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Q06826

- BMP4_RAT

UniProt

Q06826 - BMP4_RAT

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Protein

Bone morphogenetic protein 4

Gene
Bmp4, Bmp-4, Dvr-4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction By similarity.

GO - Molecular functioni

  1. BMP receptor binding Source: UniProtKB
  2. chemoattractant activity Source: UniProtKB
  3. growth factor activity Source: RGD
  4. protein homodimerization activity Source: RGD

GO - Biological processi

  1. activation of MAPKK activity Source: UniProtKB
  2. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: UniProtKB
  3. BMP signaling pathway Source: UniProtKB
  4. BMP signaling pathway involved in heart induction Source: UniProtKB
  5. BMP signaling pathway involved in nephric duct formation Source: UniProtKB
  6. BMP signaling pathway involved in renal system segmentation Source: UniProtKB
  7. BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
  8. brain development Source: RGD
  9. branching involved in ureteric bud morphogenesis Source: UniProtKB
  10. branching morphogenesis of an epithelial tube Source: UniProtKB
  11. cell proliferation Source: RGD
  12. cellular response to dexamethasone stimulus Source: UniProtKB
  13. chondrocyte differentiation Source: UniProtKB
  14. common-partner SMAD protein phosphorylation Source: UniProtKB
  15. deltoid tuberosity development Source: UniProtKB
  16. endochondral ossification Source: UniProtKB
  17. epithelial tube branching involved in lung morphogenesis Source: RGD
  18. glomerular capillary formation Source: UniProtKB
  19. growth Source: InterPro
  20. hematopoietic progenitor cell differentiation Source: UniProtKB
  21. intermediate mesodermal cell differentiation Source: UniProtKB
  22. kidney development Source: UniProtKB
  23. lymphoid progenitor cell differentiation Source: UniProtKB
  24. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  25. mesoderm development Source: RGD
  26. mesonephros development Source: UniProtKB
  27. metanephric collecting duct development Source: UniProtKB
  28. negative regulation of apoptotic process Source: UniProtKB
  29. negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
  30. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  31. negative regulation of cell cycle Source: UniProtKB
  32. negative regulation of cell death Source: UniProtKB
  33. negative regulation of cell proliferation involved in heart morphogenesis Source: UniProtKB
  34. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
  35. negative regulation of glomerulus development Source: UniProtKB
  36. negative regulation of immature T cell proliferation in thymus Source: UniProtKB
  37. negative regulation of MAP kinase activity Source: UniProtKB
  38. negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
  39. negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
  40. negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
  41. negative regulation of mitosis Source: UniProtKB
  42. negative regulation of oligodendrocyte differentiation Source: RGD
  43. negative regulation of phosphorylation Source: UniProtKB
  44. negative regulation of thymocyte apoptotic process Source: UniProtKB
  45. negative regulation of transcription, DNA-templated Source: UniProtKB
  46. odontogenesis Source: UniProtKB
  47. osteoblast differentiation Source: UniProtKB
  48. ovarian follicle development Source: RGD
  49. positive chemotaxis Source: GOC
  50. positive regulation of apoptotic process Source: UniProtKB
  51. positive regulation of BMP signaling pathway Source: UniProtKB
  52. positive regulation of bone mineralization Source: UniProtKB
  53. positive regulation of branching involved in lung morphogenesis Source: UniProtKB
  54. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  55. positive regulation of cardiac muscle fiber development Source: UniProtKB
  56. positive regulation of cell proliferation Source: RGD
  57. positive regulation of collagen biosynthetic process Source: UniProtKB
  58. positive regulation of DNA-dependent DNA replication Source: UniProtKB
  59. positive regulation of endothelial cell migration Source: UniProtKB
  60. positive regulation of endothelial cell proliferation Source: UniProtKB
  61. positive regulation of epidermal cell differentiation Source: UniProt
  62. positive regulation of epithelial cell proliferation Source: UniProtKB
  63. positive regulation of kidney development Source: UniProtKB
  64. positive regulation of ossification Source: MGI
  65. positive regulation of osteoblast differentiation Source: UniProtKB
  66. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  67. positive regulation of SMAD protein import into nucleus Source: UniProtKB
  68. positive regulation of smooth muscle cell proliferation Source: UniProtKB
  69. positive regulation of transcription, DNA-templated Source: UniProtKB
  70. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  71. protein localization to nucleus Source: UniProtKB
  72. pulmonary artery endothelial tube morphogenesis Source: UniProtKB
  73. regulation of cell differentiation Source: RGD
  74. regulation of cell fate commitment Source: UniProt
  75. regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  76. response to estradiol Source: RGD
  77. response to glucocorticoid Source: RGD
  78. response to mechanical stimulus Source: RGD
  79. response to organic cyclic compound Source: RGD
  80. response to retinoic acid Source: RGD
  81. retina development in camera-type eye Source: RGD
  82. secondary heart field specification Source: UniProtKB
  83. SMAD protein signal transduction Source: UniProtKB
  84. smooth muscle tissue development Source: UniProtKB
  85. specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
  86. steroid hormone mediated signaling pathway Source: UniProtKB
  87. tendon cell differentiation Source: UniProtKB
  88. tongue morphogenesis Source: RGD
  89. type B pancreatic cell development Source: UniProtKB
  90. ureter epithelial cell differentiation Source: UniProtKB
  91. ureter smooth muscle cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 4
Short name:
BMP-4
Alternative name(s):
Bone morphogenetic protein 2B
Short name:
BMP-2B
Gene namesi
Name:Bmp4
Synonyms:Bmp-4, Dvr-4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2213. Bmp4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. membrane-bounded vesicle Source: RGD
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Propeptidei20 – 292273PRO_0000033862Add
BLAST
Chaini293 – 408116Bone morphogenetic protein 4PRO_0000033863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi209 – 2091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi308 ↔ 373 By similarity
Disulfide bondi337 ↔ 405 By similarity
Disulfide bondi341 ↔ 407 By similarity
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi372 – 372Interchain By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiQ06826.

