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Q06880 (NBL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuroblastoma suppressor of tumorigenicity 1
Alternative name(s):
N03
Zinc finger protein DAN
Gene names
Name:Nbl1
Synonyms:Dan
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Most abundant in lung, brain, intestine and kidney.

Sequence similarities

Belongs to the DAN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 178162Neuroblastoma suppressor of tumorigenicity 1
PRO_0000006724

Regions

Domain34 – 12390CTCK
Compositional bias141 – 16929Pro-rich

Amino acid modifications

Disulfide bond34 ↔ 84 By similarity
Disulfide bond48 ↔ 98 By similarity
Disulfide bond58 ↔ 117 By similarity
Disulfide bond62 ↔ 119 By similarity
Disulfide bond81 ↔ 122 Potential

Experimental info

Sequence conflict1571C → G in AAH61833. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q06880 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 4786AF6DC3510212

FASTA17819,191
        10         20         30         40         50         60 
MLWVLVGTVL PVMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA KSIQNRACLG 

        70         80         90        100        110        120 
QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG HEEVPRVDKL VEKIVHCSCQ 

       130        140        150        160        170 
ACGKEPSHEG LNVYMQGEDG PGSQPGSHSH SHPHPGCQTP EPEEPPGAPQ VEEEGAED 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts."
Ozaki T., Sakiyama S.
Proc. Natl. Acad. Sci. U.S.A. 90:2593-2597(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and characterization of a cDNA showing tumor-suppressive activity in V-SRC-transformed 3Y1 rat fibroblasts."
Sakiyama S., Ozaki T., Enomoto H.
Adv. Enzyme Regul. 34:247-255(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66872 mRNA. Translation: CAA47344.1.
S72637 mRNA. Translation: AAB32215.1.
BC061833 mRNA. Translation: AAH61833.1.
PIRA47291.
RefSeqNP_113797.1. NM_031609.1.
UniGeneRn.4073.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248400. 1 interaction.
IntActQ06880. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000072299; ENSRNOP00000064345; ENSRNOG00000049402.
GeneID50594.
KEGGrno:50594.

Organism-specific databases

CTD4681.
RGD3151. Nbl1.

Phylogenomic databases

GeneTreeENSGT00730000111304.
HOVERGENHBG031736.
OrthoDBEOG74J97S.
PhylomeDBQ06880.

Gene expression databases

GenevestigatorQ06880.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR004133. DAN.
IPR016728. Neuroblast_suppress_tumour_1.
[Graphical view]
PANTHERPTHR15283:SF1. PTHR15283:SF1. 1 hit.
PfamPF03045. DAN. 1 hit.
[Graphical view]
PIRSFPIRSF018557. DAN_sub. 1 hit.
SMARTSM00041. CT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610438.
PROQ06880.

Entry information

Entry nameNBL1_RAT
AccessionPrimary (citable) accession number: Q06880
Secondary accession number(s): Q6P750
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families