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Q06710 (PAX8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired box protein Pax-8
Gene names
Name:PAX8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

Subunit structure

Interacts with WWTR1. Ref.8

Subcellular location

Nucleus.

Tissue specificity

Expressed in the excretory system, thyroid gland and Wilms tumors.

Developmental stage

In developing excretory system, during thyroid differentiation and in adult thyroid.

Involvement in disease

Hypothyroidism, congenital, non-goitrous, 2 (CHNG2) [MIM:218700]: A disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.10 Ref.11

Sequence similarities

Contains 1 paired domain.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseCongenital hypothyroidism
Disease mutation
   DomainPaired box
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanatomical structure morphogenesis

Traceable author statement Ref.9. Source: ProtInc

branching involved in ureteric bud morphogenesis

Inferred from expression pattern Ref.1. Source: UniProtKB

cellular response to gonadotropin stimulus

Inferred from direct assay PubMed 15961562. Source: UniProtKB

central nervous system development

Inferred from expression pattern PubMed 15494458. Source: UniProtKB

inner ear morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

kidney development

Inferred from expression pattern PubMed 15494458. Source: UniProtKB

mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from expression pattern PubMed 8861958. Source: UniProtKB

mesonephric tubule development

Inferred from electronic annotation. Source: Ensembl

mesonephros development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric S-shaped body morphogenesis

Inferred from expression pattern Ref.1. Source: UniProtKB

metanephric comma-shaped body morphogenesis

Inferred from expression pattern Ref.1. Source: UniProtKB

metanephric distal convoluted tubule development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric epithelium development

Inferred from expression pattern PubMed 7856737. Source: UniProtKB

metanephric nephron tubule formation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process involved in metanephric collecting duct development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process involved in metanephric nephron tubule development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of mesenchymal cell apoptotic process involved in metanephros development

Inferred from sequence or structural similarity. Source: UniProtKB

otic vesicle development

Inferred from expression pattern PubMed 15494458. Source: UniProtKB

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of metanephric DCT cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of thyroid hormone generation

Inferred from mutant phenotype PubMed 15356023. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 9388203. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15356023PubMed 15961562PubMed 9388203PubMed 8861958PubMed 8861958PubMed 8861958. Source: UniProtKB

pronephric field specification

Inferred from sequence or structural similarity. Source: UniProtKB

pronephros development

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of metanephric nephron tubule epithelial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of thyroid-stimulating hormone secretion

Inferred from mutant phenotype PubMed 15356023. Source: UniProtKB

thyroid gland development

Inferred from mutant phenotype Ref.9. Source: UniProtKB

thyroid-stimulating hormone signaling pathway

Traceable author statement Ref.9. Source: GOC

transcription, DNA-templated

Inferred from direct assay Ref.9Ref.2. Source: UniProtKB

urogenital system development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentnucleoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 15961562PubMed 21317881PubMed 9388203. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15961562PubMed 8861958. Source: UniProtKB

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 9388203. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 9388203Ref.9. Source: UniProtKB

thyroid-stimulating hormone receptor activity

Traceable author statement Ref.9. Source: ProtInc

transcription regulatory region DNA binding

Inferred from direct assay PubMed 15356023. Source: UniProtKB

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q06710-1)

Also known as: Pax8a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q06710-2)

Also known as: Pax8b;

The sequence of this isoform differs from the canonical sequence as follows:
     300-362: Missing.
Isoform 3 (identifier: Q06710-3)

Also known as: Pax8c;

The sequence of this isoform differs from the canonical sequence as follows:
     300-450: DPHSPFAIKQ...PTTATAFDHL → APPFWICSKS...RPGASPTPAC
Isoform 4 (identifier: Q06710-4)

Also known as: Pax8d;

The sequence of this isoform differs from the canonical sequence as follows:
     260-450: GLYPLPLLNS...PTTATAFDHL → GERWWGPRCP...RPGASPTPAC
Isoform 5 (identifier: Q06710-5)

Also known as: Pax8e;

The sequence of this isoform differs from the canonical sequence as follows:
     260-450: GLYPLPLLNS...PTTATAFDHL → EVNTLAMPMATPPTPPTARPGASPTPAC

