Reviewed,
UniProtKB/Swiss-Prot Q06945 (SOX4_HUMAN)
Last modified
November 25, 2008.
Version 70.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Transcription factor SOX-4 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 474 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. |
| Subunit structure | Interacts with UBE2I. |
| Subcellular location | |
| Tissue specificity | Testis, brain, and heart. |
| Sequence similarities | Contains 1 HMG box DNA-binding domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 474 | 474 | Transcription factor SOX-4 | PRO_0000048724 | |||||
Regions | |||||||||
| DNA binding | 59 – 127 | 69 | HMG box | ||||||
| Compositional bias | 386 – 397 | 12 | Poly-Ser | ||||||
Amino acid modifications | |||||||||
| Modified residue | 276 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 71 | 1 | Q → P in CAA46612. Ref.4 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| X70683 mRNA. Translation: CAA50018.1. AL136179 Genomic DNA. Translation: CAC03595.1. BC072668 mRNA. Translation: AAH72668.1. X65661 mRNA. Translation: CAA46612.1. | |
| PIR | I38240. |
| RefSeq | NP_003098.1. |
| UniGene | Hs.699195 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GT0 based on UniProtKB P48432. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q06945. |
Genome annotation databases | |
| Ensembl | ENSG00000124766. Homo sapiens. [Contig view] |
| GeneID | 6659. |
| KEGG | hsa:6659. |
Organism-specific databases | |
| H-InvDB | HIX0032765. |
| HGNC | HGNC:11200. SOX4. |
| MIM | 184430. gene. |
| PharmGKB | PA36037. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q06945. |
| HOVERGEN | Q06945. |
Gene expression databases | |
| ArrayExpress | Q06945. |
| CleanEx | HS_SOX4. |
| GermOnline | ENSG00000124766. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000910. HMG_1/2_box. IPR017386. SOX-12/11/4a. [Graphical view] |
| Gene3D | G3DSA:1.10.30.10. HMG-box. 1 hit. |
| Pfam | PF00505. HMG_box. 1 hit. [Graphical view] |
| PIRSF | PIRSF038098. SOX-12/11/4a. 1 hit. |
| SMART | SM00398. HMG. 1 hit. [Graphical view] |
| PROSITE | PS50118. HMG_BOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 25959. |
| SOURCE | Search... |
Entry information
| Entry name | SOX4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q06945 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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