Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q06770

- CBG_MOUSE

UniProt

Q06770 - CBG_MOUSE

Protein

Corticosteroid-binding globulin

Gene

Serpina6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei243 – 2431Conserved cysteine within steroid binding domain
    Binding sitei247 – 2471CorticosteroidBy similarity
    Binding sitei279 – 2791CorticosteroidBy similarity
    Binding sitei385 – 3851CorticosteroidBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome
    2. steroid binding Source: MGI

    GO - Biological processi

    1. glucocorticoid metabolic process Source: MGI
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of proteolysis Source: RefGenome
    4. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding, Steroid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Corticosteroid-binding globulin
    Short name:
    CBG
    Alternative name(s):
    Serpin A6
    Transcortin
    Gene namesi
    Name:Serpina6
    Synonyms:Cbg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:88278. Serpina6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 397375Corticosteroid-binding globulinPRO_0000032431Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi89 – 891N-linked (GlcNAc...)2 Publications
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi217 – 2171N-linked (GlcNAc...)1 Publication
    Glycosylationi232 – 2321N-linked (GlcNAc...)1 Publication
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ06770.
    PaxDbiQ06770.
    PRIDEiQ06770.

    Expressioni

    Tissue specificityi

    Expressed by the liver; secreted in plasma.

    Gene expression databases

    ArrayExpressiQ06770.
    BgeeiQ06770.
    GenevestigatoriQ06770.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000044033.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06770.
    SMRiQ06770. Positions 29-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids By similarity.By similarity

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000115120.
    HOGENOMiHOG000238521.
    HOVERGENiHBG005957.
    InParanoidiQ06770.
    OMAiSTREENF.
    OrthoDBiEOG7J446W.
    PhylomeDBiQ06770.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06770-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLALYTCLF WLCTSGLWTT QAVTDEDSSS HRDLAPTNVD FAFNLYKRLV    50
    ALNSDKNTLI SPVSISMALA MLSLSTRGST QYLENLGFNM SKMSEAEIHQ 100
    GFQYLNSLLQ QSDTGLEMNM GNVMFLLQNL KLKDSFLADT KHYYESEALT 150
    IPSKDWTKAG EQINNHVKNK TQGKIEHVVS DLDSSATLIL INYIFLKGIW 200
    KLPFSPENTR EEDFYVNETS TVKVPMMVQS GNISYFRDSA IPCQMVQMNY 250
    VGNGTTFIIL PDQGQMDTVV AALNRDTIDR WGKLMIPRQM NLYIPKFSMS 300
    DTYDLQDVLA DVGIKDLFTN QSDFADTTKD TPLTLTVLHK AMLQLDEGNV 350
    LPAATNGPPV HLPSESFTLK YNRPFIFLAF DKYTWSSLMM SQVMNPA 397
    Length:397
    Mass (Da):44,769
    Last modified:June 1, 1994 - v1
    Checksum:iF44255FE690458AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70533 mRNA. Translation: CAA49934.1.
    CCDSiCCDS26135.1.
    PIRiS33415.
    RefSeqiNP_031644.1. NM_007618.2.
    UniGeneiMm.290079.

    Genome annotation databases

    EnsembliENSMUST00000044159; ENSMUSP00000044033; ENSMUSG00000060807.
    GeneIDi12401.
    KEGGimmu:12401.
    UCSCiuc007owa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70533 mRNA. Translation: CAA49934.1 .
    CCDSi CCDS26135.1.
    PIRi S33415.
    RefSeqi NP_031644.1. NM_007618.2.
    UniGenei Mm.290079.

    3D structure databases

    ProteinModelPortali Q06770.
    SMRi Q06770. Positions 29-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000044033.

    Proteomic databases

    MaxQBi Q06770.
    PaxDbi Q06770.
    PRIDEi Q06770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044159 ; ENSMUSP00000044033 ; ENSMUSG00000060807 .
    GeneIDi 12401.
    KEGGi mmu:12401.
    UCSCi uc007owa.1. mouse.

    Organism-specific databases

    CTDi 866.
    MGIi MGI:88278. Serpina6.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000115120.
    HOGENOMi HOG000238521.
    HOVERGENi HBG005957.
    InParanoidi Q06770.
    OMAi STREENF.
    OrthoDBi EOG7J446W.
    PhylomeDBi Q06770.
    TreeFami TF343201.

    Miscellaneous databases

    NextBioi 281166.
    PROi Q06770.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06770.
    Bgeei Q06770.
    Genevestigatori Q06770.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice."
      Scrocchi L.A., Orava M., Smith C.L., Han V.K.M., Hammond G.L.
      Endocrinology 132:903-909(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89; ASN-217 AND ASN-232.
      Strain: C57BL/6.
      Tissue: Plasma.
    3. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiCBG_MOUSE
    AccessioniPrimary (citable) accession number: Q06770
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3