Q06778 (BLO11_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-lactamase OXA-11
EC=3.5.2.6

Gene names

Name:	bla
Synonyms:	oxa11

Encoded on

Plasmid pMLH52

Organism

Pseudomonas aeruginosa

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes carbenicillin, oxacillin and cephalosporin. Does not hydrolyze cefoxitin or carbapenems.
Catalytic activity	A beta-lactam + H2O = a substituted beta-amino acid.
Sequence similarities	Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Domain	Signal
Molecular function	Hydrolase
Technical term	Plasmid
Gene Ontology (GO)
Biological_process	antibiotic catabolic process Inferred from electronic annotation. Source: InterPro peptidoglycan-based cell wall biogenesis Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	beta-lactamase activity Inferred from electronic annotation. Source: EC penicillin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 266	246	Beta-lactamase OXA-11		PRO_0000017031
Regions
	Region	205 – 207	3	Substrate binding By similarity
Sites
	Active site	67	1	Acyl-ester intermediate By similarity
Amino acid modifications
	Modified residue	70	1	N6-carboxylysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q06778 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 01C3B2FC04A6027C	FASTA	266	29,538
	10 20 30 40 50 60 MKTFAAYVII ACLSSTALAG SITENTSWNK EFSAEAVNGV FVLCKSSSKS CATNDLARAS 70 80 90 100 110 120 KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK QWERDLTLRG AIQVSAVPVF 130 140 150 160 170 180 QQIAREVGEV RMQKYLKKFS YGSQNISGGI DKFWLEDQLR ISAVNQVEFL ESLYLNKLSA 190 200 210 220 230 240 SKENQLIVKE ALVTEAAPEY LVHSKTGFSG VGTESNPGVA WWVGWVEKET EVYFFAFNMD 250 260 IDNESKLPLR KSIPTKIMES EGIIGG

References

[1]

"OXA-11, an extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa." Hall L.M.C., Livermore D.M., Gur D., Akova M., Akalin H.E. Antimicrob. Agents Chemother. 37:1637-1644(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ABD.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z22590 Genomic DNA. Translation: CAA80304.1.
PIR	S33163.
3D structure databases
ProteinModelPortal	Q06778.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.710.10. 1 hit.
InterPro	IPR012338. Beta-lactam/transpept-like. IPR002137. Beta-lactam_class-D_AS. IPR001460. PCN-bd_Tpept. [Graphical view]
Pfam	PF00905. Transpeptidase. 1 hit. [Graphical view]
SUPFAM	SSF56601. PBP_transp_fold. 1 hit.
PROSITE	PS00337. BETA_LACTAMASE_D. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BLO11_PSEAI

Accession

Primary (citable) accession number: Q06778

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program