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Paired box protein Pax-8
PRO_0000050197

Regions

Domain9 – 135127Paired
Compositional bias315 – 32713Ser-rich

Natural variations

Alternative sequence260 – 450191GLYPL…AFDHL → GERWWGPRCPDTHPTSPPAD RAAMPPLPSQAWWQEVNTLA MPMATPPTPPTARPGASPTP AC in isoform 4.
VSP_002374
Alternative sequence260 – 450191GLYPL…AFDHL → EVNTLAMPMATPPTPPTARP GASPTPAC in isoform 5.
VSP_002375
Alternative sequence300 – 450151DPHSP…AFDHL → APPFWICSKSAPGSRPSMPF PMLPPCTGSSRARPSSQGER WWGPRCPDTHPTSPPADRAA MPPLPSQAWWQEVNTLAMPM ATPPTPPTARPGASPTPAC in isoform 3.
VSP_002373
Alternative sequence300 – 36263Missing in isoform 2.
VSP_002372
Natural variant311R → H in CHNG2; loss of activity. Ref.9
VAR_012769
Natural variant401Q → P in CHNG2; loss of activity. Ref.11
VAR_012770
Natural variant571C → Y in CHNG2; loss of activity. Ref.10
VAR_012771
Natural variant621L → R in CHNG2; loss of activity. Ref.9
VAR_012772
Natural variant3291F → L. Ref.1
Corresponds to variant rs3188996 [ dbSNP | Ensembl ].
VAR_012773

Experimental info

Sequence conflict3051F → L in X69699. Ref.1
Sequence conflict3221S → C in X69699. Ref.1
Sequence conflict4181R → G in X69699. Ref.1

Secondary structure

................... 450
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Pax8a) [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 7FDAFA8CEAF20A0E

FASTA45048,218
        10         20         30         40         50         60 
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK 

        70         80         90        100        110        120 
ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND 

       130        140        150        160        170        180 
TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY 

       190        200        210        220        230        240 
SINGLLGIAQ PGSDKRKMDD SDQDSCRLSI DSQSSSSGPR KHLRTDAFSQ HHLEPLECPF 

       250        260        270        280        290        300 
ERQHYPEAYA SPSHTKGEQG LYPLPLLNST LDDGKATLTP SNTPLGRNLS THQTYPVVAD 

       310        320        330        340        350        360 
PHSPFAIKQE TPEVSSSSST PSSLSSSAFL DLQQVGSGVP PFNAFPHAAS VYGQFTGQAL 

       370        380        390        400        410        420 
LSGREMVGPT LPGYPPHIPT SGQGSYASSA IAGMVAGSEY SGNAYGHTPY SSYSEAWRFP 

       430        440        450 
NSSLLSSPYY YSSTSRPSAP PTTATAFDHL 

« Hide

Isoform 2 (Pax8b) [UniParc].

Checksum: 8618767656E83C39
Show »

FASTA38741,741
Isoform 3 (Pax8c) [UniParc].

Checksum: B8A48B2C8916723C
Show »

FASTA39843,028
Isoform 4 (Pax8d) [UniParc].

Checksum: DE1BC715C6C75532
Show »

FASTA32134,909
Isoform 5 (Pax8e) [UniParc].

Checksum: 418320AD43B1237E
Show »

