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Protein

Chromodomain-helicase-DNA-binding protein 7

Gene

CHD7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi994 – 1001ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

rRNA processing, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 7 (EC:3.6.4.12)
Short name:
CHD-7
Alternative name(s):
ATP-dependent helicase CHD7
Gene namesi
Name:CHD7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899651 – 3011Chromodomain-helicase-DNA-binding protein 7Add BLAST3011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2561PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ06A37.

Expressioni

Tissue specificityi

Expressed in the neural epithelium, otic placodes, optic placodes, branchial arches, and the olfactory placodes,.1 Publication

Developmental stagei

Expression is pan-neuronal at stages 8-20. Expressed throughout the rostral neural ectoderm and along the rostrocaudal axis but is absent from the more lateral, non-neuronal ectoderm. Adjacent to the neural tube, detected at the optic and otic placodes. At stage 20, expression is observed in the branchial arches and olfactory placodes in addition to brain and optic and otic placodes.1 Publication

Gene expression databases

BgeeiENSGALG00000015472.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024904.

Structurei

3D structure databases

ProteinModelPortaliQ06A37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini801 – 868Chromo 1PROSITE-ProRule annotationAdd BLAST68
Domaini883 – 948Chromo 2PROSITE-ProRule annotationAdd BLAST66
Domaini981 – 1155Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini1295 – 1465Helicase C-terminalPROSITE-ProRule annotationAdd BLAST171

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2403 – 2433Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1106 – 1109DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi151 – 225Gln-richAdd BLAST75
Compositional biasi492 – 560Gln-richAdd BLAST69
Compositional biasi602 – 720Lys-richAdd BLAST119
Compositional biasi1939 – 1945Poly-Arg7
Compositional biasi2248 – 2251Poly-Asp4
Compositional biasi2728 – 2738Poly-AlaAdd BLAST11
Compositional biasi2782 – 2787Poly-Ala6
Compositional biasi2863 – 2899Thr-richAdd BLAST37