Expressioni

Gene expression databases

GenevestigatoriQ06826.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ06826.
SMRiQ06826. Positions 307-408.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiQ06826.
PhylomeDBiQ06826.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06826-1 [UniParc]FASTAAdd to Basket

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MIPGNRMLMV VLLCQVLLGG ATDASLIPET GKKKVAEIQG HAGGRRSGQS    50
HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS 100
QGTGLEYPER PASRANTVRS FHHEEHLENI PGTSESSAFR FFFNLSSIPE 150
NEVISSAELR LFREQVDQGP DWEQGFHRIN IYEVMKPPAE MVPGHLITRL 200
LDTRLVRHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT HLHQTRTHQG 250
QHVRISRSLP QGSGNWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 300
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN 350
STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM 400
VVEGCGCR 408
Length:408
Mass (Da):46,541
Last modified:June 1, 1994 - v1
Checksum:i61E92B4B8D5624F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22607 mRNA. Translation: CAA80329.1.
PIRiS38343.
UniGeneiRn.10318.

Genome annotation databases

UCSCiRGD:2213. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22607 mRNA. Translation: CAA80329.1 .
PIRi S38343.
UniGenei Rn.10318.

3D structure databases

ProteinModelPortali Q06826.
SMRi Q06826. Positions 307-408.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q06826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2213. rat.

Organism-specific databases

RGDi 2213. Bmp4.

Phylogenomic databases

eggNOGi NOG243555.
HOGENOMi HOG000249478.
HOVERGENi HBG004860.
InParanoidi Q06826.
PhylomeDBi Q06826.

Miscellaneous databases

PROi Q06826.

Gene expression databases

Genevestigatori Q06826.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell."
    Chen D., Feng J.Q., Feng M., Harris M.A., Mundy G.R., Harris S.E.
    Biochim. Biophys. Acta 1174:289-292(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBMP4_RAT
AccessioniPrimary (citable) accession number: Q06826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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