SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q06900

- Q06900_CHICK

UniProt

Q06900 - Q06900_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Activin like receptor kinase 5
Gene
ChALK5, TGFBR1
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein activity Source: AgBase
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta binding Source: AgBase
  5. transforming growth factor beta receptor activity, type I Source: AgBase
Complete GO annotation...

GO - Biological processi

  1. activation of MAPKK activity Source: Ensembl
  2. angiogenesis Source: Ensembl
  3. anterior/posterior pattern specification Source: Ensembl
  4. artery morphogenesis Source: Ensembl
  5. blastocyst development Source: Ensembl
  6. cardiac epithelial to mesenchymal transition Source: AgBase
  7. collagen fibril organization Source: Ensembl
  8. embryonic cranial skeleton morphogenesis Source: Ensembl
  9. endothelial cell activation Source: AgBase
  10. endothelial cell migration Source: Ensembl
  11. germ cell migration Source: Ensembl
  12. intracellular signal transduction Source: GOC
  13. kidney development Source: Ensembl
  14. lens development in camera-type eye Source: Ensembl
  15. mesenchymal cell differentiation Source: AgBase
  16. negative regulation of apoptotic process Source: Ensembl
  17. negative regulation of chondrocyte differentiation Source: Ensembl
  18. negative regulation of endothelial cell proliferation Source: Ensembl
  19. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  20. neuron fate commitment Source: Ensembl
  21. palate development Source: Ensembl
  22. parathyroid gland development Source: Ensembl
  23. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  24. peptidyl-serine phosphorylation Source: Ensembl
  25. peptidyl-threonine phosphorylation Source: Ensembl
  26. pharyngeal system development Source: Ensembl
  27. positive regulation of SMAD protein import into nucleus Source: Ensembl
  28. positive regulation of apoptotic signaling pathway Source: Ensembl
  29. positive regulation of cell growth Source: Ensembl
  30. positive regulation of cellular component movement Source: Ensembl
  31. positive regulation of endothelial cell proliferation Source: AgBase
  32. positive regulation of filopodium assembly Source: Ensembl
  33. positive regulation of gene expression Source: AgBase
  34. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  35. positive regulation of protein kinase B signaling Source: Ensembl
  36. positive regulation of transcription, DNA-templated Source: AgBase
  37. post-embryonic development Source: Ensembl
  38. regulation of epithelial to mesenchymal transition Source: AgBase
  39. regulation of gene expression Source: AgBase
  40. regulation of protein binding Source: Ensembl
  41. regulation of protein ubiquitination Source: Ensembl
  42. response to cholesterol Source: Ensembl
  43. thymus development Source: Ensembl
  44. transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationsImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_195006. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
REACT_195008. TGF-beta receptor signaling activates SMADs.
REACT_198125. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_211903. SMAD2/3 MH2 Domain Mutants in Cancer.
REACT_214793. Downregulation of TGF-beta receptor signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Activin like receptor kinase 5Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ChALK5Imported
Synonyms:TGFBR1Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. cell Source: AgBase
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
  4. receptor complex Source: Ensembl
  5. tight junction Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

IntActiQ06900. 1 interaction.
STRINGi9031.ENSGALP00000020569.

Structurei

3D structure databases

ProteinModelPortaliQ06900.
SMRiQ06900. Positions 27-105, 171-500.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110337.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ06900.
KOiK04674.
OMAiGGIYDEY.
OrthoDBiEOG7Q8CN3.
PhylomeDBiQ06900.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06900-1 [UniParc]FASTAAdd to Basket

« Hide

MALRGTRRLR ALLRLLVAAV LLPRAAALQC YCHLCTKDNF TCVTDGLCFT    50
SVTRTADRVI RNSMCIAEID LIPRDRPFIC APSFRDGVTT LPHCCDRDHC 100
NKIELPIPTP GPTPGRPASS LGPVELAAVI AGPVCFVCIS LMLILYLCHN 150
RTVIHHRVPS EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT 200
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ 250
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA 350
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD 400
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MKKVVCEQKL 450
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG 500
IKM 503
Length:503
Mass (Da):56,509
Last modified:October 1, 2000 - v2
Checksum:i87E16F45C5B0F837
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03002802 Genomic DNA. No translation available.
D14460 mRNA. Translation: BAA03357.2.
PIRiA56693.
RefSeqiNP_989577.1. NM_204246.1.
UniGeneiGga.143.

Genome annotation databases

EnsembliENSGALT00000020598; ENSGALP00000020569; ENSGALG00000012617.
GeneIDi374094.
KEGGigga:374094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03002802 Genomic DNA. No translation available.
D14460 mRNA. Translation: BAA03357.2 .
PIRi A56693.
RefSeqi NP_989577.1. NM_204246.1.
UniGenei Gga.143.

3D structure databases

ProteinModelPortali Q06900.
SMRi Q06900. Positions 27-105, 171-500.
ModBasei Search...

Protein-protein interaction databases

IntActi Q06900. 1 interaction.
STRINGi 9031.ENSGALP00000020569.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000020598 ; ENSGALP00000020569 ; ENSGALG00000012617 .
GeneIDi 374094.
KEGGi gga:374094.

Organism-specific databases

CTDi 7046.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110337.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi Q06900.
KOi K04674.
OMAi GGIYDEY.
OrthoDBi EOG7Q8CN3.
PhylomeDBi Q06900.
TreeFami TF314724.

Enzyme and pathway databases

Reactomei REACT_195006. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
REACT_195008. TGF-beta receptor signaling activates SMADs.
REACT_198125. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_211903. SMAD2/3 MH2 Domain Mutants in Cancer.
REACT_214793. Downregulation of TGF-beta receptor signaling.

Miscellaneous databases

NextBioi 20813613.
PROi Q06900.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-beta receptor family."
    Nohno T., Sumitomo S., Ishikawa T., Ando C., Nishida S., Noji S., Saito T.
    DNA Seq. 3:393-396(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation."
    Lai Y.T., Beason K.B., Brames G.P., Desgrosellier J.S., Cleggett M.C., Shaw M.V., Brown C.B., Barnett J.V.
    Dev. Biol. 222:1-11(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiQ06900_CHICK
AccessioniPrimary (citable) accession number: Q06900
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi