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Q06826

- BMP4_RAT

UniProt

Q06826 - BMP4_RAT

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Protein

Bone morphogenetic protein 4

Gene

Bmp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).By similarity

GO - Molecular functioni

  1. BMP receptor binding Source: UniProtKB
  2. chemoattractant activity Source: UniProtKB
  3. growth factor activity Source: RGD
  4. protein homodimerization activity Source: RGD

GO - Biological processi

  1. activation of MAPKK activity Source: UniProtKB
  2. anatomical structure regression Source: RGD
  3. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: UniProtKB
  4. BMP signaling pathway Source: UniProtKB
  5. BMP signaling pathway involved in heart induction Source: UniProtKB
  6. BMP signaling pathway involved in nephric duct formation Source: UniProtKB
  7. BMP signaling pathway involved in renal system segmentation Source: UniProtKB
  8. BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
  9. brain development Source: RGD
  10. branching involved in ureteric bud morphogenesis Source: UniProtKB
  11. branching morphogenesis of an epithelial tube Source: UniProtKB
  12. cell proliferation Source: RGD
  13. cellular response to BMP stimulus Source: RGD
  14. cellular response to dexamethasone stimulus Source: UniProtKB
  15. cellular response to mechanical stimulus Source: RGD
  16. cellular response to oxidative stress Source: RGD
  17. cellular response to thyroid hormone stimulus Source: RGD
  18. chondrocyte differentiation Source: UniProtKB
  19. common-partner SMAD protein phosphorylation Source: UniProtKB
  20. deltoid tuberosity development Source: UniProtKB
  21. endochondral ossification Source: UniProtKB
  22. epithelial tube branching involved in lung morphogenesis Source: RGD
  23. glomerular capillary formation Source: UniProtKB
  24. growth Source: InterPro
  25. hematopoietic progenitor cell differentiation Source: UniProtKB
  26. intermediate mesodermal cell differentiation Source: UniProtKB
  27. kidney development Source: UniProtKB
  28. lung lobe development Source: RGD
  29. lymphoid progenitor cell differentiation Source: UniProtKB
  30. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  31. mesoderm development Source: RGD
  32. mesonephros development Source: UniProtKB
  33. metanephric collecting duct development Source: UniProtKB
  34. negative regulation of apoptotic process Source: UniProtKB
  35. negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
  36. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  37. negative regulation of cell cycle Source: UniProtKB
  38. negative regulation of cell death Source: UniProtKB
  39. negative regulation of cell proliferation involved in heart morphogenesis Source: UniProtKB
  40. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
  41. negative regulation of glomerulus development Source: UniProtKB
  42. negative regulation of immature T cell proliferation in thymus Source: UniProtKB
  43. negative regulation of MAP kinase activity Source: UniProtKB
  44. negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
  45. negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
  46. negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
  47. negative regulation of mitosis Source: UniProtKB
  48. negative regulation of oligodendrocyte differentiation Source: RGD
  49. negative regulation of phosphorylation Source: UniProtKB
  50. negative regulation of thymocyte apoptotic process Source: UniProtKB
  51. negative regulation of transcription, DNA-templated Source: UniProtKB
  52. odontogenesis Source: UniProtKB
  53. osteoblast differentiation Source: UniProtKB
  54. ovarian follicle development Source: RGD
  55. positive chemotaxis Source: GOC
  56. positive regulation of apoptotic process Source: UniProtKB
  57. positive regulation of BMP signaling pathway Source: UniProtKB
  58. positive regulation of bone mineralization Source: UniProtKB
  59. positive regulation of branching involved in lung morphogenesis Source: UniProtKB
  60. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  61. positive regulation of calcium ion transport into cytosol Source: RGD
  62. positive regulation of cardiac muscle fiber development Source: UniProtKB
  63. positive regulation of cell proliferation Source: RGD
  64. positive regulation of collagen biosynthetic process Source: UniProtKB
  65. positive regulation of DNA-dependent DNA replication Source: UniProtKB
  66. positive regulation of endothelial cell apoptotic process Source: RGD
  67. positive regulation of endothelial cell migration Source: UniProtKB
  68. positive regulation of endothelial cell proliferation Source: UniProtKB
  69. positive regulation of epidermal cell differentiation Source: UniProt
  70. positive regulation of epithelial cell proliferation Source: BHF-UCL
  71. positive regulation of hepatocyte differentiation Source: RGD
  72. positive regulation of kidney development Source: UniProtKB
  73. positive regulation of mesenchymal stem cell proliferation Source: RGD
  74. positive regulation of neuron differentiation Source: RGD
  75. positive regulation of neuron projection development Source: RGD
  76. positive regulation of ossification Source: MGI
  77. positive regulation of osteoblast differentiation Source: UniProtKB
  78. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  79. positive regulation of SMAD protein import into nucleus Source: UniProtKB
  80. positive regulation of smooth muscle cell proliferation Source: UniProtKB
  81. positive regulation of store-operated calcium channel activity Source: RGD
  82. positive regulation of transcription, DNA-templated Source: UniProtKB
  83. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  84. protein localization to nucleus Source: UniProtKB
  85. pulmonary artery endothelial tube morphogenesis Source: UniProtKB
  86. regulation of cell differentiation Source: RGD
  87. regulation of cell fate commitment Source: UniProt
  88. regulation of ERK1 and ERK2 cascade Source: RGD
  89. regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  90. response to estradiol Source: RGD
  91. response to glucocorticoid Source: RGD
  92. response to mechanical stimulus Source: RGD
  93. response to nitric oxide Source: RGD
  94. response to organic cyclic compound Source: RGD
  95. response to retinoic acid Source: RGD
  96. response to testosterone Source: RGD
  97. retina development in camera-type eye Source: RGD
  98. secondary heart field specification Source: UniProtKB
  99. SMAD protein signal transduction Source: UniProtKB
  100. smooth muscle tissue development Source: UniProtKB
  101. specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
  102. steroid hormone mediated signaling pathway Source: UniProtKB
  103. tendon cell differentiation Source: UniProtKB
  104. tongue morphogenesis Source: RGD
  105. type B pancreatic cell development Source: UniProtKB
  106. ureter epithelial cell differentiation Source: UniProtKB
  107. ureter smooth muscle cell differentiation Source: UniProtKB
  108. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 4
Short name:
BMP-4
Alternative name(s):
Bone morphogenetic protein 2B
Short name:
BMP-2B
Gene namesi
Name:Bmp4
Synonyms:Bmp-4, Dvr-4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2213. Bmp4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. membrane-bounded vesicle Source: RGD
  4. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 292273PRO_0000033862Add
BLAST
Chaini293 – 408116Bone morphogenetic protein 4PRO_0000033863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi308 ↔ 373By similarity
Disulfide bondi337 ↔ 405By similarity
Disulfide bondi341 ↔ 407By similarity
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi372 – 372InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiQ06826.

