMHOG000231516.
HOVERGENHBG006494.
KOK04356.
OrthoDBEOG46HGBB.

Family and domain databases

InterProIPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTF3_PIG
AccessionPrimary (citable) accession number: Q06AV0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 31, 2006
Last modified: April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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