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Q06732

- ZN33B_HUMAN

UniProt

Q06732 - ZN33B_HUMAN

Protein

Zinc finger protein 33B

Gene

ZNF33B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (24 May 2005)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri329 – 35123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri357 – 37923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri385 – 40723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri413 – 43523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri441 – 46323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri469 – 49123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri497 – 51923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri553 – 57523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri581 – 60323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri609 – 63123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri637 – 65923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri665 – 68723C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri693 – 71523C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri721 – 74323C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri749 – 77123C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 33B
    Alternative name(s):
    Zinc finger protein 11B
    Zinc finger protein KOX2
    Gene namesi
    Name:ZNF33B
    Synonyms:KOX2, ZNF11B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:13097. ZNF33B.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37672.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 778778Zinc finger protein 33BPRO_0000047334Add
    BLAST

    Proteomic databases

    PaxDbiQ06732.
    PRIDEiQ06732.

    PTM databases

    PhosphoSiteiQ06732.

    Expressioni

    Gene expression databases

    BgeeiQ06732.
    CleanExiHS_ZNF33B.
    GenevestigatoriQ06732.

    Interactioni

    Protein-protein interaction databases

    BioGridi113411. 3 interactions.
    IntActiQ06732. 4 interactions.
    MINTiMINT-1411018.
    STRINGi9606.ENSP00000352444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06732.
    SMRiQ06732. Positions 12-53, 224-778.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 8372KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri329 – 35123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri357 – 37923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri385 – 40723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri413 – 43523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri441 – 46323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri469 – 49123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri497 – 51923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri553 – 57523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri581 – 60323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri609 – 63123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri637 – 65923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri665 – 68723C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri693 – 71523C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri721 – 74323C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri749 – 77123C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ06732.
    KOiK09228.
    OMAiSKDSHYE.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ06732.
    TreeFamiTF337898.

    Family and domain databases

    Gene3Di3.30.160.60. 16 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 16 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 16 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06732-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKVDQKFQG SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS    50
    VGYCAHKPEV IFRLEQGEEP WRLEEEFPSQ SFPEVWTADH LKERSQENQS 100
    KHLWEVVFIN NEMLTKEQGN VIGIPFNMDV SSFPSRKMFC QYDSRGMSFN 150
    TVSELVISKI NYLGKKSDEF NACGKLLLNI KHDETHTREK NEVLKNRNTL 200
    SHRENTLQHE KIQTLDHNFE YSICQETLLE KAVFNTRKRE NAEENNCDYN 250
    EFGRTFCDSS SLLFHQIPPS KDSHYEFSDC EKFLCVKSTL SKHDGVPVKH 300
    YDCGESGNNF RRKLCLSQLQ KGDKGEKHFE CNECGKAFWE KSHLTRHQRV 350
    HTGEKHFQCN QCGKTFWEKS NLTKHQRSHT GEKPFECNEC GKAFSHKSAL 400
    TLHQRTHTGE KPYQCNACGK TFYQKSDLTK HQRTHTGQKP YECYECGKSF 450
    CMNSHLTVHQ RTHTGEKPFE CLECGKSFCQ KSHLTQHQRT HIGDKPYECN 500
    ACGKTFYHKS VLTRHQIIHT GLKPYECYEC GKTFCLKSDL TIHQRTHTGE 550
    KPFACPECGK FFSHKSTLSQ HYRTHTGEKP YECHECGKIF YNKSYLTKHN 600
    RTHTGEKPYE CNECGKTFCQ KSQLTQHQRI HIGEKPYECN ECGKAFCHKS 650
    ALIVHQRTHT QEKPYKCNEC GKSFCVKSGL ILHERKHTGE KPYECNECGK 700
    SFSHKSSLTV HHRAHTGEKS CQCNECGKIF YRKSDLAKHQ RSHTGEKPYE 750
    CNTCRKTFSQ KSNLIVHQRT HIGEKPYE 778
    Length:778
    Mass (Da):90,683
    Last modified:May 24, 2005 - v2
    Checksum:iD53D23909751DCEF
    GO

