Q06945 (SOX4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-4

Gene names

Name:

SOX4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.
Subunit structure	Interacts with UBE2I. Ref.5
Subcellular location	Nucleus Ref.5.
Tissue specificity	Testis, brain, and heart.
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage response, detection of DNA damage Inferred from direct assay PubMed 19234109. Source: UniProtKB DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB T cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL ascending aorta morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL atrial septum primum morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL cardiac right ventricle morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL cardiac ventricle formation Inferred from sequence or structural similarity. Source: UniProtKB cellular response to glucose stimulus Inferred from sequence or structural similarity. Source: UniProtKB endocrine pancreas development Inferred from electronic annotation. Source: Compara glial cell development Inferred from sequence or structural similarity. Source: UniProtKB glial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB kidney morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL limb bud formation Inferred from sequence or structural similarity. Source: UniProtKB mitral valve morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of apoptotic process Inferred from mutant phenotype PubMed 16636670. Source: BHF-UCL negative regulation of cell proliferation Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB negative regulation of protein export from nucleus Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB negative regulation of protein ubiquitination Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB neural tube formation Inferred from sequence or structural similarity. Source: UniProtKB neuroepithelial cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB noradrenergic neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of N-terminal peptidyl-lysine acetylation Inferred from direct assay PubMed 19234109. Source: UniProtKB positive regulation of apoptotic process Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB positive regulation of canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell proliferation Inferred from mutant phenotype PubMed 17875931. Source: BHF-UCL positive regulation of insulin secretion Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of translation Inferred from mutant phenotype PubMed 19234109. Source: UniProtKB pro-B cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL protein stabilization Inferred from mutant phenotype PubMed 17875931. Source: BHF-UCL skeletal system development Inferred from sequence or structural similarity. Source: UniProtKB somatic stem cell maintenance Inferred from electronic annotation. Source: Compara spinal cord motor neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB sympathetic nervous system development Inferred from sequence or structural similarity. Source: UniProtKB ventricular septum morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	mitochondrion Inferred from direct assay. Source: HPA nucleus Inferred from direct assay PubMed 19234109. Source: UniProtKB
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 19147588. Source: UniProtKB RNA polymerase II transcription coactivator activity Inferred from sequence or structural similarity. Source: UniProtKB core promoter sequence-specific DNA binding Inferred from direct assay PubMed 20049565. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Transcription factor SOX-4		PRO_0000048724
Regions
	DNA binding	59 – 127	69	HMG box
	Compositional bias	386 – 397	12	Poly-Ser
Amino acid modifications
	Modified residue	276	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	71	1	Q → P in CAA46612. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q06945 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: CB75B76ABF507A07	FASTA	474	47,263
	10 20 30 40 50 60 MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK 70 80 90 100 110 120 RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIR EAERLRLKHM 130 140 150 160 170 180 ADYPDYKYRP RKKVKSGNAN SSSSAAASSK PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG 190 200 210 220 230 240 GGGASGGGAN SKPAQKKSCG SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE 250 260 270 280 290 300 QAGAAALLPL GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 310 320 330 340 350 360 GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA AGRSPADHRG 370 380 390 400 410 420 YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE FEDDLLDLNP SSNFESMSLG 430 440 450 460 470 SFSSSSALDR DLDFNFEPGS GSHFEFPDYC TPEVSEMISG DWLESSISNL VFTY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and mapping of the human SOX4 gene." Farr C.J., Easty D.J., Ragoussis J., Collignon J., Lovell-Badge R., Goodfellow P.N. Mamm. Genome 4:577-584(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[4]	"A conserved family of genes related to the testis determining gene, SRY." Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A. Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-123.
[5]	"Ubc9 interacts with SOX4 and represses its transcriptional activity." Pan X., Li H., Zhang P., Jin B., Man J., Tian L., Su G., Zhao J., Li W., Liu H., Gong W., Zhou T., Zhang X. Biochem. Biophys. Res. Commun. 344:727-734(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UBE2I, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70683 mRNA. Translation: CAA50018.1. AL136179 Genomic DNA. Translation: CAC03595.1. BC072668 mRNA. Translation: AAH72668.1. X65661 mRNA. Translation: CAA46612.1.
IPI	IPI00001617.
PIR	I38240.
RefSeq	NP_003098.1. NM_003107.2.
UniGene	Hs.643910.
3D structure databases
ProteinModelPortal	Q06945.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-58650N.
STRING	9606.ENSP00000244745.
PTM databases
PhosphoSite	Q06945.
Polymorphism databases
DMDM	548952.
Proteomic databases
PaxDb	Q06945.
PRIDE	Q06945.
Protocols and materials databases
DNASU	6659.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000244745; ENSP00000244745; ENSG00000124766. ENST00000543472; ENSP00000438412; ENSG00000124766.
GeneID	6659.
KEGG	hsa:6659.
UCSC	uc003ndi.3. human.
Organism-specific databases
CTD	6659.
GeneCards	GC06P021593.
HGNC	HGNC:11200. SOX4.
HPA	HPA029901.
MIM	184430. gene.
neXtProt	NX_Q06945.
PharmGKB	PA36037.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG130659.
HOGENOM	HOG000231874.
HOVERGEN	HBG005040.
InParanoid	Q06945.
KO	K09268.
OMA	AGCSPDG.
OrthoDB	EOG41VK47.
Gene expression databases
Bgee	Q06945.
CleanEx	HS_SOX4.
Genevestigator	Q06945.
GermOnline	ENSG00000124766. Homo sapiens.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR017386. SOX-12/11/4a. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
PIRSF	PIRSF038098. SOX-12/11/4a. 1 hit.
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SOX4. human.
GenomeRNAi	6659.
NextBio	25959.
SOURCE	Search...

Entry information

Entry name

SOX4_HUMAN

Accession

Primary (citable) accession number: Q06945

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.