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Q06831

- SOX4_MOUSE

UniProt

Q06831 - SOX4_MOUSE

Protein

Transcription factor SOX-4

Gene

Sox4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi59 – 12769HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter sequence-specific DNA binding Source: UniProtKB
    2. nucleic acid binding transcription factor activity Source: UniProtKB
    3. protein binding Source: IntAct
    4. protein heterodimerization activity Source: MGI
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    6. RNA polymerase II transcription coactivator activity Source: UniProtKB
    7. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    8. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    9. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. ascending aorta morphogenesis Source: BHF-UCL
    2. atrial septum primum morphogenesis Source: BHF-UCL
    3. canonical Wnt signaling pathway Source: BHF-UCL
    4. cardiac right ventricle morphogenesis Source: BHF-UCL
    5. cardiac ventricle formation Source: UniProtKB
    6. cellular response to glucose stimulus Source: UniProtKB
    7. DNA damage response, detection of DNA damage Source: UniProtKB
    8. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
    9. endocrine pancreas development Source: MGI
    10. glial cell development Source: UniProtKB
    11. glial cell proliferation Source: UniProtKB
    12. glucose homeostasis Source: UniProtKB
    13. heart development Source: BHF-UCL
    14. kidney morphogenesis Source: BHF-UCL
    15. limb bud formation Source: UniProtKB
    16. mitral valve morphogenesis Source: BHF-UCL
    17. negative regulation of cell death Source: UniProtKB
    18. negative regulation of cell proliferation Source: UniProtKB
    19. negative regulation of protein export from nucleus Source: UniProtKB
    20. negative regulation of protein ubiquitination Source: UniProtKB
    21. neural tube formation Source: UniProtKB
    22. neuroepithelial cell differentiation Source: UniProtKB
    23. noradrenergic neuron differentiation Source: UniProtKB
    24. positive regulation of apoptotic process Source: Ensembl
    25. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    26. positive regulation of cell proliferation Source: UniProtKB
    27. positive regulation of insulin secretion Source: UniProtKB
    28. positive regulation of N-terminal peptidyl-lysine acetylation Source: UniProtKB
    29. positive regulation of transcription, DNA-templated Source: UniProtKB
    30. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    31. positive regulation of translation Source: UniProtKB
    32. positive regulation of Wnt signaling pathway Source: BHF-UCL
    33. pro-B cell differentiation Source: BHF-UCL
    34. protein stabilization Source: BHF-UCL
    35. regulation of protein stability Source: UniProtKB
    36. regulation of transcription, DNA-templated Source: UniProtKB
    37. skeletal system development Source: UniProtKB
    38. somatic stem cell maintenance Source: MGI
    39. spinal cord development Source: UniProtKB
    40. spinal cord motor neuron differentiation Source: UniProtKB
    41. sympathetic nervous system development Source: UniProtKB
    42. T cell differentiation Source: BHF-UCL
    43. transcription from RNA polymerase II promoter Source: GOC
    44. ventricular septum morphogenesis Source: BHF-UCL

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-4
    Gene namesi
    Name:Sox4
    Synonyms:Sox-4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:98366. Sox4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrion Source: UniProtKB
    3. nuclear transcription factor complex Source: MGI
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Transcription factor SOX-4PRO_0000048725Add
    BLAST

    Proteomic databases

    PRIDEiQ06831.

    PTM databases

    PhosphoSiteiQ06831.

    Expressioni

    Tissue specificityi

    Expressed in lymphocytes and in molar and incisor tooth germs.

    Gene expression databases

    ArrayExpressiQ06831.
    BgeeiQ06831.
    CleanExiMM_SOX4.
    GenevestigatoriQ06831.

    Interactioni

    Subunit structurei

    Interacts with UBE2I.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TCF4P158842EBI-6262177,EBI-533224From a different organism.

    Protein-protein interaction databases

    IntActiQ06831. 5 interactions.

