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Q06880

- NBL1_RAT

UniProt

Q06880 - NBL1_RAT

Protein

Neuroblastoma suppressor of tumorigenicity 1

Gene

Nbl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

    GO - Molecular functioni

    1. morphogen activity Source: Ensembl

    GO - Biological processi

    1. determination of dorsal identity Source: Ensembl
    2. negative regulation of monocyte chemotaxis Source: Ensembl
    3. neuron projection morphogenesis Source: Ensembl
    4. positive regulation of neuron differentiation Source: Ensembl
    5. sequestering of BMP in extracellular matrix Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroblastoma suppressor of tumorigenicity 1
    Alternative name(s):
    N03
    Zinc finger protein DAN
    Gene namesi
    Name:Nbl1
    Synonyms:Dan
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi3151. Nbl1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 178162Neuroblastoma suppressor of tumorigenicity 1PRO_0000006724Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 84By similarity
    Disulfide bondi48 ↔ 98By similarity
    Disulfide bondi58 ↔ 117By similarity
    Disulfide bondi62 ↔ 119By similarity
    Disulfide bondi81 ↔ 122Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Most abundant in lung, brain, intestine and kidney.

    Gene expression databases

    GenevestigatoriQ06880.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi248400. 1 interaction.
    IntActiQ06880. 1 interaction.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 12390CTCKAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi141 – 16929Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DAN family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00730000111304.
    HOVERGENiHBG031736.
    OrthoDBiEOG74J97S.
    PhylomeDBiQ06880.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR006207. Cys_knot_C.
    IPR029034. Cystine-knot_cytokine.
    IPR004133. DAN.
    IPR016728. Neuroblast_suppress_tumour_1.
    [Graphical view]
    PANTHERiPTHR15283:SF1. PTHR15283:SF1. 1 hit.
    PfamiPF03045. DAN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018557. DAN_sub. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06880-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWVLVGTVL PVMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA    50
    KSIQNRACLG QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG 100
    HEEVPRVDKL VEKIVHCSCQ ACGKEPSHEG LNVYMQGEDG PGSQPGSHSH 150
    SHPHPGCQTP EPEEPPGAPQ VEEEGAED 178
    Length:178
    Mass (Da):19,191
    Last modified:February 1, 1995 - v1
    Checksum:i4786AF6DC3510212
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti157 – 1571C → G in AAH61833. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66872 mRNA. Translation: CAA47344.1.
    S72637 mRNA. Translation: AAB32215.1.
    BC061833 mRNA. Translation: AAH61833.1.
    PIRiA47291.
    RefSeqiNP_113797.1. NM_031609.1.
    UniGeneiRn.4073.

    Genome annotation databases

    EnsembliENSRNOT00000072299; ENSRNOP00000064345; ENSRNOG00000049402.
    GeneIDi50594.
    KEGGirno:50594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66872 mRNA. Translation: CAA47344.1 .
    S72637 mRNA. Translation: AAB32215.1 .
    BC061833 mRNA. Translation: AAH61833.1 .
    PIRi A47291.
    RefSeqi NP_113797.1. NM_031609.1.
    UniGenei Rn.4073.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248400. 1 interaction.
    IntActi Q06880. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000072299 ; ENSRNOP00000064345 ; ENSRNOG00000049402 .
    GeneIDi 50594.
    KEGGi rno:50594.

    Organism-specific databases

    CTDi 4681.
    RGDi 3151. Nbl1.

    Phylogenomic databases

    GeneTreei ENSGT00730000111304.
    HOVERGENi HBG031736.
    OrthoDBi EOG74J97S.
    PhylomeDBi Q06880.

    Miscellaneous databases

    NextBioi 610438.
    PROi Q06880.

    Gene expression databases

    Genevestigatori Q06880.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR006207. Cys_knot_C.
    IPR029034. Cystine-knot_cytokine.
    IPR004133. DAN.
    IPR016728. Neuroblast_suppress_tumour_1.
    [Graphical view ]
    PANTHERi PTHR15283:SF1. PTHR15283:SF1. 1 hit.
    Pfami PF03045. DAN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018557. DAN_sub. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts."
      Ozaki T., Sakiyama S.
      Proc. Natl. Acad. Sci. U.S.A. 90:2593-2597(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and characterization of a cDNA showing tumor-suppressive activity in V-SRC-transformed 3Y1 rat fibroblasts."
      Sakiyama S., Ozaki T., Enomoto H.
      Adv. Enzyme Regul. 34:247-255(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiNBL1_RAT
    AccessioniPrimary (citable) accession number: Q06880
    Secondary accession number(s): Q6P750
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3