ID   SOX4_MOUSE              Reviewed;         440 AA.
AC   Q06831; Q5SW95;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   14-OCT-2015, entry version 130.
DE   RecName: Full=Transcription factor SOX-4;
GN   Name=Sox4; Synonyms=Sox-4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8404853;
RA   van de Wetering M., Oosterwegel M., van Norren K., Clevers H.C.;
RT   "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in
RT   lymphocytes.";
RL   EMBO J. 12:3847-3854(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8493110; DOI=10.1093/nar/21.8.2009;
RA   Schilham M.W., van Eijk M., van de Wetering M., Clevers H.C.;
RT   "The murine Sox-4 protein is encoded on a single exon.";
RL   Nucleic Acids Res. 21:2009-2009(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 69-122.
RC   STRAIN=Swiss Webster; TISSUE=Embryonic tooth;
RX   PubMed=8921394; DOI=10.1006/geno.1996.0548;
RA   Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.;
RT   "Numerous members of the Sox family of HMG box-containing genes are
RT   expressed in developing mouse teeth.";
RL   Genomics 37:234-237(1996).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic brain;
RX   PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
RA   Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT   "Phosphoproteomic analysis of the developing mouse brain.";
RL   Mol. Cell. Proteomics 3:1093-1101(2004).
CC   -!- FUNCTION: Transcriptional activator that binds with high affinity
CC       to the T-cell enhancer motif 5'-AACAAAG-3' motif.
CC   -!- SUBUNIT: Interacts with UBE2I. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P15884:TCF4 (xeno); NbExp=2; IntAct=EBI-6262177, EBI-533224;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in lymphocytes and in molar and
CC       incisor tooth germs.
CC   -!- SIMILARITY: Contains 1 HMG box DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; X70298; CAA49779.1; -; mRNA.
DR   EMBL; AL606511; CAI24776.1; -; Genomic_DNA.
DR   EMBL; CH466561; EDL32406.1; -; Genomic_DNA.
DR   EMBL; BC052736; AAH52736.1; -; mRNA.
DR   EMBL; U70440; AAC52858.1; -; mRNA.
DR   CCDS; CCDS26411.1; -.
DR   PIR; S37303; S37303.
DR   RefSeq; NP_033264.2; NM_009238.2.
DR   UniGene; Mm.240627; -.
DR   UniGene; Mm.455819; -.
DR   PDB; 3U2B; X-ray; 2.40 A; C=57-135.
DR   PDBsum; 3U2B; -.
DR   ProteinModelPortal; Q06831; -.
DR   SMR; Q06831; 57-132.
DR   IntAct; Q06831; 5.
DR   STRING; 10090.ENSMUSP00000100013; -.
DR   PhosphoSite; Q06831; -.
DR   MaxQB; Q06831; -.
DR   PRIDE; Q06831; -.
DR   Ensembl; ENSMUST00000067230; ENSMUSP00000100013; ENSMUSG00000076431.
DR   GeneID; 20677; -.
DR   KEGG; mmu:20677; -.
DR   UCSC; uc007pyk.1; mouse.
DR   CTD; 6659; -.
DR   MGI; MGI:98366; Sox4.
DR   GeneTree; ENSGT00760000118988; -.
DR   HOGENOM; HOG000231874; -.
DR   HOVERGEN; HBG005040; -.
DR   InParanoid; Q06831; -.
DR   KO; K09268; -.
DR   OMA; SHDDEFE; -.
DR   OrthoDB; EOG7TMZVP; -.
DR   Reactome; R-MMU-3769402; deactivation of the beta-catenin transactivating complex.
DR   ChiTaRS; Sox4; mouse.
DR   NextBio; 299169; -.
DR   PRO; PR:Q06831; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   Bgee; Q06831; -.
DR   CleanEx; MM_SOX4; -.
DR   Genevisible; Q06831; MM.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0044798; C:nuclear transcription factor complex; IDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0001071; F:nucleic acid binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IDA:MGI.
DR   GO; GO:0001105; F:RNA polymerase II transcription coactivator activity; IDA:UniProtKB.
DR   GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:UniProtKB.
DR   GO; GO:0035910; P:ascending aorta morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0003289; P:atrial septum primum morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0003215; P:cardiac right ventricle morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0003211; P:cardiac ventricle formation; IMP:UniProtKB.