    Structurei

    Secondary structure

    1
    440
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi65 – 7814
    Helixi86 – 9914
    Helixi102 – 12221
    Beta strandi123 – 1253

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3U2BX-ray2.40C57-135[»]
    ProteinModelPortaliQ06831.
    SMRiQ06831. Positions 57-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi347 – 36317Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00690000101940.
    HOGENOMiHOG000231874.
    HOVERGENiHBG005040.
    InParanoidiQ5SW95.
    KOiK09268.
    OMAiAGCSPDG.
    OrthoDBiEOG7TMZVP.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR017386. SOX-12/11/4a.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06831-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS    50
    WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL 100
    KDSDKIPFIQ EAERLRLKHM ADYPDYKYRP RKKVKSGNAG AGSAATAKPG 150
    EKGDKVAGSS GHAGSSHAGG GAGGSSKPAP KKSCGPKVAG SSVGKPHAKL 200
    VPAGGSKAAA SFSPEQAALL PLGEPTAVYK VRTPSAATPA ASSSPSSALA 250
    TPAKHPADKK VKRVYLFGSL GASASPVGGL GASADPSDPL GLYEDGGPGC 300
    SPDGRSLSGR SSAASSPAAS RSPADHRGYA SLRAASPAPS SAPSHASSSL 350
    SSSSSSSSGS SSSDDEFEDD LLDLNPSSNF ESMSLGSFSS SSALDRDLDF 400
    NFEPGSGSHF EFPDYCTPEV SEMISGDWLE SSISNLVFTY 440
    Length:440
    Mass (Da):45,044
    Last modified:July 27, 2011 - v2
    Checksum:i979AADBA7F674B6D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751S → T in CAA49779. (PubMed:8404853)Curated
    Sequence conflicti179 – 1791A → T in CAA49779. (PubMed:8404853)Curated
    Sequence conflicti235 – 2362SA → QL in CAA49779. (PubMed:8404853)Curated
    Sequence conflicti263 – 2631R → H in CAA49779. (PubMed:8404853)Curated
    Sequence conflicti283 – 2831S → C in CAA49779. (PubMed:8404853)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70298 mRNA. Translation: CAA49779.1.
    AL606511 Genomic DNA. Translation: CAI24776.1.
    CH466561 Genomic DNA. Translation: EDL32406.1.
    BC052736 mRNA. Translation: AAH52736.1.
    U70440 mRNA. Translation: AAC52858.1.
    CCDSiCCDS26411.1.
    PIRiS37303.
    RefSeqiNP_033264.2. NM_009238.2.
    UniGeneiMm.240627.
    Mm.455819.

    Genome annotation databases

    EnsembliENSMUST00000067230; ENSMUSP00000100013; ENSMUSG00000076431.
    GeneIDi20677.
    KEGGimmu:20677.
    UCSCiuc007pyk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70298 mRNA. Translation: CAA49779.1 .
    AL606511 Genomic DNA. Translation: CAI24776.1 .
    CH466561 Genomic DNA. Translation: EDL32406.1 .
    BC052736 mRNA. Translation: AAH52736.1 .
    U70440 mRNA. Translation: AAC52858.1 .
    CCDSi CCDS26411.1.
    PIRi S37303.
    RefSeqi NP_033264.2. NM_009238.2.
    UniGenei Mm.240627.
    Mm.455819.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3U2B X-ray 2.40 C 57-135 [» ]
    ProteinModelPortali Q06831.
    SMRi Q06831. Positions 57-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q06831. 5 interactions.

    PTM databases

    PhosphoSitei Q06831.

    Proteomic databases

    PRIDEi Q06831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067230 ; ENSMUSP00000100013 ; ENSMUSG00000076431 .
    GeneIDi 20677.
    KEGGi mmu:20677.
    UCSCi uc007pyk.1. mouse.

    Organism-specific databases

    CTDi 6659.
    MGIi MGI:98366. Sox4.

    Phylogenomic databases

    GeneTreei ENSGT00690000101940.
    HOGENOMi HOG000231874.
    HOVERGENi HBG005040.
    InParanoidi Q5SW95.
    KOi K09268.
    OMAi AGCSPDG.
    OrthoDBi EOG7TMZVP.

    Miscellaneous databases

    ChiTaRSi SOX4. mouse.
    NextBioi 299169.
    PROi Q06831.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06831.
    Bgeei Q06831.
    CleanExi MM_SOX4.
    Genevestigatori Q06831.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR017386. SOX-12/11/4a.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes."
      van de Wetering M., Oosterwegel M., van Norren K., Clevers H.C.
      EMBO J. 12:3847-3854(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    6. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
      Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
      Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-122.
      Strain: Swiss Webster.
      Tissue: Embryonic tooth.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiSOX4_MOUSE
    AccessioniPrimary (citable) accession number: Q06831
    Secondary accession number(s): Q5SW95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3