Reviewed, UniProtKB/Swiss-Prot Q06703 (CDA2_YEAST)

Names and origin

Protein names

Recommended name:
    Chitin deacetylase 2
    EC=3.5.1.41

Gene names

Name:	CDA2
Ordered Locus Names:	YLR308W
ORF Names:	L2142.1

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.
Catalytic activity	Chitin + H2O = chitosan + acetate.
Developmental stage	Expressed exclusively during sporulation.
Sequence similarities	Belongs to the polysaccharide deacetylase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Chitin degradation Polysaccharide degradation Sporulation
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ascospore wall assembly Inferred from direct assay. Source: SGD chitin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chitin deacetylase activity Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 312	287	Chitin deacetylase 2		PRO_0000024827
Amino acid modifications
	Glycosylation	142	1	N-linked (GlcNAc...) Potential
	Glycosylation	181	1	N-linked (GlcNAc...) Potential
	Glycosylation	199	1	N-linked (GlcNAc...) Potential
	Glycosylation	246	1	N-linked (GlcNAc...) Potential
	Glycosylation	263	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q06703-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4033EEFA803F6AF1	FASTA	312	35,693
	10 20 30 40 50 60 MRIQLNTIDL QCIIALSCLG QFVHAEANRE DLKQIDFQFP VLERAATKTP FPDWLSAFTG 70 80 90 100 110 120 LKEWPGLDPP YIPLDFIDFS QIPDYKEYDQ NHCDSVPRDS CSFDCHHCTE HDDVYTCSKL 130 140 150 160 170 180 SQTFDDGPSA STTKLLDRLK HNSTFFNLGV NIVQHPDIYQ RMQKEGHLIG SHTWSHVYLP 190 200 210 220 230 240 NVSNEKIIAQ IEWSIWAMNA TGNHTPKWFR PPYGGIDNRV RAITRQFGLQ AVLWDHDTFD 250 260 270 280 290 300 WSLLLNDSVI TEQEILQNVI NWNKSGTGLI LEHDSTEKTV DLAIKINKLI GDDQSTVSHC 310 VGGIDYIKEF LS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Cloning and expression of two chitin deacetylase genes of Saccharomyces cerevisiae." Mishra C., Semino C.E., McCreath K.J., de la Vega H., Jones B.J., Specht C.A., Robbins P.W. Yeast 13:327-336(1997) [PubMed: 9133736] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U17247 Genomic DNA. Translation: AAB67355.1. AY557951 Genomic DNA. Translation: AAS56277.1.
PIR	S51440.
RefSeq	NP_013411.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4678N.
IntAct	Q06703. 1 interaction.
STRING	Q06703.
Genome annotation databases
Ensembl	YLR308W; YLR308W; YLR308W; Saccharomyces cerevisiae. [Genome view]
GeneID	851017.
GenomeReviews	Gene locus YLR308W in contig Y13138_GR.
KEGG	sce:YLR308W.
NMPDR	fig|4932.3.peg.4430.
Organism-specific databases
CYGD	YLR308w.
SGD	S000004299. CDA2.
Phylogenomic databases
HOGENOM	Q06703.
OMA	PYIPLDF.
Enzyme and pathway databases
BRENDA	3.5.1.41. 250.
Gene expression databases
ArrayExpress	Q06703.
Genevestigator	Q06703.
GermOnline	YLR308W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002509. Polysac_deacetylase. [Graphical view]
Gene3D	G3DSA:3.20.20.370. Polysac_deacetylase. 1 hit.
Pfam	PF01522. Polysacc_deac_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	967583.

Entry information

Entry name

CDA2_YEAST

Accession

Primary (citable) accession number: Q06703

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)