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Q06900 (Q06900_CHICK) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Uncharacterized protein Ensembl ENSGALP00000020569
Gene names
Name:ChALK5 EMBL BAA03357.2
Synonyms:TGFBR1 Ensembl ENSGALP00000020569
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. SAAS SAAS000333

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Contains protein kinase domain. SAAS SAAS000333

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS000333
   LigandATP-binding SAAS SAAS000333 RuleBase RU000304
Nucleotide-binding
   Molecular functionKinase
Receptor SAAS SAAS000333 EMBL BAA03357.2
Serine/threonine-protein kinase SAAS SAAS000333 RuleBase RU000305
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of MAPKK activity

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Inferred from electronic annotation. Source: Ensembl

anterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

artery morphogenesis

Inferred from electronic annotation. Source: Ensembl

blastocyst development

Inferred from electronic annotation. Source: Ensembl

cardiac epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 17250821. Source: AgBase

collagen fibril organization

Inferred from electronic annotation. Source: Ensembl

embryonic cranial skeleton morphogenesis

Inferred from electronic annotation. Source: Ensembl

endothelial cell activation

Inferred from mutant phenotype PubMed 17250821. Source: AgBase

endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

germ cell migration

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from mutant phenotype PubMed 15766759. Source: GOC

kidney development

Inferred from electronic annotation. Source: Ensembl

lens development in camera-type eye

Inferred from electronic annotation. Source: Ensembl

mesenchymal cell differentiation

Inferred from mutant phenotype PubMed 17250821. Source: AgBase

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

neuron fate commitment

Inferred from electronic annotation. Source: Ensembl

palate development

Inferred from electronic annotation. Source: Ensembl

parathyroid gland development

Inferred from electronic annotation. Source: Ensembl

pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

peptidyl-threonine phosphorylation

Inferred from electronic annotation. Source: Ensembl

pharyngeal system development

Inferred from electronic annotation. Source: Ensembl

positive regulation of SMAD protein import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of cellular component movement

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 17250821. Source: AgBase

positive regulation of filopodium assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from mutant phenotype PubMed 17250821. Source: AgBase

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.2. Source: AgBase

post-embryonic development

Inferred from electronic annotation. Source: Ensembl

regulation of epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 17250821. Source: AgBase

regulation of gene expression

Inferred from mutant phenotype PubMed 17250821. Source: AgBase

regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

regulation of protein ubiquitination

Inferred from electronic annotation. Source: Ensembl

response to cholesterol

Inferred from electronic annotation. Source: Ensembl

thymus development

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell

Inferred from direct assay PubMed 10075204. Source: AgBase

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: Ensembl

receptor complex

Inferred from electronic annotation. Source: Ensembl

tight junction

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor signaling protein activity

Inferred from mutant phenotype PubMed 15766759. Source: AgBase

transforming growth factor beta binding

Inferred from direct assay PubMed 8167376. Source: AgBase

transforming growth factor beta receptor activity, type I

Inferred from direct assay Ref.2. Source: AgBase

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q06900 [UniParc].

Last modified October 1, 2000. Version 2.
Checksum: 87E16F45C5B0F837

FASTA50356,509
        10         20         30         40         50         60 
MALRGTRRLR ALLRLLVAAV LLPRAAALQC YCHLCTKDNF TCVTDGLCFT SVTRTADRVI 

        70         80         90        100        110        120 
RNSMCIAEID LIPRDRPFIC APSFRDGVTT LPHCCDRDHC NKIELPIPTP GPTPGRPASS 

       130        140        150        160        170        180 
LGPVELAAVI AGPVCFVCIS LMLILYLCHN RTVIHHRVPS EEDPSLDRPF ISEGTTLKDL 

       190        200        210        220        230        240 
IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 

       250        260        270        280        290        300 
SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 

       310        320        330        340        350        360 
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 

       370        380        390        400        410        420 
ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 

       430        440        450        460        470        480 
HEDYQLPYYD LVPSDPSVEE MKKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 

       490        500 
ARLTALRIKK TLSQLSQQEG IKM 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-beta receptor family."
Nohno T., Sumitomo S., Ishikawa T., Ando C., Nishida S., Noji S., Saito T.
DNA Seq. 3:393-396(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation."
Lai Y.T., Beason K.B., Brames G.P., Desgrosellier J.S., Cleggett M.C., Shaw M.V., Brown C.B., Barnett J.V.
Dev. Biol. 222:1-11(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
International Chicken Genome Sequencing Consortium
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. expand/collapse author list , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Red jungle fowl Ensembl ENSGALP00000020569.
[4]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Red jungle fowl Ensembl ENSGALP00000020569.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AADN03002802 Genomic DNA. No translation available.
D14460 mRNA. Translation: BAA03357.2.
PIRA56693.
RefSeqNP_989577.1. NM_204246.1.
UniGeneGga.143.

3D structure databases

ProteinModelPortalQ06900.
SMRQ06900. Positions 27-105, 171-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ06900. 1 interaction.
STRING9031.ENSGALP00000020569.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000020598; ENSGALP00000020569; ENSGALG00000012617.
GeneID374094.
KEGGgga:374094.

Organism-specific databases

CTD7046.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110337.
HOGENOMHOG000230587.
HOVERGENHBG054502.
InParanoidQ06900.
KOK04674.
OMAGGIYDEY.
OrthoDBEOG7Q8CN3.
PhylomeDBQ06900.
TreeFamTF314724.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813613.
PROQ06900.

Entry information

Entry nameQ06900_CHICK
AccessionPrimary (citable) accession number: Q06900
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)