Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q06686 (CTR3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Copper transport protein CTR3

Short name=Copper transporter 3
Gene names
Name:CTR3
Ordered Locus Names:YLR411W
ORF Names:L9931.6
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for high affinity copper (probably reduced Cu I) transport into the cell.

Subcellular location

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Induction

By copper deprivation and repressed by copper excess.

Sequence similarities

Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Copper transport protein CTR3
PRO_0000195047

Regions

Topological domain1 – 4141Lumenal Potential
Transmembrane42 – 6221Helical; Potential
Topological domain63 – 15997Cytoplasmic Potential
Transmembrane160 – 18021Helical; Potential
Topological domain181 – 1822Lumenal Potential
Transmembrane183 – 20321Helical; Potential
Topological domain204 – 24138Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q06686 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9BFDFB9DE1EDD75C

FASTA24127,534
        10         20         30         40         50         60 
MNMGGSSSTA AKKATCKISM LWNWYTIDTC FIARSWRNDT KGKFAGSCIG CFALVVVAQW 

        70         80         90        100        110        120 
LTRFSRQFDV ELLKRQKIKH LASYSPEEYV VKCGEEDAKS DIEELQGFYN EPSWKTTLIS 

       130        140        150        160        170        180 
LQKSFIYSFY VWGPRRLNEP EDDLLKKVLS CCTLITPVDL YPTFLDHMIR VTIFVLQWGL 

       190        200        210        220        230        240 
SYIIMLLFMY YNGYIIISCL IGAIVGRFIF CYEPLGSLGA NGSAQGTVSY DKESDDRKCC 


L 

« Hide

References

« Hide 'large scale' references
[1]"A widespread transposable element masks expression of a yeast copper transport gene."
Knight S.A.B., Labbe S., Kwon L.F., Kosman D.J., Thiele D.J.
Genes Dev. 10:1917-1929(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: ATCC 96099 / S288c / SEY6210.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U81482 Genomic DNA. Translation: AAB40707.1.
U20162 Genomic DNA. Translation: AAB67496.1.
AY692929 Genomic DNA. Translation: AAT92948.1.
BK006945 Genomic DNA. Translation: DAA09713.1.
PIRS59377.
RefSeqNP_013515.3. NM_001182299.3.

3D structure databases

ProteinModelPortalQ06686.
SMRQ06686. Positions 167-193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31670. 9 interactions.
DIPDIP-4285N.
IntActQ06686. 2 interactions.
MINTMINT-554080.
STRING4932.YLR411W.

Protein family/group databases

TCDB1.A.56.1.4. the copper transporter (ctr) family.

Proteomic databases

PaxDbQ06686.
PeptideAtlasQ06686.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR411W; YLR411W; YLR411W.
GeneID851129.
KEGGsce:YLR411W.

Organism-specific databases

CYGDYLR411w.
SGDS000004403. CTR3.

Phylogenomic databases

eggNOGNOG277844.
HOGENOMHOG000183457.
OMANGLICAL.
OrthoDBEOG7WHHNT.

Enzyme and pathway databases

BioCycYEAST:G3O-32473-MONOMER.

Gene expression databases

GenevestigatorQ06686.

Family and domain databases

InterProIPR007274. Cop_transporter.
[Graphical view]
PANTHERPTHR12483. PTHR12483. 1 hit.
PfamPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio967869.

Entry information

Entry nameCTR3_YEAST
AccessionPrimary (citable) accession number: Q06686
Secondary accession number(s): D6VZ47
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families