Reviewed, UniProtKB/Swiss-Prot Q06889 (EGR3_HUMAN)

Names and origin

Protein names

Recommended name:
    Early growth response protein 3
      Short name=EGR-3
Alternative name(s):
    Zinc finger protein pilot

Gene names

Name:	EGR3
Synonyms:	PILOT

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable transcription factor involved in muscle spindle development.
Subcellular location	NucleusProbable.
Developmental stage	In T-cells, expressed 20 minutes following activation.
Sequence similarities	Belongs to the EGR C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Gene Ontology (GO)
Biological process	circadian rhythm Traceable author statement. Source: ProtInc muscle development Traceable author statement. Source: ProtInc regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transcription factor activity Ref.2 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Early growth response protein 3		PRO_0000047125
Regions
	Zinc finger	275 – 299	25	C2H2-type 1
	Zinc finger	305 – 327	23	C2H2-type 2
	Zinc finger	333 – 355	23	C2H2-type 3
Experimental info
	Sequence conflict	225	1	I → T in AAB19317. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q06889-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 77FAF7D5A278C68E	FASTA	387	42,613
	10 20 30 40 50 60 MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVVHYNQMA TENVMDIGLT 70 80 90 100 110 120 NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD NIISLMSAGI LGVPPASGAL 130 140 150 160 170 180 STQTSTASMV QPPQGDVEAM YPALPPYSNC GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK 190 200 210 220 230 240 PALDSNLFPM IPDYNLYHHP NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH 250 260 270 280 290 300 PGFGSLPQPP LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT 310 320 330 340 350 360 GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR HAKIHLKQKE 370 380 KKAEKGGAPS ASSAPPVSLA PVVTTCA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells." Mages H.W., Stamminger T., Rilke O., Bravo R., Kroczek R.A. Int. Immunol. 5:63-70(1993) [PubMed: 8443122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood T-cell.
[2]	"EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors." Patwardhan S., Gashler A., Siegel M.G., Chang L.C., Joseph L.J., Shows T.B., le Beau M.M., Sukhatme V.P. Oncogene 6:917-928(1991) [PubMed: 1906159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X63741 mRNA. Translation: CAA45275.1. S40832 mRNA. Translation: AAB19317.1. BC104765 mRNA. Translation: AAI04766.1. BC112279 mRNA. Translation: AAI12280.1.
PIR	S19885. S60519.
RefSeq	NP_004421.2.
UniGene	Hs.534313
3D structure databases
HSSP	HSSP built from PDB template 1P47 based on UniProtKB P08046.
SMR	Q06889. Positions 272-358.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000179388. Homo sapiens. [Contig view]
GeneID	1960.
KEGG	hsa:1960.
Organism-specific databases
HGNC	HGNC:3240. EGR3.
MIM	602419. gene.
PharmGKB	PA27675.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q06889.
HOVERGEN	Q06889.
Gene expression databases
ArrayExpress	Q06889.
CleanEx	HS_EGR3.
GermOnline	ENSG00000179388. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
ProDom	PD000003. Znf_C2H2. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	7951.
SOURCE	Search...

Entry information

Entry name

EGR3_HUMAN

Accession

Primary (citable) accession number: Q06889
Secondary accession number(s): Q2M3W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 25, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)