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Protein

Thrombin inhibitor rhodniin

Gene
N/A
Organism
Rhodnius prolixus (Triatomid bug)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thrombin-specific inhibitor. Appears to form 1:1 complexes with thrombin. Prevents blood clotting to allow the insect to feed on blood.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei10 – 11Reactive bond2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Protein family/group databases

MEROPSiI01.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombin inhibitor rhodniin
OrganismiRhodnius prolixus (Triatomid bug)
Taxonomic identifieri13249 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraHeteropteraPanheteropteraCimicomorphaReduviidaeTriatominaeRhodnius
Proteomesi
  • UP000015103 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000731981 – 103Thrombin inhibitor rhodniinAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 31
Disulfide bondi8 ↔ 27
Disulfide bondi16 ↔ 48
Disulfide bondi57 ↔ 84
Disulfide bondi60 ↔ 80
Disulfide bondi69 ↔ 101

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi7 – 10Combined sources4
Beta strandi15 – 17Combined sources3
Beta strandi22 – 25Combined sources4
Helixi26 – 33Combined sources8
Turni34 – 36Combined sources3
Beta strandi42 – 46Combined sources5
Helixi58 – 60Combined sources3
Beta strandi68 – 70Combined sources3
Turni71 – 73Combined sources3
Beta strandi74 – 78Combined sources5
Helixi79 – 85Combined sources7
Turni86 – 89Combined sources4
Beta strandi95 – 100Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TBQX-ray3.10R/S1-103[»]
1TBRX-ray2.60R/S1-103[»]
ProteinModelPortaliQ06684.
SMRiQ06684.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06684.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 50Kazal-like 1PROSITE-ProRule annotationAdd BLAST50
Domaini51 – 103Kazal-like 2PROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 2 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EGGEPCACPH ALHRVCGSDG ETYSNPCTLN CAKFNGKPEL VKVHDGPCEP
60 70 80 90 100
DEDEDVCQEC DGDEYKPVCG SDDITYDNNC RLECASISSS PGVELKHEGP

CRT
Length:103
Mass (Da):11,079
Last modified:February 1, 1995 - v1
Checksum:iF9588330458836B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22559 mRNA. Translation: CAA80281.1.
PIRiA47337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22559 mRNA. Translation: CAA80281.1.
PIRiA47337.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TBQX-ray3.10R/S1-103[»]
1TBRX-ray2.60R/S1-103[»]
ProteinModelPortaliQ06684.
SMRiQ06684.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI01.019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ06684.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHBI_RHOPR
AccessioniPrimary (citable) accession number: Q06684
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.