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Protein

Copper transport protein CTR3

Gene

CTR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for high affinity copper (probably reduced Cu I) transport into the cell.

GO - Molecular functioni

  • copper uptake transmembrane transporter activity Source: SGD

GO - Biological processi

  • copper ion import Source: SGD
Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper

Enzyme and pathway databases

BioCyciYEAST:G3O-32473-MONOMER.

Protein family/group databases

TCDBi1.A.56.1.4. the copper transporter (ctr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein CTR3
Short name:
Copper transporter 3
Gene namesi
Name:CTR3
Ordered Locus Names:YLR411W
ORF Names:L9931.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XII

Organism-specific databases

CYGDiYLR411w.
EuPathDBiFungiDB:YLR411W.
SGDiS000004403. CTR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141LumenalSequence AnalysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Topological domaini63 – 15997CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Topological domaini181 – 1822LumenalSequence Analysis
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Topological domaini204 – 24138CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Copper transport protein CTR3PRO_0000195047Add
BLAST

Proteomic databases

PaxDbiQ06686.
PeptideAtlasiQ06686.

Expressioni

Inductioni

By copper deprivation and repressed by copper excess.

Interactioni

Protein-protein interaction databases

BioGridi31670. 10 interactions.
DIPiDIP-4285N.
IntActiQ06686. 2 interactions.
MINTiMINT-554080.

Structurei

3D structure databases

ProteinModelPortaliQ06686.
SMRiQ06686. Positions 167-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277844.
HOGENOMiHOG000183457.
InParanoidiQ06686.
OrthoDBiEOG7WHHNT.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMGGSSSTA AKKATCKISM LWNWYTIDTC FIARSWRNDT KGKFAGSCIG
60 70 80 90 100
CFALVVVAQW LTRFSRQFDV ELLKRQKIKH LASYSPEEYV VKCGEEDAKS
110 120 130 140 150
DIEELQGFYN EPSWKTTLIS LQKSFIYSFY VWGPRRLNEP EDDLLKKVLS
160 170 180 190 200
CCTLITPVDL YPTFLDHMIR VTIFVLQWGL SYIIMLLFMY YNGYIIISCL
210 220 230 240
IGAIVGRFIF CYEPLGSLGA NGSAQGTVSY DKESDDRKCC L
Length:241
Mass (Da):27,534
Last modified:November 1, 1996 - v1
Checksum:i9BFDFB9DE1EDD75C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81482 Genomic DNA. Translation: AAB40707.1.
U20162 Genomic DNA. Translation: AAB67496.1.
AY692929 Genomic DNA. Translation: AAT92948.1.
BK006945 Genomic DNA. Translation: DAA09713.1.
PIRiS59377.
RefSeqiNP_013515.3. NM_001182299.3.

Genome annotation databases

EnsemblFungiiYLR411W; YLR411W; YLR411W.
GeneIDi851129.
KEGGisce:YLR411W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81482 Genomic DNA. Translation: AAB40707.1.
U20162 Genomic DNA. Translation: AAB67496.1.
AY692929 Genomic DNA. Translation: AAT92948.1.
BK006945 Genomic DNA. Translation: DAA09713.1.
PIRiS59377.
RefSeqiNP_013515.3. NM_001182299.3.

3D structure databases

ProteinModelPortaliQ06686.
SMRiQ06686. Positions 167-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31670. 10 interactions.
DIPiDIP-4285N.
IntActiQ06686. 2 interactions.
MINTiMINT-554080.

Protein family/group databases

TCDBi1.A.56.1.4. the copper transporter (ctr) family.

Proteomic databases

PaxDbiQ06686.
PeptideAtlasiQ06686.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR411W; YLR411W; YLR411W.
GeneIDi851129.
KEGGisce:YLR411W.

Organism-specific databases

CYGDiYLR411w.
EuPathDBiFungiDB:YLR411W.
SGDiS000004403. CTR3.

Phylogenomic databases

eggNOGiNOG277844.
HOGENOMiHOG000183457.
InParanoidiQ06686.
OrthoDBiEOG7WHHNT.

Enzyme and pathway databases

BioCyciYEAST:G3O-32473-MONOMER.

Miscellaneous databases

NextBioi967869.
PROiQ06686.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A widespread transposable element masks expression of a yeast copper transport gene."
    Knight S.A.B., Labbe S., Kwon L.F., Kosman D.J., Thiele D.J.
    Genes Dev. 10:1917-1929(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: ATCC 96099 / S288c / SEY6210.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiCTR3_YEAST
AccessioniPrimary (citable) accession number: Q06686
Secondary accession number(s): D6VZ47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.