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 2 chromo domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0383. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000246942.
HOVERGENiHBG081150.
InParanoidiQ06A37.
KOiK14437.
OrthoDBiEOG091G0022.
PhylomeDBiQ06A37.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07533. BRK. 2 hits.
PF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00592. BRK. 2 hits.
SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06A37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPGMMSLF GEDGNIFSEG LEGLGECGYP ENTVNPMGQQ MPMDQGFPSL
60 70 80 90 100
QSSLHHPPAN QNQAKLTHFD HYNQYEQQKM HLMDQPNRMI SNAPGNGIAS
110 120 130 140 150
PHSQYHNPPV PQVPHGSGAS GQMGVYPSMQ NERHGQPFVD SGSMWGPRAV
160 170 180 190 200
QVPDQIRAPY QQQQQQPQPT QPPQAPSGPP GQGHPQHMQQ MGNYMARGDF
210 220 230 240 250
SMQQHGQPQQ QRMNQFSQGQ EGLNQGNPFI ATSGPGHLSH VPQQNPSMAP
260 270 280 290 300
SLRHSVQQFH HHPPTALHGE SVAHSPRFSP NPPQQGAVRP QTLNFSSRSQ
310 320 330 340 350
TVPSPTINNS GQYSRYPYSN LNQGLVNNTG MNQNLGLTNN TPMNQSVPRY
360 370 380 390 400
PNAVGFPSNS GQGLMHQQPI HPSGSLNQMN TQTMHPSQPQ GTYASPPPMS
410 420 430 440 450
PMKAMSNPAG TPPPQVRPGS AGIPMEVGSY PNIPHPQPSH QPPGAMGIGQ
460 470 480 490 500
RNMGPRNMQQ NRPFMGMSST PREMGGHMRP NGCPGVGLAD PQAIQERLIS
510 520 530 540 550
GQQLPSQQQS FQQQMPTCPP MQPHPGIHHQ SSPPPHPHHQ PWAQLHQSPQ
560 570 580 590 600
NTPQKVPVLQ HSPSEPFLEK PVPDMTQVSG PNTQLVKSDD YLPSVEPQPQ
610 620 630 640 650
QKKKKKKNNH IAAEGPSKSF GKEDFPGGLD SQNLSRNSVD CSQEDKKKKK
660 670 680 690 700
KPKAKKEPKD PKEPKEKKEP KTPKVPKTPK EPKEKKAKNT TPKPKTSKKT
710 720 730 740 750
SNKKTDSESS AAKKKVNKGK EGSENSDLDK TPPPSPHPED EDDPGVQKRR
760 770 780 790 800
SSRQVKRKRY TEDLEFKISD EEADDADAAG RDSPSNTSQS EQQESADAEG
810 820 830 840 850
PVVEKIMSSR SVKKKMENGE EVEIEEFYVK YKNFSYLHCQ WASVEELDKD
860 870 880 890 900
KRIQQKIKRF KAKQGQNKFL SEIDDELFNP DYVEIDRILD FSRSTDDNGE
910 920 930 940 950
PVTHYLVKWC SLPYEDSTWE LKQDIDQAKI EEFEKLMSRE PEMERVERPP
960 970 980 990 1000
ADDWKKSESS REYKNNNKLR EYQLEGVNWL LFNWYNTRNC ILADEMGLGK
1010 1020 1030 1040 1050
TIQSITFLYE IYLKGIHGPF LVIAPLSTIP NWEREFRTWT ELNVVVYHGS
1060 1070 1080 1090 1100
QASRRTIQLY EMYFKDPQGR VIKGSYKFHA IITTFEMILT DCPELRNIPW
1110 1120 1130 1140 1150
RCVVIDEAHR LKNRNCKLLE GLKMMDLEHK VLLTGTPLQN TVEELFSLLH
1160 1170 1180 1190 1200
FLEPGRFPSE TTFMQEFGDL KTEEQVQKLQ AILKPMMLRR LKEDVEKNLA
1210 1220 1230 1240 1250
PKEETIIEVE LTNIQKKYYR AILEKNFAFL SKGGGQANVP NLLNTMMELR
1260 1270 1280 1290 1300
KCCNHPYLIN GAEEKILEEF KETHNADSPD FQLQAMIQAA GKLVLIDKLL
1310 1320 1330 1340 1350
PKLKAGGHRV LIFSQMVRCL DILEDYLIQR RYPYERIDGR VRGNLRQAAI
1360 1370 1380 1390 1400
DRFSRPDSDR FVFLLCTRAG GLGINLTAAD TCIIFDSDWN PQNDLQAQAR
1410 1420 1430 1440 1450
CHRIGQSKSV KIYRLITRNS YEREMFDKAS LKLGLDKAVL QSMSGRENAT
1460 1470 1480 1490 1500
NGVQQLSKKE IEDLLRKGAY GALMDEEDEG SKFCEEDIDQ ILLRRTHTIT
1510 1520 1530 1540 1550
IESEGKGSTF AKASFVASGN RTDISLDDPN FWQKWAKKAE LDIDALNGRN
1560 1570 1580 1590 1600
NLVIDTPRVR KQTRLYSAVK EDELMEFSDL ESDSEEKPST KPRRPQDKSQ
1610 1620 1630 1640 1650
GYARSECFRV EKNLLVYGWG RWTDILSHGR YKRQLTEQDV ETICRTILVY
1660 1670 1680 1690 1700
CLNHYKGDEN IKSFIWDLIT PTADGQTRAL VNHSGLSAPV PRGRKGKKVK
1710 1720 1730 1740 1750
AQSSQPMLQD ADWLTTCNPD VLFQEDSYRK HLKHHCNKVL LRVRMLYYLR
1760 1770 1780 1790 1800
QEVIGDQADR ILEGADSSEV DVWIPEPFHA EVPADWWDKE ADKSLLIGVF
1810 1820 1830 1840 1850
KHGYEKYNSM RADSTLCFLE RVGMPDAKAI AAEQRGTDML ADGGDGGEFD
