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Reviewed, UniProtKB/Swiss-Prot Q06889 (EGR3_HUMAN)

Last modified November 25, 2008. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Early growth response protein 3
      Short name=EGR-3
Alternative name(s):
    Zinc finger protein pilot
Gene names
Name: EGR3
Synonyms: PILOT
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Probable transcription factor involved in muscle spindle development.

Subcellular location

NucleusProbable.

Developmental stage

In T-cells, expressed 20 minutes following activation.

Sequence similarities

Belongs to the EGR C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Early growth response protein 3
PRO_0000047125

Regions

Zinc finger275 – 29925C2H2-type 1
Zinc finger305 – 32723C2H2-type 2
Zinc finger333 – 35523C2H2-type 3

Experimental info

Sequence conflict2251I → T in AAB19317. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q06889-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 77FAF7D5A278C68E

FASTA38742,613
        10         20         30         40         50         60 
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVVHYNQMA TENVMDIGLT 

        70         80         90        100        110        120 
NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD NIISLMSAGI LGVPPASGAL 

       130        140        150        160        170        180 
STQTSTASMV QPPQGDVEAM YPALPPYSNC GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK 

       190        200        210        220        230        240 
PALDSNLFPM IPDYNLYHHP NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH 

       250        260        270        280        290        300 
PGFGSLPQPP LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT 

       310        320        330        340        350        360 
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR HAKIHLKQKE 

       370        380 
KKAEKGGAPS ASSAPPVSLA PVVTTCA 

« Hide

References

« Hide 'large scale' references
[1]"Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells."
Mages H.W., Stamminger T., Rilke O., Bravo R., Kroczek R.A.
Int. Immunol. 5:63-70(1993) [PubMed: 8443122] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peripheral blood T-cell.
[2]"EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors."
Patwardhan S., Gashler A., Siegel M.G., Chang L.C., Joseph L.J., Shows T.B., le Beau M.M., Sukhatme V.P.
Oncogene 6:917-928(1991) [PubMed: 1906159] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

X63741 mRNA. Translation: CAA45275.1.
S40832 mRNA. Translation: AAB19317.1.
BC104765 mRNA. Translation: AAI04766.1.
BC112279 mRNA. Translation: AAI12280.1.
PIRS19885. S60519.
RefSeqNP_004421.2.
UniGeneHs.534313

3D structure databases

HSSPHSSP built from PDB template 1P47 based on UniProtKB P08046.
SMRQ06889. Positions 272-358.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000179388. Homo sapiens. [Contig view]
GeneID1960.
KEGGhsa:1960.

Organism-specific databases

HGNCHGNC:3240. EGR3.
MIM602419. gene.
PharmGKBPA27675.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ06889.
HOVERGENQ06889.

Gene expression databases

ArrayExpressQ06889.
CleanExHS_EGR3.
GermOnlineENSG00000179388. Homo sapiens.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
PfamPF00096. zf-C2H2. 3 hits.
[Graphical view]
ProDomPD000003. Znf_C2H2. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio7951.
SOURCESearch...

Entry information

Entry nameEGR3_HUMAN
AccessionPrimary (citable) accession number: Q06889
Secondary accession number(s): Q2M3W2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 25, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents