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Q06732

- ZN33B_HUMAN

UniProt

Q06732 - ZN33B_HUMAN

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Protein

Zinc finger protein 33B

Gene
ZNF33B, KOX2, ZNF11B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri329 – 35123C2H2-type 1Add
BLAST
Zinc fingeri357 – 37923C2H2-type 2Add
BLAST
Zinc fingeri385 – 40723C2H2-type 3Add
BLAST
Zinc fingeri413 – 43523C2H2-type 4Add
BLAST
Zinc fingeri441 – 46323C2H2-type 5Add
BLAST
Zinc fingeri469 – 49123C2H2-type 6Add
BLAST
Zinc fingeri497 – 51923C2H2-type 7Add
BLAST
Zinc fingeri525 – 54723C2H2-type 8Add
BLAST
Zinc fingeri553 – 57523C2H2-type 9Add
BLAST
Zinc fingeri581 – 60323C2H2-type 10Add
BLAST
Zinc fingeri609 – 63123C2H2-type 11Add
BLAST
Zinc fingeri637 – 65923C2H2-type 12Add
BLAST
Zinc fingeri665 – 68723C2H2-type 13Add
BLAST
Zinc fingeri693 – 71523C2H2-type 14Add
BLAST
Zinc fingeri721 – 74323C2H2-type 15Add
BLAST
Zinc fingeri749 – 77123C2H2-type 16Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 33B
Alternative name(s):
Zinc finger protein 11B
Zinc finger protein KOX2
Gene namesi
Name:ZNF33B
Synonyms:KOX2, ZNF11B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:13097. ZNF33B.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 778778Zinc finger protein 33BPRO_0000047334Add
BLAST

Proteomic databases

PaxDbiQ06732.
PRIDEiQ06732.

PTM databases

PhosphoSiteiQ06732.

Expressioni

Gene expression databases

BgeeiQ06732.
CleanExiHS_ZNF33B.
GenevestigatoriQ06732.

Interactioni

Protein-protein interaction databases

BioGridi113411. 3 interactions.
IntActiQ06732. 4 interactions.
MINTiMINT-1411018.
STRINGi9606.ENSP00000352444.

Structurei

3D structure databases

ProteinModelPortaliQ06732.
SMRiQ06732. Positions 12-53, 224-778.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8372KRABAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ06732.
KOiK09228.
OMAiSKDSHYE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ06732.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06732-1 [UniParc]FASTAAdd to Basket

« Hide

MNKVDQKFQG SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS    50
VGYCAHKPEV IFRLEQGEEP WRLEEEFPSQ SFPEVWTADH LKERSQENQS 100
KHLWEVVFIN NEMLTKEQGN VIGIPFNMDV SSFPSRKMFC QYDSRGMSFN 150
TVSELVISKI NYLGKKSDEF NACGKLLLNI KHDETHTREK NEVLKNRNTL 200
SHRENTLQHE KIQTLDHNFE YSICQETLLE KAVFNTRKRE NAEENNCDYN 250
EFGRTFCDSS SLLFHQIPPS KDSHYEFSDC EKFLCVKSTL SKHDGVPVKH 300
YDCGESGNNF RRKLCLSQLQ KGDKGEKHFE CNECGKAFWE KSHLTRHQRV 350
HTGEKHFQCN QCGKTFWEKS NLTKHQRSHT GEKPFECNEC GKAFSHKSAL 400
TLHQRTHTGE KPYQCNACGK TFYQKSDLTK HQRTHTGQKP YECYECGKSF 450
CMNSHLTVHQ RTHTGEKPFE CLECGKSFCQ KSHLTQHQRT HIGDKPYECN 500
ACGKTFYHKS VLTRHQIIHT GLKPYECYEC GKTFCLKSDL TIHQRTHTGE 550
KPFACPECGK FFSHKSTLSQ HYRTHTGEKP YECHECGKIF YNKSYLTKHN 600
RTHTGEKPYE CNECGKTFCQ KSQLTQHQRI HIGEKPYECN ECGKAFCHKS 650
ALIVHQRTHT QEKPYKCNEC GKSFCVKSGL ILHERKHTGE KPYECNECGK 700
SFSHKSSLTV HHRAHTGEKS CQCNECGKIF YRKSDLAKHQ RSHTGEKPYE 750
CNTCRKTFSQ KSNLIVHQRT HIGEKPYE 778
Length:778
Mass (Da):90,683
Last modified:May 24, 2005 - v2
Checksum:iD53D23909751DCEF
GO

