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Protein

Neuroblastoma suppressor of tumorigenicity 1

Gene

Nbl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma suppressor of tumorigenicity 1
Alternative name(s):
N03
Zinc finger protein DAN
Gene namesi
Name:Nbl1
Synonyms:Dan
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3151. Nbl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000672417 – 178Neuroblastoma suppressor of tumorigenicity 1Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 84By similarity
Disulfide bondi48 ↔ 98By similarity
Disulfide bondi58 ↔ 117By similarity
Disulfide bondi62 ↔ 119By similarity
Disulfide bondi81 ↔ 122Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ06880.

Expressioni

Tissue specificityi

Most abundant in lung, brain, intestine and kidney.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248400. 1 interactor.
IntActiQ06880. 1 interactor.
STRINGi10116.ENSRNOP00000064345.

Structurei

3D structure databases

SMRiQ06880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 123CTCKAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi141 – 169Pro-richAdd BLAST29

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWXT. Eukaryota.
ENOG4111SRK. LUCA.
HOVERGENiHBG031736.
InParanoidiQ06880.
KOiK19558.
PhylomeDBiQ06880.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR004133. DAN.
IPR016728. Neuroblast_suppress_tumour_1.
PfamiView protein in Pfam
PF03045. DAN. 1 hit.
PIRSFiPIRSF018557. DAN_sub. 1 hit.
SMARTiView protein in SMART
SM00041. CT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWVLVGTVL PVMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA
60 70 80 90 100
KSIQNRACLG QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG
110 120 130 140 150
HEEVPRVDKL VEKIVHCSCQ ACGKEPSHEG LNVYMQGEDG PGSQPGSHSH
160 170
SHPHPGCQTP EPEEPPGAPQ VEEEGAED
Length:178
Mass (Da):19,191
Last modified:February 1, 1995 - v1
Checksum:i4786AF6DC3510212
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157C → G in AAH61833 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66872 mRNA. Translation: CAA47344.1.
S72637 mRNA. Translation: AAB32215.1.
BC061833 mRNA. Translation: AAH61833.1.
PIRiA47291.
RefSeqiNP_113797.1. NM_031609.1.
UniGeneiRn.4073.

Genome annotation databases

GeneIDi50594.
KEGGirno:50594.

Similar proteinsi

Entry informationi

Entry nameiNBL1_RAT
AccessioniPrimary (citable) accession number: Q06880
Secondary accession number(s): Q6P750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families