1860 1870 1880 1890 1900
REDEDPEYKP TRTPFKDEID EFANSPPEDK EESIEIHPNK HSESNSELGQ
1910 1920 1930 1940 1950
LYWPNTSTLT TRLRRLITAY QRSYKRQQMR QEALMKTDRR RRRPREEVRA
1960 1970 1980 1990 2000
LEAEREAIIT EKRQKWTRRE EADFYRVVST FGIIFDPIKH QFDWNQFRAF
2010 2020 2030 2040 2050
ARLDKKSDES LEKYFNGFVN MCRRVCRMPV KPDDEPPDLS TMIEPITEER
2060 2070 2080 2090 2100
ASRTLYRIEL LRKIREQVLH HPQLGERLKL CQPSLDLPEW WECGKHDKDL
2110 2120 2130 2140 2150
LIGAAKHGVS RTDYHILNDP ELSFLEAHKN FAQNRGTGNA NTVSSLHPVG
2160 2170 2180 2190 2200
AGCSQTPPIV PSTPVQEEKS TEQTESKVEG SENPAAKEKS DIKEETDIAD
2210 2220 2230 2240 2250
KDTKQDCDAE AETGSVKCEL KDIEMSTDVD PKSISEKGSE EDEEEKLDDD
2260 2270 2280 2290 2300
DKSEESSQPE AGAVSQGKNF DEESNASMST ARDETRDGFY MEDGDPSVVQ
2310 2320 2330 2340 2350
LLHERTFAFS FWPKDRVMIN RLDNICEAVL KGKWPVNRRQ MFDFQGLIPG
2360 2370 2380 2390 2400
YTPTAVDSPL QKRSFAELSM IGQASISGSE DITASPQLSK EDALNLSVPR
2410 2420 2430 2440 2450
QRRRRRRKIE IEAERAAKRR NLMEMVAQLR ESQVVSENGQ EKVVDLSKAS
2460 2470 2480 2490 2500
REATSSTSNF SSVTSKFILP NVSTPVSDAF KTQMELLQAG LSRTPTRHLL
2510 2520 2530 2540 2550
NGSLIDGEPP MKRRRGRRKN VEGLDLLFMS NKRTSLTVED AEVTKAFEED
2560 2570 2580 2590 2600
MEALPARNIP SPGQLDPDTR IPVINLEDGT RLVGEDAPKN KDLVEWLKLH
2610 2620 2630 2640 2650
PTYTVDMPSY VPKSADVLFS SFQKPKQKRH RCRNPNKLDI NTLTGEERVP
2660 2670 2680 2690 2700
VVNKRNGKKM GGAMAPPMKD LPRWLEENPE FAVAPDWTDI VKQSGFVPES
2710 2720 2730 2740 2750
MFDRLLTGPV VREEGASRRG RRPKSEIAKA AAAAAAVAST SGINPLLMNS
2760 2770 2780 2790 2800
LFAGMDLTSL QNLQNLQSLQ LAGLMGFPPG LATAAAAGGD AKNPAAMLPL
2810 2820 2830 2840 2850
MLPGMAGLPN MFGLSGLLNN PITATTGNAT TASGQGETED GASKAEEKKN
2860 2870 2880 2890 2900
ENEEENKDSE KSTDTVSATD SANGSVSAAT AATTATATTT TTTNTGLPTN
2910 2920 2930 2940 2950
PLAFNPFLLS TMAPGLFYPS MFLPPGLGGL TLPGFPALAG LQNAVGSNEE
2960 2970 2980 2990 3000
KATDKTEGTA FKDEENLEGS DAEESLDKTA DSSILEDEIA QGEELDSLDG
3010
GEEIENNEND E
Length:3,011
Mass (Da):338,213
Last modified:October 31, 2006 - v1
Checksum:iE544AB2C80E7C6D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ978381 mRNA. Translation: ABI96999.1.
RefSeqiNP_001071054.1. NM_001077586.2.
UniGeneiGga.17320.
Gga.20865.

Genome annotation databases

EnsembliENSGALT00000047494; ENSGALP00000056921; ENSGALG00000041080.
GeneIDi421140.
KEGGigga:421140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ978381 mRNA. Translation: ABI96999.1.
RefSeqiNP_001071054.1. NM_001077586.2.
UniGeneiGga.17320.
Gga.20865.

3D structure databases

ProteinModelPortaliQ06A37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024904.

Proteomic databases

PaxDbiQ06A37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000047494; ENSGALP00000056921; ENSGALG00000041080.
GeneIDi421140.
KEGGigga:421140.

Organism-specific databases

CTDi55636.

Phylogenomic databases

eggNOGiKOG0383. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000246942.
HOVERGENiHBG081150.
InParanoidiQ06A37.
KOiK14437.
OrthoDBiEOG091G0022.
PhylomeDBiQ06A37.

Miscellaneous databases

PROiQ06A37.

Gene expression databases

BgeeiENSGALG00000015472.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07533. BRK. 2 hits.
PF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00592. BRK. 2 hits.
SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHD7_CHICK
AccessioniPrimary (citable) accession number: Q06A37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.