Q06686 (CTR3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Copper transport protein CTR3
Short name=Copper transporter 3

Gene names

Name:	CTR3
Ordered Locus Names:	YLR411W
ORF Names:	L9931.6

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for high affinity copper (probably reduced Cu I) transport into the cell.
Subcellular location	Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Induction	By copper deprivation and repressed by copper excess.
Sequence similarities	Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. [View classification]

Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cytoplasmic vesicle Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	copper ion import Inferred from direct assay PubMed 10924521. Source: SGD
Cellular_component	cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Inferred from direct assay PubMed 10924521. Source: SGD
Molecular_function	copper uptake transmembrane transporter activity Inferred from direct assay PubMed 10924521. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Copper transport protein CTR3		PRO_0000195047
Regions
	Topological domain	1 – 41	41	Lumenal Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Topological domain	63 – 159	97	Cytoplasmic Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Topological domain	181 – 182	2	Lumenal Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Topological domain	204 – 241	38	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q06686 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9BFDFB9DE1EDD75C	FASTA	241	27,534
	10 20 30 40 50 60 MNMGGSSSTA AKKATCKISM LWNWYTIDTC FIARSWRNDT KGKFAGSCIG CFALVVVAQW 70 80 90 100 110 120 LTRFSRQFDV ELLKRQKIKH LASYSPEEYV VKCGEEDAKS DIEELQGFYN EPSWKTTLIS 130 140 150 160 170 180 LQKSFIYSFY VWGPRRLNEP EDDLLKKVLS CCTLITPVDL YPTFLDHMIR VTIFVLQWGL 190 200 210 220 230 240 SYIIMLLFMY YNGYIIISCL IGAIVGRFIF CYEPLGSLGA NGSAQGTVSY DKESDDRKCC L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A widespread transposable element masks expression of a yeast copper transport gene." Knight S.A.B., Labbe S., Kwon L.F., Kosman D.J., Thiele D.J. Genes Dev. 10:1917-1929(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: ATCC 96099 / S288c / SEY6210.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U81482 Genomic DNA. Translation: AAB40707.1. U20162 Genomic DNA. Translation: AAB67496.1. AY692929 Genomic DNA. Translation: AAT92948.1. BK006945 Genomic DNA. Translation: DAA09713.1.
PIR	S59377.
RefSeq	NP_013515.3. NM_001182299.3.
3D structure databases
ProteinModelPortal	Q06686.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4285N.
IntAct	Q06686. 1 interaction.
MINT	MINT-554080.
STRING	4932.YLR411W.
Protein family/group databases
TCDB	1.A.56.1.4. copper transporter (Ctr) family.
Proteomic databases
PaxDb	Q06686.
PeptideAtlas	Q06686.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YLR411W; YLR411W; YLR411W.
GeneID	851129.
KEGG	sce:YLR411W. sce:YLR412C-A.
Organism-specific databases
CYGD	YLR411w.
SGD	S000004403. CTR3.
Phylogenomic databases
eggNOG	NOG277844.
HOGENOM	HOG000183457.
OMA	AVAYFVM.
OrthoDB	EOG4D2B0G.
Gene expression databases
Genevestigator	Q06686.
GermOnline	YLR411W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007274. Cop_transporter. [Graphical view]
PANTHER	PTHR12483. PTHR12483. 1 hit.
Pfam	PF04145. Ctr. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	967869.

Entry information

Entry name

CTR3_YEAST

Accession

Primary (citable) accession number: Q06686
Secondary accession number(s): D6VZ47

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program