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Protein

Zinc finger protein 33A

Gene

ZNF33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri328 – 35023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri552 – 57423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri580 – 60223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri608 – 63023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri636 – 65823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri664 – 68623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri692 – 71423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri720 – 74223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri748 – 77023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 33A
Alternative name(s):
Zinc finger and ZAK-associated protein with KRAB domain
Short name:
ZZaPK
Zinc finger protein 11A
Zinc finger protein KOX31
Gene namesi
Name:ZNF33A
Synonyms:KIAA0065, KOX31, ZNF11, ZNF11A, ZNF33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13096. ZNF33A.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37671.

Polymorphism and mutation databases

BioMutaiZNF33A.
DMDMi11140929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Zinc finger protein 33APRO_0000047363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki180 – 180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ06730.
PaxDbiQ06730.
PeptideAtlasiQ06730.
PRIDEiQ06730.

PTM databases

iPTMnetiQ06730.
PhosphoSiteiQ06730.

Expressioni

Gene expression databases

BgeeiENSG00000189180.
CleanExiHS_ZNF33A.
ExpressionAtlasiQ06730. baseline and differential.
GenevisibleiQ06730. HS.

Organism-specific databases

HPAiHPA056638.

Interactioni

Subunit structurei

Interacts with MLTK/ZAK.1 Publication

Protein-protein interaction databases

BioGridi113410. 7 interactions.
IntActiQ06730. 5 interactions.
STRINGi9606.ENSP00000363747.

Structurei

3D structure databases

ProteinModelPortaliQ06730.
SMRiQ06730. Positions 12-53, 223-806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8372KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri328 – 35023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri552 – 57423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri580 – 60223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri608 – 63023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri636 – 65823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri664 – 68623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri692 – 71423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri720 – 74223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri748 – 77023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ06730.
KOiK09228.
PhylomeDBiQ06730.
TreeFamiTF337898.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q06730-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKVEQKSQE SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS
60 70 80 90 100
VGYCVHKPEV IFRLQQGEEP WKQEEEFPSQ SFPVWTADHL KERSQENQSK
110 120 130 140 150
HLWEVVFINN EMLTKEQGDV IGIPFNVDVS SFPSRKMFCQ CDSCGMSFNT
160 170 180 190 200
VSELVISKIN YLGKKSDEFN ACGKLLLNIK HDETHTQEKN EVLKNRNTLS
210 220 230 240 250
HHEETLQHEK IQTLEHNFEY SICQETLLEK AVFNTQKREN AEENNCDYNE
260 270 280 290 300
FGRTLCDSSS LLFHQISPSR DNHYEFSDCE KFLCVKSTLS KPHGVSMKHY
310 320 330 340 350
DCGESGNNFR RKLCLSHLQK GDKGEKHFEC NECGKAFWEK SHLTRHQRVH
360 370 380 390 400
TGQKPFQCNE CEKAFWDKSN LTKHQRSHTG EKPFECNECG KAFSHKSALT
410 420 430 440 450
LHQRTHTGEK PYQCNACGKT FCQKSDLTKH QRTHTGLKPY ECYECGKSFR
460 470 480 490 500
VTSHLKVHQR THTGEKPFEC LECGKSFSEK SNLTQHQRIH IGDKSYECNA
510 520 530 540 550
CGKTFYHKSL LTRHQIIHTG WKPYECYECG KTFCLKSDLT VHQRTHTGQK
560 570 580 590 600
PFACPECGKF FSHKSTLSQH YRTHTGEKPY ECHECGKIFY NKSYLTKHNR
610 620 630 640 650
THTGEKPYEC NECGKAFYQK SQLTQHQRIH IGEKPYKCNE CGKAFCHKSA
660 670 680 690 700
LIVHQRTHTQ EKPYKCNECG KSFCVKSGLI FHERKHTGEK PYECNECGKF
710 720 730 740 750
FRHKSSLTVH HRAHTGEKSC QCNECGKIFY RKSELAQHQR SHTGEKPYEC
760 770 780 790 800
NTCRKTFSQK SNLIVHQRRH IGENLMNEMD IRNFQPQVSL HNASEYSHCG
810
ESPDDILNVQ
Length:810
Mass (Da):94,384
Last modified:December 1, 2000 - v3
Checksum:i96AD969EF541B73E
GO
Isoform 2 (identifier: Q06730-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-83: P → PE

Note: No experimental confirmation available.
Show »
Length:811
Mass (Da):94,513
Checksum:i639D2A6A5315F7FB
GO
Isoform 3 (identifier: Q06730-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MNK → MANATRRGSG

Show »
Length:817
Mass (Da):95,013
Checksum:iA45C996AB65DB86B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1291V → A in BAG64490 (PubMed:14702039).Curated
Sequence conflicti389 – 3891C → R in BAG64490 (PubMed:14702039).Curated
Sequence conflicti721 – 7211Q → H in BAF85533 (PubMed:14702039).Curated
Sequence conflicti745 – 7451E → K in BAF85533 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti549 – 5491Q → E.1 Publication
Corresponds to variant rs2505232 [ dbSNP | Ensembl ].
VAR_052749
Natural varianti614 – 6141G → R.
Corresponds to variant rs12256916 [ dbSNP | Ensembl ].
VAR_052750
Natural varianti804 – 8041D → H.
Corresponds to variant rs10508862 [ dbSNP | Ensembl ].
VAR_052751