Expressioni

Gene expression databases

GenevestigatoriQ06826.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ06826.
SMRiQ06826. Positions 307-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiQ06826.
PhylomeDBiQ06826.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06826-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPGNRMLMV VLLCQVLLGG ATDASLIPET GKKKVAEIQG HAGGRRSGQS
60 70 80 90 100
HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS
110 120 130 140 150
QGTGLEYPER PASRANTVRS FHHEEHLENI PGTSESSAFR FFFNLSSIPE
160 170 180 190 200
NEVISSAELR LFREQVDQGP DWEQGFHRIN IYEVMKPPAE MVPGHLITRL
210 220 230 240 250
LDTRLVRHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT HLHQTRTHQG
260 270 280 290 300
QHVRISRSLP QGSGNWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR
310 320 330 340 350
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN
360 370 380 390 400
STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM

VVEGCGCR
Length:408
Mass (Da):46,541
Last modified:June 1, 1994 - v1
Checksum:i61E92B4B8D5624F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22607 mRNA. Translation: CAA80329.1.
PIRiS38343.
UniGeneiRn.10318.

Genome annotation databases

UCSCiRGD:2213. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22607 mRNA. Translation: CAA80329.1 .
PIRi S38343.
UniGenei Rn.10318.

3D structure databases

ProteinModelPortali Q06826.
SMRi Q06826. Positions 307-408.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q06826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2213. rat.

Organism-specific databases

RGDi 2213. Bmp4.

Phylogenomic databases

eggNOGi NOG243555.
HOGENOMi HOG000249478.
HOVERGENi HBG004860.
InParanoidi Q06826.
PhylomeDBi Q06826.

Miscellaneous databases

PROi Q06826.

Gene expression databases

Genevestigatori Q06826.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell."
    Chen D., Feng J.Q., Feng M., Harris M.A., Mundy G.R., Harris S.E.
    Biochim. Biophys. Acta 1174:289-292(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBMP4_RAT
AccessioniPrimary (citable) accession number: Q06826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3