ID   NBL1_RAT                Reviewed;         178 AA.
AC   Q06880; Q6P750;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   08-NOV-2023, entry version 115.
DE   RecName: Full=Neuroblastoma suppressor of tumorigenicity 1;
DE   AltName: Full=N03;
DE   AltName: Full=Zinc finger protein DAN;
DE   Flags: Precursor;
GN   Name=Nbl1; Synonyms=Dan;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8385338; DOI=10.1073/pnas.90.7.2593;
RA   Ozaki T., Sakiyama S.;
RT   "Molecular cloning and characterization of a cDNA showing negative
RT   regulation in v-src-transformed 3Y1 rat fibroblasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2593-2597(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7942277; DOI=10.1016/0065-2571(94)90019-1;
RA   Sakiyama S., Ozaki T., Enomoto H.;
RT   "Molecular cloning and characterization of a cDNA showing tumor-suppressive
RT   activity in V-SRC-transformed 3Y1 rat fibroblasts.";
RL   Adv. Enzyme Regul. 34:247-255(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Possible candidate as a tumor suppressor gene of
CC       neuroblastoma. May play an important role in preventing cells from
CC       entering the final stage (G1/S) of the transformation process.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Most abundant in lung, brain, intestine and kidney.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000305}.
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DR   EMBL; X66872; CAA47344.1; -; mRNA.
DR   EMBL; S72637; AAB32215.1; -; mRNA.
DR   EMBL; BC061833; AAH61833.1; -; mRNA.
DR   PIR; A47291; A47291.
DR   RefSeq; NP_113797.1; NM_031609.1.
DR   AlphaFoldDB; Q06880; -.
DR   SMR; Q06880; -.
DR   BioGRID; 248400; 1.
DR   IntAct; Q06880; 1.
DR   STRING; 10116.ENSRNOP00000064345; -.
DR   PhosphoSitePlus; Q06880; -.
DR   PaxDb; 10116-ENSRNOP00000064345; -.
DR   GeneID; 50594; -.
DR   KEGG; rno:50594; -.
DR   AGR; RGD:3151; -.
DR   CTD; 4681; -.
DR   RGD; 3151; Nbl1.
DR   eggNOG; ENOG502RYP0; Eukaryota.
DR   InParanoid; Q06880; -.
DR   OrthoDB; 3684148at2759; -.
DR   PhylomeDB; Q06880; -.
DR   PRO; PR:Q06880; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0036122; F:BMP binding; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0016015; F:morphogen activity; ISO:RGD.
DR   GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0048263; P:determination of dorsal identity; ISO:RGD.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:0090027; P:negative regulation of monocyte chemotaxis; ISO:RGD.
DR   GO; GO:0007399; P:nervous system development; ISO:RGD.
DR   GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR   GO; GO:0048812; P:neuron projection morphogenesis; ISO:RGD.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR   GO; GO:0038098; P:sequestering of BMP from receptor via BMP binding; ISO:RGD.
DR   GO; GO:0035582; P:sequestering of BMP in extracellular matrix; ISO:RGD.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   InterPro; IPR016728; Neuroblast_suppress_tumour_1.
DR   PANTHER; PTHR15283; GREMLIN 1; 1.
DR   PANTHER; PTHR15283:SF5; NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1; 1.
DR   Pfam; PF03045; DAN; 1.
DR   PIRSF; PIRSF018557; DAN_sub; 1.
DR   SMART; SM00041; CT; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal; Tumor suppressor.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..178
FT                   /note="Neuroblastoma suppressor of tumorigenicity 1"
FT                   /id="PRO_0000006724"
FT   DOMAIN          34..123
FT                   /note="CTCK"
FT   REGION          130..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        34..84
FT                   /evidence="ECO:0000250"
FT   DISULFID        48..98
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..119
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..122
FT                   /evidence="ECO:0000255"
FT   CONFLICT        157
FT                   /note="C -> G (in Ref. 3; AAH61833)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   178 AA;  19191 MW;  4786AF6DC3510212 CRC64;
     MLWVLVGTVL PVMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA KSIQNRACLG
     QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG HEEVPRVDKL VEKIVHCSCQ
     ACGKEPSHEG LNVYMQGEDG PGSQPGSHSH SHPHPGCQTP EPEEPPGAPQ VEEEGAED
//