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Q06831

- SOX4_MOUSE

UniProt

Q06831 - SOX4_MOUSE

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Protein

Transcription factor SOX-4

Gene

Sox4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi59 – 12769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: UniProtKB
  2. nucleic acid binding transcription factor activity Source: UniProtKB
  3. protein heterodimerization activity Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  5. RNA polymerase II transcription coactivator activity Source: UniProtKB
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. ascending aorta morphogenesis Source: BHF-UCL
  2. atrial septum primum morphogenesis Source: BHF-UCL
  3. canonical Wnt signaling pathway Source: BHF-UCL
  4. cardiac right ventricle morphogenesis Source: BHF-UCL
  5. cardiac ventricle formation Source: UniProtKB
  6. cellular response to glucose stimulus Source: UniProtKB
  7. DNA damage response, detection of DNA damage Source: UniProtKB
  8. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
  9. endocrine pancreas development Source: MGI
  10. glial cell development Source: UniProtKB
  11. glial cell proliferation Source: UniProtKB
  12. glucose homeostasis Source: UniProtKB
  13. heart development Source: BHF-UCL
  14. kidney morphogenesis Source: BHF-UCL
  15. limb bud formation Source: UniProtKB
  16. mitral valve morphogenesis Source: BHF-UCL
  17. negative regulation of cell death Source: UniProtKB
  18. negative regulation of cell proliferation Source: UniProtKB
  19. negative regulation of protein export from nucleus Source: UniProtKB
  20. negative regulation of protein ubiquitination Source: UniProtKB
  21. neural tube formation Source: UniProtKB
  22. neuroepithelial cell differentiation Source: UniProtKB
  23. noradrenergic neuron differentiation Source: UniProtKB
  24. positive regulation of apoptotic process Source: Ensembl
  25. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  26. positive regulation of cell proliferation Source: UniProtKB
  27. positive regulation of insulin secretion Source: UniProtKB
  28. positive regulation of N-terminal peptidyl-lysine acetylation Source: UniProtKB
  29. positive regulation of transcription, DNA-templated Source: UniProtKB
  30. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  31. positive regulation of translation Source: UniProtKB
  32. positive regulation of Wnt signaling pathway Source: BHF-UCL
  33. pro-B cell differentiation Source: BHF-UCL
  34. protein stabilization Source: BHF-UCL
  35. regulation of protein stability Source: UniProtKB
  36. regulation of transcription, DNA-templated Source: UniProtKB
  37. skeletal system development Source: UniProtKB
  38. somatic stem cell maintenance Source: MGI
  39. spinal cord development Source: UniProtKB
  40. spinal cord motor neuron differentiation Source: UniProtKB
  41. sympathetic nervous system development Source: UniProtKB
  42. T cell differentiation Source: BHF-UCL
  43. transcription from RNA polymerase II promoter Source: GOC
  44. ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-4
Gene namesi
Name:Sox4
Synonyms:Sox-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:98366. Sox4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. mitochondrion Source: UniProtKB
  3. nuclear transcription factor complex Source: MGI
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Transcription factor SOX-4PRO_0000048725Add
BLAST

Proteomic databases

MaxQBiQ06831.
PRIDEiQ06831.

PTM databases

PhosphoSiteiQ06831.

Expressioni

Tissue specificityi

Expressed in lymphocytes and in molar and incisor tooth germs.

Gene expression databases

BgeeiQ06831.
CleanExiMM_SOX4.
ExpressionAtlasiQ06831. baseline and differential.
GenevestigatoriQ06831.

Interactioni

Subunit structurei

Interacts with UBE2I.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158842EBI-6262177,EBI-533224From a different organism.

Protein-protein interaction databases

IntActiQ06831. 5 interactions.

