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Q06750

- CYSE_BACSU

UniProt

Q06750 - CYSE_BACSU

Protein

Serine acetyltransferase

Gene

cysE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the acetylation of serine by acetyl-CoA to produce O-acetylserine (OAS).

    Catalytic activityi

    Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.1 Publication

    Enzyme regulationi

    Inhibited by cysteine.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. serine O-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cysteine biosynthetic process from serine Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Cysteine biosynthesis

    Enzyme and pathway databases

    BioCyciBSUB:BSU00930-MONOMER.
    UniPathwayiUPA00136; UER00199.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine acetyltransferase (EC:2.3.1.30)
    Short name:
    SAT
    Gene namesi
    Name:cysE
    Synonyms:cysA
    Ordered Locus Names:BSU00930
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU00930. [Micado]

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Serine acetyltransferasePRO_0000068665Add
    BLAST

    Proteomic databases

    PaxDbiQ06750.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU00930.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06750.
    SMRiQ06750. Positions 2-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1045.
    HOGENOMiHOG000049432.
    KOiK00640.
    OMAiDNVTVYQ.
    OrthoDBiEOG6HMXK6.
    PhylomeDBiQ06750.

    Family and domain databases

    InterProiIPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010493. Ser_AcTrfase_N.
    IPR005881. Ser_O-AcTrfase.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF00132. Hexapep. 1 hit.
    PF06426. SATase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000441. CysE. 1 hit.
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01172. cysE. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06750-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFRMLKEDI DTVFDQDPAA RSYFEVILTY SGLHAIWAHR IAHALYKRKF    50
    YFLARLISQV SRFFTGIEIH PGATIGRRFF IDHGMGVVIG ETCEIGNNVT 100
    VFQGVTLGGT GKEKGKRHPT IKDDALIATG AKVLGSITVG EGSKIGAGSV 150
    VLHDVPDFST VVGIPGRVVV QNGKKVRRDL NHQDLPDPVA DRFKSLEQQI 200
    LELKAELEDR KERINQK 217
    Length:217
    Mass (Da):24,143
    Last modified:June 1, 1994 - v1
    Checksum:i14EFA32FA1086D9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14580 Genomic DNA. Translation: AAA21797.1.
    D26185 Genomic DNA. Translation: BAA05327.1.
    AL009126 Genomic DNA. Translation: CAB11869.1.
    PIRiB53402.
    RefSeqiNP_387974.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB11869; CAB11869; BSU00930.
    GeneIDi936831.
    KEGGibsu:BSU00930.
    PATRICi18971695. VBIBacSub10457_0096.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14580 Genomic DNA. Translation: AAA21797.1 .
    D26185 Genomic DNA. Translation: BAA05327.1 .
    AL009126 Genomic DNA. Translation: CAB11869.1 .
    PIRi B53402.
    RefSeqi NP_387974.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali Q06750.
    SMRi Q06750. Positions 2-215.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU00930.

    Proteomic databases

    PaxDbi Q06750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB11869 ; CAB11869 ; BSU00930 .
    GeneIDi 936831.
    KEGGi bsu:BSU00930.
    PATRICi 18971695. VBIBacSub10457_0096.

    Organism-specific databases

    GenoListi BSU00930. [Micado ]

    Phylogenomic databases

    eggNOGi COG1045.
    HOGENOMi HOG000049432.
    KOi K00640.
    OMAi DNVTVYQ.
    OrthoDBi EOG6HMXK6.
    PhylomeDBi Q06750.

    Enzyme and pathway databases

    UniPathwayi UPA00136 ; UER00199 .
    BioCyci BSUB:BSU00930-MONOMER.

    Family and domain databases

    InterProi IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010493. Ser_AcTrfase_N.
    IPR005881. Ser_O-AcTrfase.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF00132. Hexapep. 1 hit.
    PF06426. SATase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000441. CysE. 1 hit.
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01172. cysE. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Clustering and co-transcription of the Bacillus subtilis genes encoding the aminoacyl-tRNA synthetases specific for glutamate and for cysteine and the first enzyme for cysteine biosynthesis."
      Gagnon Y., Breton R., Putzer H., Pelchat M., Grunberg-Manago M., Lapointe J.
      J. Biol. Chem. 269:7473-7482(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin."
      Ogasawara N., Nakai S., Yoshikawa H.
      DNA Res. 1:1-14(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    4. "The CymR regulator in complex with the enzyme CysK controls cysteine metabolism in Bacillus subtilis."
      Tanous C., Soutourina O., Raynal B., Hullo M.-F., Mervelet P., Gilles A.-M., Noirot P., Danchin A., England P., Martin-Verstraete I.
      J. Biol. Chem. 283:35551-35560(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY, ENZYME REGULATION.
      Strain: 168.

    Entry informationi

    Entry nameiCYSE_BACSU
    AccessioniPrimary (citable) accession number: Q06750
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3