Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine acetyltransferase

Gene

cysE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the acetylation of serine by acetyl-CoA to produce O-acetylserine (OAS).

Catalytic activityi

Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.1 Publication

Enzyme regulationi

Inhibited by cysteine.1 Publication

Pathwayi: L-cysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-cysteine from L-serine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Serine acetyltransferase (cysE)
  2. Probable cysteine synthase (ytkP), Cysteine synthase (cysK)
This subpathway is part of the pathway L-cysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-cysteine from L-serine, the pathway L-cysteine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • serine O-acetyltransferase activity Source: CAFA

GO - Biological processi

  • cysteine biosynthetic process Source: CAFA
  • cysteine biosynthetic process from serine Source: InterPro
  • methionine catabolic process Source: CAFA

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Cysteine biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU00930-MONOMER
UniPathwayiUPA00136; UER00199

Names & Taxonomyi

Protein namesi
Recommended name:
Serine acetyltransferase (EC:2.3.1.30)
Short name:
SAT
Gene namesi
Name:cysE
Synonyms:cysA
Ordered Locus Names:BSU00930
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686651 – 217Serine acetyltransferaseAdd BLAST217

Proteomic databases

PaxDbiQ06750
PRIDEiQ06750

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000485

Structurei

3D structure databases

ProteinModelPortaliQ06750
SMRiQ06750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105D7W Bacteria
COG1045 LUCA
HOGENOMiHOG000049432
InParanoidiQ06750
KOiK00640
OMAiDGCTIYQ
PhylomeDBiQ06750

Family and domain databases

InterProiView protein in InterPro
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR010493 Ser_AcTrfase_N
IPR005881 Ser_O-AcTrfase
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00132 Hexapep, 2 hits
PF06426 SATase_N, 1 hit
PIRSFiPIRSF000441 CysE, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01172 cysE, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q06750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFRMLKEDI DTVFDQDPAA RSYFEVILTY SGLHAIWAHR IAHALYKRKF
60 70 80 90 100
YFLARLISQV SRFFTGIEIH PGATIGRRFF IDHGMGVVIG ETCEIGNNVT
110 120 130 140 150
VFQGVTLGGT GKEKGKRHPT IKDDALIATG AKVLGSITVG EGSKIGAGSV
160 170 180 190 200
VLHDVPDFST VVGIPGRVVV QNGKKVRRDL NHQDLPDPVA DRFKSLEQQI
210
LELKAELEDR KERINQK
Length:217
Mass (Da):24,143
Last modified:June 1, 1994 - v1
Checksum:i14EFA32FA1086D9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14580 Genomic DNA Translation: AAA21797.1
D26185 Genomic DNA Translation: BAA05327.1
AL009126 Genomic DNA Translation: CAB11869.1
PIRiB53402
RefSeqiNP_387974.1, NC_000964.3
WP_003225749.1, NZ_JNCM01000029.1

Genome annotation databases

EnsemblBacteriaiCAB11869; CAB11869; BSU00930
GeneIDi936831
KEGGibsu:BSU00930
PATRICifig|224308.179.peg.96

Similar proteinsi

Entry informationi

Entry nameiCYSE_BACSU
AccessioniPrimary (citable) accession number: Q06750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health