Reviewed, UniProtKB/Swiss-Prot Q06945 (SOX4_HUMAN)

Names and origin

Protein names

Recommended name:
    Transcription factor SOX-4

Gene names

Name:

SOX4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.
Subunit structure	Interacts with UBE2I.
Subcellular location	Nucleus.
Tissue specificity	Testis, brain, and heart.
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	T cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB Wnt receptor signaling pathway through beta-catenin Inferred from sequence or structural similarity. Source: UniProtKB heart development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptosis Inferred from mutant phenotype. Source: UniProtKB positive regulation of Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of apoptosis Inferred from mutant phenotype. Source: UniProtKB positive regulation of cell proliferation Inferred from mutant phenotype. Source: UniProtKB positive regulation of transcription, DNA-dependent Ref.5 Inferred from direct assay. Source: UniProtKB pro-B cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB protein stabilization Inferred from mutant phenotype. Source: UniProtKB
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB nucleus Ref.5 Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Ref.5 Inferred from physical interaction. Source: UniProtKB transcription factor activity Ref.1 Ref.5 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Transcription factor SOX-4		PRO_0000048724
Regions
	DNA binding	59 – 127	69	HMG box
	Compositional bias	386 – 397	12	Poly-Ser
Amino acid modifications
	Modified residue	276	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	71	1	Q → P in CAA46612. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q06945-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: CB75B76ABF507A07	FASTA	474	47,263
	10 20 30 40 50 60 MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK 70 80 90 100 110 120 RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIR EAERLRLKHM 130 140 150 160 170 180 ADYPDYKYRP RKKVKSGNAN SSSSAAASSK PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG 190 200 210 220 230 240 GGGASGGGAN SKPAQKKSCG SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE 250 260 270 280 290 300 QAGAAALLPL GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 310 320 330 340 350 360 GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA AGRSPADHRG 370 380 390 400 410 420 YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE FEDDLLDLNP SSNFESMSLG 430 440 450 460 470 SFSSSSALDR DLDFNFEPGS GSHFEFPDYC TPEVSEMISG DWLESSISNL VFTY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and mapping of the human SOX4 gene." Farr C.J., Easty D.J., Ragoussis J., Collignon J., Lovell-Badge R., Goodfellow P.N. Mamm. Genome 4:577-584(1993) [PubMed: 8268656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[4]	"A conserved family of genes related to the testis determining gene, SRY." Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A. Nucleic Acids Res. 20:2887-2887(1992) [PubMed: 1614875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-123.
[5]	"Ubc9 interacts with SOX4 and represses its transcriptional activity." Pan X., Li H., Zhang P., Jin B., Man J., Tian L., Su G., Zhao J., Li W., Liu H., Gong W., Zhou T., Zhang X. Biochem. Biophys. Res. Commun. 344:727-734(2006) [PubMed: 16631117] [Abstract] Cited for: INTERACTION WITH UBE2I, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X70683 mRNA. Translation: CAA50018.1. AL136179 Genomic DNA. Translation: CAC03595.1. BC072668 mRNA. Translation: AAH72668.1. X65661 mRNA. Translation: CAA46612.1.
PIR	I38240.
RefSeq	NP_003098.1.
UniGene	Hs.699195
3D structure databases
HSSP	HSSP built from PDB template 1GT0 based on UniProtKB P48432.
ModBase	Search...
PTM databases
PhosphoSite	Q06945.
Genome annotation databases
Ensembl	ENSG00000124766. Homo sapiens. [Contig view]
GeneID	6659.
KEGG	hsa:6659.
Organism-specific databases
H-InvDB	HIX0032765.
HGNC	HGNC:11200. SOX4.
MIM	184430. gene.
PharmGKB	PA36037.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q06945.
HOVERGEN	Q06945.
Gene expression databases
ArrayExpress	Q06945.
CleanEx	HS_SOX4.
GermOnline	ENSG00000124766. Homo sapiens.
Family and domain databases
InterPro	IPR000910. HMG_1/2_box. IPR017386. SOX-12/11/4a. [Graphical view]
Gene3D	G3DSA:1.10.30.10. HMG-box. 1 hit.
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
PIRSF	PIRSF038098. SOX-12/11/4a. 1 hit.
SMART	SM00398. HMG. 1 hit. [Graphical view]
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	25959.
SOURCE	Search...

Entry information

Entry name

SOX4_HUMAN

Accession

Primary (citable) accession number: Q06945

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 25, 2008
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)