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Protein

Chitin deacetylase 1

Gene

CDA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.

Catalytic activityi

Chitin + H2O = chitosan + acetate.

GO - Molecular functioni

  • chitin deacetylase activity Source: SGD

GO - Biological processi

  • ascospore wall assembly Source: SGD
  • chitin catabolic process Source: UniProtKB-KW
  • polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation, Sporulation

Enzyme and pathway databases

BioCyciMetaCyc:YLR307W-MONOMER.
YEAST:YLR307W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitin deacetylase 1 (EC:3.5.1.41)
Gene namesi
Name:CDA1
Ordered Locus Names:YLR307W
ORF Names:L2142.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR307W.
SGDiS000004298. CDA1.

Subcellular locationi

GO - Cellular componenti

  • chitosan layer of spore wall Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 301277Chitin deacetylase 1PRO_0000024826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Expressed exclusively during sporulation.

Interactioni

Protein-protein interaction databases

BioGridi31572. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ06702.
SMRiQ06702. Positions 109-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 288181NodB homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family.Curated
Contains 1 NodB homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000014281.
HOGENOMiHOG000094344.
InParanoidiQ06702.
KOiK01452.
OMAiVAQIEWS.
OrthoDBiEOG7H4F57.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFNTIQSV LFAAFFLKQG NCLASNGSTA LMGEVDMQTP FPEWLTEFTN
60 70 80 90 100
LTQWPGIDPP YIPLDYINLT EVPELDRYYP GQCPKISREQ CSFDCYNCID
110 120 130 140 150
VDDVTSCFKL SQTFDDGPAP ATEALLKKLR QRTTFFVLGI NTVNYPDIYE
160 170 180 190 200
HILERGHLIG THTWSHEFLP SLSNEEIVAQ IEWSIWAMNA TGKHFPKYFR
210 220 230 240 250
PPYGAIDNRV RAIVKQFGLT VVLWDLDTFD WKLITNDDFR TEEEILMDIN
260 270 280 290 300
TWKGKRKGLI LEHDGARRTV EVAIKINELI GSDQLTIAEC IGDTDYIERY

D
Length:301
Mass (Da):34,642
Last modified:November 1, 1996 - v1
Checksum:i72FEB92E5BF5E252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17247 Genomic DNA. Translation: AAB67356.1.
AY557948 Genomic DNA. Translation: AAS56274.1.
BK006945 Genomic DNA. Translation: DAA09616.1.
PIRiS51439.
RefSeqiNP_013410.1. NM_001182195.1.

Genome annotation databases

EnsemblFungiiYLR307W; YLR307W; YLR307W.
GeneIDi851016.
KEGGisce:YLR307W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17247 Genomic DNA. Translation: AAB67356.1.
AY557948 Genomic DNA. Translation: AAS56274.1.
BK006945 Genomic DNA. Translation: DAA09616.1.
PIRiS51439.
RefSeqiNP_013410.1. NM_001182195.1.

3D structure databases

ProteinModelPortaliQ06702.
SMRiQ06702. Positions 109-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31572. 8 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR307W; YLR307W; YLR307W.
GeneIDi851016.
KEGGisce:YLR307W.

Organism-specific databases

EuPathDBiFungiDB:YLR307W.
SGDiS000004298. CDA1.

Phylogenomic databases

GeneTreeiENSGT00390000014281.
HOGENOMiHOG000094344.
InParanoidiQ06702.
KOiK01452.
OMAiVAQIEWS.
OrthoDBiEOG7H4F57.

Enzyme and pathway databases

BioCyciMetaCyc:YLR307W-MONOMER.
YEAST:YLR307W-MONOMER.

Miscellaneous databases

PROiQ06702.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Cloning and expression of two chitin deacetylase genes of Saccharomyces cerevisiae."
    Mishra C., Semino C.E., McCreath K.J., de la Vega H., Jones B.J., Specht C.A., Robbins P.W.
    Yeast 13:327-336(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCDA1_YEAST
AccessioniPrimary (citable) accession number: Q06702
Secondary accession number(s): D6VYV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.