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Q06698

- YL419_YEAST

UniProt

Q06698 - YL419_YEAST

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Protein
Putative ATP-dependent RNA helicase YLR419W
Gene
YLR419W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable ATP-binding RNA helicase By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi627 – 6348ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase YLR419W (EC:3.6.4.13)
Gene namesi
Ordered Locus Names:YLR419W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR419w.
SGDiS000004411. YLR419W.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14351435Putative ATP-dependent RNA helicase YLR419W
PRO_0000247257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine1 Publication
Modified residuei816 – 8161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06698.
PaxDbiQ06698.
PeptideAtlasiQ06698.
PRIDEiQ06698.

Expressioni

Gene expression databases

GenevestigatoriQ06698.

Interactioni

Protein-protein interaction databases

BioGridi31677. 12 interactions.
IntActiQ06698. 3 interactions.
MINTiMINT-2492948.
STRINGi4932.YLR419W.

Structurei

3D structure databases

ProteinModelPortaliQ06698.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini365 – 40642UBA
Add
BLAST
Domaini430 – 531102RWD
Add
BLAST
Domaini614 – 782169Helicase ATP-binding
Add
BLAST
Domaini845 – 1020176Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi729 – 7324DEAH box

Sequence similaritiesi

Contains 1 RWD domain.
Contains 1 UBA domain.

Phylogenomic databases

eggNOGiCOG1643.
GeneTreeiENSGT00740000115350.
HOGENOMiHOG000167651.
OMAiIDDCVAT.
OrthoDBiEOG757D5M.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00591. RWD. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54495. SSF54495. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50908. RWD. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06698-1 [UniParc]FASTAAdd to Basket

« Hide

MAKKTKNNSK SSTPVNDVPT TAGKKKAKGK KGQEPEPEDD KRAKQQSNRA     50
KVTSTASWTG KLPHTILHET CQKRKWNKVE YDMKKIGDKG FIAIAVLSFT 100
DPKTKETLTA RMNDPTYDKA SGKGLVIPQE TPIEARHMAS TIALYRIAYN 150
TNLHMMLPPN HRKTWYALDD FRKDNLKTDE KRINKLFDLD PFKTMVEDRK 200
LKAQREKEQV AQNNQAQKEQ VARTILSSHG GISSSGKDRQ ERKVASHKNS 250
HNPSLVRFPK KVWENSIFVD LDESSRQLIE TSLKEKIDWQ AKKISHKNET 300
IAENREDLKA KLLTLQFRPK HVEEAMLYKD PLSFLLFNLP EDDLPPFFHK 350
KKGDTKNKVE ITNLPLSTRM IVERLTEIGV SSDEALLALQ QNDMNENEAA 400
GFLTREILPT LNSNTNEPVS ETESIECWNQ ELESLESIYE GCVMDAKEDS 450
HYTLNLIEKL KIKLKVYRTK NYPASLPGIV VSTFDKNYKL PDYIKKQILT 500
RLLHYLQEGN LIGDMLVYHI YEWLKENISK IIDNPGPLIP DSDSKGAINK 550
RNISNGKRSI NNSSSRKFTK TTISEDTLSV LREEYTKRIK SSEYKSMQLV 600
REQLPAWKKQ KVIIDIINKN EVVLITGETG SGKSTQVVQF ILDFLQKEKG 650
DFGKTKIVCT QPRRISAIGL AERVSDERCV TCGEEVGYVI RGVNKTKAST 700
RIKFMTTGVL VRLLQNARTM LENTIVVIDE VHERSIDTDL IVTLMKNLLH 750
RVRGMKIVLM SATVNVDLFK KFFPGLATCH IEGRTFPITD YFLEDILSDL 800
DFKIKREKAL SYDDDSVDER NNDDQYLKPR ADSKFFTSGQ INYDLLCQVV 850
EYVHKRLKAA NDNGSIIVFL PGVGEINKCC NLLANKSNEA DFMVLPLHSA 900
LTPEDQKRVF KKYHGKRKVV VSTNIAETSI TIDDCVATID TGRAKSMFYN 950
PKDNTTKLIE SFISKAEVKQ RRGRAGRVRE GLSYKLFSKN LYENDMISMP 1000
IPEIKRIPLE SLYLSVKAMG IKDVKAFLST ALDAPPLPAL QKAERILTTI 1050
GLVDESDKSL TQLGQFISLM PVMDSKHGKL LIYGILFGCT DISVLLVSIL 1100
GIGVLPFIGG FENREKIKKL LCKYESRGDL FAVLEIVRDY FKIKDSSIKR 1150
KYLRDNLLSY NKINEIKSST AQYYSILKDV GFLPMDYKVG SISDLNRNER 1200
NFDILRAILT GAFYPHIARV QLPDVKYLST SSGAVEKDPE AKMIKYWIRS 1250
EEYQDKLEEY KTKISQETQK VDLEDLPLPA TRAFIHPSSV LFSTNSVNLE 1300
DAKLLSEVDG PISRQSKIPT VVKYPFVLFT TSQVTNKLYL RDLTPTTTLS 1350
LLLFGGAISY DIGGTIHSPG IVVDNWLPIR TWCKNGVLIK ELRTQLDEAI 1400
RKKLESPDYA KKSQIDNSGA DKTLKIVEKI IASEQ 1435
Length:1,435
Mass (Da):163,045
Last modified:November 1, 1996 - v1
Checksum:i0F91A40BB8C7772B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20162 Genomic DNA. Translation: AAB67492.1.
BK006945 Genomic DNA. Translation: DAA09721.1.
PIRiS59384.
RefSeqiNP_013523.3. NM_001182307.3.

Genome annotation databases

EnsemblFungiiYLR419W; YLR419W; YLR419W.
GeneIDi851137.
KEGGisce:YLR419W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20162 Genomic DNA. Translation: AAB67492.1 .
BK006945 Genomic DNA. Translation: DAA09721.1 .
PIRi S59384.
RefSeqi NP_013523.3. NM_001182307.3.

3D structure databases

ProteinModelPortali Q06698.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31677. 12 interactions.
IntActi Q06698. 3 interactions.
MINTi MINT-2492948.
STRINGi 4932.YLR419W.

Proteomic databases

MaxQBi Q06698.
PaxDbi Q06698.
PeptideAtlasi Q06698.
PRIDEi Q06698.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR419W ; YLR419W ; YLR419W .
GeneIDi 851137.
KEGGi sce:YLR419W.

Organism-specific databases

CYGDi YLR419w.
SGDi S000004411. YLR419W.

Phylogenomic databases

eggNOGi COG1643.
GeneTreei ENSGT00740000115350.
HOGENOMi HOG000167651.
OMAi IDDCVAT.
OrthoDBi EOG757D5M.

Enzyme and pathway databases

BioCyci YEAST:G3O-32480-MONOMER.

Miscellaneous databases

NextBioi 967890.

Gene expression databases

Genevestigatori Q06698.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00591. RWD. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54495. SSF54495. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50908. RWD. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-816, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYL419_YEAST
AccessioniPrimary (citable) accession number: Q06698
Secondary accession number(s): D6VZ55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

Similar proteinsi