Reviewed,
UniProtKB/Swiss-Prot Q06862 (ACCC_ANASP)
Last modified
February 9, 2010.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Biotin carboxylase EC=6.3.4.14 Alternative name(s): Acetyl-CoA carboxylase subunit A Short name=ACC EC=6.4.1.2 | ||||
| Gene names |
| ||||
| Organism | Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 103690 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc |
Protein attributes
| Sequence length | 447 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA By similarity. |
| Catalytic activity | ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. |
| Pathway | Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. |
| Subunit structure | Acetyl-CoA carboxylase is an heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex By similarity. |
| Sequence similarities | Contains 1 ATP-grasp domain. Contains 1 biotin carboxylation domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Lipid synthesis |
| Ligand | ATP-binding Biotin Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetyl-CoA carboxylase activityInferred from electronic annotation. Source: EC biotin bindingInferred from electronic annotation. Source: InterPro biotin carboxylase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 447 | 447 | Biotin carboxylase | PRO_0000146787 | |||||
Regions | |||||||||
| Domain | 1 – 447 | 447 | Biotin carboxylation | ||||||
| Domain | 121 – 318 | 198 | ATP-grasp | ||||||
Sites | |||||||||
| Active site | 293 | 1 | By similarity | ||||||
| Binding site | 117 | 1 | ATP By similarity | ||||||
| Binding site | 201 | 1 | ATP By similarity | ||||||
| Binding site | 236 | 1 | ATP By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genes for two subunits of acetyl coenzyme A carboxylase of Anabaena sp. strain PCC 7120: biotin carboxylase and biotin carboxyl carrier protein." Gornicki P., Scappino L.A., Haselkorn R. J. Bacteriol. 175:5268-5272(1993) [PubMed: 8102363] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. Tabata S.DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L14862 Genomic DNA. Translation: AAB51770.1. BA000019 Genomic DNA. Translation: BAB72896.1. |
| PIR | A53311. AH1923. |
| RefSeq | NP_484982.1. |
3D structure databases | |
| SMR | Q06862. Positions 3-444. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q06862. |
Genome annotation databases | |
| GeneID | 1104533. |
| GenomeReviews | Gene locus alr0939 in contig BA000019_GR. |
| KEGG | ana:alr0939. |
| NMPDR | fig|103690.1.peg.1249. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0439. |
| HOGENOM | HBG535236. |
| OMA | ESIAMTK. |
| PhylomeDB | Q06862. |
Enzyme and pathway databases | |
| BioCyc | NSP103690:ALR0939-MONOMER. |
Family and domain databases | |
| InterPro | IPR004549. Acetyl_CoA_COase_biotin_COase. IPR011761. ATP-grasp. IPR013816. ATP_grasp_subdomain_2. IPR011764. Biotin_carboxylation_dom. IPR005482. Biotin_COase_C. IPR005479. CarbamoylP_synth_lsu_ATP-bd. IPR005481. CarbamoylP_synth_lsu_N. IPR013817. Pre-ATP_grasp. IPR016185. PreATP-grasp-like. IPR011054. Rudment_hybrid_motif. [Graphical view] |
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| Pfam | PF02785. Biotin_carb_C. 1 hit. PF00289. CPSase_L_chain. 1 hit. PF02786. CPSase_L_D2. 1 hit. [Graphical view] |
| SMART | SM00878. Biotin_carb_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00514. accC. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS50979. BC. 1 hit. PS00866. CPSASE_1. 1 hit. PS00867. CPSASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ACCC_ANASP | ||||||||
| Accession | Primary (citable) accession number: Q06862 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


