Q06AU9 (PNMT_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phenylethanolamine N-methyltransferase
Short name=PNMTase
EC=2.1.1.28

Alternative name(s):
Noradrenaline N-methyltransferase

Gene names

Name:

PNMT

Organism

Sus scrofa (Pig) [Complete proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts noradrenaline to adrenaline By similarity.
Catalytic activity	S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
Pathway	Catecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)-adrenaline from (R)-noradrenaline: step 1/1.
Sequence similarities	Belongs to the NNMT/PNMT/TEMT family.

Ontologies

Keywords
Biological process	Catecholamine biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	catecholamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phenylethanolamine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Phenylethanolamine N-methyltransferase		PRO_0000289662
Regions
	Region	79 – 80	2	S-adenosyl-L-methionine binding By similarity
	Region	158 – 159	2	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	35	1	S-adenosyl-L-methionine By similarity
	Binding site	40	1	S-adenosyl-L-methionine By similarity
	Binding site	85	1	S-adenosyl-L-methionine By similarity
	Binding site	101	1	S-adenosyl-L-methionine By similarity
	Binding site	106	1	S-adenosyl-L-methionine By similarity
	Binding site	181	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	219	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q06AU9 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 15ADE065A8F4B8C4	FASTA	283	30,879
	10 20 30 40 50 60 MSGTGQSHAA DAAPDSDPGQ AAVALAYQHF EPRAYLRNNY APPRGDLSSP DGVGPWKLRC 70 80 90 100 110 120 LAQTFATGEV SGRALIDIGS GPTIYQLLSA CAHFEDITMT DFLEVNRQEL GLWLREEPGA 130 140 150 160 170 180 FDWSVYSQHV CLIEGKGESC QEKERQLRAR VKRILPIDVH QPQPLGTGSL APLPADALVS 190 200 210 220 230 240 AFCLEAVSPD LASFQRALDH ITTLLRSGGH LLLIGALEES WYLAGEARLA VVPVCEEEVR 250 260 270 280 EALARSGYEV RDLRTYVMPA HLRTGVDDVK GIFFAWAQKK VGV

References

[1]	Liu G.Y. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ917626 mRNA. Translation: ABI97171.1.
RefSeq	NP_001116636.1. NM_001123164.1.
UniGene	Ssc.13910.
3D structure databases
ProteinModelPortal	Q06AU9.
SMR	Q06AU9. Positions 13-279.
ModBase	Search...
Protein-protein interaction databases
STRING	Q06AU9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000019054; ENSSSCP00000018549; ENSSSCG00000017501.
GeneID	100144479.
KEGG	ssc:100144479.
Organism-specific databases
CTD	5409.
Phylogenomic databases
GeneTree	ENSGT00390000011708.
HOVERGEN	HBG000797.
OMA	ALEESWY.
OrthoDB	EOG4WSWBJ.
Family and domain databases
InterPro	IPR000940. NNMT_TEMT_trans. [Graphical view]
KO	K00553.
PANTHER	PTHR10867. NNMT_TEMT_trans. 1 hit.
Pfam	PF01234. NNMT_PNMT_TEMT. 1 hit. [Graphical view]
PIRSF	PIRSF000384. PNMTase. 1 hit.
PROSITE	PS01100. NNMT_PNMT_TEMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PNMT_PIG

Accession

Primary (citable) accession number: Q06AU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 31, 2006
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program