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Protein

Transcription factor SOX-4

Gene

Sox4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi59 – 12769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • ascending aorta morphogenesis Source: BHF-UCL
  • atrial septum primum morphogenesis Source: BHF-UCL
  • canonical Wnt signaling pathway Source: BHF-UCL
  • cardiac right ventricle morphogenesis Source: BHF-UCL
  • cardiac ventricle formation Source: UniProtKB
  • cellular response to glucose stimulus Source: UniProtKB
  • DNA damage response, detection of DNA damage Source: UniProtKB
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
  • endocrine pancreas development Source: MGI
  • glial cell development Source: UniProtKB
  • glial cell proliferation Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • heart development Source: BHF-UCL
  • kidney morphogenesis Source: BHF-UCL
  • limb bud formation Source: UniProtKB
  • mitral valve morphogenesis Source: BHF-UCL
  • negative regulation of cell death Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of protein export from nucleus Source: UniProtKB
  • negative regulation of protein ubiquitination Source: UniProtKB
  • neural tube formation Source: UniProtKB
  • neuroepithelial cell differentiation Source: UniProtKB
  • noradrenergic neuron differentiation Source: UniProtKB
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of insulin secretion Source: UniProtKB
  • positive regulation of N-terminal peptidyl-lysine acetylation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • positive regulation of Wnt signaling pathway Source: BHF-UCL
  • pro-B cell differentiation Source: BHF-UCL
  • protein stabilization Source: BHF-UCL
  • regulation of protein stability Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • skeletal system development Source: UniProtKB
  • somatic stem cell maintenance Source: MGI
  • spinal cord development Source: UniProtKB
  • spinal cord motor neuron differentiation Source: UniProtKB
  • sympathetic nervous system development Source: UniProtKB
  • T cell differentiation Source: BHF-UCL
  • transcription from RNA polymerase II promoter Source: GOC
  • ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_351655. deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-4
Gene namesi
Name:Sox4
Synonyms:Sox-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:98366. Sox4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nuclear transcription factor complex Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Transcription factor SOX-4PRO_0000048725Add
BLAST

Proteomic databases

MaxQBiQ06831.
PRIDEiQ06831.

PTM databases

PhosphoSiteiQ06831.

Expressioni

Tissue specificityi

Expressed in lymphocytes and in molar and incisor tooth germs.

Gene expression databases

BgeeiQ06831.
CleanExiMM_SOX4.
ExpressionAtlasiQ06831. baseline and differential.
GenevisibleiQ06831. MM.

Interactioni

Subunit structurei

Interacts with UBE2I.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158842EBI-6262177,EBI-533224From a different organism.

Protein-protein interaction databases

IntActiQ06831. 5 interactions.
STRINGi10090.ENSMUSP00000100013.

Structurei

Secondary structure

1
440
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi65 – 7814Combined sources
Helixi86 – 9914Combined sources
Helixi102 – 12221Combined sources
Beta strandi123 – 1253Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U2BX-ray2.40C57-135[»]
ProteinModelPortaliQ06831.
SMRiQ06831. Positions 57-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi347 – 36317Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiQ06831.
KOiK09268.
OMAiSHDDEFE.
OrthoDBiEOG7TMZVP.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS
60 70 80 90 100
WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL
110 120 130 140 150
KDSDKIPFIQ EAERLRLKHM ADYPDYKYRP RKKVKSGNAG AGSAATAKPG
160 170 180 190 200
EKGDKVAGSS GHAGSSHAGG GAGGSSKPAP KKSCGPKVAG SSVGKPHAKL
210 220 230 240 250
VPAGGSKAAA SFSPEQAALL PLGEPTAVYK VRTPSAATPA ASSSPSSALA
260 270 280 290 300
TPAKHPADKK VKRVYLFGSL GASASPVGGL GASADPSDPL GLYEDGGPGC
310 320 330 340 350
SPDGRSLSGR SSAASSPAAS RSPADHRGYA SLRAASPAPS SAPSHASSSL
360 370 380 390 400
SSSSSSSSGS SSSDDEFEDD LLDLNPSSNF ESMSLGSFSS SSALDRDLDF
410 420 430 440
NFEPGSGSHF EFPDYCTPEV SEMISGDWLE SSISNLVFTY
Length:440
Mass (Da):45,044
Last modified:July 27, 2011 - v2
Checksum:i979AADBA7F674B6D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751S → T in CAA49779 (PubMed:8404853).Curated
Sequence conflicti179 – 1791A → T in CAA49779 (PubMed:8404853).Curated
Sequence conflicti235 – 2362SA → QL in CAA49779 (PubMed:8404853).Curated
Sequence conflicti263 – 2631R → H in CAA49779 (PubMed:8404853).Curated
Sequence conflicti283 – 2831S → C in CAA49779 (PubMed:8404853).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70298 mRNA. Translation: CAA49779.1.
AL606511 Genomic DNA. Translation: CAI24776.1.
CH466561 Genomic DNA. Translation: EDL32406.1.
BC052736 mRNA. Translation: AAH52736.1.
U70440 mRNA. Translation: AAC52858.1.
CCDSiCCDS26411.1.
PIRiS37303.
RefSeqiNP_033264.2. NM_009238.2.
UniGeneiMm.240627.
Mm.455819.

Genome annotation databases

EnsembliENSMUST00000067230; ENSMUSP00000100013; ENSMUSG00000076431.
GeneIDi20677.
KEGGimmu:20677.
UCSCiuc007pyk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70298 mRNA. Translation: CAA49779.1.
AL606511 Genomic DNA. Translation: CAI24776.1.
CH466561 Genomic DNA. Translation: EDL32406.1.
BC052736 mRNA. Translation: AAH52736.1.
U70440 mRNA. Translation: AAC52858.1.
CCDSiCCDS26411.1.
PIRiS37303.
RefSeqiNP_033264.2. NM_009238.2.
UniGeneiMm.240627.
Mm.455819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U2BX-ray2.40C57-135[»]
ProteinModelPortaliQ06831.
SMRiQ06831. Positions 57-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ06831. 5 interactions.
STRINGi10090.ENSMUSP00000100013.

PTM databases

PhosphoSiteiQ06831.

Proteomic databases

MaxQBiQ06831.
PRIDEiQ06831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067230; ENSMUSP00000100013; ENSMUSG00000076431.
GeneIDi20677.
KEGGimmu:20677.
UCSCiuc007pyk.1. mouse.

Organism-specific databases

CTDi6659.
MGIiMGI:98366. Sox4.

Phylogenomic databases

GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiQ06831.
KOiK09268.
OMAiSHDDEFE.
OrthoDBiEOG7TMZVP.

Enzyme and pathway databases

ReactomeiREACT_351655. deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

ChiTaRSiSox4. mouse.
NextBioi299169.
PROiQ06831.
SOURCEiSearch...

Gene expression databases

BgeeiQ06831.
CleanExiMM_SOX4.
ExpressionAtlasiQ06831. baseline and differential.
GenevisibleiQ06831. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes."
    van de Wetering M., Oosterwegel M., van Norren K., Clevers H.C.
    EMBO J. 12:3847-3854(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
    Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
    Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-122.
    Strain: Swiss Webster.
    Tissue: Embryonic tooth.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiSOX4_MOUSE
AccessioniPrimary (citable) accession number: Q06831
Secondary accession number(s): Q5SW95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.