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Protein
Submitted name:

Cytochrome P-450

Gene

Cyp3a23/3a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211958. Miscellaneous substrates.
R-RNO-211981. Xenobiotics.
R-RNO-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P-450Imported
Submitted name:
Cytochrome P450 3A2Imported
Submitted name:
Cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1Imported
Submitted name:
Cytochrome P450/6 beta BImported
Submitted name:
Cytochrome P450IIIA23Imported
Submitted name:
RCG42817Imported
Submitted name:
Testosterone-6-beta hydroxylaseImported
Gene namesi
Name:Cyp3a23/3a1Imported
Synonyms:3a1Imported, CYP3A1Imported, Cyp3a2Imported, CYP3A23Imported, Cyp3a23Imported, Cyp3a73Imported, LOC100910877Imported
ORF Names:rCG_42817Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi708379. Cyp3a2.
628626. Cyp3a23/3a1.
6495986. LOC100910877.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2520HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23119HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065082.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOVERGENiHBG108567.
KOiK07424.
OrthoDBiEOG744TBS.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLSALTLE TWVLLAVVLV LLYGFGTRTH GLFKKQGIPG PKPLPFFGTV
60 70 80 90 100
LNYYMGLWKF DVECHKKYGK IWGLFDGQMP LFAITDTEMI KNVLVKECFS
110 120 130 140 150
VFTNRRDFGP VGIMGKAISV SKDEEWKRYR ALLSPTFTSG RLKEMFPVIE
160 170 180 190 200
QYGDILVKYL RQEKGKPVPV KEVFGAYSMD VITSTSFGVN VDSLNNPKDP
210 220 230 240 250
FVEKAKKLLR IDFFDPLFLS VVLFPFLTPV YEMLNICMFP KDSIEFFKKF
260 270 280 290 300
VYRMKETRLD SVQKHRVDFL QLMMNAHNDS KDKESHTALS DMEITAQSII
310 320 330 340 350
FIFAGYEPTS STLSFVLHSL ATHPDTQKKL QEEIDRALPN KAPPTYDTVM
360 370 380 390 400
EMEYLDMVLN ETLRLYPIGN RLERVCKKDV EINGVFMPKG SVVMIPSYAL
410 420 430 440 450
HRDPQHWPEP EEFRPERFSK ENKGSIDPYV YLPFGNGPRN CIGMRFALMN
460 470 480 490 500
MKLALTKVLQ NFSFQPCKET QIPLKLSRQG LLQPTKPIIL KVVPRDEIIT

GS
Length:502
Mass (Da):57,676
Last modified:November 1, 1996 - v1
Checksum:iB37837D1E180697D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07035372 Genomic DNA. No translation available.
AABR07035373 Genomic DNA. No translation available.
AABR07035374 Genomic DNA. No translation available.
AABR07035375 Genomic DNA. No translation available.
L24207 mRNA. Translation: AAA41023.1.
BC088163 mRNA. Translation: AAH88163.1.
D13912 mRNA. Translation: BAA03008.1.
AB008388 Genomic DNA. Translation: BAA23003.1.
X96721 mRNA. Translation: CAA65482.1.
CH474012 Genomic DNA. Translation: EDL89596.1.
PIRiA26997.
C26997.
JX0334.
RefSeqiNP_037237.2. NM_013105.2.
XP_003751175.1. XM_003751127.3.
UniGeneiRn.91120.

Genome annotation databases

EnsembliENSRNOT00000051244; ENSRNOP00000041138; ENSRNOG00000032560.
GeneIDi100910877.
25642.
KEGGirno:100910877.
rno:25642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07035372 Genomic DNA. No translation available.
AABR07035373 Genomic DNA. No translation available.
AABR07035374 Genomic DNA. No translation available.
AABR07035375 Genomic DNA. No translation available.
L24207 mRNA. Translation: AAA41023.1.
BC088163 mRNA. Translation: AAH88163.1.
D13912 mRNA. Translation: BAA03008.1.
AB008388 Genomic DNA. Translation: BAA23003.1.
X96721 mRNA. Translation: CAA65482.1.
CH474012 Genomic DNA. Translation: EDL89596.1.
PIRiA26997.
C26997.
JX0334.
RefSeqiNP_037237.2. NM_013105.2.
XP_003751175.1. XM_003751127.3.
UniGeneiRn.91120.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051244; ENSRNOP00000041138; ENSRNOG00000032560.
GeneIDi100910877.
25642.
KEGGirno:100910877.
rno:25642.

Organism-specific databases

CTDi25642.
RGDi708379. Cyp3a2.
628626. Cyp3a23/3a1.
6495986. LOC100910877.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOVERGENiHBG108567.
KOiK07424.
OrthoDBiEOG744TBS.
TreeFamiTF105087.

Enzyme and pathway databases

ReactomeiR-RNO-211958. Miscellaneous substrates.
R-RNO-211981. Xenobiotics.
R-RNO-5423646. Aflatoxin activation and detoxification.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence for functional and structural multiplicity of pregnenolone-16 alpha-carbonitrile-inducible cytochrome P-450 isozymes in rat liver microsomes."
    Graves P.E., Kaminsky L.S., Halpert J.
    Biochemistry 26:3887-3894(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  2. "cDNA cloning and characterization of a novel member of steroid-induced cytochrome P450 3A in rats."
    Kirita S., Matsubara T.
    Arch. Biochem. Biophys. 307:253-258(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SLC-wistarImported.
    Tissue: LiverImported.
  3. "Nucleotide and deduced amino acid sequences of a new rat CYP3A form."
    Miyata M., Nagata K., Yamazoe Y., Kato R.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: LiverImported.
  4. "A major glucocorticoid-inducible P450 in rat liver is not P450 3A1."
    Komori M., Oda Y.
    J. Biochem. 116:114-120(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  5. Strotkamp D., Roos P.H., Hanstein W.G.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  6. "Nucleotide and deduced amino acid sequences of a new rat CYP3A form."
    Miyata M., Nagata K., Yamazoe Y., Kato R.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  7. "Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein."
    Nagata K., Ogino M., Shimada M., Miyata M., Gonzalez F.J., Yamazoe Y.
    Arch. Biochem. Biophys. 362:242-253(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague DawleyImported.
    Tissue: LiverImported.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LiverImported.
  9. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  12. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ06884_RAT
AccessioniPrimary (citable) accession number: Q06884
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.