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Protein

H/ACA ribonucleoprotein complex subunit 1

Gene

gar1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. Essential for growth.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 1
Alternative name(s):
snoRNP protein GAR1
Gene namesi
Name:gar1
ORF Names:SPBC20F10.01, SPBC25H2.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC20F10.01.
PomBaseiSPBC20F10.01. gar1.

Subcellular locationi

GO - Cellular componenti

  • box H/ACA snoRNP complex Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002085651 – 194H/ACA ribonucleoprotein complex subunit 1Add BLAST194

Proteomic databases

MaxQBiQ06975.
PRIDEiQ06975.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).By similarity

Protein-protein interaction databases

BioGridi277228. 15 interactors.
MINTiMINT-4693533.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 17RGG-box 1Add BLAST14
Regioni137 – 194RGG-box 2Add BLAST58

Sequence similaritiesi

Belongs to the GAR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ06975.
KOiK11128.
OMAiHFNAQIF.
OrthoDBiEOG092C5OR3.

Family and domain databases

InterProiIPR021154. H/ACA_rnp_Gar1.
IPR007504. H/ACA_rnp_Gar1/Naf1.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR23237. PTHR23237. 1 hit.
PfamiPF04410. Gar1. 1 hit.
[Graphical view]
ProDomiPD020235. Gar1_RNA_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRGGRGGG FRGGRGGSRP FTPSGPPDQV IELGLFMHDC EGEMVCQSTN
60 70 80 90 100
VKIPYFNAPI YLENKSQIGK IDEVFGPMNQ VYFTVKPSEG IVSSSFKVGD
110 120 130 140 150
KVYLSGDKLI PLDRFLPKPK TVGPKKPKGA RNGPAGRGGR GGFRGGRGGS
160 170 180 190
RGGFGGNSRG GFGGGSRGGF GGGSRGGSRG GFRGGSRGGF RGRF
Length:194
Mass (Da):20,131
Last modified:June 1, 1994 - v1
Checksum:i5C2BC416535D38D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19576 Genomic DNA. Translation: CAA79628.1.
AB000537 mRNA. Translation: BAA19143.1.
CU329671 Genomic DNA. Translation: CAB08787.1.
PIRiS33691.
RefSeqiNP_596365.1. NM_001022286.2.

Genome annotation databases

EnsemblFungiiSPBC20F10.01.1; SPBC20F10.01.1:pep; SPBC20F10.01.
GeneIDi2540705.
KEGGispo:SPBC20F10.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19576 Genomic DNA. Translation: CAA79628.1.
AB000537 mRNA. Translation: BAA19143.1.
CU329671 Genomic DNA. Translation: CAB08787.1.
PIRiS33691.
RefSeqiNP_596365.1. NM_001022286.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277228. 15 interactors.
MINTiMINT-4693533.

Proteomic databases

MaxQBiQ06975.
PRIDEiQ06975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC20F10.01.1; SPBC20F10.01.1:pep; SPBC20F10.01.
GeneIDi2540705.
KEGGispo:SPBC20F10.01.

Organism-specific databases

EuPathDBiFungiDB:SPBC20F10.01.
PomBaseiSPBC20F10.01. gar1.

Phylogenomic databases

InParanoidiQ06975.
KOiK11128.
OMAiHFNAQIF.
OrthoDBiEOG092C5OR3.

Miscellaneous databases

PROiQ06975.

Family and domain databases

InterProiIPR021154. H/ACA_rnp_Gar1.
IPR007504. H/ACA_rnp_Gar1/Naf1.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR23237. PTHR23237. 1 hit.
PfamiPF04410. Gar1. 1 hit.
[Graphical view]
ProDomiPD020235. Gar1_RNA_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGAR1_SCHPO
AccessioniPrimary (citable) accession number: Q06975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.