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 33MNK → MANATRRGSG in isoform 3. 1 PublicationVSP_055165
Alternative sequencei83 – 831P → PE in isoform 2. 1 PublicationVSP_046420

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184389 mRNA. Translation: AAO24702.1.
D31763 mRNA. Translation: BAA06541.1.
AK292844 mRNA. Translation: BAF85533.1.
AK303445 mRNA. Translation: BAG64490.1.
AL161931, AL117337 Genomic DNA. Translation: CAH69953.1.
AL117337, AL161931 Genomic DNA. Translation: CAH73315.1.
X68686 Genomic DNA. Translation: CAA48645.1.
X68687 mRNA. Translation: CAA48646.1.
X68689 Genomic DNA. Translation: CAA48648.1.
CCDSiCCDS31182.1. [Q06730-1]
CCDS44372.1. [Q06730-2]
CCDS60514.1. [Q06730-3]
PIRiS33991.
S33992. S33990.
RefSeqiNP_001265099.1. NM_001278170.1. [Q06730-3]
NP_001265100.1. NM_001278171.1.
NP_001265102.1. NM_001278173.1.
NP_001265103.1. NM_001278174.1.
NP_001265104.1. NM_001278175.1.
NP_001265105.1. NM_001278176.1.
NP_001265106.1. NM_001278177.1.
NP_001265107.1. NM_001278178.1.
NP_001265108.1. NM_001278179.1.
NP_008885.1. NM_006954.1. [Q06730-2]
NP_008905.1. NM_006974.2. [Q06730-1]
XP_011517952.1. XM_011519650.2. [Q06730-2]
XP_011517953.1. XM_011519651.2. [Q06730-1]
UniGeneiHs.435774.

Genome annotation databases

EnsembliENST00000432900; ENSP00000402467; ENSG00000189180. [Q06730-2]
ENST00000458705; ENSP00000387713; ENSG00000189180. [Q06730-1]
ENST00000628825; ENSP00000485869; ENSG00000189180. [Q06730-3]
GeneIDi7581.
KEGGihsa:7581.
UCSCiuc001izg.4. human. [Q06730-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184389 mRNA. Translation: AAO24702.1.
D31763 mRNA. Translation: BAA06541.1.
AK292844 mRNA. Translation: BAF85533.1.
AK303445 mRNA. Translation: BAG64490.1.
AL161931, AL117337 Genomic DNA. Translation: CAH69953.1.
AL117337, AL161931 Genomic DNA. Translation: CAH73315.1.
X68686 Genomic DNA. Translation: CAA48645.1.
X68687 mRNA. Translation: CAA48646.1.
X68689 Genomic DNA. Translation: CAA48648.1.
CCDSiCCDS31182.1. [Q06730-1]
CCDS44372.1. [Q06730-2]
CCDS60514.1. [Q06730-3]
PIRiS33991.
S33992. S33990.
RefSeqiNP_001265099.1. NM_001278170.1. [Q06730-3]
NP_001265100.1. NM_001278171.1.
NP_001265102.1. NM_001278173.1.
NP_001265103.1. NM_001278174.1.
NP_001265104.1. NM_001278175.1.
NP_001265105.1. NM_001278176.1.
NP_001265106.1. NM_001278177.1.
NP_001265107.1. NM_001278178.1.
NP_001265108.1. NM_001278179.1.
NP_008885.1. NM_006954.1. [Q06730-2]
NP_008905.1. NM_006974.2. [Q06730-1]
XP_011517952.1. XM_011519650.2. [Q06730-2]
XP_011517953.1. XM_011519651.2. [Q06730-1]
UniGeneiHs.435774.

3D structure databases

ProteinModelPortaliQ06730.
SMRiQ06730. Positions 12-53, 223-806.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113410. 7 interactions.
IntActiQ06730. 5 interactions.
STRINGi9606.ENSP00000363747.

PTM databases

iPTMnetiQ06730.
PhosphoSiteiQ06730.

Polymorphism and mutation databases

BioMutaiZNF33A.
DMDMi11140929.

Proteomic databases

MaxQBiQ06730.
PaxDbiQ06730.
PeptideAtlasiQ06730.
PRIDEiQ06730.

Protocols and materials databases

DNASUi7581.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432900; ENSP00000402467; ENSG00000189180. [Q06730-2]
ENST00000458705; ENSP00000387713; ENSG00000189180. [Q06730-1]
ENST00000628825; ENSP00000485869; ENSG00000189180. [Q06730-3]
GeneIDi7581.
KEGGihsa:7581.
UCSCiuc001izg.4. human. [Q06730-1]

Organism-specific databases

CTDi7581.
GeneCardsiZNF33A.
HGNCiHGNC:13096. ZNF33A.
HPAiHPA056638.
MIMi194521. gene.
neXtProtiNX_Q06730.
PharmGKBiPA37671.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ06730.
KOiK09228.
PhylomeDBiQ06730.
TreeFamiTF337898.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF33A.
GenomeRNAii7581.
PROiQ06730.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189180.
CleanExiHS_ZNF33A.
ExpressionAtlasiQ06730. baseline and differential.
GenevisibleiQ06730. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN33A_HUMAN
AccessioniPrimary (citable) accession number: Q06730
Secondary accession number(s): A8K9X9
, B4E0M8, F6TH33, F8WAJ5, P17013, Q5VZ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.