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Q06900

- Q06900_CHICK

UniProt

Q06900 - Q06900_CHICK

Protein
Submitted name:

Activin like receptor kinase 5

Gene

ChALK5

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. receptor signaling protein activity Source: AgBase
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. transforming growth factor beta binding Source: AgBase
    5. transforming growth factor beta receptor activity, type I Source: AgBase

    GO - Biological processi

    1. activation of MAPKK activity Source: Ensembl
    2. angiogenesis Source: Ensembl
    3. anterior/posterior pattern specification Source: Ensembl
    4. artery morphogenesis Source: Ensembl
    5. blastocyst development Source: Ensembl
    6. cardiac epithelial to mesenchymal transition Source: AgBase
    7. collagen fibril organization Source: Ensembl
    8. embryonic cranial skeleton morphogenesis Source: Ensembl
    9. endothelial cell activation Source: AgBase
    10. endothelial cell migration Source: Ensembl
    11. germ cell migration Source: Ensembl
    12. intracellular signal transduction Source: GOC
    13. kidney development Source: Ensembl
    14. lens development in camera-type eye Source: Ensembl
    15. mesenchymal cell differentiation Source: AgBase
    16. negative regulation of apoptotic process Source: Ensembl
    17. negative regulation of chondrocyte differentiation Source: Ensembl
    18. negative regulation of endothelial cell proliferation Source: Ensembl
    19. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    20. neuron fate commitment Source: Ensembl
    21. palate development Source: Ensembl
    22. parathyroid gland development Source: Ensembl
    23. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    24. peptidyl-serine phosphorylation Source: Ensembl
    25. peptidyl-threonine phosphorylation Source: Ensembl
    26. pharyngeal system development Source: Ensembl
    27. positive regulation of apoptotic signaling pathway Source: Ensembl
    28. positive regulation of cell growth Source: Ensembl
    29. positive regulation of cellular component movement Source: Ensembl
    30. positive regulation of endothelial cell proliferation Source: AgBase
    31. positive regulation of filopodium assembly Source: Ensembl
    32. positive regulation of gene expression Source: AgBase
    33. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    34. positive regulation of protein kinase B signaling Source: Ensembl
    35. positive regulation of SMAD protein import into nucleus Source: Ensembl
    36. positive regulation of transcription, DNA-templated Source: AgBase
    37. post-embryonic development Source: Ensembl
    38. regulation of epithelial to mesenchymal transition Source: AgBase
    39. regulation of gene expression Source: AgBase
    40. regulation of protein binding Source: Ensembl
    41. regulation of protein ubiquitination Source: Ensembl
    42. response to cholesterol Source: Ensembl
    43. thymus development Source: Ensembl
    44. transforming growth factor beta receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_195006. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
    REACT_195008. TGF-beta receptor signaling activates SMADs.
    REACT_198125. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_211903. SMAD2/3 MH2 Domain Mutants in Cancer.
    REACT_214793. Downregulation of TGF-beta receptor signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Activin like receptor kinase 5Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:ChALK5Imported
    Synonyms:TGFBR1Imported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. cell Source: AgBase
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl
    4. receptor complex Source: Ensembl
    5. tight junction Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Interactioni

    Protein-protein interaction databases

    IntActiQ06900. 1 interaction.
    STRINGi9031.ENSGALP00000020569.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06900.
    SMRiQ06900. Positions 27-105, 171-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110337.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiQ06900.
    KOiK04674.
    OMAiGGIYDEY.
    OrthoDBiEOG7Q8CN3.
    PhylomeDBiQ06900.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06900-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRGTRRLR ALLRLLVAAV LLPRAAALQC YCHLCTKDNF TCVTDGLCFT    50
    SVTRTADRVI RNSMCIAEID LIPRDRPFIC APSFRDGVTT LPHCCDRDHC 100
    NKIELPIPTP GPTPGRPASS LGPVELAAVI AGPVCFVCIS LMLILYLCHN 150
    RTVIHHRVPS EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT 200
    IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ 250
    TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300
    GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA 350
    DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD 400
    IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MKKVVCEQKL 450
    RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG 500
    IKM 503
    Length:503
    Mass (Da):56,509
    Last modified:October 1, 2000 - v2
    Checksum:i87E16F45C5B0F837
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03002802 Genomic DNA. No translation available.
    D14460 mRNA. Translation: BAA03357.2.
    PIRiA56693.
    RefSeqiNP_989577.1. NM_204246.1.
    UniGeneiGga.143.

    Genome annotation databases

    EnsembliENSGALT00000020598; ENSGALP00000020569; ENSGALG00000012617.
    GeneIDi374094.
    KEGGigga:374094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03002802 Genomic DNA. No translation available.
    D14460 mRNA. Translation: BAA03357.2 .
    PIRi A56693.
    RefSeqi NP_989577.1. NM_204246.1.
    UniGenei Gga.143.

    3D structure databases

    ProteinModelPortali Q06900.
    SMRi Q06900. Positions 27-105, 171-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q06900. 1 interaction.
    STRINGi 9031.ENSGALP00000020569.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000020598 ; ENSGALP00000020569 ; ENSGALG00000012617 .
    GeneIDi 374094.
    KEGGi gga:374094.

    Organism-specific databases

    CTDi 7046.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110337.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi Q06900.
    KOi K04674.
    OMAi GGIYDEY.
    OrthoDBi EOG7Q8CN3.
    PhylomeDBi Q06900.
    TreeFami TF314724.

    Enzyme and pathway databases

    Reactomei REACT_195006. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
    REACT_195008. TGF-beta receptor signaling activates SMADs.
    REACT_198125. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_211903. SMAD2/3 MH2 Domain Mutants in Cancer.
    REACT_214793. Downregulation of TGF-beta receptor signaling.

    Miscellaneous databases

    NextBioi 20813613.
    PROi Q06900.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-beta receptor family."
      Nohno T., Sumitomo S., Ishikawa T., Ando C., Nishida S., Noji S., Saito T.
      DNA Seq. 3:393-396(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation."
      Lai Y.T., Beason K.B., Brames G.P., Desgrosellier J.S., Cleggett M.C., Shaw M.V., Brown C.B., Barnett J.V.
      Dev. Biol. 222:1-11(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
      International Chicken Genome Sequencing Consortium
      Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
      , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
      Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Red jungle fowlImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Red jungle fowlImported.

    Entry informationi

    Entry nameiQ06900_CHICK
    AccessioniPrimary (citable) accession number: Q06900
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3