Sequence cautioni

The sequence AAH48313.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451R → C.2 Publications
Corresponds to variant rs210280 [ dbSNP | Ensembl ].
VAR_024192
Natural varianti356 – 3561H → R.
Corresponds to variant rs7914982 [ dbSNP | Ensembl ].
VAR_052752

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti392 – 3921K → E in CAA36559. 1 Publication
Sequence conflicti420 – 4201K → E in CAA36559. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ491697 mRNA. Translation: CAD36956.1.
AL022345 Genomic DNA. Translation: CAI23623.1.
BC048313 mRNA. Translation: AAH48313.1. Sequence problems.
X68684 mRNA. Translation: CAA48643.1.
X68685 Genomic DNA. Translation: CAA48644.1.
X68688 Genomic DNA. Translation: CAA48647.1.
X52333 mRNA. Translation: CAA36559.1.
CCDSiCCDS7198.1.
PIRiI37959.
S33989. S33994.
S33993.
RefSeqiNP_008886.1. NM_006955.1.
UniGeneiHs.732284.

Genome annotation databases

EnsembliENST00000359467; ENSP00000352444; ENSG00000196693.
GeneIDi7582.
KEGGihsa:7582.
UCSCiuc001jaf.1. human.

Polymorphism databases

DMDMi66774229.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ491697 mRNA. Translation: CAD36956.1 .
AL022345 Genomic DNA. Translation: CAI23623.1 .
BC048313 mRNA. Translation: AAH48313.1 . Sequence problems.
X68684 mRNA. Translation: CAA48643.1 .
X68685 Genomic DNA. Translation: CAA48644.1 .
X68688 Genomic DNA. Translation: CAA48647.1 .
X52333 mRNA. Translation: CAA36559.1 .
CCDSi CCDS7198.1.
PIRi I37959.
S33989. S33994.
S33993.
RefSeqi NP_008886.1. NM_006955.1.
UniGenei Hs.732284.

3D structure databases

ProteinModelPortali Q06732.
SMRi Q06732. Positions 12-53, 224-778.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113411. 3 interactions.
IntActi Q06732. 4 interactions.
MINTi MINT-1411018.
STRINGi 9606.ENSP00000352444.

PTM databases

PhosphoSitei Q06732.

Polymorphism databases

DMDMi 66774229.

Proteomic databases

PaxDbi Q06732.
PRIDEi Q06732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359467 ; ENSP00000352444 ; ENSG00000196693 .
GeneIDi 7582.
KEGGi hsa:7582.
UCSCi uc001jaf.1. human.

Organism-specific databases

CTDi 7582.
GeneCardsi GC10M043084.
HGNCi HGNC:13097. ZNF33B.
MIMi 194522. gene.
neXtProti NX_Q06732.
PharmGKBi PA37672.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q06732.
KOi K09228.
OMAi SKDSHYE.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q06732.
TreeFami TF337898.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF33B.
GenomeRNAii 7582.
NextBioi 29645.
PROi Q06732.
SOURCEi Search...

Gene expression databases

Bgeei Q06732.
CleanExi HS_ZNF33B.
Genevestigatori Q06732.

Family and domain databases

Gene3Di 3.30.160.60. 16 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p."
    Guy J., Hearn T., Crosier M., Mudge J., Viggiano L., Koczan D., Thiesen H.-J., Bailey J.A., Horvath J.E., Eichler E.E., Earthrowl M.E., Deloukas P., French L., Rogers J., Bentley D., Jackson M.S.
    Genome Res. 13:159-172(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-579, VARIANT CYS-145.
    Tissue: Duodenum.
  4. "Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution."
    Tunnacliffe A., Liu L., Moore J.K., Leversha M.A., Jackson M.S., Ferguson-Smith M.A., Thiesen H.-J., Ponder B.A.
    Nucleic Acids Res. 21:1409-1417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 76-454 AND 745-778, VARIANT CYS-145.
  5. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 385-440.
    Tissue: Lymphoid tissue.

Entry informationi

Entry nameiZN33B_HUMAN
AccessioniPrimary (citable) accession number: Q06732
Secondary accession number(s): Q06731
, Q32MA2, Q86XY8, Q8NDW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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