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Q06826 (BMP4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 4

Short name=BMP-4
Alternative name(s):
Bone morphogenetic protein 2B
Short name=BMP-2B
Gene names
Name:Bmp4
Synonyms:Bmp-4, Dvr-4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction By similarity.

Subunit structure

Homodimer; disulfide-linked. Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

BMP signaling pathway involved in heart induction

Inferred from sequence or structural similarity. Source: UniProtKB

BMP signaling pathway involved in nephric duct formation

Inferred from sequence or structural similarity. Source: UniProtKB

BMP signaling pathway involved in renal system segmentation

Inferred from sequence or structural similarity. Source: UniProtKB

BMP signaling pathway involved in ureter morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

SMAD protein signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

activation of MAPKK activity

Inferred from sequence or structural similarity. Source: UniProtKB

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

brain development

Inferred from expression pattern PubMed 14643011. Source: RGD

branching involved in ureteric bud morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

branching morphogenesis of an epithelial tube

Inferred from sequence or structural similarity. Source: UniProtKB

cell proliferation

Non-traceable author statement PubMed 12552124. Source: RGD

cellular response to dexamethasone stimulus

Inferred from direct assay PubMed 17537984. Source: UniProtKB

chondrocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

common-partner SMAD protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

deltoid tuberosity development

Inferred from sequence or structural similarity. Source: UniProtKB

endochondral ossification

Inferred from sequence or structural similarity. Source: UniProtKB

epithelial tube branching involved in lung morphogenesis

Inferred from expression pattern PubMed 8769111. Source: RGD

glomerular capillary formation

Inferred from sequence or structural similarity. Source: UniProtKB

growth

Inferred from electronic annotation. Source: InterPro

hematopoietic progenitor cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

intermediate mesodermal cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

kidney development

Inferred from sequence or structural similarity. Source: UniProtKB

lymphoid progenitor cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

mesoderm development

Non-traceable author statement PubMed 12552124. Source: RGD

mesonephros development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric collecting duct development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of MAP kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of branching involved in ureteric bud morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell cycle

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell death

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell proliferation involved in heart morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of glomerular mesangial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of glomerulus development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of immature T cell proliferation in thymus

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of mesenchymal cell proliferation involved in ureter development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of metanephric S-shaped body morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of metanephric comma-shaped body morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of mitosis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of oligodendrocyte differentiation

Inferred from mutant phenotype PubMed 16388796. Source: RGD

negative regulation of phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of thymocyte apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

odontogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

osteoblast differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

ovarian follicle development

Inferred from mutant phenotype PubMed 12801979. Source: RGD

positive chemotaxis

Inferred from sequence or structural similarity. Source: GOC

positive regulation of BMP signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of DNA-dependent DNA replication

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of SMAD protein import into nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of bone mineralization

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of branching involved in lung morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from mutant phenotype PubMed 17537984. Source: UniProtKB

positive regulation of cardiac muscle fiber development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 17286956. Source: RGD

positive regulation of collagen biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of epidermal cell differentiation

Inferred from sequence or structural similarity. Source: UniProt

positive regulation of epithelial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of kidney development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of ossification

Inferred from direct assay PubMed 7911662. Source: MGI

positive regulation of osteoblast differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of smooth muscle cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 7911662. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

protein localization to nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

pulmonary artery endothelial tube morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell differentiation

Inferred from direct assay PubMed 12514223. Source: RGD

regulation of cell fate commitment

Inferred from sequence or structural similarity. Source: UniProt

regulation of pathway-restricted SMAD protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

response to estradiol

Inferred from expression pattern PubMed 16551644. Source: RGD

response to glucocorticoid

Inferred from expression pattern PubMed 17537984. Source: RGD

response to mechanical stimulus

Inferred from expression pattern PubMed 10404008PubMed 17272757. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 12730624. Source: RGD

response to retinoic acid

Inferred from expression pattern PubMed 8385738. Source: RGD

retina development in camera-type eye

Inferred from expression pattern PubMed 17069773. Source: RGD

secondary heart field specification

Inferred from sequence or structural similarity. Source: UniProtKB

smooth muscle tissue development

Inferred from sequence or structural similarity. Source: UniProtKB

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

steroid hormone mediated signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

tendon cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

tongue morphogenesis

Inferred from expression pattern PubMed 16828469. Source: RGD

type B pancreatic cell development

Inferred from sequence or structural similarity. Source: UniProtKB

ureter epithelial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

ureter smooth muscle cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15589212. Source: RGD

extracellular space

Inferred from direct assay PubMed 18758911. Source: RGD

membrane-bounded vesicle

Inferred from direct assay PubMed 18758911. Source: RGD

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionBMP receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

chemoattractant activity

Inferred from sequence or structural similarity. Source: UniProtKB

growth factor activity

Inferred from direct assay PubMed 12475223. Source: RGD

protein homodimerization activity

Inferred from direct assay PubMed 16245174. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 292273
PRO_0000033862
Chain293 – 408116Bone morphogenetic protein 4
PRO_0000033863

Amino acid modifications

Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation2091N-linked (GlcNAc...) Potential
Glycosylation3501N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Disulfide bond308 ↔ 373 By similarity
Disulfide bond337 ↔ 405 By similarity
Disulfide bond341 ↔ 407 By similarity
Disulfide bond372Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
Q06826 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 61E92B4B8D5624F3

FASTA40846,541
        10         20         30         40         50         60 
MIPGNRMLMV VLLCQVLLGG ATDASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 

        70         80         90        100        110        120 
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS 

       130        140        150        160        170        180 
FHHEEHLENI PGTSESSAFR FFFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN 

       190        200        210        220        230        240 
IYEVMKPPAE MVPGHLITRL LDTRLVRHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT 

       250        260        270        280        290        300 
HLHQTRTHQG QHVRISRSLP QGSGNWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 

       310        320        330        340        350        360 
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 

       370        380        390        400 
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR 

« Hide

References

[1]"Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell."
Chen D., Feng J.Q., Feng M., Harris M.A., Mundy G.R., Harris S.E.
Biochim. Biophys. Acta 1174:289-292(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z22607 mRNA. Translation: CAA80329.1.
PIRS38343.
UniGeneRn.10318.

3D structure databases

ProteinModelPortalQ06826.
SMRQ06826. Positions 307-408.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ06826.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2213. rat.

Organism-specific databases

RGD2213. Bmp4.

Phylogenomic databases

eggNOGNOG243555.
HOGENOMHOG000249478.
HOVERGENHBG004860.
InParanoidQ06826.
PhylomeDBQ06826.

Gene expression databases

GenevestigatorQ06826.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ06826.

Entry information

Entry nameBMP4_RAT
AccessionPrimary (citable) accession number: Q06826
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families