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Protein

Transcription factor SOX-4

Gene

SOX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi59 – 127HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3769402. Deactivation of the beta-catenin transactivating complex.
SIGNORiQ06945.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-4
Gene namesi
Name:SOX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124766.5.
HGNCiHGNC:11200. SOX4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6659.
OpenTargetsiENSG00000124766.
PharmGKBiPA36037.

Polymorphism and mutation databases

BioMutaiSOX4.
DMDMi548952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487241 – 474Transcription factor SOX-4Add BLAST474

Proteomic databases

EPDiQ06945.
MaxQBiQ06945.
PaxDbiQ06945.
PeptideAtlasiQ06945.
PRIDEiQ06945.

PTM databases

iPTMnetiQ06945.
PhosphoSitePlusiQ06945.

Expressioni

Tissue specificityi

Testis, brain, and heart.

Gene expression databases

BgeeiENSG00000124766.
CleanExiHS_SOX4.
GenevisibleiQ06945. HS.

Organism-specific databases

HPAiHPA029901.

Interactioni

Subunit structurei

Interacts with UBE2I.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112542. 27 interactors.
CORUMiQ06945.
DIPiDIP-58650N.
IntActiQ06945. 7 interactors.
STRINGi9606.ENSP00000244745.

Structurei

3D structure databases

ProteinModelPortaliQ06945.
SMRiQ06945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi386 – 397Poly-SerAdd BLAST12

Phylogenomic databases

eggNOGiENOG410IPZ6. Eukaryota.
ENOG4111U1K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiQ06945.
KOiK09268.
OMAiGENPAWC.
OrthoDBiEOG091G0F15.
PhylomeDBiQ06945.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR017386. SOX-11/4.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS
60 70 80 90 100
WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL
110 120 130 140 150
KDSDKIPFIR EAERLRLKHM ADYPDYKYRP RKKVKSGNAN SSSSAAASSK
160 170 180 190 200
PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG GGGASGGGAN SKPAQKKSCG
210 220 230 240 250
SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE QAGAAALLPL
260 270 280 290 300
GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG
310 320 330 340 350
GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA
360 370 380 390 400
AGRSPADHRG YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE
410 420 430 440 450
FEDDLLDLNP SSNFESMSLG SFSSSSALDR DLDFNFEPGS GSHFEFPDYC
460 470
TPEVSEMISG DWLESSISNL VFTY
Length:474
Mass (Da):47,263
Last modified:June 1, 1994 - v1
Checksum:iCB75B76ABF507A07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71Q → P in CAA46612 (PubMed:1614875).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70683 mRNA. Translation: CAA50018.1.
AL136179 Genomic DNA. No translation available.
BC072668 mRNA. Translation: AAH72668.1.
X65661 mRNA. Translation: CAA46612.1.
CCDSiCCDS4547.1.
PIRiI38240.
RefSeqiNP_003098.1. NM_003107.2.
UniGeneiHs.643910.

Genome annotation databases

EnsembliENST00000244745; ENSP00000244745; ENSG00000124766.
GeneIDi6659.
KEGGihsa:6659.
UCSCiuc003ndi.4. human.

Similar proteinsi

Entry informationi

Entry nameiSOX4_HUMAN
AccessioniPrimary (citable) accession number: Q06945
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 27, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot