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Q06880

- NBL1_RAT

UniProt

Q06880 - NBL1_RAT

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Protein

Neuroblastoma suppressor of tumorigenicity 1

Gene

Nbl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

GO - Molecular functioni

  1. morphogen activity Source: Ensembl

GO - Biological processi

  1. determination of dorsal identity Source: Ensembl
  2. negative regulation of monocyte chemotaxis Source: Ensembl
  3. neuron projection morphogenesis Source: Ensembl
  4. positive regulation of neuron differentiation Source: Ensembl
  5. sequestering of BMP in extracellular matrix Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma suppressor of tumorigenicity 1
Alternative name(s):
N03
Zinc finger protein DAN
Gene namesi
Name:Nbl1
Synonyms:Dan
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi3151. Nbl1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 178162Neuroblastoma suppressor of tumorigenicity 1PRO_0000006724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 84By similarity
Disulfide bondi48 ↔ 98By similarity
Disulfide bondi58 ↔ 117By similarity
Disulfide bondi62 ↔ 119By similarity
Disulfide bondi81 ↔ 122Sequence Analysis

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Most abundant in lung, brain, intestine and kidney.

Gene expression databases

GenevestigatoriQ06880.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi248400. 1 interaction.
IntActiQ06880. 1 interaction.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 12390CTCKAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi141 – 16929Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000111304.
HOVERGENiHBG031736.
InParanoidiQ06880.
OrthoDBiEOG74J97S.
PhylomeDBiQ06880.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR004133. DAN.
IPR016728. Neuroblast_suppress_tumour_1.
[Graphical view]
PANTHERiPTHR15283:SF1. PTHR15283:SF1. 1 hit.
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF018557. DAN_sub. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06880-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWVLVGTVL PVMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA
60 70 80 90 100
KSIQNRACLG QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG
110 120 130 140 150
HEEVPRVDKL VEKIVHCSCQ ACGKEPSHEG LNVYMQGEDG PGSQPGSHSH
160 170
SHPHPGCQTP EPEEPPGAPQ VEEEGAED
Length:178
Mass (Da):19,191
Last modified:February 1, 1995 - v1
Checksum:i4786AF6DC3510212
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571C → G in AAH61833. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66872 mRNA. Translation: CAA47344.1.
S72637 mRNA. Translation: AAB32215.1.
BC061833 mRNA. Translation: AAH61833.1.
PIRiA47291.
RefSeqiNP_113797.1. NM_031609.1.
UniGeneiRn.4073.

Genome annotation databases

EnsembliENSRNOT00000072299; ENSRNOP00000064345; ENSRNOG00000049402.
GeneIDi50594.
KEGGirno:50594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66872 mRNA. Translation: CAA47344.1 .
S72637 mRNA. Translation: AAB32215.1 .
BC061833 mRNA. Translation: AAH61833.1 .
PIRi A47291.
RefSeqi NP_113797.1. NM_031609.1.
UniGenei Rn.4073.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248400. 1 interaction.
IntActi Q06880. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000072299 ; ENSRNOP00000064345 ; ENSRNOG00000049402 .
GeneIDi 50594.
KEGGi rno:50594.

Organism-specific databases

CTDi 4681.
RGDi 3151. Nbl1.

Phylogenomic databases

GeneTreei ENSGT00730000111304.
HOVERGENi HBG031736.
InParanoidi Q06880.
OrthoDBi EOG74J97S.
PhylomeDBi Q06880.

Miscellaneous databases

NextBioi 610438.
PROi Q06880.

Gene expression databases

Genevestigatori Q06880.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR004133. DAN.
IPR016728. Neuroblast_suppress_tumour_1.
[Graphical view ]
PANTHERi PTHR15283:SF1. PTHR15283:SF1. 1 hit.
Pfami PF03045. DAN. 1 hit.
[Graphical view ]
PIRSFi PIRSF018557. DAN_sub. 1 hit.
SMARTi SM00041. CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts."
    Ozaki T., Sakiyama S.
    Proc. Natl. Acad. Sci. U.S.A. 90:2593-2597(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and characterization of a cDNA showing tumor-suppressive activity in V-SRC-transformed 3Y1 rat fibroblasts."
    Sakiyama S., Ozaki T., Enomoto H.
    Adv. Enzyme Regul. 34:247-255(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiNBL1_RAT
AccessioniPrimary (citable) accession number: Q06880
Secondary accession number(s): Q6P750
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3