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Q06770

- CBG_MOUSE

UniProt

Q06770 - CBG_MOUSE

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Protein

Corticosteroid-binding globulin

Gene

Serpina6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei243 – 2431Conserved cysteine within steroid binding domain
Binding sitei247 – 2471CorticosteroidBy similarity
Binding sitei279 – 2791CorticosteroidBy similarity
Binding sitei385 – 3851CorticosteroidBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome
  2. steroid binding Source: MGI

GO - Biological processi

  1. glucocorticoid metabolic process Source: MGI
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of proteolysis Source: RefGenome
  4. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding, Steroid-binding

Protein family/group databases

MEROPSiI04.954.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid-binding globulin
Short name:
CBG
Alternative name(s):
Serpin A6
Transcortin
Gene namesi
Name:Serpina6
Synonyms:Cbg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:88278. Serpina6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 397375Corticosteroid-binding globulinPRO_0000032431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi89 – 891N-linked (GlcNAc...)2 Publications
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi217 – 2171N-linked (GlcNAc...)1 Publication
Glycosylationi232 – 2321N-linked (GlcNAc...)1 Publication
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ06770.
PaxDbiQ06770.
PRIDEiQ06770.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Gene expression databases

BgeeiQ06770.
ExpressionAtlasiQ06770. baseline and differential.
GenevestigatoriQ06770.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044033.

Structurei

3D structure databases

ProteinModelPortaliQ06770.
SMRiQ06770. Positions 29-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ06770.
OMAiSTREENF.
OrthoDBiEOG7J446W.
PhylomeDBiQ06770.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06770-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLALYTCLF WLCTSGLWTT QAVTDEDSSS HRDLAPTNVD FAFNLYKRLV
60 70 80 90 100
ALNSDKNTLI SPVSISMALA MLSLSTRGST QYLENLGFNM SKMSEAEIHQ
110 120 130 140 150
GFQYLNSLLQ QSDTGLEMNM GNVMFLLQNL KLKDSFLADT KHYYESEALT
160 170 180 190 200
IPSKDWTKAG EQINNHVKNK TQGKIEHVVS DLDSSATLIL INYIFLKGIW
210 220 230 240 250
KLPFSPENTR EEDFYVNETS TVKVPMMVQS GNISYFRDSA IPCQMVQMNY
260 270 280 290 300
VGNGTTFIIL PDQGQMDTVV AALNRDTIDR WGKLMIPRQM NLYIPKFSMS
310 320 330 340 350
DTYDLQDVLA DVGIKDLFTN QSDFADTTKD TPLTLTVLHK AMLQLDEGNV
360 370 380 390
LPAATNGPPV HLPSESFTLK YNRPFIFLAF DKYTWSSLMM SQVMNPA
Length:397
Mass (Da):44,769
Last modified:June 1, 1994 - v1
Checksum:iF44255FE690458AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70533 mRNA. Translation: CAA49934.1.
CCDSiCCDS26135.1.
PIRiS33415.
RefSeqiNP_031644.1. NM_007618.2.
UniGeneiMm.290079.

Genome annotation databases

EnsembliENSMUST00000044159; ENSMUSP00000044033; ENSMUSG00000060807.
GeneIDi12401.
KEGGimmu:12401.
UCSCiuc007owa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70533 mRNA. Translation: CAA49934.1 .
CCDSi CCDS26135.1.
PIRi S33415.
RefSeqi NP_031644.1. NM_007618.2.
UniGenei Mm.290079.

3D structure databases

ProteinModelPortali Q06770.
SMRi Q06770. Positions 29-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000044033.

Protein family/group databases

MEROPSi I04.954.

Proteomic databases

MaxQBi Q06770.
PaxDbi Q06770.
PRIDEi Q06770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044159 ; ENSMUSP00000044033 ; ENSMUSG00000060807 .
GeneIDi 12401.
KEGGi mmu:12401.
UCSCi uc007owa.1. mouse.

Organism-specific databases

CTDi 866.
MGIi MGI:88278. Serpina6.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118839.
HOGENOMi HOG000238521.
HOVERGENi HBG005957.
InParanoidi Q06770.
OMAi STREENF.
OrthoDBi EOG7J446W.
PhylomeDBi Q06770.
TreeFami TF343201.

Miscellaneous databases

NextBioi 281166.
PROi Q06770.
SOURCEi Search...

Gene expression databases

Bgeei Q06770.
ExpressionAtlasi Q06770. baseline and differential.
Genevestigatori Q06770.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice."
    Scrocchi L.A., Orava M., Smith C.L., Han V.K.M., Hammond G.L.
    Endocrinology 132:903-909(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89; ASN-217 AND ASN-232.
    Strain: C57BL/6.
    Tissue: Plasma.
  3. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiCBG_MOUSE
AccessioniPrimary (citable) accession number: Q06770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3