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Protein

Beta-lactamase OXA-11

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes carbenicillin, oxacillin and cephalosporin. Does not hydrolyze cefoxitin or carbapenems.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-11 (EC:3.5.2.6)
Gene namesi
Name:bla
Synonyms:oxa11
Encoded oniPlasmid pMLH520 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001703121 – 266Beta-lactamase OXA-11Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70N6-carboxylysineBy similarity1

Proteomic databases

PRIDEiQ06778

Structurei

3D structure databases

ProteinModelPortaliQ06778
SMRiQ06778
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni205 – 207Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18792

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR002137 Beta-lactam_class-D_AS
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00337 BETA_LACTAMASE_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFAAYVII ACLSSTALAG SITENTSWNK EFSAEAVNGV FVLCKSSSKS
60 70 80 90 100
CATNDLARAS KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK
110 120 130 140 150
QWERDLTLRG AIQVSAVPVF QQIAREVGEV RMQKYLKKFS YGSQNISGGI
160 170 180 190 200
DKFWLEDQLR ISAVNQVEFL ESLYLNKLSA SKENQLIVKE ALVTEAAPEY
210 220 230 240 250
LVHSKTGFSG VGTESNPGVA WWVGWVEKET EVYFFAFNMD IDNESKLPLR
260
KSIPTKIMES EGIIGG
Length:266
Mass (Da):29,538
Last modified:June 1, 1994 - v1
Checksum:i01C3B2FC04A6027C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22590 Genomic DNA Translation: CAA80304.1
PIRiS33163
RefSeqiWP_063860939.1, NG_049402.1

Genome annotation databases

KEGGiag:CAA80304

Similar proteinsi

Entry informationi

Entry nameiBLO11_PSEAI
AccessioniPrimary (citable) accession number: Q06778
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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