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Q06903

- PPCE_AERHY

UniProt

Q06903 - PPCE_AERHY

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Protein
Prolyl endopeptidase
Gene
N/A
Organism
Aeromonas hydrophila
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond.

Catalytic activityi

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei538 – 5381Charge relay system By similarity
Active sitei657 – 6571Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type exopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prolyl endopeptidase (EC:3.4.21.26)
    Short name:
    PE
    Alternative name(s):
    Post-proline cleaving enzyme
    OrganismiAeromonas hydrophila
    Taxonomic identifieri644 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 690689Prolyl endopeptidase
    PRO_0000122399Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ06903.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9A family.

    Family and domain databases

    Gene3Di2.130.10.120. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR023302. Pept_S9A_N.
    IPR001375. Peptidase_S9.
    IPR002470. Peptidase_S9A.
    [Graphical view]
    PANTHERiPTHR11757. PTHR11757. 1 hit.
    PfamiPF00326. Peptidase_S9. 1 hit.
    PF02897. Peptidase_S9_N. 1 hit.
    [Graphical view]
    PRINTSiPR00862. PROLIGOPTASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06903-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKARLHYP VTRQSEQLDH YFGQAVADPY RWLEDDRSPE TEAWVKAQNR    50
    VTQDYLAQIP FRDAIKGKLA TSWNYAKEGA PFREGRYHYF FKNDGLQNQN 100
    VLCGQLAGKP AEVFLDPNLL SPDGTTALDQ LSFSRDGKTL AYSLSLAGSD 150
    WREIHLMDVE SKQPLETPLR DVKFSGISWL GNEGFFYSSY DKPDGSELSA 200
    RTDQHKLYFH RLGTAQEEDR LVFGAIPAQR HRYVGATVTE DDRYLLISAA 250
    DSTSGNRLYV KDLTREGAPL LTVQGDLAAD VSLVDNKGSR LYLLTNRDAP 300
    NRRLVTVEAD NPGPEQWRDL IPERQQVLTV HSGGGYLFAE YMVDATARVE 350
    QFDHDGKRVR EVGLPGLGSV SGFNGKQDDP ALYFGFENYA QPPTLYKFEP 400
    NSGAISLYRA SAAPFKPEDY VSEQRFYRSK DGTRVPLIIS YRKGLKLDGS 450
    NPTILYGYGG FDVSLTPSFS VSVANWLDLG GVYAVANLRG GGEYGQAWHL 500
    AGTRMNKQNV FDDFIAAAEY LKAEGYTRTD RLAIRGGSNG GLLVGAVMTQ 550
    RPDLMRVACQ AVGVLDMLRY HTFTAGAGWA YDYGTSADSE AMFDYLKGYS 600
    PLHSVRAGVS YPSTLVTTAD HDDRVVPAHS FKFAATLQAD DAGPHPQLIR 650
    IETNAGHGAG TPVAKLIEQS ADIYAFTLFE MGYRQLPRQP 690
    Length:690
    Mass (Da):76,515
    Last modified:January 23, 2007 - v2
    Checksum:i854677C4AE753EB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14005 Genomic DNA. Translation: BAA03105.1.
    PIRiJN0585.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14005 Genomic DNA. Translation: BAA03105.1 .
    PIRi JN0585.

    3D structure databases

    ProteinModelPortali Q06903.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.130.10.120. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR023302. Pept_S9A_N.
    IPR001375. Peptidase_S9.
    IPR002470. Peptidase_S9A.
    [Graphical view ]
    PANTHERi PTHR11757. PTHR11757. 1 hit.
    Pfami PF00326. Peptidase_S9. 1 hit.
    PF02897. Peptidase_S9_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00862. PROLIGOPTASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prolyl endopeptidase from Aeromonas hydrophila: cloning, sequencing, and expression of the enzyme gene, and characterization of the expressed enzyme."
      Kanatani A., Yoshimoto T., Kitazono A., Kokubo T., Tsuru D.
      J. Biochem. 113:790-796(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Strain: AK-9.

    Entry informationi

    Entry nameiPPCE_AERHY
    AccessioniPrimary (citable) accession number: Q06903
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: June 11, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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