Structurei

Secondary structure

1
440
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi65 – 7814Combined sources
Helixi86 – 9914Combined sources
Helixi102 – 12221Combined sources
Beta strandi123 – 1253Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U2BX-ray2.40C57-135[»]
ProteinModelPortaliQ06831.
SMRiQ06831. Positions 57-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi347 – 36317Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiQ06831.
KOiK09268.
OMAiAGCSPDG.
OrthoDBiEOG7TMZVP.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06831-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS
60 70 80 90 100
WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL
110 120 130 140 150
KDSDKIPFIQ EAERLRLKHM ADYPDYKYRP RKKVKSGNAG AGSAATAKPG
160 170 180 190 200
EKGDKVAGSS GHAGSSHAGG GAGGSSKPAP KKSCGPKVAG SSVGKPHAKL
210 220 230 240 250
VPAGGSKAAA SFSPEQAALL PLGEPTAVYK VRTPSAATPA ASSSPSSALA
260 270 280 290 300
TPAKHPADKK VKRVYLFGSL GASASPVGGL GASADPSDPL GLYEDGGPGC
310 320 330 340 350
SPDGRSLSGR SSAASSPAAS RSPADHRGYA SLRAASPAPS SAPSHASSSL
360 370 380 390 400
SSSSSSSSGS SSSDDEFEDD LLDLNPSSNF ESMSLGSFSS SSALDRDLDF
410 420 430 440
NFEPGSGSHF EFPDYCTPEV SEMISGDWLE SSISNLVFTY
Length:440
Mass (Da):45,044
Last modified:July 27, 2011 - v2
Checksum:i979AADBA7F674B6D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751S → T in CAA49779. (PubMed:8404853)Curated
Sequence conflicti179 – 1791A → T in CAA49779. (PubMed:8404853)Curated
Sequence conflicti235 – 2362SA → QL in CAA49779. (PubMed:8404853)Curated
Sequence conflicti263 – 2631R → H in CAA49779. (PubMed:8404853)Curated
Sequence conflicti283 – 2831S → C in CAA49779. (PubMed:8404853)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70298 mRNA. Translation: CAA49779.1.
AL606511 Genomic DNA. Translation: CAI24776.1.
CH466561 Genomic DNA. Translation: EDL32406.1.
BC052736 mRNA. Translation: AAH52736.1.
U70440 mRNA. Translation: AAC52858.1.
CCDSiCCDS26411.1.
PIRiS37303.
RefSeqiNP_033264.2. NM_009238.2.
UniGeneiMm.240627.
Mm.455819.

Genome annotation databases

EnsembliENSMUST00000067230; ENSMUSP00000100013; ENSMUSG00000076431.
GeneIDi20677.
KEGGimmu:20677.
UCSCiuc007pyk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70298 mRNA. Translation: CAA49779.1 .
AL606511 Genomic DNA. Translation: CAI24776.1 .
CH466561 Genomic DNA. Translation: EDL32406.1 .
BC052736 mRNA. Translation: AAH52736.1 .
U70440 mRNA. Translation: AAC52858.1 .
CCDSi CCDS26411.1.
PIRi S37303.
RefSeqi NP_033264.2. NM_009238.2.
UniGenei Mm.240627.
Mm.455819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3U2B X-ray 2.40 C 57-135 [» ]
ProteinModelPortali Q06831.
SMRi Q06831. Positions 57-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q06831. 5 interactions.

PTM databases

PhosphoSitei Q06831.

Proteomic databases

MaxQBi Q06831.
PRIDEi Q06831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067230 ; ENSMUSP00000100013 ; ENSMUSG00000076431 .
GeneIDi 20677.
KEGGi mmu:20677.
UCSCi uc007pyk.1. mouse.

Organism-specific databases

CTDi 6659.
MGIi MGI:98366. Sox4.

Phylogenomic databases

GeneTreei ENSGT00760000118988.
HOGENOMi HOG000231874.
HOVERGENi HBG005040.
InParanoidi Q06831.
KOi K09268.
OMAi AGCSPDG.
OrthoDBi EOG7TMZVP.

Miscellaneous databases

ChiTaRSi Sox4. mouse.
NextBioi 299169.
PROi Q06831.
SOURCEi Search...

Gene expression databases

Bgeei Q06831.
CleanExi MM_SOX4.
ExpressionAtlasi Q06831. baseline and differential.
Genevestigatori Q06831.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes."
    van de Wetering M., Oosterwegel M., van Norren K., Clevers H.C.
    EMBO J. 12:3847-3854(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
    Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
    Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-122.
    Strain: Swiss Webster.
    Tissue: Embryonic tooth.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiSOX4_MOUSE
AccessioniPrimary (citable) accession number: Q06831
Secondary accession number(s): Q5SW95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3