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Q06862

- ACCC_NOSS1

UniProt

Q06862 - ACCC_NOSS1

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Protein
Biotin carboxylase
Gene
accC, alr0939
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA By similarity.

Catalytic activityi

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171ATP By similarity
Binding sitei201 – 2011ATP By similarity
Binding sitei236 – 2361ATP By similarity
Active sitei293 – 2931 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acetyl-CoA carboxylase activity Source: UniProtKB-EC
  3. biotin carboxylase activity Source: UniProtKB-EC
  4. metal ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylase (EC:6.3.4.14)
Alternative name(s):
Acetyl-CoA carboxylase subunit A (EC:6.4.1.2)
Short name:
ACC
Gene namesi
Name:accC
Ordered Locus Names:alr0939
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Biotin carboxylase
PRO_0000146787Add
BLAST

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex By similarity.

Protein-protein interaction databases

STRINGi103690.alr0939.

Structurei

3D structure databases

ProteinModelPortaliQ06862.
SMRiQ06862. Positions 3-444.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 447447Biotin carboxylation
Add
BLAST
Domaini121 – 318198ATP-grasp
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG0439.
HOGENOMiHOG000008988.
KOiK01961.
OMAiFNQDDIH.
OrthoDBiEOG6CVV6Z.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00514. accC. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06862-1 [UniParc]FASTAAdd to Basket

« Hide

MKFDKILIAN RGEIALRILR ACEEMGIATI AVHSTVDRNA LHVQLADEAV    50
CIGEPASAKS YLNIPNIIAA ALTRNASAIH PGYGFLSENA KFAEICADHH 100
IAFIGPTPEA IRLMGDKSTA KETMQKAGVP TVPGSEGLVE TEQEGLELAK 150
DIGYPVMIKA TAGGGGRGMR LVRSPDEFVK LFLAAQGEAG AAFGNAGVYI 200
EKFIERPRHI EFQILADNYG NVIHLGERDC SIQRRNQKLL EEAPSPALDS 250
DLREKMGQAA VKAAQFINYT GAGTIEFLLD RSGQFYFMEM NTRIQVEHPV 300
TEMVTGVDLL VEQIRIAQGE RLRLTQDQVV LRGHAIECRI NAEDPDHDFR 350
PAPGRISGYL PPGGPGVRID SHVYTDYQIP PYYDSLIGKL IVWGPDRATA 400
INRMKRALRE CAITGLPTTI GFHQRIMENP QFLQGNVSTS FVQEMNK 447
Length:447
Mass (Da):49,104
Last modified:February 1, 1995 - v1
Checksum:i8A541B38B39E00F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14862 Genomic DNA. Translation: AAB51770.1.
BA000019 Genomic DNA. Translation: BAB72896.1.
PIRiA53311.
AH1923.
RefSeqiNP_484982.1. NC_003272.1.
WP_010995113.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB72896; BAB72896; BAB72896.
GeneIDi1104533.
KEGGiana:alr0939.
PATRICi22771750. VBINosSp37423_1359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14862 Genomic DNA. Translation: AAB51770.1 .
BA000019 Genomic DNA. Translation: BAB72896.1 .
PIRi A53311.
AH1923.
RefSeqi NP_484982.1. NC_003272.1.
WP_010995113.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q06862.
SMRi Q06862. Positions 3-444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr0939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB72896 ; BAB72896 ; BAB72896 .
GeneIDi 1104533.
KEGGi ana:alr0939.
PATRICi 22771750. VBINosSp37423_1359.

Phylogenomic databases

eggNOGi COG0439.
HOGENOMi HOG000008988.
KOi K01961.
OMAi FNQDDIH.
OrthoDBi EOG6CVV6Z.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00514. accC. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes for two subunits of acetyl coenzyme A carboxylase of Anabaena sp. strain PCC 7120: biotin carboxylase and biotin carboxyl carrier protein."
    Gornicki P., Scappino L.A., Haselkorn R.
    J. Bacteriol. 175:5268-5272(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiACCC_NOSS1
AccessioniPrimary (citable) accession number: Q06862
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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