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Protein

Polyprotein ABA-1

Gene

ABA-1

Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has high binding affinity for fatty acids and retinoids.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lipid-binding, Retinol-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprotein ABA-1
Alternative name(s):
Body fluid allergen 1
Nematode polyprotein allergen ABA-1
Short name:
NPA ABA-1
Allergen: Asc s 1
Cleaved into the following 6 chains:
Gene namesi
Name:ABA-1
OrganismiAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifieri6253 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3541. Asc s 1.0101.
61. Asc s 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 1365›1365Polyprotein ABA-1PRO_0000287126Add
BLAST
Peptidei‹1 – 133›133ABA-1B1 repeat unitCuratedPRO_0000042221Add
BLAST
Peptidei134 – 266133ABA-1A4 repeat unitCuratedPRO_0000042222Add
BLAST
Peptidei267 – 399133ABA-1A3 repeat unitCuratedPRO_0000042223Add
BLAST
Peptidei400 – 533134ABA-1A2 repeat unitCuratedPRO_0000042224Add
BLAST
Peptidei534 – 666133ABA-1A1 repeat unitCuratedPRO_0000042225Add
BLAST
Peptidei667 – 799133ABA-1A1 repeat unitCuratedPRO_0000042226Add
BLAST
Peptidei800 – 932133ABA-1A1 repeat unitCuratedPRO_0000042227Add
BLAST
Peptidei933 – 1065133ABA-1A1 repeat unitCuratedPRO_0000042228Add
BLAST
Peptidei1066 – 1198133ABA-1A1 repeat unitCuratedPRO_0000020606Add
BLAST
Peptidei1199 – 1331133ABA-1A1 repeat unitCuratedPRO_0000020607Add
BLAST
Peptidei1332 – 136534C-terminal extension peptideSequence analysisPRO_0000020608Add
BLAST

Post-translational modificationi

Nematode polyprotein allergens (NPAs) are synthesized as large polypeptides that are subsequently proteolytically cleaved to active polypeptide units.

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Pseudocoelomic fluid.

Structurei

Secondary structure

1
1365
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1066 – 10683Combined sources
Helixi1071 – 10733Combined sources
Turni1074 – 10807Combined sources
Helixi1083 – 109412Combined sources
Helixi1099 – 111113Combined sources
Helixi1115 – 113622Combined sources
Helixi1138 – 115114Combined sources
Helixi1155 – 116511Combined sources
Helixi1172 – 11809Combined sources
Helixi1182 – 11887Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XV9NMR-A1066-1194[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPA family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR032487. ABA-1_nematode.
[Graphical view]
PfamiPF16469. NPA. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TMEHYLKTYL SWLTEEQKEK LKEMKEAGKT KAEIQHEVMH YYDQLHGEEK
60 70 80 90 100
QQATEKLKVG CKMLLKGIIG EEKVVELRNM KEAGADIQEL QQKVEKMLSE
110 120 130 140 150
VTDEKQKEKV HEYGPACKKI FGATTLQHHR RRRHHFTLES SLDTHLKWLS
160 170 180 190 200
QEQKDELLKM KKDGKTKKEL EAKILHYYDE LEGDAKKEAT EHLKGGCGEI
210 220 230 240 250
LKHVVGEEKA AELKNLKDSG ASKEELKAKV EEALHAVTDE EKKQYIADFG
260 270 280 290 300
PACKKIYGVH TSRRRRHHFT LESSLDTHLK WLSQEQKDEL LKMKKDGKAK
310 320 330 340 350
KELEAKILHY YDELEGDAKK EATEHLKGGC AEILKHVVGE EKAAELKNLK
360 370 380 390 400
DSGASKEELK AKVEEALHAV TDEEKKQYIA DFGPACKKIY GVHTSRRRRH
410 420 430 440 450
HFTLESSLDT HLKWLSQEQK DELLKMKKDG KTKKDLQAKI LHYYDELEGD
460 470 480 490 500
AKKEATEHLK DGCREILKHV VGEEKEAELK KLKDSGASKE EVKAKVEEAL
510 520 530 540 550
HAVTDEEKKQ YIADFGPACK KIFGAAHTSR RRRHHFTLES SLDTHLKWLS
560 570 580 590 600
QEQKDELLKM KKDGKAKKEL EAKILHYYDE LEGDAKKEAT EHLKGGCREI
610 620 630 640 650
LKHVVGEEKA AELKNLKDSG ASKEELKAKV EEALHAVTDE EKKQYIADFG
660 670 680 690 700
PACKKIYGVH TSRRRRHHFT LESSLDTHLK WLSQEQKDEL LKMKKDGKAK
710 720 730 740 750
KELEAKILHY YDELEGDAKK EATEHLKGGC REILKHVVGE EKAAELKNLK
760 770 780 790 800
DSGASKEELK AKVEEALHAV TDEEKKQYIA DFGPACKKIY GVHTSRRRRH
810 820 830 840 850
HFTLESSLDT HLKWLSQEQK DELLKMKKDG KAKKELEAKI LHYYDELEGD
860 870 880 890 900
AKKEATEHLK GGCREILKHV VGEEKAAELK NLKDSGASKE ELKAKVEEAL
910 920 930 940 950
HAVTDEEKKQ YIADFGPACK KIYGVHTSRR RRHHFTLESS LDTHLKWLSQ
960 970 980 990 1000
EQKDELLKMK KDGKAKKELE AKILHYYDEL EGDAKKEATE HLKGGCREIL
1010 1020 1030 1040 1050
KHVVGEEKAA ELKNLKDSGA SKEELKAKVE EALHAVTDEE KKQYIADFGP
1060 1070 1080 1090 1100
ACKKIYGVHT SRRRRHHFTL ESSLDTHLKW LSQEQKDELL KMKKDGKAKK
1110 1120 1130 1140 1150
ELEAKILHYY DELEGDAKKE ATEHLKGGCR EILKHVVGEE KAAELKNLKD
1160 1170 1180 1190 1200
SGASKEELKA KVEEALHAVT DEEKKQYIAD FGPACKKIYG VHTSRRRRHH
1210 1220 1230 1240 1250
FTLESSLDTH LKWLSQEQKD ELLKMKKDGK AKKELEAKIL HYYDELEGDA
1260 1270 1280 1290 1300
KKEATEHLKG GCREILKHVV GEEKAAELKN LKDSGASKEE LKAKVEEALH
1310 1320 1330 1340 1350
AVTDEEKKQY IADFGPACKK IYGVHTSRRR RYHAEDGTDD IDGLAQSRQR
1360
RSGFFEKLID VFAFF
Length:1,365
Mass (Da):156,880
Last modified:October 11, 2005 - v2
Checksum:iF7F43B78606863DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051702 mRNA. Translation: AAC06015.1.
L03211 mRNA. Translation: AAB41117.1.
PIRiA48576.
T31423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051702 mRNA. Translation: AAC06015.1.
L03211 mRNA. Translation: AAB41117.1.
PIRiA48576.
T31423.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XV9NMR-A1066-1194[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3541. Asc s 1.0101.
61. Asc s 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR032487. ABA-1_nematode.
[Graphical view]
PfamiPF16469. NPA. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABA1_ASCSU
AccessioniPrimary (citable) accession number: Q06811
Secondary accession number(s): O61566, Q9TWU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: November 11, 2015
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.