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Q06945

- SOX4_HUMAN

UniProt

Q06945 - SOX4_HUMAN

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Protein
Transcription factor SOX-4
Gene
SOX4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi59 – 12769HMG box
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  2. RNA polymerase II transcription coactivator activity Source: UniProtKB
  3. core promoter sequence-specific DNA binding Source: UniProtKB
  4. nucleic acid binding transcription factor activity Source: UniProtKB
  5. protein binding Source: UniProtKB
  6. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  7. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. DNA damage response, detection of DNA damage Source: UniProtKB
  2. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
  3. T cell differentiation Source: BHF-UCL
  4. ascending aorta morphogenesis Source: BHF-UCL
  5. atrial septum primum morphogenesis Source: BHF-UCL
  6. canonical Wnt signaling pathway Source: BHF-UCL
  7. cardiac right ventricle morphogenesis Source: BHF-UCL
  8. cardiac ventricle formation Source: UniProtKB
  9. cellular response to glucose stimulus Source: UniProtKB
  10. endocrine pancreas development Source: Ensembl
  11. glial cell development Source: UniProtKB
  12. glial cell proliferation Source: UniProtKB
  13. glucose homeostasis Source: UniProtKB
  14. heart development Source: BHF-UCL
  15. kidney morphogenesis Source: BHF-UCL
  16. limb bud formation Source: UniProtKB
  17. mitral valve morphogenesis Source: BHF-UCL
  18. negative regulation of cell death Source: UniProtKB
  19. negative regulation of cell proliferation Source: UniProtKB
  20. negative regulation of protein export from nucleus Source: UniProtKB
  21. negative regulation of protein ubiquitination Source: UniProtKB
  22. neural tube formation Source: UniProtKB
  23. neuroepithelial cell differentiation Source: UniProtKB
  24. noradrenergic neuron differentiation Source: UniProtKB
  25. positive regulation of N-terminal peptidyl-lysine acetylation Source: UniProtKB
  26. positive regulation of Wnt signaling pathway Source: BHF-UCL
  27. positive regulation of apoptotic process Source: UniProtKB
  28. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  29. positive regulation of cell proliferation Source: BHF-UCL
  30. positive regulation of insulin secretion Source: UniProtKB
  31. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  32. positive regulation of transcription, DNA-templated Source: UniProtKB
  33. positive regulation of translation Source: UniProtKB
  34. pro-B cell differentiation Source: BHF-UCL
  35. protein stabilization Source: BHF-UCL
  36. regulation of protein stability Source: UniProtKB
  37. regulation of transcription, DNA-templated Source: BHF-UCL
  38. skeletal system development Source: UniProtKB
  39. somatic stem cell maintenance Source: Ensembl
  40. spinal cord development Source: UniProtKB
  41. spinal cord motor neuron differentiation Source: UniProtKB
  42. sympathetic nervous system development Source: UniProtKB
  43. ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-4
Gene namesi
Name:SOX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:11200. SOX4.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. mitochondrion Source: HPA
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Transcription factor SOX-4
PRO_0000048724Add
BLAST

Proteomic databases

PaxDbiQ06945.
PRIDEiQ06945.

PTM databases

PhosphoSiteiQ06945.

Expressioni

Tissue specificityi

Testis, brain, and heart.

Gene expression databases

BgeeiQ06945.
CleanExiHS_SOX4.
GenevestigatoriQ06945.

Organism-specific databases

HPAiHPA029901.

Interactioni

Subunit structurei

Interacts with UBE2I.1 Publication

Protein-protein interaction databases

BioGridi112542. 7 interactions.
DIPiDIP-58650N.
IntActiQ06945. 1 interaction.
STRINGi9606.ENSP00000244745.

Structurei

3D structure databases

ProteinModelPortaliQ06945.
SMRiQ06945. Positions 57-163.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi386 – 39712Poly-Ser
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG130659.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiQ06945.
KOiK09268.
OMAiAGCSPDG.
OrthoDBiEOG7TMZVP.
PhylomeDBiQ06945.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06945-1 [UniParc]FASTAAdd to Basket

« Hide

MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS    50
WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL 100
KDSDKIPFIR EAERLRLKHM ADYPDYKYRP RKKVKSGNAN SSSSAAASSK 150
PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG GGGASGGGAN SKPAQKKSCG 200
SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE QAGAAALLPL 250
GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 300
GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA 350
AGRSPADHRG YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE 400
FEDDLLDLNP SSNFESMSLG SFSSSSALDR DLDFNFEPGS GSHFEFPDYC 450
TPEVSEMISG DWLESSISNL VFTY 474
Length:474
Mass (Da):47,263
Last modified:June 1, 1994 - v1
Checksum:iCB75B76ABF507A07
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711Q → P in CAA46612. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70683 mRNA. Translation: CAA50018.1.
AL136179 Genomic DNA. Translation: CAC03595.1.
BC072668 mRNA. Translation: AAH72668.1.
X65661 mRNA. Translation: CAA46612.1.
CCDSiCCDS4547.1.
PIRiI38240.
RefSeqiNP_003098.1. NM_003107.2.
UniGeneiHs.643910.

Genome annotation databases

EnsembliENST00000244745; ENSP00000244745; ENSG00000124766.
ENST00000543472; ENSP00000438412; ENSG00000124766.
GeneIDi6659.
KEGGihsa:6659.
UCSCiuc003ndi.3. human.

Polymorphism databases

DMDMi548952.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70683 mRNA. Translation: CAA50018.1 .
AL136179 Genomic DNA. Translation: CAC03595.1 .
BC072668 mRNA. Translation: AAH72668.1 .
X65661 mRNA. Translation: CAA46612.1 .
CCDSi CCDS4547.1.
PIRi I38240.
RefSeqi NP_003098.1. NM_003107.2.
UniGenei Hs.643910.

3D structure databases

ProteinModelPortali Q06945.
SMRi Q06945. Positions 57-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112542. 7 interactions.
DIPi DIP-58650N.
IntActi Q06945. 1 interaction.
STRINGi 9606.ENSP00000244745.

PTM databases

PhosphoSitei Q06945.

Polymorphism databases

DMDMi 548952.

Proteomic databases

PaxDbi Q06945.
PRIDEi Q06945.

Protocols and materials databases

DNASUi 6659.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244745 ; ENSP00000244745 ; ENSG00000124766 .
ENST00000543472 ; ENSP00000438412 ; ENSG00000124766 .
GeneIDi 6659.
KEGGi hsa:6659.
UCSCi uc003ndi.3. human.

Organism-specific databases

CTDi 6659.
GeneCardsi GC06P021593.
HGNCi HGNC:11200. SOX4.
HPAi HPA029901.
MIMi 184430. gene.
neXtProti NX_Q06945.
PharmGKBi PA36037.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG130659.
HOGENOMi HOG000231874.
HOVERGENi HBG005040.
InParanoidi Q06945.
KOi K09268.
OMAi AGCSPDG.
OrthoDBi EOG7TMZVP.
PhylomeDBi Q06945.

Miscellaneous databases

ChiTaRSi SOX4. human.
GeneWikii SOX4.
GenomeRNAii 6659.
NextBioi 25959.
PROi Q06945.
SOURCEi Search...

Gene expression databases

Bgeei Q06945.
CleanExi HS_SOX4.
Genevestigatori Q06945.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. "A conserved family of genes related to the testis determining gene, SRY."
    Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
    Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-123.
  5. Cited for: INTERACTION WITH UBE2I, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSOX4_HUMAN
AccessioniPrimary (citable) accession number: Q06945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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