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Protein

Early growth response protein 3

Gene

EGR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in muscle spindle development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri275 – 29925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. cell migration involved in sprouting angiogenesis Source: BHF-UCL
  2. cellular response to cAMP Source: GO_Central
  3. cellular response to fibroblast growth factor stimulus Source: BHF-UCL
  4. cellular response to gonadotropin stimulus Source: GO_Central
  5. cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
  6. circadian rhythm Source: ProtInc
  7. endothelial cell chemotaxis Source: BHF-UCL
  8. muscle organ development Source: ProtInc
  9. negative regulation of apoptotic process Source: BHF-UCL
  10. neuromuscular synaptic transmission Source: Ensembl
  11. peripheral nervous system development Source: Ensembl
  12. positive regulation of endothelial cell proliferation Source: BHF-UCL
  13. positive regulation of T cell differentiation in thymus Source: Ensembl
  14. regulation of gamma-delta T cell differentiation Source: Ensembl
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ06889.

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 3
Short name:
EGR-3
Alternative name(s):
Zinc finger protein pilot
Gene namesi
Name:EGR3
Synonyms:PILOT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:3240. EGR3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Early growth response protein 3PRO_0000047125Add
BLAST

Proteomic databases

PaxDbiQ06889.
PRIDEiQ06889.

PTM databases

PhosphoSiteiQ06889.

Expressioni

Developmental stagei

In T-cells, expressed 20 minutes following activation.

Gene expression databases

BgeeiQ06889.
CleanExiHS_EGR3.
ExpressionAtlasiQ06889. baseline and differential.
GenevestigatoriQ06889.

Organism-specific databases

HPAiCAB009373.
HPA006206.

Interactioni

Protein-protein interaction databases

MINTiMINT-234110.
STRINGi9606.ENSP00000318057.

Structurei

3D structure databases

ProteinModelPortaliQ06889.
SMRiQ06889. Positions 273-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri275 – 29925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiQ06889.
KOiK12497.
OMAiDYNLFHH.
OrthoDBiEOG75XGKR.
PhylomeDBiQ06889.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q06889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVVHYNQMA
60 70 80 90 100
TENVMDIGLT NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD
110 120 130 140 150
NIISLMSAGI LGVPPASGAL STQTSTASMV QPPQGDVEAM YPALPPYSNC
160 170 180 190 200
GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP
210 220 230 240 250
NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP
260 270 280 290 300
LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT
310 320 330 340 350
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR
360 370 380
HAKIHLKQKE KKAEKGGAPS ASSAPPVSLA PVVTTCA
Length:387
Mass (Da):42,613
Last modified:February 1, 1995 - v1
Checksum:i77FAF7D5A278C68E
GO
Isoform 2 (identifier: Q06889-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVVHYNQMAT → MEPCAAWSPRGGR

Note: No experimental confirmation available.

Show »
Length:349
Mass (Da):38,478
Checksum:i32ED293BBFB500B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021I → T in BAG58157 (PubMed:14702039).Curated
Sequence conflicti225 – 2251I → T in AAB19317 (PubMed:1906159).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5151MTGKL…NQMAT → MEPCAAWSPRGGR in isoform 2. 1 PublicationVSP_045954Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63741 mRNA. Translation: CAA45275.1.
S40832 mRNA. Translation: AAB19317.1.
AK292464 mRNA. Translation: BAF85153.1.
AK295134 mRNA. Translation: BAG58157.1.
AK313604 mRNA. Translation: BAG36369.1.
AC105046 Genomic DNA. No translation available.
BC104765 mRNA. Translation: AAI04766.1.
BC112279 mRNA. Translation: AAI12280.1.
CCDSiCCDS56528.1. [Q06889-2]
CCDS6033.1. [Q06889-1]
PIRiS60519. S19885.
RefSeqiNP_001186809.1. NM_001199880.1. [Q06889-2]
NP_001186810.1. NM_001199881.1.
NP_004421.2. NM_004430.2. [Q06889-1]
XP_005273483.1. XM_005273426.1. [Q06889-2]
UniGeneiHs.534313.

Genome annotation databases

EnsembliENST00000317216; ENSP00000318057; ENSG00000179388. [Q06889-1]
ENST00000522910; ENSP00000430310; ENSG00000179388. [Q06889-2]
GeneIDi1960.
KEGGihsa:1960.
UCSCiuc003xcm.1. human. [Q06889-1]

Polymorphism databases

DMDMi730328.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63741 mRNA. Translation: CAA45275.1.
S40832 mRNA. Translation: AAB19317.1.
AK292464 mRNA. Translation: BAF85153.1.
AK295134 mRNA. Translation: BAG58157.1.
AK313604 mRNA. Translation: BAG36369.1.
AC105046 Genomic DNA. No translation available.
BC104765 mRNA. Translation: AAI04766.1.
BC112279 mRNA. Translation: AAI12280.1.
CCDSiCCDS56528.1. [Q06889-2]
CCDS6033.1. [Q06889-1]
PIRiS60519. S19885.
RefSeqiNP_001186809.1. NM_001199880.1. [Q06889-2]
NP_001186810.1. NM_001199881.1.
NP_004421.2. NM_004430.2. [Q06889-1]
XP_005273483.1. XM_005273426.1. [Q06889-2]
UniGeneiHs.534313.

3D structure databases

ProteinModelPortaliQ06889.
SMRiQ06889. Positions 273-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-234110.
STRINGi9606.ENSP00000318057.

PTM databases

PhosphoSiteiQ06889.

Polymorphism databases

DMDMi730328.

Proteomic databases

PaxDbiQ06889.
PRIDEiQ06889.

Protocols and materials databases

DNASUi1960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317216; ENSP00000318057; ENSG00000179388. [Q06889-1]
ENST00000522910; ENSP00000430310; ENSG00000179388. [Q06889-2]
GeneIDi1960.
KEGGihsa:1960.
UCSCiuc003xcm.1. human. [Q06889-1]

Organism-specific databases

CTDi1960.
GeneCardsiGC08M022545.
HGNCiHGNC:3240. EGR3.
HPAiCAB009373.
HPA006206.
MIMi602419. gene.
neXtProtiNX_Q06889.
PharmGKBiPA27675.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiQ06889.
KOiK12497.
OMAiDYNLFHH.
OrthoDBiEOG75XGKR.
PhylomeDBiQ06889.
TreeFamiTF318980.

Enzyme and pathway databases

SignaLinkiQ06889.

Miscellaneous databases

ChiTaRSiEGR3. human.
GeneWikiiEGR3.
GenomeRNAii1960.
NextBioi7951.
PROiQ06889.
SOURCEiSearch...

Gene expression databases

BgeeiQ06889.
CleanExiHS_EGR3.
ExpressionAtlasiQ06889. baseline and differential.
GenevestigatoriQ06889.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells."
    Mages H.W., Stamminger T., Rilke O., Bravo R., Kroczek R.A.
    Int. Immunol. 5:63-70(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Peripheral blood T-cell.
  2. "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors."
    Patwardhan S., Gashler A., Siegel M.G., Chang L.C., Joseph L.J., Shows T.B., le Beau M.M., Sukhatme V.P.
    Oncogene 6:917-928(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiEGR3_HUMAN
AccessioniPrimary (citable) accession number: Q06889
Secondary accession number(s): A8K8U9
, B4DHJ5, E7EW38, Q2M3W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 4, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.