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Q06686

- CTR3_YEAST

UniProt

Q06686 - CTR3_YEAST

Protein

Copper transport protein CTR3

Gene

CTR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Required for high affinity copper (probably reduced Cu I) transport into the cell.

    GO - Molecular functioni

    1. copper uptake transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. copper ion import Source: SGD

    Keywords - Biological processi

    Copper transport, Ion transport, Transport

    Keywords - Ligandi

    Copper

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32473-MONOMER.

    Protein family/group databases

    TCDBi1.A.56.1.4. the copper transporter (ctr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Copper transport protein CTR3
    Short name:
    Copper transporter 3
    Gene namesi
    Name:CTR3
    Ordered Locus Names:YLR411W
    ORF Names:L9931.6
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR411w.
    SGDiS000004403. CTR3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Copper transport protein CTR3PRO_0000195047Add
    BLAST

    Proteomic databases

    PaxDbiQ06686.
    PeptideAtlasiQ06686.

    Expressioni

    Inductioni

    By copper deprivation and repressed by copper excess.

    Gene expression databases

    GenevestigatoriQ06686.

    Interactioni

    Protein-protein interaction databases

    BioGridi31670. 9 interactions.
    DIPiDIP-4285N.
    IntActiQ06686. 2 interactions.
    MINTiMINT-554080.
    STRINGi4932.YLR411W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06686.
    SMRiQ06686. Positions 167-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141LumenalSequence AnalysisAdd
    BLAST
    Topological domaini63 – 15997CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 1822LumenalSequence Analysis
    Topological domaini204 – 24138CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277844.
    HOGENOMiHOG000183457.
    OMAiNGLICAL.
    OrthoDBiEOG7WHHNT.

    Family and domain databases

    InterProiIPR007274. Cop_transporter.
    [Graphical view]
    PANTHERiPTHR12483. PTHR12483. 1 hit.
    PfamiPF04145. Ctr. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06686-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNMGGSSSTA AKKATCKISM LWNWYTIDTC FIARSWRNDT KGKFAGSCIG    50
    CFALVVVAQW LTRFSRQFDV ELLKRQKIKH LASYSPEEYV VKCGEEDAKS 100
    DIEELQGFYN EPSWKTTLIS LQKSFIYSFY VWGPRRLNEP EDDLLKKVLS 150
    CCTLITPVDL YPTFLDHMIR VTIFVLQWGL SYIIMLLFMY YNGYIIISCL 200
    IGAIVGRFIF CYEPLGSLGA NGSAQGTVSY DKESDDRKCC L 241
    Length:241
    Mass (Da):27,534
    Last modified:November 1, 1996 - v1
    Checksum:i9BFDFB9DE1EDD75C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81482 Genomic DNA. Translation: AAB40707.1.
    U20162 Genomic DNA. Translation: AAB67496.1.
    AY692929 Genomic DNA. Translation: AAT92948.1.
    BK006945 Genomic DNA. Translation: DAA09713.1.
    PIRiS59377.
    RefSeqiNP_013515.3. NM_001182299.3.

    Genome annotation databases

    EnsemblFungiiYLR411W; YLR411W; YLR411W.
    GeneIDi851129.
    KEGGisce:YLR411W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81482 Genomic DNA. Translation: AAB40707.1 .
    U20162 Genomic DNA. Translation: AAB67496.1 .
    AY692929 Genomic DNA. Translation: AAT92948.1 .
    BK006945 Genomic DNA. Translation: DAA09713.1 .
    PIRi S59377.
    RefSeqi NP_013515.3. NM_001182299.3.

    3D structure databases

    ProteinModelPortali Q06686.
    SMRi Q06686. Positions 167-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31670. 9 interactions.
    DIPi DIP-4285N.
    IntActi Q06686. 2 interactions.
    MINTi MINT-554080.
    STRINGi 4932.YLR411W.

    Protein family/group databases

    TCDBi 1.A.56.1.4. the copper transporter (ctr) family.

    Proteomic databases

    PaxDbi Q06686.
    PeptideAtlasi Q06686.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR411W ; YLR411W ; YLR411W .
    GeneIDi 851129.
    KEGGi sce:YLR411W.

    Organism-specific databases

    CYGDi YLR411w.
    SGDi S000004403. CTR3.

    Phylogenomic databases

    eggNOGi NOG277844.
    HOGENOMi HOG000183457.
    OMAi NGLICAL.
    OrthoDBi EOG7WHHNT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32473-MONOMER.

    Miscellaneous databases

    NextBioi 967869.

    Gene expression databases

    Genevestigatori Q06686.

    Family and domain databases

    InterProi IPR007274. Cop_transporter.
    [Graphical view ]
    PANTHERi PTHR12483. PTHR12483. 1 hit.
    Pfami PF04145. Ctr. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A widespread transposable element masks expression of a yeast copper transport gene."
      Knight S.A.B., Labbe S., Kwon L.F., Kosman D.J., Thiele D.J.
      Genes Dev. 10:1917-1929(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: ATCC 96099 / S288c / SEY6210.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiCTR3_YEAST
    AccessioniPrimary (citable) accession number: Q06686
    Secondary accession number(s): D6VZ47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3