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Q06698

- YL419_YEAST

UniProt

Q06698 - YL419_YEAST

Protein

Putative ATP-dependent RNA helicase YLR419W

Gene

YLR419W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probable ATP-binding RNA helicase.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi627 – 6348ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. nucleic acid binding Source: InterPro

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32480-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ATP-dependent RNA helicase YLR419W (EC:3.6.4.13)
    Gene namesi
    Ordered Locus Names:YLR419W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR419w.
    SGDiS000004411. YLR419W.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14351435Putative ATP-dependent RNA helicase YLR419WPRO_0000247257Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Phosphoserine1 Publication
    Modified residuei816 – 8161Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ06698.
    PaxDbiQ06698.
    PeptideAtlasiQ06698.
    PRIDEiQ06698.

    Expressioni

    Gene expression databases

    GenevestigatoriQ06698.

    Interactioni

    Protein-protein interaction databases

    BioGridi31677. 12 interactions.
    IntActiQ06698. 3 interactions.
    MINTiMINT-2492948.
    STRINGi4932.YLR419W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06698.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini365 – 40642UBAPROSITE-ProRule annotationAdd
    BLAST
    Domaini430 – 531102RWDPROSITE-ProRule annotationAdd
    BLAST
    Domaini614 – 782169Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini845 – 1020176Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi729 – 7324DEAH box

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 RWD domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1643.
    GeneTreeiENSGT00740000115350.
    HOGENOMiHOG000167651.
    OMAiIDDCVAT.
    OrthoDBiEOG757D5M.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR006575. RWD-domain.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    PF05773. RWD. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00591. RWD. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF54495. SSF54495. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50908. RWD. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06698-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKKTKNNSK SSTPVNDVPT TAGKKKAKGK KGQEPEPEDD KRAKQQSNRA     50
    KVTSTASWTG KLPHTILHET CQKRKWNKVE YDMKKIGDKG FIAIAVLSFT 100
    DPKTKETLTA RMNDPTYDKA SGKGLVIPQE TPIEARHMAS TIALYRIAYN 150
    TNLHMMLPPN HRKTWYALDD FRKDNLKTDE KRINKLFDLD PFKTMVEDRK 200
    LKAQREKEQV AQNNQAQKEQ VARTILSSHG GISSSGKDRQ ERKVASHKNS 250
    HNPSLVRFPK KVWENSIFVD LDESSRQLIE TSLKEKIDWQ AKKISHKNET 300
    IAENREDLKA KLLTLQFRPK HVEEAMLYKD PLSFLLFNLP EDDLPPFFHK 350
    KKGDTKNKVE ITNLPLSTRM IVERLTEIGV SSDEALLALQ QNDMNENEAA 400
    GFLTREILPT LNSNTNEPVS ETESIECWNQ ELESLESIYE GCVMDAKEDS 450
    HYTLNLIEKL KIKLKVYRTK NYPASLPGIV VSTFDKNYKL PDYIKKQILT 500
    RLLHYLQEGN LIGDMLVYHI YEWLKENISK IIDNPGPLIP DSDSKGAINK 550
    RNISNGKRSI NNSSSRKFTK TTISEDTLSV LREEYTKRIK SSEYKSMQLV 600
    REQLPAWKKQ KVIIDIINKN EVVLITGETG SGKSTQVVQF ILDFLQKEKG 650
    DFGKTKIVCT QPRRISAIGL AERVSDERCV TCGEEVGYVI RGVNKTKAST 700
    RIKFMTTGVL VRLLQNARTM LENTIVVIDE VHERSIDTDL IVTLMKNLLH 750
    RVRGMKIVLM SATVNVDLFK KFFPGLATCH IEGRTFPITD YFLEDILSDL 800
    DFKIKREKAL SYDDDSVDER NNDDQYLKPR ADSKFFTSGQ INYDLLCQVV 850
    EYVHKRLKAA NDNGSIIVFL PGVGEINKCC NLLANKSNEA DFMVLPLHSA 900
    LTPEDQKRVF KKYHGKRKVV VSTNIAETSI TIDDCVATID TGRAKSMFYN 950
    PKDNTTKLIE SFISKAEVKQ RRGRAGRVRE GLSYKLFSKN LYENDMISMP 1000
    IPEIKRIPLE SLYLSVKAMG IKDVKAFLST ALDAPPLPAL QKAERILTTI 1050
    GLVDESDKSL TQLGQFISLM PVMDSKHGKL LIYGILFGCT DISVLLVSIL 1100
    GIGVLPFIGG FENREKIKKL LCKYESRGDL FAVLEIVRDY FKIKDSSIKR 1150
    KYLRDNLLSY NKINEIKSST AQYYSILKDV GFLPMDYKVG SISDLNRNER 1200
    NFDILRAILT GAFYPHIARV QLPDVKYLST SSGAVEKDPE AKMIKYWIRS 1250
    EEYQDKLEEY KTKISQETQK VDLEDLPLPA TRAFIHPSSV LFSTNSVNLE 1300
    DAKLLSEVDG PISRQSKIPT VVKYPFVLFT TSQVTNKLYL RDLTPTTTLS 1350
    LLLFGGAISY DIGGTIHSPG IVVDNWLPIR TWCKNGVLIK ELRTQLDEAI 1400
    RKKLESPDYA KKSQIDNSGA DKTLKIVEKI IASEQ 1435
    Length:1,435
    Mass (Da):163,045
    Last modified:November 1, 1996 - v1
    Checksum:i0F91A40BB8C7772B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20162 Genomic DNA. Translation: AAB67492.1.
    BK006945 Genomic DNA. Translation: DAA09721.1.
    PIRiS59384.
    RefSeqiNP_013523.3. NM_001182307.3.

    Genome annotation databases

    EnsemblFungiiYLR419W; YLR419W; YLR419W.
    GeneIDi851137.
    KEGGisce:YLR419W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20162 Genomic DNA. Translation: AAB67492.1 .
    BK006945 Genomic DNA. Translation: DAA09721.1 .
    PIRi S59384.
    RefSeqi NP_013523.3. NM_001182307.3.

    3D structure databases

    ProteinModelPortali Q06698.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31677. 12 interactions.
    IntActi Q06698. 3 interactions.
    MINTi MINT-2492948.
    STRINGi 4932.YLR419W.

    Proteomic databases

    MaxQBi Q06698.
    PaxDbi Q06698.
    PeptideAtlasi Q06698.
    PRIDEi Q06698.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR419W ; YLR419W ; YLR419W .
    GeneIDi 851137.
    KEGGi sce:YLR419W.

    Organism-specific databases

    CYGDi YLR419w.
    SGDi S000004411. YLR419W.

    Phylogenomic databases

    eggNOGi COG1643.
    GeneTreei ENSGT00740000115350.
    HOGENOMi HOG000167651.
    OMAi IDDCVAT.
    OrthoDBi EOG757D5M.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32480-MONOMER.

    Miscellaneous databases

    NextBioi 967890.

    Gene expression databases

    Genevestigatori Q06698.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR006575. RWD-domain.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    PF05773. RWD. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00591. RWD. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF54495. SSF54495. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50908. RWD. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-816, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYL419_YEAST
    AccessioniPrimary (citable) accession number: Q06698
    Secondary accession number(s): D6VZ55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 195 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3