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Q06814

- CALR_SCHMA

UniProt

Q06814 - CALR_SCHMA

Protein

Calreticulin

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei107 – 1071CarbohydrateBy similarity
    Binding sitei109 – 1091CarbohydrateBy similarity
    Binding sitei126 – 1261CarbohydrateBy similarity
    Binding sitei133 – 1331CarbohydrateBy similarity
    Binding sitei315 – 3151CarbohydrateBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    Calcium, Lectin, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calreticulin
    Alternative name(s):
    Protein SM4
    OrganismiSchistosoma mansoni (Blood fluke)
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 393377CalreticulinPRO_0000004183Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi103 ↔ 135By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ06814.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06814.
    SMRiQ06814. Positions 204-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati189 – 200121-1Add
    BLAST
    Repeati208 – 219121-2Add
    BLAST
    Repeati225 – 236121-3Add
    BLAST
    Repeati242 – 253121-4Add
    BLAST
    Repeati257 – 267112-1Add
    BLAST
    Repeati271 – 281112-2Add
    BLAST
    Repeati285 – 295112-3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni189 – 253654 X 12 AA approximate repeatsAdd
    BLAST
    Regioni257 – 295393 X 11 AA approximate repeatsAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi390 – 3934Prevents secretion from ER

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi350 – 38940Asp/Glu/Lys-richAdd
    BLAST

    Domaini

    Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.By similarity
    The interaction with glycans occurs through a binding site in the globular lectin domain.By similarity
    The zinc binding sites are localized to the N-domain.By similarity

    Sequence similaritiesi

    Belongs to the calreticulin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOGENOMiHOG000192435.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR001580. Calret/calnex.
    IPR018124. Calret/calnex_CS.
    IPR009169. Calreticulin.
    IPR009033. Calreticulin/calnexin_P_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view]
    PANTHERiPTHR11073. PTHR11073. 1 hit.
    PfamiPF00262. Calreticulin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002356. Calreticulin. 1 hit.
    PRINTSiPR00626. CALRETICULIN.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF63887. SSF63887. 1 hit.
    PROSITEiPS00803. CALRETICULIN_1. 1 hit.
    PS00804. CALRETICULIN_2. 1 hit.
    PS00805. CALRETICULIN_REPEAT. 1 hit.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06814-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSILLTLLL SKYALGHEVW FSETFPNESI ENWVQSTYNA EKQGEFKVEA    50
    GKSPVDPIED LGLKTTQDAR FYGIARKISE PFSNRGKTMV LQFTVKFDKT 100
    VSCGGAYIKL LGSDIDPKKF HGESPYKIMF GPDICGMATK KVHVIFNYKG 150
    KNHLIKKEIP CKDDLKTHLY TLIVNPNNKY EVLVDNAKVE EGSLEDDWDM 200
    LPPKKIDDPN DKKPDDWVDE QFIDDPDDKK PDNWDQPKTI PDMDAKKPDD 250
    WDDAMDGEWE RPQKDNPEYK GEWTPRRIDN PKYKGEWKPV QIDNPEYKHD 300
    PELYVLNDIG YVGFDLWQVD SGSIFDNILI TDSPDFAKEE GERLWRKRYD 350
    AEVAKEQSSA KDDKEEAEET KERKELPYDA KASDEPSGDH DEL 393
    Length:393
    Mass (Da):45,398
    Last modified:February 1, 1996 - v2
    Checksum:i45F59857C21940D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 902MV → IL in AAA19024. (PubMed:8139623)Curated
    Sequence conflicti188 – 20720Missing in AAA19024. (PubMed:8139623)CuratedAdd
    BLAST
    Sequence conflicti378 – 3781Y → D in AAA19024. (PubMed:8139623)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93097 mRNA. Translation: AAA29854.1.
    L24159 Genomic DNA. Translation: AAA19024.1.
    PIRiA48573.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93097 mRNA. Translation: AAA29854.1 .
    L24159 Genomic DNA. Translation: AAA19024.1 .
    PIRi A48573.

    3D structure databases

    ProteinModelPortali Q06814.
    SMRi Q06814. Positions 204-303.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q06814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000192435.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR001580. Calret/calnex.
    IPR018124. Calret/calnex_CS.
    IPR009169. Calreticulin.
    IPR009033. Calreticulin/calnexin_P_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view ]
    PANTHERi PTHR11073. PTHR11073. 1 hit.
    Pfami PF00262. Calreticulin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002356. Calreticulin. 1 hit.
    PRINTSi PR00626. CALRETICULIN.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF63887. SSF63887. 1 hit.
    PROSITEi PS00803. CALRETICULIN_1. 1 hit.
    PS00804. CALRETICULIN_2. 1 hit.
    PS00805. CALRETICULIN_REPEAT. 1 hit.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the gene encoding a Schistosoma mansoni antigen homologous to human Ro/SS-A autoantigen."
      Khalife J., Trottein F., Schacht A.-M., Godin C., Pierce R.J., Capron A.
      Mol. Biochem. Parasitol. 57:193-202(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Puerto Rican.
    2. "Cloning and sequencing of the gene encoding Schistosoma mansoni calreticulin."
      Khalife J., Pierce R.J., Godin C., Capron A.
      Mol. Biochem. Parasitol. 62:313-315(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Puerto Rican.

    Entry informationi

    Entry nameiCALR_SCHMA
    AccessioniPrimary (citable) accession number: Q06814
    Secondary accession number(s): Q26562
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3