FASTA28731,044

References

« Hide 'large scale' references
[1]"PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors."
Poleev A., Fickenscher H., Mundlos S., Winterpacht A., Zabel B., Fidler A., Gruss P., Plachov D.
Development 116:611-623(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-329.
Tissue: Kidney.
[2]"Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties."
Kozmik Z., Kurzbauer R., Doerfler P., Busslinger M.
Mol. Cell. Biol. 13:6024-6035(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
Tissue: Kidney.
[3]"Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors."
Poleev A., Wendler F., Fickenscher H., Zannini M.S., Yaginuma K., Abbott C., Plachov D.
Eur. J. Biochem. 228:899-911(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cervix.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[8]"TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation."
Di Palma T., D'Andrea B., Liguori G.L., Liguoro A., de Cristofaro T., Del Prete D., Pappalardo A., Mascia A., Zannini M.
Exp. Cell Res. 315:162-175(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WWTR1.
[9]"PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis."
Macchia P.E., Lapi P., Krude H., Pirro M.T., Missero C., Chiovato L., Souabni A., Baserga M., Tassi V., Pinchera A., Fenzi G., Gruters A., Busslinger M., Di Lauro R.
Nat. Genet. 19:83-86(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS CHNG2 HIS-31 AND ARG-62.
[10]"Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8."
Vilain C., Rydlewski C., Duprez L., Heinrichs C., Abramowicz M., Malvaux P., Renneboog B., Parma J., Costagliola S., Vassart G.
J. Clin. Endocrinol. Metab. 86:234-238(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT CHNG2 TYR-57.
[11]"A novel mutation (Q40P) in PAX8 associated with congenital hypothyroidism and thyroid hypoplasia: evidence for phenotypic variability in mother and child."
Congdon T., Nguyen L.Q., Nogueira C.R., Habiby R.L., Medeiros-Neto G., Kopp P.
J. Clin. Endocrinol. Metab. 86:3962-3967(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT CHNG2 PRO-40.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69699 mRNA. No translation available.
L19606 mRNA. Translation: AAA03539.1.
S77904 mRNA. Translation: AAB34216.1.
S77905 mRNA. Translation: AAB34217.2.
S77906 mRNA. Translation: AAB34218.2.
AK292191 mRNA. Translation: BAF84880.1.
AC016683 Genomic DNA. Translation: AAX88880.1.
CH471217 Genomic DNA. Translation: EAW73629.1.
BC001060 mRNA. Translation: AAH01060.1.
PIRA54429.
I53340.
RefSeqNP_003457.1. NM_003466.3.
NP_039246.1. NM_013952.3.
NP_039247.1. NM_013953.3.
NP_054698.1. NM_013992.3.
UniGeneHs.469728.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2K27NMR-A1-146[»]
ProteinModelPortalQ06710.
SMRQ06710. Positions 1-146, 222-276.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113604. 7 interactions.
IntActQ06710. 13 interactions.
STRING9606.ENSP00000395498.

Chemistry

ChEMBLCHEMBL2362980.

PTM databases

PhosphoSiteQ06710.

Polymorphism databases

DMDM215273928.

Proteomic databases

PaxDbQ06710.
PRIDEQ06710.

Protocols and materials databases

DNASU7849.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263334; ENSP00000263334; ENSG00000125618. [Q06710-3]
ENST00000263335; ENSP00000263335; ENSG00000125618. [Q06710-4]
ENST00000348715; ENSP00000314750; ENSG00000125618. [Q06710-3]
ENST00000397647; ENSP00000380768; ENSG00000125618. [Q06710-5]
ENST00000429538; ENSP00000395498; ENSG00000125618. [Q06710-1]
GeneID7849.
KEGGhsa:7849.
UCSCuc002tjm.3. human. [Q06710-4]
uc002tjn.3. human. [Q06710-5]
uc010fku.1. human. [Q06710-1]
uc010yxu.2. human. [Q06710-3]

Organism-specific databases

CTD7849.
GeneCardsGC02M113973.
HGNCHGNC:8622. PAX8.
HPAHPA030062.
MIM167415. gene.
218700. phenotype.
neXtProtNX_Q06710.
Orphanet95713. Athyreosis.
95720. Thyroid hypoplasia.
PharmGKBPA32962.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG326044.
HOVERGENHBG009115.
InParanoidQ06710.
KOK09293.
OMADTFSQHH.
OrthoDBEOG7WT431.
PhylomeDBQ06710.
TreeFamTF315397.

Gene expression databases

ArrayExpressQ06710.
BgeeQ06710.
CleanExHS_PAX8.
GenevestigatorQ06710.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
InterProIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view]
PRINTSPR00027. PAIREDBOX.
SMARTSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPAX8. human.
EvolutionaryTraceQ06710.
GeneWikiPAX8.
GenomeRNAi7849.
NextBio30264.
PROQ06710.
SOURCESearch...

Entry information

Entry namePAX8_HUMAN
AccessionPrimary (citable) accession number: Q06710
Secondary accession number(s): Q09155 expand/collapse secondary AC list , Q16337, Q16338, Q16339, Q4ZG35, Q96J49
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM