ID   Q06AH7_HUMAN            Unreviewed;       698 AA.
AC   Q06AH7;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   24-JAN-2024, entry version 77.
DE   RecName: Full=Serotransferrin {ECO:0000256|ARBA:ARBA00016768};
DE   AltName: Full=Beta-1 metal-binding globulin {ECO:0000256|ARBA:ARBA00031058};
DE   AltName: Full=Siderophilin {ECO:0000256|ARBA:ARBA00032359};
GN   Name=TF {ECO:0000313|EMBL:ABI97197.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABI97197.1};
RN   [1] {ECO:0000313|EMBL:ABI97197.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wang F., Huang L.;
RT   "Cloning and sequence analysis of human transferrin gene.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transferrins are iron binding transport proteins which can
CC       bind two Fe(3+) ions in association with the binding of an anion,
CC       usually bicarbonate. It is responsible for the transport of iron from
CC       sites of absorption and heme degradation to those of storage and
CC       utilization. Serum transferrin may also have a further role in
CC       stimulating cell proliferation. {ECO:0000256|ARBA:ARBA00025170}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the transferrin family.
CC       {ECO:0000256|PIRNR:PIRNR002549}.
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DR   EMBL; DQ923758; ABI97197.1; -; mRNA.
DR   RefSeq; NP_001054.1; NM_001063.3.
DR   AlphaFoldDB; Q06AH7; -.
DR   SMR; Q06AH7; -.
DR   IntAct; Q06AH7; 2.
DR   MEROPS; S60.975; -.
DR   DNASU; 7018; -.
DR   GeneID; 7018; -.
DR   KEGG; hsa:7018; -.
DR   CTD; 7018; -.
DR   PharmGKB; PA36457; -.
DR   BioGRID-ORCS; 7018; 18 hits in 1166 CRISPR screens.
DR   ChiTaRS; TF; human.
DR   GenomeRNAi; 7018; -.
DR   GO; GO:0097433; C:dense body; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008199; F:ferric iron binding; IEA:InterPro.
DR   GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:InterPro.
DR   GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR   CDD; cd13617; PBP2_transferrin_C; 1.
DR   CDD; cd13618; PBP2_transferrin_N; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 4.
DR   InterPro; IPR030685; Serotransferrin_mammal.
DR   InterPro; IPR016357; Transferrin.
DR   InterPro; IPR001156; Transferrin-like_dom.
DR   InterPro; IPR018195; Transferrin_Fe_BS.
DR   PANTHER; PTHR11485:SF31; SEROTRANSFERRIN; 1.
DR   PANTHER; PTHR11485; TRANSFERRIN; 1.
DR   Pfam; PF00405; Transferrin; 2.
DR   PIRSF; PIRSF500682; Serotransferrin; 1.
DR   PIRSF; PIRSF002549; Transferrin; 1.
DR   PRINTS; PR00422; TRANSFERRIN.
DR   SMART; SM00094; TR_FER; 2.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR   PROSITE; PS00205; TRANSFERRIN_LIKE_1; 2.
DR   PROSITE; PS00206; TRANSFERRIN_LIKE_2; 2.
DR   PROSITE; PS00207; TRANSFERRIN_LIKE_3; 2.
DR   PROSITE; PS51408; TRANSFERRIN_LIKE_4; 2.
DR   Genevisible; Q06AH7; HS.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..698
FT                   /note="Serotransferrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004165272"
FT   DOMAIN          25..347
FT                   /note="Transferrin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51408"
FT   DOMAIN          361..683
FT                   /note="Transferrin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51408"
SQ   SEQUENCE   698 AA;  76960 MW;  F4DC27D4E96B3310 CRC64;
     MRLAVGALLV CAVLGLCLAV PDKTVRWCAV SEHEATKCQS FRDHMKSVIP SDGPSVACVK
     KASYLDCIRA IAANEADAVT LDAGLVYDAY LAPNNLKPVV AEFYGSKEDP QTFYYAVAVV
     KKDSGFQMNQ LRGKKSCHTG LGRSAGWNIP IGLLYCDLPE PRKPLEKAVA NFFSGSCAPC
     ADGTDFPQLC QLCPGCGCST LNQYFGYSGA FKCLKDGAGD VAFVKHSTIF ENLANKADRD
     QYELLCLDNT RKPVDEYKDC HLAQVPSHTV VARSIGGKED LIWELLNQAQ EHFGKDKSKE
     FQLFSSPHGK DLLFKDSAHG FLKVPPRMDA KMYLGYEYVT AIRNLREGTC PEAPTDECKP
     VKWCALSHHE RLKCDEWSVN SVGKIECVSA ETTEDCIAKI MNGEADAMSL DGGFVYIAGK
     CGLVPVLAEN YNKSDNCEDT PGAGYFAVAV VKKSASDLTW DNLKGKKSCH TAVGRTAGWN
     IPMGLLYNKI NHCRFDEFFS EGCAPGSKKD SSLCKLCMGS GLNLCEPNNK EGYYGYTGAF
     RCLVEKGDVA FVKHQTVPQN TGGKNPDPWA KNLNEKDYEL LCLDGTRKPV EEYANCHLAR
     APNHAVVTRK DKEACVHKIL RQQQHLFGSN VTDCSGNFCL FRSETKDLLF RDDTVCLAKL
     HDRNTYEKYL GEEYVKAVGN LRKCSTSSLL EACTFRRP
//