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Q06945 (SOX4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-4
Gene names
Name:SOX4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Subunit structure

Interacts with UBE2I. Ref.5

Subcellular location

Nucleus Ref.5.

Tissue specificity

Testis, brain, and heart.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA damage response, detection of DNA damage

Inferred from direct assay PubMed 19234109. Source: UniProtKB

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB

T cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

ascending aorta morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

atrial septum primum morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

cardiac right ventricle morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

cardiac ventricle formation

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to glucose stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

endocrine pancreas development

Inferred from electronic annotation. Source: Ensembl

glial cell development

Inferred from sequence or structural similarity. Source: UniProtKB

glial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

glucose homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

heart development

Inferred from sequence or structural similarity. Source: BHF-UCL

kidney morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

limb bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

mitral valve morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of cell death

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB

negative regulation of protein export from nucleus

Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB

negative regulation of protein ubiquitination

Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB

neural tube formation

Inferred from sequence or structural similarity. Source: UniProtKB

neuroepithelial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

noradrenergic neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of N-terminal peptidyl-lysine acetylation

Inferred from direct assay PubMed 19234109. Source: UniProtKB

positive regulation of Wnt signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB

positive regulation of canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 17875931. Source: BHF-UCL

positive regulation of insulin secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19147588. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 19147588. Source: UniProtKB

positive regulation of translation

Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB

pro-B cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

protein stabilization

Inferred from mutant phenotype PubMed 17875931. Source: BHF-UCL

regulation of protein stability

Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB

regulation of transcription, DNA-templated

Inferred from direct assay Ref.5PubMed 7706298. Source: BHF-UCL

skeletal system development

Inferred from sequence or structural similarity. Source: UniProtKB

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

spinal cord development

Inferred from sequence or structural similarity. Source: UniProtKB

spinal cord motor neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

sympathetic nervous system development

Inferred from sequence or structural similarity. Source: UniProtKB

ventricular septum morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 17875931. Source: BHF-UCL

mitochondrion

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay PubMed 19234109. Source: UniProtKB

   Molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from direct assay PubMed 19147588. Source: UniProtKB

RNA polymerase II transcription coactivator activity

Inferred from sequence or structural similarity. Source: UniProtKB

core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 20049565. Source: UniProtKB

nucleic acid binding transcription factor activity

Inferred from mutant phenotype PubMed 20049565. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.5PubMed 7706298. Source: BHF-UCL

transcription regulatory region sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Transcription factor SOX-4
PRO_0000048724

Regions

DNA binding59 – 12769HMG box
Compositional bias386 – 39712Poly-Ser

Experimental info

Sequence conflict711Q → P in CAA46612. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q06945 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: CB75B76ABF507A07

FASTA47447,263
        10         20         30         40         50         60 
MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK 

        70         80         90        100        110        120 
RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIR EAERLRLKHM 

       130        140        150        160        170        180 
ADYPDYKYRP RKKVKSGNAN SSSSAAASSK PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG 

       190        200        210        220        230        240 
GGGASGGGAN SKPAQKKSCG SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE 

       250        260        270        280        290        300 
QAGAAALLPL GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 

       310        320        330        340        350        360 
GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA AGRSPADHRG 

       370        380        390        400        410        420 
YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE FEDDLLDLNP SSNFESMSLG 

       430        440        450        460        470 
SFSSSSALDR DLDFNFEPGS GSHFEFPDYC TPEVSEMISG DWLESSISNL VFTY 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and mapping of the human SOX4 gene."
Farr C.J., Easty D.J., Ragoussis J., Collignon J., Lovell-Badge R., Goodfellow P.N.
Mamm. Genome 4:577-584(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[4]"A conserved family of genes related to the testis determining gene, SRY."
Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-123.
[5]"Ubc9 interacts with SOX4 and represses its transcriptional activity."
Pan X., Li H., Zhang P., Jin B., Man J., Tian L., Su G., Zhao J., Li W., Liu H., Gong W., Zhou T., Zhang X.
Biochem. Biophys. Res. Commun. 344:727-734(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UBE2I, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70683 mRNA. Translation: CAA50018.1.
AL136179 Genomic DNA. Translation: CAC03595.1.
BC072668 mRNA. Translation: AAH72668.1.
X65661 mRNA. Translation: CAA46612.1.
PIRI38240.
RefSeqNP_003098.1. NM_003107.2.
UniGeneHs.643910.

3D structure databases

ProteinModelPortalQ06945.
SMRQ06945. Positions 57-163.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112542. 7 interactions.
DIPDIP-58650N.
IntActQ06945. 1 interaction.
STRING9606.ENSP00000244745.

PTM databases

PhosphoSiteQ06945.

Polymorphism databases

DMDM548952.

Proteomic databases

PaxDbQ06945.
PRIDEQ06945.

Protocols and materials databases

DNASU6659.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244745; ENSP00000244745; ENSG00000124766.
ENST00000543472; ENSP00000438412; ENSG00000124766.
GeneID6659.
KEGGhsa:6659.
UCSCuc003ndi.3. human.

Organism-specific databases

CTD6659.
GeneCardsGC06P021593.
HGNCHGNC:11200. SOX4.
HPAHPA029901.
MIM184430. gene.
neXtProtNX_Q06945.
PharmGKBPA36037.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG130659.
HOGENOMHOG000231874.
HOVERGENHBG005040.
InParanoidQ06945.
KOK09268.
OMAAGCSPDG.
OrthoDBEOG7TMZVP.
PhylomeDBQ06945.

Gene expression databases

BgeeQ06945.
CleanExHS_SOX4.
GenevestigatorQ06945.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSOX4. human.
GeneWikiSOX4.
GenomeRNAi6659.
NextBio25959.
PROQ06945.
SOURCESearch...

Entry information

Entry nameSOX4_HUMAN
AccessionPrimary (citable) accession number: Q06945
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM