Q06880 (NBL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroblastoma suppressor of tumorigenicity 1

Alternative name(s):
N03
Zinc finger protein DAN

Gene names

Name:	Nbl1
Synonyms:	Dan

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
Subcellular location	Secreted By similarity.
Tissue specificity	Most abundant in lung, brain, intestine and kidney.
Sequence similarities	Belongs to the DAN family. Contains 1 CTCK (C-terminal cystine knot-like) domain.

Ontologies

Keywords
Cellular component	Secreted
Disease	Tumor suppressor
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 178	162	Neuroblastoma suppressor of tumorigenicity 1		PRO_0000006724
Regions
	Domain	34 – 123	90	CTCK
	Compositional bias	141 – 169	29	Pro-rich
Amino acid modifications
	Disulfide bond	34 ↔ 84		By similarity
	Disulfide bond	48 ↔ 98		By similarity
	Disulfide bond	58 ↔ 117		By similarity
	Disulfide bond	62 ↔ 119		By similarity
	Disulfide bond	81 ↔ 122		Potential
Experimental info
	Sequence conflict	157	1	C → G in AAH61833. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q06880 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 4786AF6DC3510212	FASTA	178	19,191
	10 20 30 40 50 60 MLWVLVGTVL PVMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA KSIQNRACLG 70 80 90 100 110 120 QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG HEEVPRVDKL VEKIVHCSCQ 130 140 150 160 170 ACGKEPSHEG LNVYMQGEDG PGSQPGSHSH SHPHPGCQTP EPEEPPGAPQ VEEEGAED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts." Ozaki T., Sakiyama S. Proc. Natl. Acad. Sci. U.S.A. 90:2593-2597(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and characterization of a cDNA showing tumor-suppressive activity in V-SRC-transformed 3Y1 rat fibroblasts." Sakiyama S., Ozaki T., Enomoto H. Adv. Enzyme Regul. 34:247-255(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X66872 mRNA. Translation: CAA47344.1. S72637 mRNA. Translation: AAB32215.1. BC061833 mRNA. Translation: AAH61833.1.
IPI	IPI00197041.
PIR	A47291.
RefSeq	NP_113797.1. NM_031609.1.
UniGene	Rn.4073.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q06880. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000072299; ENSRNOP00000064345; ENSRNOG00000049402.
GeneID	50594.
KEGG	rno:50594.
Organism-specific databases
CTD	4681.
RGD	3151. Nbl1.
Phylogenomic databases
GeneTree	ENSGT00510000046909.
HOVERGEN	HBG031736.
Gene expression databases
Genevestigator	Q06880.
Family and domain databases
InterPro	IPR006207. Cys_knot_C. IPR004133. DAN. IPR016728. Neuroblast_suppress_tumour_1. [Graphical view]
PANTHER	PTHR15283:SF0. PTHR15283:SF0. 1 hit.
Pfam	PF03045. DAN. 1 hit. [Graphical view]
PIRSF	PIRSF018557. DAN_sub. 1 hit.
SMART	SM00041. CT. 1 hit. [Graphical view]
PROSITE	PS01225. CTCK_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	610438.

Entry information

Entry name

NBL1_RAT

Accession

Primary (citable) accession number: Q06880
Secondary accession number(s): Q6P750

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program