    Sequence cautioni

    The sequence AAH48313.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti392 – 3921K → E in CAA36559. (PubMed:2288909)Curated
    Sequence conflicti420 – 4201K → E in CAA36559. (PubMed:2288909)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti145 – 1451R → C.2 Publications
    Corresponds to variant rs210280 [ dbSNP | Ensembl ].
    VAR_024192
    Natural varianti356 – 3561H → R.
    Corresponds to variant rs7914982 [ dbSNP | Ensembl ].
    VAR_052752

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ491697 mRNA. Translation: CAD36956.1.
    AL022345 Genomic DNA. Translation: CAI23623.1.
    BC048313 mRNA. Translation: AAH48313.1. Sequence problems.
    X68684 mRNA. Translation: CAA48643.1.
    X68685 Genomic DNA. Translation: CAA48644.1.
    X68688 Genomic DNA. Translation: CAA48647.1.
    X52333 mRNA. Translation: CAA36559.1.
    CCDSiCCDS7198.1.
    PIRiI37959.
    S33989. S33994.
    S33993.
    RefSeqiNP_008886.1. NM_006955.1.
    UniGeneiHs.732284.

    Genome annotation databases

    EnsembliENST00000359467; ENSP00000352444; ENSG00000196693.
    GeneIDi7582.
    KEGGihsa:7582.
    UCSCiuc001jaf.1. human.

    Polymorphism databases

    DMDMi66774229.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ491697 mRNA. Translation: CAD36956.1 .
    AL022345 Genomic DNA. Translation: CAI23623.1 .
    BC048313 mRNA. Translation: AAH48313.1 . Sequence problems.
    X68684 mRNA. Translation: CAA48643.1 .
    X68685 Genomic DNA. Translation: CAA48644.1 .
    X68688 Genomic DNA. Translation: CAA48647.1 .
    X52333 mRNA. Translation: CAA36559.1 .
    CCDSi CCDS7198.1.
    PIRi I37959.
    S33989. S33994.
    S33993.
    RefSeqi NP_008886.1. NM_006955.1.
    UniGenei Hs.732284.

    3D structure databases

    ProteinModelPortali Q06732.
    SMRi Q06732. Positions 12-53, 224-778.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113411. 3 interactions.
    IntActi Q06732. 4 interactions.
    MINTi MINT-1411018.
    STRINGi 9606.ENSP00000352444.

    PTM databases

    PhosphoSitei Q06732.

    Polymorphism databases

    DMDMi 66774229.

    Proteomic databases

    PaxDbi Q06732.
    PRIDEi Q06732.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359467 ; ENSP00000352444 ; ENSG00000196693 .
    GeneIDi 7582.
    KEGGi hsa:7582.
    UCSCi uc001jaf.1. human.

    Organism-specific databases

    CTDi 7582.
    GeneCardsi GC10M043084.
    HGNCi HGNC:13097. ZNF33B.
    MIMi 194522. gene.
    neXtProti NX_Q06732.
    PharmGKBi PA37672.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q06732.
    KOi K09228.
    OMAi SKDSHYE.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q06732.
    TreeFami TF337898.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF33B.
    GenomeRNAii 7582.
    NextBioi 29645.
    PROi Q06732.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q06732.
    CleanExi HS_ZNF33B.
    Genevestigatori Q06732.

    Family and domain databases

    Gene3Di 3.30.160.60. 16 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 16 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 16 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p."
      Guy J., Hearn T., Crosier M., Mudge J., Viggiano L., Koczan D., Thiesen H.-J., Bailey J.A., Horvath J.E., Eichler E.E., Earthrowl M.E., Deloukas P., French L., Rogers J., Bentley D., Jackson M.S.
      Genome Res. 13:159-172(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-579, VARIANT CYS-145.
      Tissue: Duodenum.
    4. "Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution."
      Tunnacliffe A., Liu L., Moore J.K., Leversha M.A., Jackson M.S., Ferguson-Smith M.A., Thiesen H.-J., Ponder B.A.
      Nucleic Acids Res. 21:1409-1417(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 76-454 AND 745-778, VARIANT CYS-145.
    5. "Multiple genes encoding zinc finger domains are expressed in human T cells."
      Thiesen H.-J.
      New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 385-440.
      Tissue: Lymphoid tissue.

    Entry informationi

    Entry nameiZN33B_HUMAN
    AccessioniPrimary (citable) accession number: Q06732
    Secondary accession number(s): Q06731
    , Q32MA2, Q86XY8, Q8NDW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3