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Protein

Chitin deacetylase 2

Gene

CDA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.

Catalytic activityi

Chitin + H2O = chitosan + acetate.

GO - Molecular functioni

  • chitin deacetylase activity Source: SGD

GO - Biological processi

  • ascospore wall assembly Source: SGD
  • chitin catabolic process Source: UniProtKB-KW
  • polysaccharide catabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation, Sporulation

Enzyme and pathway databases

BioCyciMetaCyc:YLR308W-MONOMER.
YEAST:YLR308W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitin deacetylase 2 (EC:3.5.1.41)
Gene namesi
Name:CDA2
Ordered Locus Names:YLR308W
ORF Names:L2142.1
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR308W.
SGDiS000004299. CDA2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002482726 – 312Chitin deacetylase 2Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Expressed exclusively during sporulation.

Interactioni

Protein-protein interaction databases

BioGridi31573. 46 interactors.
DIPiDIP-4678N.
MINTiMINT-561979.
STRINGi4932.YLR308W.

Structurei

3D structure databases

ProteinModelPortaliQ06703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 307NodB homologyPROSITE-ProRule annotationAdd BLAST190

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000014281.
HOGENOMiHOG000094344.
InParanoidiQ06703.
KOiK01452.
OMAiQWSIWAM.
OrthoDBiEOG092C4BVT.

Family and domain databases

InterProiView protein in InterPro
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
PfamiView protein in Pfam
PF01522. Polysacc_deac_1. 1 hit.
SUPFAMiSSF88713. SSF88713. 1 hit.
PROSITEiView protein in PROSITE
PS51677. NODB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIQLNTIDL QCIIALSCLG QFVHAEANRE DLKQIDFQFP VLERAATKTP
60 70 80 90 100
FPDWLSAFTG LKEWPGLDPP YIPLDFIDFS QIPDYKEYDQ NHCDSVPRDS
110 120 130 140 150
CSFDCHHCTE HDDVYTCSKL SQTFDDGPSA STTKLLDRLK HNSTFFNLGV
160 170 180 190 200
NIVQHPDIYQ RMQKEGHLIG SHTWSHVYLP NVSNEKIIAQ IEWSIWAMNA
210 220 230 240 250
TGNHTPKWFR PPYGGIDNRV RAITRQFGLQ AVLWDHDTFD WSLLLNDSVI
260 270 280 290 300
TEQEILQNVI NWNKSGTGLI LEHDSTEKTV DLAIKINKLI GDDQSTVSHC
310
VGGIDYIKEF LS
Length:312
Mass (Da):35,693
Last modified:November 1, 1996 - v1
Checksum:i4033EEFA803F6AF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17247 Genomic DNA. Translation: AAB67355.1.
AY557951 Genomic DNA. Translation: AAS56277.1.
BK006945 Genomic DNA. Translation: DAA09618.1.
PIRiS51440.
RefSeqiNP_013411.1. NM_001182196.1.

Genome annotation databases

EnsemblFungiiYLR308W; YLR308W; YLR308W.
GeneIDi851017.
KEGGisce:YLR308W.

Similar proteinsi

Entry informationi

Entry nameiCDA2_YEAST
AccessioniPrimary (citable) accession number: Q06703
Secondary accession number(s): D6VYV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names