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Protein

Receptor protein serine/threonine kinase

Gene

ChALK5

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-2173788. Downregulation of TGF-beta receptor signaling.
R-GGA-2173789. TGF-beta receptor signaling activates SMADs.
R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-GGA-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:ChALK5Imported
Synonyms:TGFBR1Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei126 – 148HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • bicellular tight junction Source: AgBase
  • cell Source: AgBase
  • cell surface Source: AgBase
  • endosome Source: AgBase
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: Ensembl
  • membrane Source: AgBase
  • membrane raft Source: AgBase
  • plasma membrane Source: AgBase
  • receptor complex Source: AgBase

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501083998528 – 503Receptor protein serine/threonine kinaseSequence analysisAdd BLAST476

Expressioni

Gene expression databases

BgeeiENSGALG00000012617.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ06900. 1 interactor.
STRINGi9031.ENSGALP00000020569.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 204GSInterPro annotationAdd BLAST30
Domaini205 – 495Protein kinaseInterPro annotationAdd BLAST291

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
KOiK04674.
OMAiMIEMTTS.
OrthoDBiEOG091G0BIU.
TreeFamiTF314724.

Family and domain databases

InterProiView protein in InterPro
IPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiView protein in Pfam
PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
SMARTiView protein in SMART
SM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRGTRRLR ALLRLLVAAV LLPRAAALQC YCHLCTKDNF TCVTDGLCFT
60 70 80 90 100
SVTRTADRVI RNSMCIAEID LIPRDRPFIC APSFRDGVTT LPHCCDRDHC
110 120 130 140 150
NKIELPIPTP GPTPGRPASS LGPVELAAVI AGPVCFVCIS LMLILYLCHN
160 170 180 190 200
RTVIHHRVPS EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT
210 220 230 240 250
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ
260 270 280 290 300
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE
310 320 330 340 350
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA
360 370 380 390 400
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD
410 420 430 440 450
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MKKVVCEQKL
460 470 480 490 500
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG

IKM
Length:503
Mass (Da):56,509
Last modified:October 1, 2000 - v2
Checksum:i87E16F45C5B0F837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000072 Genomic DNA. No translation available.
D14460 mRNA. Translation: BAA03357.2.
PIRiA56693.
RefSeqiNP_989577.1. NM_204246.1.
UniGeneiGga.143.

Genome annotation databases

EnsembliENSGALT00000047776; ENSGALP00000054311; ENSGALG00000033179.
GeneIDi374094.
KEGGigga:374094.

Similar proteinsi

Entry informationi

Entry nameiQ06900_CHICK
AccessioniPrimary (citable) accession number: Q06900
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported