Q06900 (Q06900_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Activin like receptor kinase 5 EMBL BAA03357.2

Submitted name:
Uncharacterized protein Ensembl ENSGALP00000020569

Gene names

Name:	ChALK5 EMBL BAA03357.2
Synonyms:	TGFBR1 Ensembl ENSGALP00000020569

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Receptor EMBL BAA03357.2 Serine/threonine-protein kinase RuleBase RU000305 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPKK activity Inferred from electronic annotation. Source: Compara angiogenesis Inferred from electronic annotation. Source: Compara anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara artery morphogenesis Inferred from electronic annotation. Source: Compara blastocyst development Inferred from electronic annotation. Source: Compara cardiac epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 17250821. Source: AgBase collagen fibril organization Inferred from electronic annotation. Source: Compara embryonic cranial skeleton morphogenesis Inferred from electronic annotation. Source: Compara endothelial cell activation Inferred from mutant phenotype PubMed 17250821. Source: AgBase endothelial cell migration Inferred from electronic annotation. Source: Compara germ cell migration Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara kidney development Inferred from electronic annotation. Source: Compara lens development in camera-type eye Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of chondrocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara neuron fate commitment Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara parathyroid gland development Inferred from electronic annotation. Source: Compara pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara pharyngeal system development Inferred from electronic annotation. Source: Compara positive regulation of SMAD protein import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of cellular component movement Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from mutant phenotype PubMed 17250821. Source: AgBase positive regulation of filopodium assembly Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.2. Source: AgBase post-embryonic development Inferred from electronic annotation. Source: Compara regulation of epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 17250821. Source: AgBase regulation of protein binding Inferred from electronic annotation. Source: Compara regulation of protein ubiquitination Inferred from electronic annotation. Source: Compara response to cholesterol Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	cell Inferred from direct assay PubMed 10075204. Source: AgBase plasma membrane part Inferred from electronic annotation. Source: Compara receptor complex Inferred from electronic annotation. Source: Compara tight junction Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein activity Inferred from mutant phenotype PubMed 15766759. Source: AgBase transforming growth factor beta binding Inferred from direct assay PubMed 8167376. Source: AgBase transforming growth factor beta receptor activity, type I Inferred from direct assay Ref.2. Source: AgBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q06900 [UniParc]. Last modified October 1, 2000. Version 2. Checksum: 87E16F45C5B0F837	FASTA	503	56,509
	10 20 30 40 50 60 MALRGTRRLR ALLRLLVAAV LLPRAAALQC YCHLCTKDNF TCVTDGLCFT SVTRTADRVI 70 80 90 100 110 120 RNSMCIAEID LIPRDRPFIC APSFRDGVTT LPHCCDRDHC NKIELPIPTP GPTPGRPASS 130 140 150 160 170 180 LGPVELAAVI AGPVCFVCIS LMLILYLCHN RTVIHHRVPS EEDPSLDRPF ISEGTTLKDL 190 200 210 220 230 240 IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 250 260 270 280 290 300 SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 310 320 330 340 350 360 GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 370 380 390 400 410 420 ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 430 440 450 460 470 480 HEDYQLPYYD LVPSDPSVEE MKKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 490 500 ARLTALRIKK TLSQLSQQEG IKM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-beta receptor family." Nohno T., Sumitomo S., Ishikawa T., Ando C., Nishida S., Noji S., Saito T. DNA Seq. 3:393-396(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation." Lai Y.T., Beason K.B., Brames G.P., Desgrosellier J.S., Cleggett M.C., Shaw M.V., Brown C.B., Barnett J.V. Dev. Biol. 222:1-11(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution." International Chicken Genome Sequencing Consortium Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K. Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Red jungle fowl Ensembl ENSGALP00000020569.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Red jungle fowl Ensembl ENSGALP00000020569.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AADN02027358 Genomic DNA. No translation available. D14460 mRNA. Translation: BAA03357.2.
IPI	IPI00598427.
PIR	A56693.
RefSeq	NP_989577.1. NM_204246.1.
UniGene	Gga.143.
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
SMR	Q06900. Positions 27-105, 171-500.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000020569.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000020598; ENSGALP00000020569; ENSGALG00000012617.
GeneID	374094.
KEGG	gga:374094.
Organism-specific databases
CTD	7046.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00560000076615.
HOGENOM	HOG000230587.
HOVERGEN	HBG054502.
InParanoid	Q06900.
KO	K04674.
OMA	CISLMLI.
OrthoDB	EOG4JQ3XG.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20813613.

Entry information

Entry name

Q06900_CHICK

Accession

Primary (citable) accession number: Q06900

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)