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Q06732 (ZN33B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 33B
Alternative name(s):
Zinc finger protein 11B
Zinc finger protein KOX2
Gene names
Name:ZNF33B
Synonyms:KOX2, ZNF11B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length778 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 16 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAH48313.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 778778Zinc finger protein 33B
PRO_0000047334

Regions

Domain12 – 8372KRAB
Zinc finger329 – 35123C2H2-type 1
Zinc finger357 – 37923C2H2-type 2
Zinc finger385 – 40723C2H2-type 3
Zinc finger413 – 43523C2H2-type 4
Zinc finger441 – 46323C2H2-type 5
Zinc finger469 – 49123C2H2-type 6
Zinc finger497 – 51923C2H2-type 7
Zinc finger525 – 54723C2H2-type 8
Zinc finger553 – 57523C2H2-type 9
Zinc finger581 – 60323C2H2-type 10
Zinc finger609 – 63123C2H2-type 11
Zinc finger637 – 65923C2H2-type 12
Zinc finger665 – 68723C2H2-type 13
Zinc finger693 – 71523C2H2-type 14
Zinc finger721 – 74323C2H2-type 15
Zinc finger749 – 77123C2H2-type 16

Natural variations

Natural variant1451R → C. Ref.3 Ref.4
Corresponds to variant rs210280 [ dbSNP | Ensembl ].
VAR_024192
Natural variant3561H → R.
Corresponds to variant rs7914982 [ dbSNP | Ensembl ].
VAR_052752

Experimental info

Sequence conflict3921K → E in CAA36559. Ref.5
Sequence conflict4201K → E in CAA36559. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q06732 [UniParc].

Last modified May 24, 2005. Version 2.
Checksum: D53D23909751DCEF

FASTA77890,683
        10         20         30         40         50         60 
MNKVDQKFQG SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS VGYCAHKPEV 

        70         80         90        100        110        120 
IFRLEQGEEP WRLEEEFPSQ SFPEVWTADH LKERSQENQS KHLWEVVFIN NEMLTKEQGN 

       130        140        150        160        170        180 
VIGIPFNMDV SSFPSRKMFC QYDSRGMSFN TVSELVISKI NYLGKKSDEF NACGKLLLNI 

       190        200        210        220        230        240 
KHDETHTREK NEVLKNRNTL SHRENTLQHE KIQTLDHNFE YSICQETLLE KAVFNTRKRE 

       250        260        270        280        290        300 
NAEENNCDYN EFGRTFCDSS SLLFHQIPPS KDSHYEFSDC EKFLCVKSTL SKHDGVPVKH 

       310        320        330        340        350        360 
YDCGESGNNF RRKLCLSQLQ KGDKGEKHFE CNECGKAFWE KSHLTRHQRV HTGEKHFQCN 

       370        380        390        400        410        420 
QCGKTFWEKS NLTKHQRSHT GEKPFECNEC GKAFSHKSAL TLHQRTHTGE KPYQCNACGK 

       430        440        450        460        470        480 
TFYQKSDLTK HQRTHTGQKP YECYECGKSF CMNSHLTVHQ RTHTGEKPFE CLECGKSFCQ 

       490        500        510        520        530        540 
KSHLTQHQRT HIGDKPYECN ACGKTFYHKS VLTRHQIIHT GLKPYECYEC GKTFCLKSDL 

       550        560        570        580        590        600 
TIHQRTHTGE KPFACPECGK FFSHKSTLSQ HYRTHTGEKP YECHECGKIF YNKSYLTKHN 

       610        620        630        640        650        660 
RTHTGEKPYE CNECGKTFCQ KSQLTQHQRI HIGEKPYECN ECGKAFCHKS ALIVHQRTHT 

       670        680        690        700        710        720 
QEKPYKCNEC GKSFCVKSGL ILHERKHTGE KPYECNECGK SFSHKSSLTV HHRAHTGEKS 

       730        740        750        760        770 
CQCNECGKIF YRKSDLAKHQ RSHTGEKPYE CNTCRKTFSQ KSNLIVHQRT HIGEKPYE 

« Hide

References

« Hide 'large scale' references
[1]"Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p."
Guy J., Hearn T., Crosier M., Mudge J., Viggiano L., Koczan D., Thiesen H.-J., Bailey J.A., Horvath J.E., Eichler E.E., Earthrowl M.E., Deloukas P., French L., Rogers J., Bentley D., Jackson M.S.
Genome Res. 13:159-172(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-579, VARIANT CYS-145.
Tissue: Duodenum.
[4]"Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution."
Tunnacliffe A., Liu L., Moore J.K., Leversha M.A., Jackson M.S., Ferguson-Smith M.A., Thiesen H.-J., Ponder B.A.
Nucleic Acids Res. 21:1409-1417(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 76-454 AND 745-778, VARIANT CYS-145.
[5]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 385-440.
Tissue: Lymphoid tissue.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ491697 mRNA. Translation: CAD36956.1.
AL022345 Genomic DNA. Translation: CAI23623.1.
BC048313 mRNA. Translation: AAH48313.1. Sequence problems.
X68684 mRNA. Translation: CAA48643.1.
X68685 Genomic DNA. Translation: CAA48644.1.
X68688 Genomic DNA. Translation: CAA48647.1.
X52333 mRNA. Translation: CAA36559.1.
CCDSCCDS7198.1.
PIRI37959.
S33994. S33989.
S33993.
RefSeqNP_008886.1. NM_006955.1.
UniGeneHs.732284.

3D structure databases

ProteinModelPortalQ06732.
SMRQ06732. Positions 12-53, 224-778.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113411. 3 interactions.
IntActQ06732. 4 interactions.
MINTMINT-1411018.
STRING9606.ENSP00000352444.

PTM databases

PhosphoSiteQ06732.

Polymorphism databases

DMDM66774229.

Proteomic databases

PaxDbQ06732.
PRIDEQ06732.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359467; ENSP00000352444; ENSG00000196693.
GeneID7582.
KEGGhsa:7582.
UCSCuc001jaf.1. human.

Organism-specific databases

CTD7582.
GeneCardsGC10M043084.
HGNCHGNC:13097. ZNF33B.
MIM194522. gene.
neXtProtNX_Q06732.
PharmGKBPA37672.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ06732.
KOK09228.
OMASKDSHYE.
OrthoDBEOG7KSX7Q.
PhylomeDBQ06732.
TreeFamTF337898.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ06732.
CleanExHS_ZNF33B.
GenevestigatorQ06732.

Family and domain databases

Gene3D3.30.160.60. 16 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF33B.
GenomeRNAi7582.
NextBio29645.
PROQ06732.
SOURCESearch...

Entry information

Entry nameZN33B_HUMAN
AccessionPrimary (citable) accession number: Q06732
Secondary accession number(s): Q06731 expand/collapse secondary AC list , Q32MA2, Q86XY8, Q8NDW3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM