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Q06698

- YL419_YEAST

UniProt

Q06698 - YL419_YEAST

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Protein

Putative ATP-dependent RNA helicase YLR419W

Gene

YLR419W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable ATP-binding RNA helicase.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi627 – 6348ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase YLR419W (EC:3.6.4.13)
Gene namesi
Ordered Locus Names:YLR419W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR419w.
SGDiS000004411. YLR419W.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14351435Putative ATP-dependent RNA helicase YLR419WPRO_0000247257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine1 Publication
Modified residuei816 – 8161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06698.
PaxDbiQ06698.
PeptideAtlasiQ06698.
PRIDEiQ06698.

Expressioni

Gene expression databases

GenevestigatoriQ06698.

Interactioni

Protein-protein interaction databases

BioGridi31677. 13 interactions.
IntActiQ06698. 3 interactions.
MINTiMINT-2492948.
STRINGi4932.YLR419W.

Structurei

3D structure databases

ProteinModelPortaliQ06698.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini365 – 40642UBAPROSITE-ProRule annotationAdd
BLAST
Domaini430 – 531102RWDPROSITE-ProRule annotationAdd
BLAST
Domaini614 – 782169Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini845 – 1020176Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi729 – 7324DEAH box

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 RWD domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1643.
GeneTreeiENSGT00760000119189.
HOGENOMiHOG000167651.
InParanoidiQ06698.
OMAiIDDCVAT.
OrthoDBiEOG757D5M.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00591. RWD. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54495. SSF54495. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50908. RWD. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06698-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKKTKNNSK SSTPVNDVPT TAGKKKAKGK KGQEPEPEDD KRAKQQSNRA
60 70 80 90 100
KVTSTASWTG KLPHTILHET CQKRKWNKVE YDMKKIGDKG FIAIAVLSFT
110 120 130 140 150
DPKTKETLTA RMNDPTYDKA SGKGLVIPQE TPIEARHMAS TIALYRIAYN
160 170 180 190 200
TNLHMMLPPN HRKTWYALDD FRKDNLKTDE KRINKLFDLD PFKTMVEDRK
210 220 230 240 250
LKAQREKEQV AQNNQAQKEQ VARTILSSHG GISSSGKDRQ ERKVASHKNS
260 270 280 290 300
HNPSLVRFPK KVWENSIFVD LDESSRQLIE TSLKEKIDWQ AKKISHKNET
310 320 330 340 350
IAENREDLKA KLLTLQFRPK HVEEAMLYKD PLSFLLFNLP EDDLPPFFHK
360 370 380 390 400
KKGDTKNKVE ITNLPLSTRM IVERLTEIGV SSDEALLALQ QNDMNENEAA
410 420 430 440 450
GFLTREILPT LNSNTNEPVS ETESIECWNQ ELESLESIYE GCVMDAKEDS
460 470 480 490 500
HYTLNLIEKL KIKLKVYRTK NYPASLPGIV VSTFDKNYKL PDYIKKQILT
510 520 530 540 550
RLLHYLQEGN LIGDMLVYHI YEWLKENISK IIDNPGPLIP DSDSKGAINK
560 570 580 590 600
RNISNGKRSI NNSSSRKFTK TTISEDTLSV LREEYTKRIK SSEYKSMQLV
610 620 630 640 650
REQLPAWKKQ KVIIDIINKN EVVLITGETG SGKSTQVVQF ILDFLQKEKG
660 670 680 690 700
DFGKTKIVCT QPRRISAIGL AERVSDERCV TCGEEVGYVI RGVNKTKAST
710 720 730 740 750
RIKFMTTGVL VRLLQNARTM LENTIVVIDE VHERSIDTDL IVTLMKNLLH
760 770 780 790 800
RVRGMKIVLM SATVNVDLFK KFFPGLATCH IEGRTFPITD YFLEDILSDL
810 820 830 840 850
DFKIKREKAL SYDDDSVDER NNDDQYLKPR ADSKFFTSGQ INYDLLCQVV
860 870 880 890 900
EYVHKRLKAA NDNGSIIVFL PGVGEINKCC NLLANKSNEA DFMVLPLHSA
910 920 930 940 950
LTPEDQKRVF KKYHGKRKVV VSTNIAETSI TIDDCVATID TGRAKSMFYN
960 970 980 990 1000
PKDNTTKLIE SFISKAEVKQ RRGRAGRVRE GLSYKLFSKN LYENDMISMP
1010 1020 1030 1040 1050
IPEIKRIPLE SLYLSVKAMG IKDVKAFLST ALDAPPLPAL QKAERILTTI
1060 1070 1080 1090 1100
GLVDESDKSL TQLGQFISLM PVMDSKHGKL LIYGILFGCT DISVLLVSIL
1110 1120 1130 1140 1150
GIGVLPFIGG FENREKIKKL LCKYESRGDL FAVLEIVRDY FKIKDSSIKR
1160 1170 1180 1190 1200
KYLRDNLLSY NKINEIKSST AQYYSILKDV GFLPMDYKVG SISDLNRNER
1210 1220 1230 1240 1250
NFDILRAILT GAFYPHIARV QLPDVKYLST SSGAVEKDPE AKMIKYWIRS
1260 1270 1280 1290 1300
EEYQDKLEEY KTKISQETQK VDLEDLPLPA TRAFIHPSSV LFSTNSVNLE
1310 1320 1330 1340 1350
DAKLLSEVDG PISRQSKIPT VVKYPFVLFT TSQVTNKLYL RDLTPTTTLS
1360 1370 1380 1390 1400
LLLFGGAISY DIGGTIHSPG IVVDNWLPIR TWCKNGVLIK ELRTQLDEAI
1410 1420 1430
RKKLESPDYA KKSQIDNSGA DKTLKIVEKI IASEQ
Length:1,435
Mass (Da):163,045
Last modified:November 1, 1996 - v1
Checksum:i0F91A40BB8C7772B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20162 Genomic DNA. Translation: AAB67492.1.
BK006945 Genomic DNA. Translation: DAA09721.1.
PIRiS59384.
RefSeqiNP_013523.3. NM_001182307.3.

Genome annotation databases

EnsemblFungiiYLR419W; YLR419W; YLR419W.
GeneIDi851137.
KEGGisce:YLR419W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20162 Genomic DNA. Translation: AAB67492.1 .
BK006945 Genomic DNA. Translation: DAA09721.1 .
PIRi S59384.
RefSeqi NP_013523.3. NM_001182307.3.

3D structure databases

ProteinModelPortali Q06698.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31677. 13 interactions.
IntActi Q06698. 3 interactions.
MINTi MINT-2492948.
STRINGi 4932.YLR419W.

Proteomic databases

MaxQBi Q06698.
PaxDbi Q06698.
PeptideAtlasi Q06698.
PRIDEi Q06698.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR419W ; YLR419W ; YLR419W .
GeneIDi 851137.
KEGGi sce:YLR419W.

Organism-specific databases

CYGDi YLR419w.
SGDi S000004411. YLR419W.

Phylogenomic databases

eggNOGi COG1643.
GeneTreei ENSGT00760000119189.
HOGENOMi HOG000167651.
InParanoidi Q06698.
OMAi IDDCVAT.
OrthoDBi EOG757D5M.

Enzyme and pathway databases

BioCyci YEAST:G3O-32480-MONOMER.

Miscellaneous databases

NextBioi 967890.

Gene expression databases

Genevestigatori Q06698.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00591. RWD. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54495. SSF54495. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50908. RWD. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-816, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYL419_YEAST
AccessioniPrimary (citable) accession number: Q06698
Secondary accession number(s): D6VZ55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3