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Reviewed, UniProtKB/Swiss-Prot Q06815 (MRL1_YEAST)

Last modified November 24, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mannose 6-phosphate receptor-like protein 1
Gene names
Name: MRL1
Ordered Locus Names: YPR079W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Sorting receptor involved in the transport of vacuolar enzymes from the Golgi complex to the vacuole. Involved in the delivery and maturation of PEP4 (vacuolar proteinase A) and PRB1 (vacuolar proteinase B). Ref.2

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the MRL1/IGF2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 381358Mannose 6-phosphate receptor-like protein 1
PRO_0000042715

Regions

Topological domain24 – 236213Lumenal Potential
Transmembrane237 – 25721 Potential
Topological domain258 – 381124Cytoplasmic Potential

Amino acid modifications

Modified residue3341Phosphoserine Ref.7
Modified residue3351Phosphoserine Ref.7 Ref.4 Ref.5 Ref.6
Modified residue3371Phosphoserine Ref.7 Ref.6
Modified residue3391Phosphoserine Ref.7 Ref.4 Ref.5
Modified residue3401Phosphoserine Ref.7
Modified residue3421Phosphoserine Ref.5
Modified residue3711Phosphoserine Ref.7
Modified residue3801Phosphoserine Ref.7
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1361N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q06815-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4E89311978E85A4F

FASTA38142,706
        10         20         30         40         50         60 
MLKRSSLIYL SCVLIITIPI LLHVYNGPGL SHEANEHRAS HKQKRTLANP DKPKSENDED 

        70         80         90        100        110        120 
LFCAVTNPVT GSYIDLSQLS STPNKLREGQ KQISGNNKHE SSKTKWSVRG WGYDTNFTLG 

       130        140        150        160        170        180 
ICSSPVGEAE SQQLSNLTGA FYVDQLNENN LVSIGDFSTR PALVGGSTAK KLTLKYENGS 

       190        200        210        220        230        240 
MCPNGKDKKA TLLNFVCDKE IQSKAQISYI GNLHNCSYFF EVRSIHACPT SNKKNEVNVL 

       250        260        270        280        290        300 
GIFIGIFAIF FLVEFAGRRW IYAKLNRHLK NDDELHDISP SLNEQPHWDL IEDGSRWSKF 

       310        320        330        340        350        360 
FNGIIKTTRR FTKSLMRSLV RGRNSRQGGI RLRSSPSASS SSLANREFFR DMEAQNEIID 

       370        380 
SLDINSHTTE SDHPTLADNS V 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed: 9169875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"A yeast homolog of the mammalian mannose 6-phosphate receptors contributes to the sorting of vacuolar hydrolases."
Whyte J.R., Munro S.
Curr. Biol. 11:1074-1078(2001) [PubMed: 11470415] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-339, MASS SPECTROMETRY.
[5]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335; SER-339 AND SER-342, MASS SPECTROMETRY.
[6]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-337, MASS SPECTROMETRY.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-335; SER-337; SER-339; SER-340; SER-371 AND SER-380, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

U51033 Genomic DNA. Translation: AAB68128.1.
PIRS69065.
RefSeqNP_015404.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:2873N.
IntActQ06815. 7 interactions.
STRINGQ06815.

Proteomic databases

PeptideAtlasQ06815.

Genome annotation databases

EnsemblYPR079W; YPR079W; YPR079W; Saccharomyces cerevisiae. [Genome view]
GeneID856194.
KEGGsce:YPR079W.
NMPDRfig|4932.3.peg.6541.

Organism-specific databases

CYGDYPR079w.
SGDS000006283. MRL1.

Phylogenomic databases

HOGENOMQ06815.
OMAKYENGSM
OrthoDBEOG9B5QP5

Gene expression databases

ArrayExpressQ06815.
GenevestigatorQ06815.
GermOnlineYPR079W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR009011. Man6P_isomerase_rcpt_bd.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio981381.

Entry information

Entry nameMRL1_YEAST
AccessionPrimary (citable) accession number: Q06815
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: November 24, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents