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Protein

Chitin deacetylase 2

Gene

CDA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.

Catalytic activityi

Chitin + H2O = chitosan + acetate.

GO - Molecular functioni

  • chitin deacetylase activity Source: SGD

GO - Biological processi

  • ascospore wall assembly Source: SGD
  • chitin catabolic process Source: UniProtKB-KW
  • polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation, Sporulation

Enzyme and pathway databases

BioCyciMetaCyc:YLR308W-MONOMER.
YEAST:YLR308W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitin deacetylase 2 (EC:3.5.1.41)
Gene namesi
Name:CDA2
Ordered Locus Names:YLR308W
ORF Names:L2142.1
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR308W.
SGDiS000004299. CDA2.

Subcellular locationi

GO - Cellular componenti

  • chitosan layer of spore wall Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 312287Chitin deacetylase 2PRO_0000024827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence analysis
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Expressed exclusively during sporulation.

Interactioni

Protein-protein interaction databases

BioGridi31573. 16 interactions.
DIPiDIP-4678N.
MINTiMINT-561979.

Structurei

3D structure databases

ProteinModelPortaliQ06703.
SMRiQ06703. Positions 115-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 307190NodB homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family.Curated
Contains 1 NodB homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000014281.
HOGENOMiHOG000094344.
InParanoidiQ06703.
KOiK01452.
OMAiQWSIWAM.
OrthoDBiEOG092C4BVT.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIQLNTIDL QCIIALSCLG QFVHAEANRE DLKQIDFQFP VLERAATKTP
60 70 80 90 100
FPDWLSAFTG LKEWPGLDPP YIPLDFIDFS QIPDYKEYDQ NHCDSVPRDS
110 120 130 140 150
CSFDCHHCTE HDDVYTCSKL SQTFDDGPSA STTKLLDRLK HNSTFFNLGV
160 170 180 190 200
NIVQHPDIYQ RMQKEGHLIG SHTWSHVYLP NVSNEKIIAQ IEWSIWAMNA
210 220 230 240 250
TGNHTPKWFR PPYGGIDNRV RAITRQFGLQ AVLWDHDTFD WSLLLNDSVI
260 270 280 290 300
TEQEILQNVI NWNKSGTGLI LEHDSTEKTV DLAIKINKLI GDDQSTVSHC
310
VGGIDYIKEF LS
Length:312
Mass (Da):35,693
Last modified:November 1, 1996 - v1
Checksum:i4033EEFA803F6AF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17247 Genomic DNA. Translation: AAB67355.1.
AY557951 Genomic DNA. Translation: AAS56277.1.
BK006945 Genomic DNA. Translation: DAA09618.1.
PIRiS51440.
RefSeqiNP_013411.1. NM_001182196.1.

Genome annotation databases

EnsemblFungiiYLR308W; YLR308W; YLR308W.
GeneIDi851017.
KEGGisce:YLR308W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17247 Genomic DNA. Translation: AAB67355.1.
AY557951 Genomic DNA. Translation: AAS56277.1.
BK006945 Genomic DNA. Translation: DAA09618.1.
PIRiS51440.
RefSeqiNP_013411.1. NM_001182196.1.

3D structure databases

ProteinModelPortaliQ06703.
SMRiQ06703. Positions 115-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31573. 16 interactions.
DIPiDIP-4678N.
MINTiMINT-561979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR308W; YLR308W; YLR308W.
GeneIDi851017.
KEGGisce:YLR308W.

Organism-specific databases

EuPathDBiFungiDB:YLR308W.
SGDiS000004299. CDA2.

Phylogenomic databases

GeneTreeiENSGT00390000014281.
HOGENOMiHOG000094344.
InParanoidiQ06703.
KOiK01452.
OMAiQWSIWAM.
OrthoDBiEOG092C4BVT.

Enzyme and pathway databases

BioCyciMetaCyc:YLR308W-MONOMER.
YEAST:YLR308W-MONOMER.

Miscellaneous databases

PROiQ06703.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDA2_YEAST
AccessioniPrimary (citable) accession number: Q06703
Secondary accession number(s): D6VYV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.