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Q06951

- RFBB_VIBCH

UniProt

Q06951 - RFBB_VIBCH

Protein

Phosphomannomutase

Gene

rfbB

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides.

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei103 – 1031Phosphoserine intermediateBy similarity
    Metal bindingi103 – 1031Magnesium; via phosphate groupBy similarity
    Metal bindingi248 – 2481MagnesiumBy similarity
    Metal bindingi250 – 2501MagnesiumBy similarity
    Metal bindingi252 – 2521MagnesiumBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphomannomutase activity Source: TIGR

    GO - Biological processi

    1. carbohydrate metabolic process Source: TIGR
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    3. O antigen biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciVCHO:VC0242-MONOMER.
    UniPathwayiUPA00126; UER00424.
    UPA00281.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    Name:rfbB
    Ordered Locus Names:VC_0242
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463PhosphomannomutasePRO_0000147827Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC0242.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06951.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Phylogenomic databases

    eggNOGiCOG1109.
    KOiK01840.
    OMAiVVGCDIR.
    OrthoDBiEOG6W9X55.

    Family and domain databases

    Gene3Di3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view]
    PRINTSiPR00509. PGMPMM.
    SUPFAMiSSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06951-1 [UniParc]FASTAAdd to Basket

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    MKELTCFKAY DIRGQLGSEL DNEIAYRIGR SYGQFLKSEN DADKTVVVGG    50
    DVRLTSEALK QALANGLMDA GINVIDIGVT GTEEIYFATF YLGVDGGIEV 100
    TASHNPMDYN GMKLVREGSK PISGDTGLRE IQALAEKNEF MDVEVKGNYK 150
    KVSLLPEYVD HLISYITPAK IKPMKLVINS GNGAAGHVID ELEKRFIELS 200
    IPLEIIKVHH EEDGNFPNGI PNPLLPECRA DTANAVKEHK ADMGIAFDGD 250
    FDRCFLFDEN GDFIEGYYIV GLLAEAFLQK EQGAKIIHDP RLSWNTIDVV 300
    TKSGGVPVMS KTGHAFIKER MRKEDAIYGG EMSAHHYFRD FGYCDSGMIP 350
    WLLITELLSL APDISLSKLI SAKRFLFPCS GEINFKVKQA KLIMEQVYLH 400
    YYENSIHFSA IDGISLEFEG WRFNLRDSNT EPLLRLNVES KQNIALMNDK 450
    VEELTKLIKK LDI 463
    Length:463
    Mass (Da):51,838
    Last modified:February 1, 1995 - v1
    Checksum:i7212EA3A64BFC6BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59554 Genomic DNA. Translation: CAA42135.1.
    AE003852 Genomic DNA. Translation: AAF93418.1.
    PIRiS28469.
    RefSeqiNP_229899.1. NC_002505.1.
    WP_000661577.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF93418; AAF93418; VC_0242.
    GeneIDi2614705.
    KEGGivch:VC0242.
    PATRICi20079528. VBIVibCho83274_0223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59554 Genomic DNA. Translation: CAA42135.1 .
    AE003852 Genomic DNA. Translation: AAF93418.1 .
    PIRi S28469.
    RefSeqi NP_229899.1. NC_002505.1.
    WP_000661577.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q06951.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC0242.

    Protocols and materials databases

    DNASUi 2614705.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF93418 ; AAF93418 ; VC_0242 .
    GeneIDi 2614705.
    KEGGi vch:VC0242.
    PATRICi 20079528. VBIVibCho83274_0223.

    Phylogenomic databases

    eggNOGi COG1109.
    KOi K01840.
    OMAi VVGCDIR.
    OrthoDBi EOG6W9X55.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    UPA00281 .
    BioCyci VCHO:VC0242-MONOMER.

    Family and domain databases

    Gene3Di 3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view ]
    PRINTSi PR00509. PGMPMM.
    SUPFAMi SSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: El Tor O17 / Serotype O1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiRFBB_VIBCH
    AccessioniPrimary (citable) accession number: Q06951
    Secondary accession number(s): Q9JQ14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3