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Q06826

- BMP4_RAT

UniProt

Q06826 - BMP4_RAT

Protein

Bone morphogenetic protein 4

Gene

Bmp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction By similarity.By similarity

    GO - Molecular functioni

    1. BMP receptor binding Source: UniProtKB
    2. chemoattractant activity Source: UniProtKB
    3. growth factor activity Source: RGD
    4. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. activation of MAPKK activity Source: UniProtKB
    2. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: UniProtKB
    3. BMP signaling pathway Source: UniProtKB
    4. BMP signaling pathway involved in heart induction Source: UniProtKB
    5. BMP signaling pathway involved in nephric duct formation Source: UniProtKB
    6. BMP signaling pathway involved in renal system segmentation Source: UniProtKB
    7. BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
    8. brain development Source: RGD
    9. branching involved in ureteric bud morphogenesis Source: UniProtKB
    10. branching morphogenesis of an epithelial tube Source: UniProtKB
    11. cell proliferation Source: RGD
    12. cellular response to dexamethasone stimulus Source: UniProtKB
    13. chondrocyte differentiation Source: UniProtKB
    14. common-partner SMAD protein phosphorylation Source: UniProtKB
    15. deltoid tuberosity development Source: UniProtKB
    16. endochondral ossification Source: UniProtKB
    17. epithelial tube branching involved in lung morphogenesis Source: RGD
    18. glomerular capillary formation Source: UniProtKB
    19. growth Source: InterPro
    20. hematopoietic progenitor cell differentiation Source: UniProtKB
    21. intermediate mesodermal cell differentiation Source: UniProtKB
    22. kidney development Source: UniProtKB
    23. lymphoid progenitor cell differentiation Source: UniProtKB
    24. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
    25. mesoderm development Source: RGD
    26. mesonephros development Source: UniProtKB
    27. metanephric collecting duct development Source: UniProtKB
    28. negative regulation of apoptotic process Source: UniProtKB
    29. negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
    30. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    31. negative regulation of cell cycle Source: UniProtKB
    32. negative regulation of cell death Source: UniProtKB
    33. negative regulation of cell proliferation involved in heart morphogenesis Source: UniProtKB
    34. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
    35. negative regulation of glomerulus development Source: UniProtKB
    36. negative regulation of immature T cell proliferation in thymus Source: UniProtKB
    37. negative regulation of MAP kinase activity Source: UniProtKB
    38. negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
    39. negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
    40. negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
    41. negative regulation of mitosis Source: UniProtKB
    42. negative regulation of oligodendrocyte differentiation Source: RGD
    43. negative regulation of phosphorylation Source: UniProtKB
    44. negative regulation of thymocyte apoptotic process Source: UniProtKB
    45. negative regulation of transcription, DNA-templated Source: UniProtKB
    46. odontogenesis Source: UniProtKB
    47. osteoblast differentiation Source: UniProtKB
    48. ovarian follicle development Source: RGD
    49. positive chemotaxis Source: GOC
    50. positive regulation of apoptotic process Source: UniProtKB
    51. positive regulation of BMP signaling pathway Source: UniProtKB
    52. positive regulation of bone mineralization Source: UniProtKB
    53. positive regulation of branching involved in lung morphogenesis Source: UniProtKB
    54. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    55. positive regulation of cardiac muscle fiber development Source: UniProtKB
    56. positive regulation of cell proliferation Source: RGD
    57. positive regulation of collagen biosynthetic process Source: UniProtKB
    58. positive regulation of DNA-dependent DNA replication Source: UniProtKB
    59. positive regulation of endothelial cell migration Source: UniProtKB
    60. positive regulation of endothelial cell proliferation Source: UniProtKB
    61. positive regulation of epidermal cell differentiation Source: UniProt
    62. positive regulation of epithelial cell proliferation Source: BHF-UCL
    63. positive regulation of kidney development Source: UniProtKB
    64. positive regulation of ossification Source: MGI
    65. positive regulation of osteoblast differentiation Source: UniProtKB
    66. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    67. positive regulation of SMAD protein import into nucleus Source: UniProtKB
    68. positive regulation of smooth muscle cell proliferation Source: UniProtKB
    69. positive regulation of transcription, DNA-templated Source: UniProtKB
    70. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    71. protein localization to nucleus Source: UniProtKB
    72. pulmonary artery endothelial tube morphogenesis Source: UniProtKB
    73. regulation of cell differentiation Source: RGD
    74. regulation of cell fate commitment Source: UniProt
    75. regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    76. response to estradiol Source: RGD
    77. response to glucocorticoid Source: RGD
    78. response to mechanical stimulus Source: RGD
    79. response to organic cyclic compound Source: RGD
    80. response to retinoic acid Source: RGD
    81. retina development in camera-type eye Source: RGD
    82. secondary heart field specification Source: UniProtKB
    83. SMAD protein signal transduction Source: UniProtKB
    84. smooth muscle tissue development Source: UniProtKB
    85. specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
    86. steroid hormone mediated signaling pathway Source: UniProtKB
    87. tendon cell differentiation Source: UniProtKB
    88. tongue morphogenesis Source: RGD
    89. type B pancreatic cell development Source: UniProtKB
    90. ureter epithelial cell differentiation Source: UniProtKB
    91. ureter smooth muscle cell differentiation Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 4
    Short name:
    BMP-4
    Alternative name(s):
    Bone morphogenetic protein 2B
    Short name:
    BMP-2B
    Gene namesi
    Name:Bmp4
    Synonyms:Bmp-4, Dvr-4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2213. Bmp4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. extracellular space Source: RGD
    3. membrane-bounded vesicle Source: RGD
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 292273PRO_0000033862Add
    BLAST
    Chaini293 – 408116Bone morphogenetic protein 4PRO_0000033863Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi308 ↔ 373By similarity
    Disulfide bondi337 ↔ 405By similarity
    Disulfide bondi341 ↔ 407By similarity
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi372 – 372InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    PTM databases

