Mannose 6-phosphate receptor-like protein 1 precursor - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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Q06815 (MRL1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 91. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Mannose 6-phosphate receptor-like protein 1

Gene names

Name:	MRL1
Ordered Locus Names:	YPR079W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sorting receptor involved in the transport of vacuolar enzymes from the Golgi complex to the vacuole. Involved in the delivery and maturation of PEP4 (vacuolar proteinase A) and PRB1 (vacuolar proteinase B). Ref.3
Subcellular location	Golgi apparatus › trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Ref.3 Ref.4.
Sequence similarities	Belongs to the MRL1/IGF2R family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Endosome Golgi apparatus Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW vacuolar transport Inferred from genetic interaction Ref.3. Source: SGD
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome Inferred from direct assay Ref.3. Source: SGD
Molecular function	signal sequence binding Inferred from genetic interaction Ref.3. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

Potential

Chain

24 – 381

358

Mannose 6-phosphate receptor-like protein 1

PRO_0000042715

Regions

Topological domain

24 – 236

213

Lumenal Potential

Transmembrane

237 – 257

Helical; Potential

Topological domain

258 – 381

124

Cytoplasmic Potential

Amino acid modifications

Modified residue

334

Phosphoserine Ref.8

Modified residue

335

Phosphoserine Ref.5 Ref.6 Ref.7 Ref.8

Modified residue

337

Phosphoserine Ref.7 Ref.8

Modified residue

339

Phosphoserine Ref.5 Ref.6 Ref.8

Modified residue

340

Phosphoserine Ref.8

Modified residue

342

Phosphoserine Ref.6

Modified residue

371

Phosphoserine Ref.8

Modified residue

380

Phosphoserine Ref.8

Glycosylation

116

N-linked (GlcNAc...) Potential

Glycosylation

136

N-linked (GlcNAc...) Potential

Glycosylation

178

N-linked (GlcNAc...) Potential

Glycosylation

215

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q06815 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4E89311978E85A4F
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FASTA

381

42,706

        10         20         30         40         50         60 
MLKRSSLIYL SCVLIITIPI LLHVYNGPGL SHEANEHRAS HKQKRTLANP DKPKSENDED 

        70         80         90        100        110        120 
LFCAVTNPVT GSYIDLSQLS STPNKLREGQ KQISGNNKHE SSKTKWSVRG WGYDTNFTLG 

       130        140        150        160        170        180 
ICSSPVGEAE SQQLSNLTGA FYVDQLNENN LVSIGDFSTR PALVGGSTAK KLTLKYENGS 

       190        200        210        220        230        240 
MCPNGKDKKA TLLNFVCDKE IQSKAQISYI GNLHNCSYFF EVRSIHACPT SNKKNEVNVL 

       250        260        270        280        290        300 
GIFIGIFAIF FLVEFAGRRW IYAKLNRHLK NDDELHDISP SLNEQPHWDL IEDGSRWSKF 

       310        320        330        340        350        360 
FNGIIKTTRR FTKSLMRSLV RGRNSRQGGI RLRSSPSASS SSLANREFFR DMEAQNEIID 

       370        380 
SLDINSHTTE SDHPTLADNS V

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"A yeast homolog of the mammalian mannose 6-phosphate receptors contributes to the sorting of vacuolar hydrolases." Whyte J.R., Munro S. Curr. Biol. 11:1074-1078(2001) [PubMed: 11470415] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-339, MASS SPECTROMETRY. Strain: YAL6B.
[6]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335; SER-339 AND SER-342, MASS SPECTROMETRY. Strain: ADR376.
[7]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-337, MASS SPECTROMETRY.
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-335; SER-337; SER-339; SER-340; SER-371 AND SER-380, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U51033 Genomic DNA. Translation: AAB68128.1. BK006949 Genomic DNA. Translation: DAA11497.1.
PIR	S69065.
RefSeq	NP_015404.1. NM_001184176.1.
3D structure databases
ProteinModelPortal	Q06815.
SMR	Q06815. Positions 63-231.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2873N.
IntAct	Q06815. 16 interactions.
MINT	MINT-1678629.
STRING	Q06815.
Proteomic databases
PeptideAtlas	Q06815.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPR079W; YPR079W; YPR079W.
GeneID	856194.
KEGG	sce:YPR079W.
NMPDR	fig\|4932.3.peg.6541.
Organism-specific databases
CYGD	YPR079w.
SGD	S000006283. MRL1.
Phylogenomic databases
eggNOG	fuNOG09081.
GeneTree	EFGT00050000005394.
HOGENOM	HBG203975.
OMA	YENGSMC.
OrthoDB	EOG4MPN00.
Gene expression databases
ArrayExpress	Q06815.
Genevestigator	Q06815.
GermOnline	YPR079W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009011. Man6P_isomerase_rcpt-bd. [Graphical view]
KO	K10089.
SUPFAM	SSF50911. Man6php_recept. 1 hit.
ProtoNet	Search...
Other
NextBio	981381.

Entry information

Entry name

MRL1_YEAST

Accession

Primary (citable) accession number: Q06815
Secondary accession number(s): D6W481

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents