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Protein

Golgin IMH1

Gene

IMH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in vesicular transport between an endosomal compartment and the Golgi apparatus.2 Publications

GO - Biological processi

  • Golgi to plasma membrane protein transport Source: SGD
  • protein targeting to Golgi Source: InterPro
  • response to endoplasmic reticulum stress Source: SGD
  • vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Stress response, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32395-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin IMH1
Alternative name(s):
Integrins and myosins homology protein 1
Gene namesi
Name:IMH1
Synonyms:SYS3
Ordered Locus Names:YLR309C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR309C.
SGDiS000004300. IMH1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • Golgi apparatus Source: SGD
  • Golgi membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi870Y → A: Impairs interaction with ARL1 and Golgi localization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002403701 – 911Golgin IMH1Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei308PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1
Modified residuei830PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06704.
PRIDEiQ06704.

PTM databases

iPTMnetiQ06704.

Expressioni

Inductioni

By cold.1 Publication

Interactioni

Subunit structurei

Forms oligomers and is present in high-molecular-mass complexes. Interacts with ARL1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL1P381163EBI-33343,EBI-2869

Protein-protein interaction databases

BioGridi31574. 51 interactors.
DIPiDIP-5583N.
IntActiQ06704. 4 interactors.
MINTiMINT-565482.

Structurei

3D structure databases

ProteinModelPortaliQ06704.
SMRiQ06704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini861 – 909GRIPPROSITE-ProRule annotationAdd BLAST49

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili101 – 280Sequence analysisAdd BLAST180
Coiled coili312 – 735Sequence analysisAdd BLAST424
Coiled coili766 – 814Sequence analysisAdd BLAST49

Domaini

The GRIP domain may serve as a Golgi targeting domain through its interaction with the ARL1 Golgi protein.2 Publications

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000113062.
InParanoidiQ06704.
OMAiINTEEYD.
OrthoDBiEOG092C4284.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKQLSQIGK NLTDELAKGL ADDMSPTPSE QQIEDDKSGL PKEIQAKLRK
60 70 80 90 100
FEKYEQKYPL LLSAYKNEKL KSEKLEAVEK ILAENTPISN IDDAVDTLPA
110 120 130 140 150
FFQDLNNKNN LLNDEIKRLT KQNSEIPESA SSETLKDKEE EFLKKEQNYK
160 170 180 190 200
NDIDDLKKKM EALNIELDTV QKEKNDTVSG LREKIVALEN ILKEEREAKK
210 220 230 240 250
QKEEVSISEL KEELAIKNHS LEDSRMKITE LEQNLSSKST IMEEKSSELA
260 270 280 290 300
ELNITLKEKE RKLSELEKKM KELPKAISHQ NVGNNNRRKK NRNKGKKNKG
310 320 330 340 350
GITTGDISEE ETVDNSINTE EYDKLKENLQ ELQEKYKDCE DWKQKYEDIE
360 370 380 390 400
AELKDAKELE NSQLEKSAKE LETLNTELID TKKSLKEKNS ELEEVRDMLR
410 420 430 440 450
TVGNELVDAK DEIKESSSKQ NEEVKTVKLE LDDLRHKNAT MIEAYEAKNT
460 470 480 490 500
ELRSKIELLS KKVEHLKNLC TEKEKEQTTS QNKVAKLNEE ISQLTYEKSN
510 520 530 540 550
ITKELTSLRT SYKQKEKTVS YLEEQVKQFS EQKDVAEKST EQLRKDHAKI
560 570 580 590 600
SNRLDLLKKE NETLHNDIAK NSNSYEEYLK ENGKLSERLN ILQEKYNTLQ
610 620 630 640 650
NVKSNSNEHI DSIKRQCEEL NVKLKESTKK ILSLEDELNE YANIVQDKTR
660 670 680 690 700
EANTLRRLVS DSQTDDSSKQ KELENKLAYL TDEKNKLEAE LDLQTSRKAT
710 720 730 740 750
ELQEWKHTVT ELKSEIHALK LREEGLKSEV DALKHVNNDI KRKTQATSDD
760 770 780 790 800
SDQLEQITSN LKLSLSKADE KNFELQSANE KLLNLNNELN KKFDRLLKNY
810 820 830 840 850
RSLSSQLNAL KERQYSDKSG RVSRSGSIGT LANANIDSSP ANNSNPTKLE
860 870 880 890 900
KIRSSSSLEL DSEKNEKIAY IKNVLLGFLE HKEQRNQLLP VISMLLQLDS
910
TDEKRLVMSL K
Length:911
Mass (Da):105,225
Last modified:November 1, 1996 - v1
Checksum:i090BD9AA5702C01D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17247 Genomic DNA. Translation: AAB67359.1.
BK006945 Genomic DNA. Translation: DAA09619.1.
PIRiS51441.
RefSeqiNP_013412.1. NM_001182197.2.

Genome annotation databases

EnsemblFungiiYLR309C; YLR309C; YLR309C.
GeneIDi851018.
KEGGisce:YLR309C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17247 Genomic DNA. Translation: AAB67359.1.
BK006945 Genomic DNA. Translation: DAA09619.1.
PIRiS51441.
RefSeqiNP_013412.1. NM_001182197.2.

3D structure databases

ProteinModelPortaliQ06704.
SMRiQ06704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31574. 51 interactors.
DIPiDIP-5583N.
IntActiQ06704. 4 interactors.
MINTiMINT-565482.

PTM databases

iPTMnetiQ06704.

Proteomic databases

MaxQBiQ06704.
PRIDEiQ06704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR309C; YLR309C; YLR309C.
GeneIDi851018.
KEGGisce:YLR309C.

Organism-specific databases

EuPathDBiFungiDB:YLR309C.
SGDiS000004300. IMH1.

Phylogenomic databases

HOGENOMiHOG000113062.
InParanoidiQ06704.
OMAiINTEEYD.
OrthoDBiEOG092C4284.

Enzyme and pathway databases

BioCyciYEAST:G3O-32395-MONOMER.

Miscellaneous databases

PROiQ06704.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMH1_YEAST
AccessioniPrimary (citable) accession number: Q06704
Secondary accession number(s): D6VYV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2350 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.