Q06815 (MRL1_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 91.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Mannose 6-phosphate receptor-like protein 1 | ||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||
| Taxonomic identifier | 559292 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 381 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Sorting receptor involved in the transport of vacuolar enzymes from the Golgi complex to the vacuole. Involved in the delivery and maturation of PEP4 (vacuolar proteinase A) and PRB1 (vacuolar proteinase B). Ref.3 |
| Subcellular location | Golgi apparatus › trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Ref.3 Ref.4. |
| Sequence similarities | Belongs to the MRL1/IGF2R family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Endosome Golgi apparatus Membrane |
| Domain | Signal Transmembrane Transmembrane helix |
| PTM | Glycoprotein Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: UniProtKB-KW vacuolar transportInferred from genetic interaction Ref.3. Source: SGD |
| Cellular component | Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell endosome membraneInferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW late endosomeInferred from direct assay Ref.3. Source: SGD |
| Molecular function | signal sequence binding Inferred from genetic interaction Ref.3. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | ||||||
| Chain | 24 – 381 | 358 | Mannose 6-phosphate receptor-like protein 1 | PRO_0000042715 | |||||
Regions | |||||||||
| Topological domain | 24 – 236 | 213 | Lumenal Potential | ||||||
| Transmembrane | 237 – 257 | 21 | Helical; Potential | ||||||
| Topological domain | 258 – 381 | 124 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 334 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 335 | 1 | Phosphoserine Ref.5 Ref.6 Ref.7 Ref.8 | ||||||
| Modified residue | 337 | 1 | Phosphoserine Ref.7 Ref.8 | ||||||
| Modified residue | 339 | 1 | Phosphoserine Ref.5 Ref.6 Ref.8 | ||||||
| Modified residue | 340 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 342 | 1 | Phosphoserine Ref.6 | ||||||
| Modified residue | 371 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 380 | 1 | Phosphoserine Ref.8 | ||||||
| Glycosylation | 116 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 136 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 178 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 215 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. Hani J.Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [2] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [3] | "A yeast homolog of the mammalian mannose 6-phosphate receptors contributes to the sorting of vacuolar hydrolases." Whyte J.R., Munro S. Curr. Biol. 11:1074-1078(2001) [PubMed: 11470415] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. |
| [4] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [5] | "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-339, MASS SPECTROMETRY. Strain: YAL6B. |
| [6] | "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335; SER-339 AND SER-342, MASS SPECTROMETRY. Strain: ADR376. |
| [7] | "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-337, MASS SPECTROMETRY. |
| [8] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-335; SER-337; SER-339; SER-340; SER-371 AND SER-380, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U51033 Genomic DNA. Translation: AAB68128.1. BK006949 Genomic DNA. Translation: DAA11497.1. |
| PIR | S69065. |
| RefSeq | NP_015404.1. NM_001184176.1. |
3D structure databases | |
| ProteinModelPortal | Q06815. |
| SMR | Q06815. Positions 63-231. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-2873N. |
| IntAct | Q06815. 16 interactions. |
| MINT | MINT-1678629. |
| STRING | Q06815. |
Proteomic databases | |
| PeptideAtlas | Q06815. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YPR079W; YPR079W; YPR079W. |
| GeneID | 856194. |
| KEGG | sce:YPR079W. |
| NMPDR | fig|4932.3.peg.6541. |
Organism-specific databases | |
| CYGD | YPR079w. |
| SGD | S000006283. MRL1. |
Phylogenomic databases | |
| eggNOG | fuNOG09081. |
| GeneTree | EFGT00050000005394. |
| HOGENOM | HBG203975. |
| OMA | YENGSMC. |
| OrthoDB | EOG4MPN00. |
Gene expression databases | |
| ArrayExpress | Q06815. |
| Genevestigator | Q06815. |
| GermOnline | YPR079W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR009011. Man6P_isomerase_rcpt-bd. [Graphical view] |
| KO | K10089. |
| SUPFAM | SSF50911. Man6php_recept. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 981381. |
Entry information
| Entry name | MRL1_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q06815 Secondary accession number(s): D6W481 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| SIMILARITY comments Index of protein domains and families |

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