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Q06945

- SOX4_HUMAN

UniProt

Q06945 - SOX4_HUMAN

Protein

Transcription factor SOX-4

Gene

SOX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi59 – 12769HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter sequence-specific DNA binding Source: UniProtKB
    2. nucleic acid binding transcription factor activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    5. RNA polymerase II transcription coactivator activity Source: UniProtKB
    6. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    7. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. ascending aorta morphogenesis Source: BHF-UCL
    2. atrial septum primum morphogenesis Source: BHF-UCL
    3. canonical Wnt signaling pathway Source: BHF-UCL
    4. cardiac right ventricle morphogenesis Source: BHF-UCL
    5. cardiac ventricle formation Source: UniProtKB
    6. cellular response to glucose stimulus Source: UniProtKB
    7. DNA damage response, detection of DNA damage Source: UniProtKB
    8. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
    9. endocrine pancreas development Source: Ensembl
    10. glial cell development Source: UniProtKB
    11. glial cell proliferation Source: UniProtKB
    12. glucose homeostasis Source: UniProtKB
    13. heart development Source: BHF-UCL
    14. kidney morphogenesis Source: BHF-UCL
    15. limb bud formation Source: UniProtKB
    16. mitral valve morphogenesis Source: BHF-UCL
    17. negative regulation of cell death Source: UniProtKB
    18. negative regulation of cell proliferation Source: UniProtKB
    19. negative regulation of protein export from nucleus Source: UniProtKB
    20. negative regulation of protein ubiquitination Source: UniProtKB
    21. neural tube formation Source: UniProtKB
    22. neuroepithelial cell differentiation Source: UniProtKB
    23. noradrenergic neuron differentiation Source: UniProtKB
    24. positive regulation of apoptotic process Source: UniProtKB
    25. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    26. positive regulation of cell proliferation Source: BHF-UCL
    27. positive regulation of insulin secretion Source: UniProtKB
    28. positive regulation of N-terminal peptidyl-lysine acetylation Source: UniProtKB
    29. positive regulation of transcription, DNA-templated Source: UniProtKB
    30. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    31. positive regulation of translation Source: UniProtKB
    32. positive regulation of Wnt signaling pathway Source: BHF-UCL
    33. pro-B cell differentiation Source: BHF-UCL
    34. protein stabilization Source: BHF-UCL
    35. regulation of protein stability Source: UniProtKB
    36. regulation of transcription, DNA-templated Source: BHF-UCL
    37. skeletal system development Source: UniProtKB
    38. somatic stem cell maintenance Source: Ensembl
    39. spinal cord development Source: UniProtKB
    40. spinal cord motor neuron differentiation Source: UniProtKB
    41. sympathetic nervous system development Source: UniProtKB
    42. T cell differentiation Source: BHF-UCL
    43. ventricular septum morphogenesis Source: BHF-UCL

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-4
    Gene namesi
    Name:SOX4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11200. SOX4.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. mitochondrion Source: HPA
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36037.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Transcription factor SOX-4PRO_0000048724Add
    BLAST

    Proteomic databases

    PaxDbiQ06945.
    PRIDEiQ06945.

    PTM databases

    PhosphoSiteiQ06945.

    Expressioni

    Tissue specificityi

    Testis, brain, and heart.

    Gene expression databases

    BgeeiQ06945.
    CleanExiHS_SOX4.
    GenevestigatoriQ06945.

    Organism-specific databases

    HPAiHPA029901.

    Interactioni

    Subunit structurei

    Interacts with UBE2I.1 Publication

    Protein-protein interaction databases

    BioGridi112542. 7 interactions.
    DIPiDIP-58650N.
    IntActiQ06945. 1 interaction.
    STRINGi9606.ENSP00000244745.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06945.
    SMRiQ06945. Positions 57-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi386 – 39712Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG130659.
    HOGENOMiHOG000231874.
    HOVERGENiHBG005040.
    InParanoidiQ06945.
    KOiK09268.
    OMAiAGCSPDG.
    OrthoDBiEOG7TMZVP.
    PhylomeDBiQ06945.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR017386. SOX-12/11/4a.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06945-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS    50
    WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL 100
    KDSDKIPFIR EAERLRLKHM ADYPDYKYRP RKKVKSGNAN SSSSAAASSK 150
    PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG GGGASGGGAN SKPAQKKSCG 200
    SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE QAGAAALLPL 250
    GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 300
    GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA 350
    AGRSPADHRG YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE 400
    FEDDLLDLNP SSNFESMSLG SFSSSSALDR DLDFNFEPGS GSHFEFPDYC 450
    TPEVSEMISG DWLESSISNL VFTY 474
    Length:474
    Mass (Da):47,263
    Last modified:June 1, 1994 - v1
    Checksum:iCB75B76ABF507A07
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711Q → P in CAA46612. (PubMed:1614875)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70683 mRNA. Translation: CAA50018.1.
    AL136179 Genomic DNA. Translation: CAC03595.1.
    BC072668 mRNA. Translation: AAH72668.1.
    X65661 mRNA. Translation: CAA46612.1.
    CCDSiCCDS4547.1.
    PIRiI38240.
    RefSeqiNP_003098.1. NM_003107.2.
    UniGeneiHs.643910.

    Genome annotation databases

    EnsembliENST00000244745; ENSP00000244745; ENSG00000124766.
    GeneIDi6659.
    KEGGihsa:6659.
    UCSCiuc003ndi.3. human.

    Polymorphism databases

    DMDMi548952.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70683 mRNA. Translation: CAA50018.1 .
    AL136179 Genomic DNA. Translation: CAC03595.1 .
    BC072668 mRNA. Translation: AAH72668.1 .
    X65661 mRNA. Translation: CAA46612.1 .
    CCDSi CCDS4547.1.
    PIRi I38240.
    RefSeqi NP_003098.1. NM_003107.2.
    UniGenei Hs.643910.

    3D structure databases

    ProteinModelPortali Q06945.
    SMRi Q06945. Positions 57-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112542. 7 interactions.
    DIPi DIP-58650N.
    IntActi Q06945. 1 interaction.
    STRINGi 9606.ENSP00000244745.

    PTM databases

    PhosphoSitei Q06945.

    Polymorphism databases

    DMDMi 548952.

    Proteomic databases

    PaxDbi Q06945.
    PRIDEi Q06945.

    Protocols and materials databases

    DNASUi 6659.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000244745 ; ENSP00000244745 ; ENSG00000124766 .
    GeneIDi 6659.
    KEGGi hsa:6659.
    UCSCi uc003ndi.3. human.

    Organism-specific databases

    CTDi 6659.
    GeneCardsi GC06P021593.
    HGNCi HGNC:11200. SOX4.
    HPAi HPA029901.
    MIMi 184430. gene.
    neXtProti NX_Q06945.
    PharmGKBi PA36037.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG130659.
    HOGENOMi HOG000231874.
    HOVERGENi HBG005040.
    InParanoidi Q06945.
    KOi K09268.
    OMAi AGCSPDG.
    OrthoDBi EOG7TMZVP.
    PhylomeDBi Q06945.

    Miscellaneous databases

    ChiTaRSi SOX4. human.
    GeneWikii SOX4.
    GenomeRNAii 6659.
    NextBioi 25959.
    PROi Q06945.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q06945.
    CleanExi HS_SOX4.
    Genevestigatori Q06945.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR017386. SOX-12/11/4a.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    4. "A conserved family of genes related to the testis determining gene, SRY."
      Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
      Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-123.
    5. Cited for: INTERACTION WITH UBE2I, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSOX4_HUMAN
    AccessioniPrimary (citable) accession number: Q06945
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3