DR   GO; GO:0071333; P:cellular response to glucose stimulus; IMP:UniProtKB.
DR   GO; GO:0042769; P:DNA damage response, detection of DNA damage; ISS:UniProtKB.
DR   GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; ISS:UniProtKB.
DR   GO; GO:0031018; P:endocrine pancreas development; IMP:MGI.
DR   GO; GO:0021782; P:glial cell development; IMP:UniProtKB.
DR   GO; GO:0014009; P:glial cell proliferation; IMP:UniProtKB.
DR   GO; GO:0042593; P:glucose homeostasis; IMP:UniProtKB.
DR   GO; GO:0007507; P:heart development; IMP:BHF-UCL.
DR   GO; GO:0060993; P:kidney morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0060174; P:limb bud formation; IMP:UniProtKB.
DR   GO; GO:0003183; P:mitral valve morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0060548; P:negative regulation of cell death; IMP:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
DR   GO; GO:0046826; P:negative regulation of protein export from nucleus; ISS:UniProtKB.
DR   GO; GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0001841; P:neural tube formation; IMP:UniProtKB.
DR   GO; GO:0060563; P:neuroepithelial cell differentiation; IMP:UniProtKB.
DR   GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IMP:UniProtKB.
DR   GO; GO:2000761; P:positive regulation of N-terminal peptidyl-lysine acetylation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   GO; GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
DR   GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0002328; P:pro-B cell differentiation; IMP:BHF-UCL.
DR   GO; GO:0050821; P:protein stabilization; IMP:BHF-UCL.
DR   GO; GO:0031647; P:regulation of protein stability; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0001501; P:skeletal system development; IMP:UniProtKB.
DR   GO; GO:0035019; P:somatic stem cell maintenance; IDA:MGI.
DR   GO; GO:0021510; P:spinal cord development; IMP:UniProtKB.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:UniProtKB.
DR   GO; GO:0048485; P:sympathetic nervous system development; IMP:UniProtKB.
DR   GO; GO:0030217; P:T cell differentiation; IMP:BHF-UCL.
DR   GO; GO:0006366; P:transcription from RNA polymerase II promoter; IDA:GOC.
DR   GO; GO:0060412; P:ventricular septum morphogenesis; IMP:BHF-UCL.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Complete proteome; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN         1    440       Transcription factor SOX-4.
FT                                /FTId=PRO_0000048725.
FT   DNA_BIND     59    127       HMG box. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00267}.
FT   COMPBIAS    347    363       Poly-Ser.
FT   CONFLICT    175    175       S -> T (in Ref. 1; CAA49779).
FT                                {ECO:0000305}.
FT   CONFLICT    179    179       A -> T (in Ref. 1; CAA49779).
FT                                {ECO:0000305}.
FT   CONFLICT    235    236       SA -> QL (in Ref. 1; CAA49779).
FT                                {ECO:0000305}.
FT   CONFLICT    263    263       R -> H (in Ref. 1; CAA49779).
FT                                {ECO:0000305}.
FT   CONFLICT    283    283       S -> C (in Ref. 1; CAA49779).
FT                                {ECO:0000305}.
FT   HELIX        65     78       {ECO:0000244|PDB:3U2B}.
FT   HELIX        86     99       {ECO:0000244|PDB:3U2B}.
FT   HELIX       102    122       {ECO:0000244|PDB:3U2B}.
FT   STRAND      123    125       {ECO:0000244|PDB:3U2B}.
SQ   SEQUENCE   440 AA;  45044 MW;  979AADBA7F674B6D CRC64;
     MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK
     RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIQ EAERLRLKHM
     ADYPDYKYRP RKKVKSGNAG AGSAATAKPG EKGDKVAGSS GHAGSSHAGG GAGGSSKPAP
     KKSCGPKVAG SSVGKPHAKL VPAGGSKAAA SFSPEQAALL PLGEPTAVYK VRTPSAATPA
     ASSSPSSALA TPAKHPADKK VKRVYLFGSL GASASPVGGL GASADPSDPL GLYEDGGPGC
     SPDGRSLSGR SSAASSPAAS RSPADHRGYA SLRAASPAPS SAPSHASSSL SSSSSSSSGS
     SSSDDEFEDD LLDLNPSSNF ESMSLGSFSS SSALDRDLDF NFEPGSGSHF EFPDYCTPEV
     SEMISGDWLE SSISNLVFTY
//