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Protein

Zinc finger protein 33B

Gene

ZNF33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri329 – 351C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 33B
Alternative name(s):
Zinc finger protein 11B
Zinc finger protein KOX2
Gene namesi
Name:ZNF33B
Synonyms:KOX2, ZNF11B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000196693.14
HGNCiHGNC:13097 ZNF33B
MIMi194522 gene
neXtProtiNX_Q06732

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196693
PharmGKBiPA37672

Polymorphism and mutation databases

BioMutaiZNF33B
DMDMi66774229

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473341 – 778Zinc finger protein 33BAdd BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki677Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ06732
PaxDbiQ06732
PeptideAtlasiQ06732
PRIDEiQ06732

PTM databases

iPTMnetiQ06732
PhosphoSitePlusiQ06732

Expressioni

Gene expression databases

BgeeiENSG00000196693
CleanExiHS_ZNF33B
ExpressionAtlasiQ06732 baseline and differential
GenevisibleiQ06732 HS

Organism-specific databases

HPAiHPA005538
HPA056638

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA12P433653EBI-474142,EBI-749530

Protein-protein interaction databases

BioGridi1134114 interactors.
IntActiQ06732 5 interactors.
STRINGi9606.ENSP00000352444

Structurei

3D structure databases

ProteinModelPortaliQ06732
SMRiQ06732
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 83KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri329 – 351C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ06732
KOiK09228
PhylomeDBiQ06732
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequencei

Sequence statusi: Complete.

Q06732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKVDQKFQG SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS
60 70 80 90 100
VGYCAHKPEV IFRLEQGEEP WRLEEEFPSQ SFPEVWTADH LKERSQENQS
110 120 130 140 150
KHLWEVVFIN NEMLTKEQGN VIGIPFNMDV SSFPSRKMFC QYDSRGMSFN
160 170 180 190 200
TVSELVISKI NYLGKKSDEF NACGKLLLNI KHDETHTREK NEVLKNRNTL
210 220 230 240 250
SHRENTLQHE KIQTLDHNFE YSICQETLLE KAVFNTRKRE NAEENNCDYN
260 270 280 290 300
EFGRTFCDSS SLLFHQIPPS KDSHYEFSDC EKFLCVKSTL SKHDGVPVKH
310 320 330 340 350
YDCGESGNNF RRKLCLSQLQ KGDKGEKHFE CNECGKAFWE KSHLTRHQRV
360 370 380 390 400
HTGEKHFQCN QCGKTFWEKS NLTKHQRSHT GEKPFECNEC GKAFSHKSAL
410 420 430 440 450
TLHQRTHTGE KPYQCNACGK TFYQKSDLTK HQRTHTGQKP YECYECGKSF
460 470 480 490 500
CMNSHLTVHQ RTHTGEKPFE CLECGKSFCQ KSHLTQHQRT HIGDKPYECN
510 520 530 540 550
ACGKTFYHKS VLTRHQIIHT GLKPYECYEC GKTFCLKSDL TIHQRTHTGE
560 570 580 590 600
KPFACPECGK FFSHKSTLSQ HYRTHTGEKP YECHECGKIF YNKSYLTKHN
610 620 630 640 650
RTHTGEKPYE CNECGKTFCQ KSQLTQHQRI HIGEKPYECN ECGKAFCHKS
660 670 680 690 700
ALIVHQRTHT QEKPYKCNEC GKSFCVKSGL ILHERKHTGE KPYECNECGK
710 720 730 740 750
SFSHKSSLTV HHRAHTGEKS CQCNECGKIF YRKSDLAKHQ RSHTGEKPYE
760 770
CNTCRKTFSQ KSNLIVHQRT HIGEKPYE
Length:778
Mass (Da):90,683
Last modified:May 24, 2005 - v2
Checksum:iD53D23909751DCEF
GO

Sequence cautioni

The sequence AAH48313 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti392K → E in CAA36559 (PubMed:2288909).Curated1
Sequence conflicti420K → E in CAA36559 (PubMed:2288909).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024192145R → C2 PublicationsCorresponds to variant dbSNP:rs210280Ensembl.1
Natural variantiVAR_052752356H → R. Corresponds to variant dbSNP:rs7914982Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491697 mRNA Translation: CAD36956.1
AL022345 Genomic DNA No translation available.
BC048313 mRNA Translation: AAH48313.1 Sequence problems.
X68684 mRNA Translation: CAA48643.1
X68685 Genomic DNA Translation: CAA48644.1
X68688 Genomic DNA Translation: CAA48647.1
X52333 mRNA Translation: CAA36559.1
CCDSiCCDS7198.1
PIRiI37959
S33989 S33994
S33993
RefSeqiNP_001291962.1, NM_001305033.1
NP_001291964.1, NM_001305035.1
NP_001291965.1, NM_001305036.1
NP_001291966.1, NM_001305037.1
NP_001291967.1, NM_001305038.1
NP_001291968.1, NM_001305039.1
NP_001291969.1, NM_001305040.1
NP_008886.1, NM_006955.2
UniGeneiHs.435774
Hs.499453
Hs.732284

Genome annotation databases

EnsembliENST00000359467; ENSP00000352444; ENSG00000196693
GeneIDi7582
KEGGihsa:7582
UCSCiuc001jaf.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN33B_HUMAN
AccessioniPrimary (citable) accession number: Q06732
Secondary accession number(s): Q06731
, Q32MA2, Q86XY8, Q8NDW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome