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Protein

Zinc finger protein 33B

Gene

ZNF33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri329 – 35123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 60323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri637 – 65923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri665 – 68723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri693 – 71523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri721 – 74323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri749 – 77123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 33B
Alternative name(s):
Zinc finger protein 11B
Zinc finger protein KOX2
Gene namesi
Name:ZNF33B
Synonyms:KOX2, ZNF11B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:13097. ZNF33B.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 778778Zinc finger protein 33BPRO_0000047334Add
BLAST

Proteomic databases

PaxDbiQ06732.
PRIDEiQ06732.

PTM databases

PhosphoSiteiQ06732.

Expressioni

Gene expression databases

BgeeiQ06732.
CleanExiHS_ZNF33B.
GenevestigatoriQ06732.

Interactioni

Protein-protein interaction databases

BioGridi113411. 3 interactions.
IntActiQ06732. 4 interactions.
MINTiMINT-1411018.
STRINGi9606.ENSP00000352444.

Structurei

3D structure databases

ProteinModelPortaliQ06732.
SMRiQ06732. Positions 12-53, 224-778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8372KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri329 – 35123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 60323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri637 – 65923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri665 – 68723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri693 – 71523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri721 – 74323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri749 – 77123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118917.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ06732.
KOiK09228.
OMAiSKDSHYE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ06732.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06732-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKVDQKFQG SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS
60 70 80 90 100
VGYCAHKPEV IFRLEQGEEP WRLEEEFPSQ SFPEVWTADH LKERSQENQS
110 120 130 140 150
KHLWEVVFIN NEMLTKEQGN VIGIPFNMDV SSFPSRKMFC QYDSRGMSFN
160 170 180 190 200
TVSELVISKI NYLGKKSDEF NACGKLLLNI KHDETHTREK NEVLKNRNTL
210 220 230 240 250
SHRENTLQHE KIQTLDHNFE YSICQETLLE KAVFNTRKRE NAEENNCDYN
260 270 280 290 300
EFGRTFCDSS SLLFHQIPPS KDSHYEFSDC EKFLCVKSTL SKHDGVPVKH
310 320 330 340 350
YDCGESGNNF RRKLCLSQLQ KGDKGEKHFE CNECGKAFWE KSHLTRHQRV
360 370 380 390 400
HTGEKHFQCN QCGKTFWEKS NLTKHQRSHT GEKPFECNEC GKAFSHKSAL
410 420 430 440 450
TLHQRTHTGE KPYQCNACGK TFYQKSDLTK HQRTHTGQKP YECYECGKSF
460 470 480 490 500
CMNSHLTVHQ RTHTGEKPFE CLECGKSFCQ KSHLTQHQRT HIGDKPYECN
510 520 530 540 550
ACGKTFYHKS VLTRHQIIHT GLKPYECYEC GKTFCLKSDL TIHQRTHTGE
560 570 580 590 600
KPFACPECGK FFSHKSTLSQ HYRTHTGEKP YECHECGKIF YNKSYLTKHN
610 620 630 640 650
RTHTGEKPYE CNECGKTFCQ KSQLTQHQRI HIGEKPYECN ECGKAFCHKS
660 670 680 690 700
ALIVHQRTHT QEKPYKCNEC GKSFCVKSGL ILHERKHTGE KPYECNECGK
710 720 730 740 750
SFSHKSSLTV HHRAHTGEKS CQCNECGKIF YRKSDLAKHQ RSHTGEKPYE
760 770
CNTCRKTFSQ KSNLIVHQRT HIGEKPYE
Length:778
Mass (Da):90,683
Last modified:May 24, 2005 - v2
Checksum:iD53D23909751DCEF
GO

