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Q06778 (BLO11_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase OXA-11

EC=3.5.2.6
Gene names
Name:bla
Synonyms:oxa11
Encoded onPlasmid pMLH52
OrganismPseudomonas aeruginosa
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes carbenicillin, oxacillin and cephalosporin. Does not hydrolyze cefoxitin or carbapenems.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 266246Beta-lactamase OXA-11
PRO_0000017031

Regions

Region205 – 2073Substrate binding By similarity

Sites

Active site671Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue701N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q06778 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 01C3B2FC04A6027C

FASTA26629,538
        10         20         30         40         50         60 
MKTFAAYVII ACLSSTALAG SITENTSWNK EFSAEAVNGV FVLCKSSSKS CATNDLARAS 

        70         80         90        100        110        120 
KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK QWERDLTLRG AIQVSAVPVF 

       130        140        150        160        170        180 
QQIAREVGEV RMQKYLKKFS YGSQNISGGI DKFWLEDQLR ISAVNQVEFL ESLYLNKLSA 

       190        200        210        220        230        240 
SKENQLIVKE ALVTEAAPEY LVHSKTGFSG VGTESNPGVA WWVGWVEKET EVYFFAFNMD 

       250        260 
IDNESKLPLR KSIPTKIMES EGIIGG 

« Hide

References

[1]"OXA-11, an extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa."
Hall L.M.C., Livermore D.M., Gur D., Akova M., Akalin H.E.
Antimicrob. Agents Chemother. 37:1637-1644(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ABD.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z22590 Genomic DNA. Translation: CAA80304.1.
PIRS33163.

3D structure databases

ProteinModelPortalQ06778.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLO11_PSEAI
AccessionPrimary (citable) accession number: Q06778
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families