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Protein

Putative ATP-dependent RNA helicase YLR419W

Gene

YLR419W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable ATP-binding RNA helicase.By similarity

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi627 – 634ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32480-MONOMER
ReactomeiR-SCE-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase YLR419W (EC:3.6.4.13)
Gene namesi
Ordered Locus Names:YLR419W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR419W
SGDiS000004411 YLR419W

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472571 – 1435Putative ATP-dependent RNA helicase YLR419WAdd BLAST1435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei816PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06698
PaxDbiQ06698
PRIDEiQ06698

PTM databases

iPTMnetiQ06698

Interactioni

Protein-protein interaction databases

BioGridi31677, 50 interactors
IntActiQ06698, 4 interactors
MINTiQ06698
STRINGi4932.YLR419W

Structurei

3D structure databases

ProteinModelPortaliQ06698
SMRiQ06698
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini365 – 406UBAPROSITE-ProRule annotationAdd BLAST42
Domaini430 – 531RWDPROSITE-ProRule annotationAdd BLAST102
Domaini614 – 782Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini845 – 1020Helicase C-terminalPROSITE-ProRule annotationAdd BLAST176

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi729 – 732DEAH box4

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000119189
HOGENOMiHOG000167651
InParanoidiQ06698
OMAiMYEADPF
OrthoDBiEOG092C0B8Q

Family and domain databases

CDDicd00079 HELICc, 1 hit
cd14271 UBA_YLR419W_like, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR006575 RWD-domain
IPR015940 UBA
IPR009060 UBA-like_sf
IPR016135 UBQ-conjugating_enzyme/RWD
IPR035467 YLR419W_like_UBA
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
PF05773 RWD, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SM00591 RWD, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF52540 SSF52540, 2 hits
SSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50908 RWD, 1 hit
PS50030 UBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q06698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKTKNNSK SSTPVNDVPT TAGKKKAKGK KGQEPEPEDD KRAKQQSNRA
60 70 80 90 100
KVTSTASWTG KLPHTILHET CQKRKWNKVE YDMKKIGDKG FIAIAVLSFT
110 120 130 140 150
DPKTKETLTA RMNDPTYDKA SGKGLVIPQE TPIEARHMAS TIALYRIAYN
160 170 180 190 200
TNLHMMLPPN HRKTWYALDD FRKDNLKTDE KRINKLFDLD PFKTMVEDRK
210 220 230 240 250
LKAQREKEQV AQNNQAQKEQ VARTILSSHG GISSSGKDRQ ERKVASHKNS
260 270 280 290 300
HNPSLVRFPK KVWENSIFVD LDESSRQLIE TSLKEKIDWQ AKKISHKNET
310 320 330 340 350
IAENREDLKA KLLTLQFRPK HVEEAMLYKD PLSFLLFNLP EDDLPPFFHK
360 370 380 390 400
KKGDTKNKVE ITNLPLSTRM IVERLTEIGV SSDEALLALQ QNDMNENEAA
410 420 430 440 450
GFLTREILPT LNSNTNEPVS ETESIECWNQ ELESLESIYE GCVMDAKEDS
460 470 480 490 500
HYTLNLIEKL KIKLKVYRTK NYPASLPGIV VSTFDKNYKL PDYIKKQILT
510 520 530 540 550
RLLHYLQEGN LIGDMLVYHI YEWLKENISK IIDNPGPLIP DSDSKGAINK
560 570 580 590 600
RNISNGKRSI NNSSSRKFTK TTISEDTLSV LREEYTKRIK SSEYKSMQLV
610 620 630 640 650
REQLPAWKKQ KVIIDIINKN EVVLITGETG SGKSTQVVQF ILDFLQKEKG
660 670 680 690 700
DFGKTKIVCT QPRRISAIGL AERVSDERCV TCGEEVGYVI RGVNKTKAST
710 720 730 740 750
RIKFMTTGVL VRLLQNARTM LENTIVVIDE VHERSIDTDL IVTLMKNLLH
760 770 780 790 800
RVRGMKIVLM SATVNVDLFK KFFPGLATCH IEGRTFPITD YFLEDILSDL
810 820 830 840 850
DFKIKREKAL SYDDDSVDER NNDDQYLKPR ADSKFFTSGQ INYDLLCQVV
860 870 880 890 900
EYVHKRLKAA NDNGSIIVFL PGVGEINKCC NLLANKSNEA DFMVLPLHSA
910 920 930 940 950
LTPEDQKRVF KKYHGKRKVV VSTNIAETSI TIDDCVATID TGRAKSMFYN
960 970 980 990 1000
PKDNTTKLIE SFISKAEVKQ RRGRAGRVRE GLSYKLFSKN LYENDMISMP
1010 1020 1030 1040 1050
IPEIKRIPLE SLYLSVKAMG IKDVKAFLST ALDAPPLPAL QKAERILTTI
1060 1070 1080 1090 1100
GLVDESDKSL TQLGQFISLM PVMDSKHGKL LIYGILFGCT DISVLLVSIL
1110 1120 1130 1140 1150
GIGVLPFIGG FENREKIKKL LCKYESRGDL FAVLEIVRDY FKIKDSSIKR
1160 1170 1180 1190 1200
KYLRDNLLSY NKINEIKSST AQYYSILKDV GFLPMDYKVG SISDLNRNER
1210 1220 1230 1240 1250
NFDILRAILT GAFYPHIARV QLPDVKYLST SSGAVEKDPE AKMIKYWIRS
1260 1270 1280 1290 1300
EEYQDKLEEY KTKISQETQK VDLEDLPLPA TRAFIHPSSV LFSTNSVNLE
1310 1320 1330 1340 1350
DAKLLSEVDG PISRQSKIPT VVKYPFVLFT TSQVTNKLYL RDLTPTTTLS
1360 1370 1380 1390 1400
LLLFGGAISY DIGGTIHSPG IVVDNWLPIR TWCKNGVLIK ELRTQLDEAI
1410 1420 1430
RKKLESPDYA KKSQIDNSGA DKTLKIVEKI IASEQ
Length:1,435
Mass (Da):163,045
Last modified:November 1, 1996 - v1
Checksum:i0F91A40BB8C7772B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20162 Genomic DNA Translation: AAB67492.1
BK006945 Genomic DNA Translation: DAA09721.1
PIRiS59384
RefSeqiNP_013523.3, NM_001182307.3

Genome annotation databases

EnsemblFungiiYLR419W; YLR419W; YLR419W
GeneIDi851137
KEGGisce:YLR419W

Similar proteinsi

Entry informationi

Entry nameiYL419_YEAST
AccessioniPrimary (citable) accession number: Q06698
Secondary accession number(s): D6VZ55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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