Sequence cautioni

The sequence AAH48313.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti392 – 3921K → E in CAA36559. (PubMed:2288909)Curated
Sequence conflicti420 – 4201K → E in CAA36559. (PubMed:2288909)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451R → C.2 Publications
Corresponds to variant rs210280 [ dbSNP | Ensembl ].
VAR_024192
Natural varianti356 – 3561H → R.
Corresponds to variant rs7914982 [ dbSNP | Ensembl ].
VAR_052752

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491697 mRNA. Translation: CAD36956.1.
AL022345 Genomic DNA. Translation: CAI23623.1.
BC048313 mRNA. Translation: AAH48313.1. Sequence problems.
X68684 mRNA. Translation: CAA48643.1.
X68685 Genomic DNA. Translation: CAA48644.1.
X68688 Genomic DNA. Translation: CAA48647.1.
X52333 mRNA. Translation: CAA36559.1.
CCDSiCCDS7198.1.
PIRiI37959.
S33989. S33994.
S33993.
RefSeqiNP_008886.1. NM_006955.1.
UniGeneiHs.732284.

Genome annotation databases

EnsembliENST00000359467; ENSP00000352444; ENSG00000196693.
GeneIDi7582.
KEGGihsa:7582.
UCSCiuc001jaf.1. human.

Polymorphism databases

DMDMi66774229.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491697 mRNA. Translation: CAD36956.1.
AL022345 Genomic DNA. Translation: CAI23623.1.
BC048313 mRNA. Translation: AAH48313.1. Sequence problems.
X68684 mRNA. Translation: CAA48643.1.
X68685 Genomic DNA. Translation: CAA48644.1.
X68688 Genomic DNA. Translation: CAA48647.1.
X52333 mRNA. Translation: CAA36559.1.
CCDSiCCDS7198.1.
PIRiI37959.
S33989. S33994.
S33993.
RefSeqiNP_008886.1. NM_006955.1.
UniGeneiHs.732284.

3D structure databases

ProteinModelPortaliQ06732.
SMRiQ06732. Positions 12-53, 224-778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113411. 3 interactions.
IntActiQ06732. 4 interactions.
MINTiMINT-1411018.
STRINGi9606.ENSP00000352444.

PTM databases

PhosphoSiteiQ06732.

Polymorphism databases

DMDMi66774229.

Proteomic databases

PaxDbiQ06732.
PRIDEiQ06732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359467; ENSP00000352444; ENSG00000196693.
GeneIDi7582.
KEGGihsa:7582.
UCSCiuc001jaf.1. human.

Organism-specific databases

CTDi7582.
GeneCardsiGC10M043084.
HGNCiHGNC:13097. ZNF33B.
MIMi194522. gene.
neXtProtiNX_Q06732.
PharmGKBiPA37672.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118917.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ06732.
KOiK09228.
OMAiSKDSHYE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ06732.
TreeFamiTF337898.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF33B.
GenomeRNAii7582.
NextBioi29645.
PROiQ06732.
SOURCEiSearch...

Gene expression databases

BgeeiQ06732.
CleanExiHS_ZNF33B.
GenevestigatoriQ06732.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p."
    Guy J., Hearn T., Crosier M., Mudge J., Viggiano L., Koczan D., Thiesen H.-J., Bailey J.A., Horvath J.E., Eichler E.E., Earthrowl M.E., Deloukas P., French L., Rogers J., Bentley D., Jackson M.S.
    Genome Res. 13:159-172(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-579, VARIANT CYS-145.
    Tissue: Duodenum.
  4. "Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution."
    Tunnacliffe A., Liu L., Moore J.K., Leversha M.A., Jackson M.S., Ferguson-Smith M.A., Thiesen H.-J., Ponder B.A.
    Nucleic Acids Res. 21:1409-1417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 76-454 AND 745-778, VARIANT CYS-145.
  5. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 385-440.
    Tissue: Lymphoid tissue.

Entry informationi

Entry nameiZN33B_HUMAN
AccessioniPrimary (citable) accession number: Q06732
Secondary accession number(s): Q06731
, Q32MA2, Q86XY8, Q8NDW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: February 4, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.