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Q06770 (CBG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Corticosteroid-binding globulin

Short name=CBG
Alternative name(s):
Serpin A6
Transcortin
Gene names
Name:Serpina6
Synonyms:Cbg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Subcellular location

Secreted.

Tissue specificity

Expressed by the liver; secreted in plasma.

Domain

Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids By similarity.

Sequence similarities

Belongs to the serpin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 397375Corticosteroid-binding globulin
PRO_0000032431

Sites

Binding site2471Corticosteroid By similarity
Binding site2791Corticosteroid By similarity
Binding site3851Corticosteroid By similarity
Site2431Conserved cysteine within steroid binding domain

Amino acid modifications

Glycosylation891N-linked (GlcNAc...) Ref.2 Ref.3
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation2171N-linked (GlcNAc...) Ref.2
Glycosylation2321N-linked (GlcNAc...) Ref.2
Glycosylation2531N-linked (GlcNAc...) Potential
Glycosylation3201N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q06770 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: F44255FE690458AF

FASTA39744,769
        10         20         30         40         50         60 
MSLALYTCLF WLCTSGLWTT QAVTDEDSSS HRDLAPTNVD FAFNLYKRLV ALNSDKNTLI 

        70         80         90        100        110        120 
SPVSISMALA MLSLSTRGST QYLENLGFNM SKMSEAEIHQ GFQYLNSLLQ QSDTGLEMNM 

       130        140        150        160        170        180 
GNVMFLLQNL KLKDSFLADT KHYYESEALT IPSKDWTKAG EQINNHVKNK TQGKIEHVVS 

       190        200        210        220        230        240 
DLDSSATLIL INYIFLKGIW KLPFSPENTR EEDFYVNETS TVKVPMMVQS GNISYFRDSA 

       250        260        270        280        290        300 
IPCQMVQMNY VGNGTTFIIL PDQGQMDTVV AALNRDTIDR WGKLMIPRQM NLYIPKFSMS 

       310        320        330        340        350        360 
DTYDLQDVLA DVGIKDLFTN QSDFADTTKD TPLTLTVLHK AMLQLDEGNV LPAATNGPPV 

       370        380        390 
HLPSESFTLK YNRPFIFLAF DKYTWSSLMM SQVMNPA 

« Hide

References

« Hide 'large scale' references
[1]"Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice."
Scrocchi L.A., Orava M., Smith C.L., Han V.K.M., Hammond G.L.
Endocrinology 132:903-909(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89; ASN-217 AND ASN-232.
Strain: C57BL/6.
Tissue: Plasma.
[3]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70533 mRNA. Translation: CAA49934.1.
PIRS33415.
RefSeqNP_031644.1. NM_007618.2.
UniGeneMm.290079.

3D structure databases

ProteinModelPortalQ06770.
SMRQ06770. Positions 29-397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000044033.

Proteomic databases

PaxDbQ06770.
PRIDEQ06770.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044159; ENSMUSP00000044033; ENSMUSG00000060807.
GeneID12401.
KEGGmmu:12401.
UCSCuc007owa.1. mouse.

Organism-specific databases

CTD866.
MGIMGI:88278. Serpina6.

Phylogenomic databases

eggNOGCOG4826.
GeneTreeENSGT00740000115120.
HOGENOMHOG000238521.
HOVERGENHBG005957.
InParanoidQ06770.
OMASTREENF.
OrthoDBEOG7J446W.
PhylomeDBQ06770.
TreeFamTF343201.

Gene expression databases

ArrayExpressQ06770.
BgeeQ06770.
GenevestigatorQ06770.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281166.
PROQ06770.
SOURCESearch...

Entry information

Entry nameCBG_MOUSE
AccessionPrimary (citable) accession number: Q06770
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot