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Q06778

- BLO11_PSEAI

UniProt

Q06778 - BLO11_PSEAI

Protein

Beta-lactamase OXA-11

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes carbenicillin, oxacillin and cephalosporin. Does not hydrolyze cefoxitin or carbapenems.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase OXA-11 (EC:3.5.2.6)
    Gene namesi
    Name:bla
    Synonyms:oxa11
    Encoded oniPlasmid pMLH520 Publication
    OrganismiPseudomonas aeruginosa
    Taxonomic identifieri287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 266246Beta-lactamase OXA-11PRO_0000017031Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701N6-carboxylysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ06778.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni205 – 2073Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-D beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06778-1 [UniParc]FASTAAdd to Basket

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    MKTFAAYVII ACLSSTALAG SITENTSWNK EFSAEAVNGV FVLCKSSSKS    50
    CATNDLARAS KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK 100
    QWERDLTLRG AIQVSAVPVF QQIAREVGEV RMQKYLKKFS YGSQNISGGI 150
    DKFWLEDQLR ISAVNQVEFL ESLYLNKLSA SKENQLIVKE ALVTEAAPEY 200
    LVHSKTGFSG VGTESNPGVA WWVGWVEKET EVYFFAFNMD IDNESKLPLR 250
    KSIPTKIMES EGIIGG 266
    Length:266
    Mass (Da):29,538
    Last modified:June 1, 1994 - v1
    Checksum:i01C3B2FC04A6027C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22590 Genomic DNA. Translation: CAA80304.1.
    PIRiS33163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22590 Genomic DNA. Translation: CAA80304.1 .
    PIRi S33163.

    3D structure databases

    ProteinModelPortali Q06778.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "OXA-11, an extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa."
      Hall L.M.C., Livermore D.M., Gur D., Akova M., Akalin H.E.
      Antimicrob. Agents Chemother. 37:1637-1644(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ABD.

    Entry informationi

    Entry nameiBLO11_PSEAI
    AccessioniPrimary (citable) accession number: Q06778
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3