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Protein
Submitted name:

Cytochrome P-450

Gene

Cyp3a23/3a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211981. Xenobiotics.
R-RNO-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P-450Imported
Submitted name:
Cytochrome P450 3A2Imported
Submitted name:
Cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1Imported
Submitted name:
Cytochrome P450/6 beta BImported
Submitted name:
Cytochrome P450IIIA23Imported
Submitted name:
RCG42817Imported
Submitted name:
Testosterone-6-beta hydroxylaseImported
Gene namesi
Name:Cyp3a23/3a1Imported
Synonyms:3a1Imported, CYP3A1Imported, Cyp3a2Imported, CYP3A23Imported, Cyp3a23Imported, Cyp3a73Imported, LOC100910877Imported
ORF Names:rCG_42817Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi708379. Cyp3a2.
628626. Cyp3a23/3a1.
6495986. LOC100910877.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei213 – 231HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000032560.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065082.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOVERGENiHBG108567.
KOiK07424.
OrthoDBiEOG091G0JNC.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLSALTLE TWVLLAVVLV LLYGFGTRTH GLFKKQGIPG PKPLPFFGTV
60 70 80 90 100
LNYYMGLWKF DVECHKKYGK IWGLFDGQMP LFAITDTEMI KNVLVKECFS
110 120 130 140 150
VFTNRRDFGP VGIMGKAISV SKDEEWKRYR ALLSPTFTSG RLKEMFPVIE
160 170 180 190 200
QYGDILVKYL RQEKGKPVPV KEVFGAYSMD VITSTSFGVN VDSLNNPKDP
210 220 230 240 250
FVEKAKKLLR IDFFDPLFLS VVLFPFLTPV YEMLNICMFP KDSIEFFKKF
260 270 280 290 300
VYRMKETRLD SVQKHRVDFL QLMMNAHNDS KDKESHTALS DMEITAQSII
310 320 330 340 350
FIFAGYEPTS STLSFVLHSL ATHPDTQKKL QEEIDRALPN KAPPTYDTVM
360 370 380 390 400
EMEYLDMVLN ETLRLYPIGN RLERVCKKDV EINGVFMPKG SVVMIPSYAL
410 420 430 440 450
HRDPQHWPEP EEFRPERFSK ENKGSIDPYV YLPFGNGPRN CIGMRFALMN
460 470 480 490 500
MKLALTKVLQ NFSFQPCKET QIPLKLSRQG LLQPTKPIIL KVVPRDEIIT

GS
Length:502
Mass (Da):57,676
Last modified:November 1, 1996 - v1
Checksum:iB37837D1E180697D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07035372 Genomic DNA. No translation available.
AABR07035373 Genomic DNA. No translation available.
AABR07035374 Genomic DNA. No translation available.
AABR07035375 Genomic DNA. No translation available.
L24207 mRNA. Translation: AAA41023.1.
BC088163 mRNA. Translation: AAH88163.1.
D13912 mRNA. Translation: BAA03008.1.
AB008388 Genomic DNA. Translation: BAA23003.1.
X96721 mRNA. Translation: CAA65482.1.
CH474012 Genomic DNA. Translation: EDL89596.1.
PIRiA26997.
C26997.
JX0334.
RefSeqiNP_037237.2. NM_013105.2.
XP_003751175.1. XM_003751127.4.
UniGeneiRn.91120.

Genome annotation databases

EnsembliENSRNOT00000051244; ENSRNOP00000041138; ENSRNOG00000032560.
GeneIDi100910877.
25642.
KEGGirno:100910877.
rno:25642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07035372 Genomic DNA. No translation available.
AABR07035373 Genomic DNA. No translation available.
AABR07035374 Genomic DNA. No translation available.
AABR07035375 Genomic DNA. No translation available.
L24207 mRNA. Translation: AAA41023.1.
BC088163 mRNA. Translation: AAH88163.1.
D13912 mRNA. Translation: BAA03008.1.
AB008388 Genomic DNA. Translation: BAA23003.1.
X96721 mRNA. Translation: CAA65482.1.
CH474012 Genomic DNA. Translation: EDL89596.1.
PIRiA26997.
C26997.
JX0334.
RefSeqiNP_037237.2. NM_013105.2.
XP_003751175.1. XM_003751127.4.
UniGeneiRn.91120.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051244; ENSRNOP00000041138; ENSRNOG00000032560.
GeneIDi100910877.
25642.
KEGGirno:100910877.
rno:25642.

Organism-specific databases

CTDi25642.
RGDi708379. Cyp3a2.
628626. Cyp3a23/3a1.
6495986. LOC100910877.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOVERGENiHBG108567.
KOiK07424.
OrthoDBiEOG091G0JNC.
TreeFamiTF105087.

Enzyme and pathway databases

ReactomeiR-RNO-211981. Xenobiotics.
R-RNO-5423646. Aflatoxin activation and detoxification.

Gene expression databases

BgeeiENSRNOG00000032560.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ06884_RAT
AccessioniPrimary (citable) accession number: Q06884
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.