    PhosphoSiteiQ06826.

    Expressioni

    Gene expression databases

    GenevestigatoriQ06826.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ06826.
    SMRiQ06826. Positions 307-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG243555.
    HOGENOMiHOG000249478.
    HOVERGENiHBG004860.
    InParanoidiQ06826.
    PhylomeDBiQ06826.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06826-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPGNRMLMV VLLCQVLLGG ATDASLIPET GKKKVAEIQG HAGGRRSGQS    50
    HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS 100
    QGTGLEYPER PASRANTVRS FHHEEHLENI PGTSESSAFR FFFNLSSIPE 150
    NEVISSAELR LFREQVDQGP DWEQGFHRIN IYEVMKPPAE MVPGHLITRL 200
    LDTRLVRHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT HLHQTRTHQG 250
    QHVRISRSLP QGSGNWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 300
    SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN 350
    STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM 400
    VVEGCGCR 408
    Length:408
    Mass (Da):46,541
    Last modified:June 1, 1994 - v1
    Checksum:i61E92B4B8D5624F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22607 mRNA. Translation: CAA80329.1.
    PIRiS38343.
    UniGeneiRn.10318.

    Genome annotation databases

    UCSCiRGD:2213. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22607 mRNA. Translation: CAA80329.1 .
    PIRi S38343.
    UniGenei Rn.10318.

    3D structure databases

    ProteinModelPortali Q06826.
    SMRi Q06826. Positions 307-408.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q06826.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2213. rat.

    Organism-specific databases

    RGDi 2213. Bmp4.

    Phylogenomic databases

    eggNOGi NOG243555.
    HOGENOMi HOG000249478.
    HOVERGENi HBG004860.
    InParanoidi Q06826.
    PhylomeDBi Q06826.

    Miscellaneous databases

    PROi Q06826.

    Gene expression databases

    Genevestigatori Q06826.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell."
      Chen D., Feng J.Q., Feng M., Harris M.A., Mundy G.R., Harris S.E.
      Biochim. Biophys. Acta 1174:289-292(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiBMP4_RAT
    AccessioniPrimary (citable) accession number: Q06826
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3