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Protein

Cell division control protein 73

Gene

CDC73

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.3 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD
  • RNA polymerase II core binding Source: SGD
  • RNA polymerase II C-terminal domain phosphoserine binding Source: SGD
  • transcription factor activity, RNA polymerase II transcription factor binding Source: SGD
  • transcription factor activity, TFIIF-class transcription factor binding Source: SGD

GO - Biological processi

  • histone modification Source: InterPro
  • mRNA 3'-end processing Source: SGD
  • negative regulation of DNA recombination Source: SGD
  • positive regulation of histone H3-K36 trimethylation Source: SGD
  • positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues Source: SGD
  • positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription elongation from RNA polymerase I promoter Source: SGD
  • recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex Source: SGD
  • regulation of histone H2B conserved C-terminal lysine ubiquitination Source: SGD
  • regulation of transcription-coupled nucleotide-excision repair Source: SGD
  • transcription elongation from RNA polymerase II promoter Source: SGD
  • transcription elongation from RNA polymerase I promoter Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32479-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 73
Alternative name(s):
RNA polymerase-associated protein CDC73
Gene namesi
Name:CDC73
Ordered Locus Names:YLR418C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR418C.
SGDiS000004410. CDC73.

Subcellular locationi

GO - Cellular componenti

  • Cdc73/Paf1 complex Source: SGD
  • nucleus Source: SGD
  • transcriptionally active chromatin Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002385801 – 393Cell division control protein 73Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06697.
PRIDEiQ06697.

PTM databases

iPTMnetiQ06697.

Interactioni

Subunit structurei

Component of the PAF1 complex which consists of at least CDC73, CTR9, LEO1, PAF1 and RTF1. Interacts with FACT subunits POB3 and SPT16.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PAF1P383518EBI-29913,EBI-12855
RPO21P0405017EBI-29913,EBI-15760
RTF1P5306410EBI-29913,EBI-16303
SLT2Q007722EBI-29913,EBI-17372
SPT5P276926EBI-29913,EBI-17937

GO - Molecular functioni

  • RNA polymerase II core binding Source: SGD
  • RNA polymerase II C-terminal domain phosphoserine binding Source: SGD

Protein-protein interaction databases

BioGridi31676. 675 interactors.
DIPiDIP-1148N.
IntActiQ06697. 22 interactors.
MINTiMINT-545984.

Structurei

Secondary structure

1393
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi239 – 241Combined sources3
Beta strandi248 – 250Combined sources3
Turni252 – 254Combined sources3
Helixi255 – 261Combined sources7
Helixi267 – 269Combined sources3
Beta strandi276 – 282Combined sources7
Beta strandi287 – 289Combined sources3
Beta strandi291 – 299Combined sources9
Helixi305 – 310Combined sources6
Beta strandi311 – 315Combined sources5
Helixi320 – 323Combined sources4
Beta strandi326 – 328Combined sources3
Helixi331 – 337Combined sources7
Beta strandi338 – 345Combined sources8
Helixi352 – 356Combined sources5
Beta strandi357 – 364Combined sources8
Helixi369 – 371Combined sources3
Helixi372 – 389Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V46X-ray1.55A230-393[»]
4DM4X-ray2.19A/B235-393[»]
ProteinModelPortaliQ06697.
SMRiQ06697.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC73 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001114.
HOGENOMiHOG000163861.
InParanoidiQ06697.
KOiK15175.
OMAiEYWNRIV.
OrthoDBiEOG092C3TEE.

Family and domain databases

InterProiIPR007852. Cdc73/Parafibromin.
IPR031336. CDC73_C.
[Graphical view]
PANTHERiPTHR12466. PTHR12466. 1 hit.
PfamiPF05179. CDC73_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSLDRLRE HLKNGDKLVL KNNEGQSTDD ITKATMVETL SSDGSTQDSF
60 70 80 90 100
PLNEETEIEI DGSLVQLRII VHCWMNKDSS AADYLADCQN KQLTNVSFLQ
110 120 130 140 150
RTDLINWLSG NTESSQYLKA PGQKGETSDK VDIENKTLAG ELSTVKSTTS
160 170 180 190 200
ASLENDSEVS DPVVVETMKH ERILVDHNSA LRGAKPINFG YLIKDAELKL
210 220 230 240 250
VQSIKGSLRG SKLPPGHKGA HGRISKTNGS SGGPRKDPII LIPSAASSIL
260 270 280 290 300
TVANIKQFLL ESKYVNPRNL PSVPNGLVNI EKNFERISRP IRFIIVDNTR
310 320 330 340 350
MFTKPEYWDR VVAIFTTGHT WQFNNYQWNS PQELFQRCKG YYFHFAGDSV
360 370 380 390
PQHVQQWNVE KVELDKNKRF KDVEVVRYFW HSLEKELISR GYR
Length:393
Mass (Da):44,456
Last modified:November 1, 1996 - v1
Checksum:i9580B53EEFB75345
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20162 Genomic DNA. Translation: AAB67500.1.
BK006945 Genomic DNA. Translation: DAA09720.1.
PIRiS59383.
RefSeqiNP_013522.1. NM_001182306.1.

Genome annotation databases

EnsemblFungiiYLR418C; YLR418C; YLR418C.
GeneIDi851136.
KEGGisce:YLR418C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20162 Genomic DNA. Translation: AAB67500.1.
BK006945 Genomic DNA. Translation: DAA09720.1.
PIRiS59383.
RefSeqiNP_013522.1. NM_001182306.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V46X-ray1.55A230-393[»]
4DM4X-ray2.19A/B235-393[»]
ProteinModelPortaliQ06697.
SMRiQ06697.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31676. 675 interactors.
DIPiDIP-1148N.
IntActiQ06697. 22 interactors.
MINTiMINT-545984.

PTM databases

iPTMnetiQ06697.

Proteomic databases

MaxQBiQ06697.
PRIDEiQ06697.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR418C; YLR418C; YLR418C.
GeneIDi851136.
KEGGisce:YLR418C.

Organism-specific databases

EuPathDBiFungiDB:YLR418C.
SGDiS000004410. CDC73.

Phylogenomic databases

GeneTreeiENSGT00390000001114.
HOGENOMiHOG000163861.
InParanoidiQ06697.
KOiK15175.
OMAiEYWNRIV.
OrthoDBiEOG092C3TEE.

Enzyme and pathway databases

BioCyciYEAST:G3O-32479-MONOMER.

Miscellaneous databases

PROiQ06697.

Family and domain databases

InterProiIPR007852. Cdc73/Parafibromin.
IPR031336. CDC73_C.
[Graphical view]
PANTHERiPTHR12466. PTHR12466. 1 hit.
PfamiPF05179. CDC73_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC73_YEAST
AccessioniPrimary (citable) accession number: Q06697
Secondary accession number(s): D6VZ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.