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Protein

Transcription factor SOX-4

Gene

Sox4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi59 – 127HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • core promoter sequence-specific DNA binding Source: MGI
  • DNA binding transcription factor activity Source: UniProtKB
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II transcription coactivator activity Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
  • transcription regulatory region sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • ascending aorta morphogenesis Source: BHF-UCL
  • atrial septum primum morphogenesis Source: BHF-UCL
  • canonical Wnt signaling pathway Source: BHF-UCL
  • cardiac right ventricle morphogenesis Source: BHF-UCL
  • cardiac ventricle formation Source: UniProtKB
  • cellular response to glucose stimulus Source: UniProtKB
  • DNA damage response, detection of DNA damage Source: UniProtKB
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
  • endocrine pancreas development Source: MGI
  • glial cell development Source: UniProtKB
  • glial cell proliferation Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • heart development Source: BHF-UCL
  • kidney morphogenesis Source: BHF-UCL
  • limb bud formation Source: UniProtKB
  • mitral valve morphogenesis Source: BHF-UCL
  • negative regulation of cell death Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of protein ubiquitination Source: UniProtKB
  • neural tube formation Source: UniProtKB
  • neuroepithelial cell differentiation Source: UniProtKB
  • noradrenergic neuron differentiation Source: UniProtKB
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of insulin secretion Source: UniProtKB
  • positive regulation of N-terminal peptidyl-lysine acetylation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • positive regulation of Wnt signaling pathway Source: BHF-UCL
  • pro-B cell differentiation Source: BHF-UCL
  • protein stabilization Source: BHF-UCL
  • regulation of protein stability Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • response to hypoxia Source: MGI
  • skeletal system development Source: UniProtKB
  • somatic stem cell population maintenance Source: MGI
  • spinal cord development Source: UniProtKB
  • spinal cord motor neuron differentiation Source: UniProtKB
  • sympathetic nervous system development Source: UniProtKB
  • T cell differentiation Source: BHF-UCL
  • ventricular septum morphogenesis Source: BHF-UCL

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-4
Gene namesi
Name:Sox4
Synonyms:Sox-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:98366 Sox4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487251 – 440Transcription factor SOX-4Add BLAST440

Proteomic databases

MaxQBiQ06831
PaxDbiQ06831
PeptideAtlasiQ06831
PRIDEiQ06831

PTM databases

iPTMnetiQ06831
PhosphoSitePlusiQ06831

Expressioni

Tissue specificityi

Expressed in lymphocytes and in molar and incisor tooth germs.

Gene expression databases

BgeeiENSMUSG00000076431
CleanExiMM_SOX4
GenevisibleiQ06831 MM

Interactioni

Subunit structurei

Interacts with UBE2I.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158842EBI-6262177,EBI-533224From Homo sapiens.

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

IntActiQ06831, 5 interactors
STRINGi10090.ENSMUSP00000100013

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi65 – 78Combined sources14
Helixi86 – 99Combined sources14
Helixi102 – 122Combined sources21
Beta strandi123 – 125Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U2BX-ray2.40C57-135[»]
ProteinModelPortaliQ06831
SMRiQ06831
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi347 – 363Poly-SerAdd BLAST17

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG4111U1K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231874
HOVERGENiHBG005040
InParanoidiQ06831
KOiK09268
OMAiGENPAWC
OrthoDBiEOG091G0F15

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017386 SOX-11/4
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF038098 SOX-12/11/4a, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q06831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS
60 70 80 90 100
WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL
110 120 130 140 150
KDSDKIPFIQ EAERLRLKHM ADYPDYKYRP RKKVKSGNAG AGSAATAKPG
160 170 180 190 200
EKGDKVAGSS GHAGSSHAGG GAGGSSKPAP KKSCGPKVAG SSVGKPHAKL
210 220 230 240 250
VPAGGSKAAA SFSPEQAALL PLGEPTAVYK VRTPSAATPA ASSSPSSALA
260 270 280 290 300
TPAKHPADKK VKRVYLFGSL GASASPVGGL GASADPSDPL GLYEDGGPGC
310 320 330 340 350
SPDGRSLSGR SSAASSPAAS RSPADHRGYA SLRAASPAPS SAPSHASSSL
360 370 380 390 400
SSSSSSSSGS SSSDDEFEDD LLDLNPSSNF ESMSLGSFSS SSALDRDLDF
410 420 430 440
NFEPGSGSHF EFPDYCTPEV SEMISGDWLE SSISNLVFTY
Length:440
Mass (Da):45,044
Last modified:July 27, 2011 - v2
Checksum:i979AADBA7F674B6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175S → T in CAA49779 (PubMed:8404853).Curated1
Sequence conflicti179A → T in CAA49779 (PubMed:8404853).Curated1
Sequence conflicti235 – 236SA → QL in CAA49779 (PubMed:8404853).Curated2
Sequence conflicti263R → H in CAA49779 (PubMed:8404853).Curated1
Sequence conflicti283S → C in CAA49779 (PubMed:8404853).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70298 mRNA Translation: CAA49779.1
AL606511 Genomic DNA Translation: CAI24776.1
CH466561 Genomic DNA Translation: EDL32406.1
BC052736 mRNA Translation: AAH52736.1
U70440 mRNA Translation: AAC52858.1
CCDSiCCDS26411.1
PIRiS37303
RefSeqiNP_033264.2, NM_009238.2
UniGeneiMm.240627
Mm.455819

Genome annotation databases

EnsembliENSMUST00000067230; ENSMUSP00000100013; ENSMUSG00000076431
GeneIDi20677
KEGGimmu:20677
UCSCiuc007pyk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSOX4_MOUSE
AccessioniPrimary (citable) accession number: Q06831
Secondary accession number(s): Q5SW95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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