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Protein

H/ACA ribonucleoprotein complex subunit 1

Gene

gar1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. Essential for growth.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 1
Alternative name(s):
snoRNP protein GAR1
Gene namesi
Name:gar1
ORF Names:SPBC20F10.01, SPBC25H2.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC20F10.01
PomBaseiSPBC20F10.01 gar1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002085651 – 194H/ACA ribonucleoprotein complex subunit 1Add BLAST194

Proteomic databases

MaxQBiQ06975
PaxDbiQ06975
PRIDEiQ06975

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).By similarity

Protein-protein interaction databases

BioGridi277228, 16 interactors
STRINGi4896.SPBC20F10.01.1

Structurei

3D structure databases

SMRiQ06975
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 17RGG-box 1Add BLAST14
Regioni137 – 194RGG-box 2Add BLAST58

Sequence similaritiesi

Belongs to the GAR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ06975
KOiK11128
OMAiFQQRDMG
OrthoDBiEOG092C5OR3

Family and domain databases

Gene3Di2.40.10.230, 1 hit
InterProiView protein in InterPro
IPR038664 Gar1/Naf1_Cbf5-bd_sf
IPR021154 H/ACA_rnp_Gar1
IPR007504 H/ACA_rnp_Gar1/Naf1
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR23237 PTHR23237, 1 hit
PfamiView protein in Pfam
PF04410 Gar1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD020235 Gar1_RNA_bd, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit

Sequencei

Sequence statusi: Complete.

Q06975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRGGRGGG FRGGRGGSRP FTPSGPPDQV IELGLFMHDC EGEMVCQSTN
60 70 80 90 100
VKIPYFNAPI YLENKSQIGK IDEVFGPMNQ VYFTVKPSEG IVSSSFKVGD
110 120 130 140 150
KVYLSGDKLI PLDRFLPKPK TVGPKKPKGA RNGPAGRGGR GGFRGGRGGS
160 170 180 190
RGGFGGNSRG GFGGGSRGGF GGGSRGGSRG GFRGGSRGGF RGRF
Length:194
Mass (Da):20,131
Last modified:June 1, 1994 - v1
Checksum:i5C2BC416535D38D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19576 Genomic DNA Translation: CAA79628.1
AB000537 mRNA Translation: BAA19143.1
CU329671 Genomic DNA Translation: CAB08787.1
PIRiS33691
RefSeqiNP_596365.1, NM_001022286.2

Genome annotation databases

EnsemblFungiiSPBC20F10.01.1; SPBC20F10.01.1:pep; SPBC20F10.01
GeneIDi2540705
KEGGispo:SPBC20F10.01

Similar proteinsi

Entry informationi

Entry nameiGAR1_SCHPO
AccessioniPrimary (citable) accession number: Q06975
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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