Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thrombin inhibitor rhodniin

Gene
N/A
Organism
Rhodnius prolixus (Triatomid bug)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thrombin-specific inhibitor. Appears to form 1:1 complexes with thrombin. Prevents blood clotting to allow the insect to feed on blood.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei10 – 112Reactive bond

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Protein family/group databases

MEROPSiI01.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombin inhibitor rhodniin
OrganismiRhodnius prolixus (Triatomid bug)
Taxonomic identifieri13249 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraHeteropteraPanheteropteraCimicomorphaReduviidaeTriatominaeRhodnius
Proteomesi
  • UP000015103 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Thrombin inhibitor rhodniinPRO_0000073198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi6 ↔ 31
Disulfide bondi8 ↔ 27
Disulfide bondi16 ↔ 48
Disulfide bondi57 ↔ 84
Disulfide bondi60 ↔ 80
Disulfide bondi69 ↔ 101

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
103
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63Combined sources
Beta strandi7 – 104Combined sources
Beta strandi15 – 173Combined sources
Beta strandi22 – 254Combined sources
Helixi26 – 338Combined sources
Turni34 – 363Combined sources
Beta strandi42 – 465Combined sources
Helixi58 – 603Combined sources
Beta strandi68 – 703Combined sources
Turni71 – 733Combined sources
Beta strandi74 – 785Combined sources
Helixi79 – 857Combined sources
Turni86 – 894Combined sources
Beta strandi95 – 1006Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TBQX-ray3.10R/S1-103[»]
1TBRX-ray2.60R/S1-103[»]
ProteinModelPortaliQ06684.
SMRiQ06684. Positions 1-103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06684.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5050Kazal-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini51 – 10353Kazal-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EGGEPCACPH ALHRVCGSDG ETYSNPCTLN CAKFNGKPEL VKVHDGPCEP
60 70 80 90 100
DEDEDVCQEC DGDEYKPVCG SDDITYDNNC RLECASISSS PGVELKHEGP

CRT
Length:103
Mass (Da):11,079
Last modified:February 1, 1995 - v1
Checksum:iF9588330458836B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22559 mRNA. Translation: CAA80281.1.
PIRiA47337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22559 mRNA. Translation: CAA80281.1.
PIRiA47337.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TBQX-ray3.10R/S1-103[»]
1TBRX-ray2.60R/S1-103[»]
ProteinModelPortaliQ06684.
SMRiQ06684. Positions 1-103.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI01.019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ06684.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A Kazal-type inhibitor with thrombin specificity from Rhodnius prolixus."
    Friedrich T., Kroeger B., Bialojan S., Lemaire H.G., Hoeffken H.W., Reuschenbach P., Otte M., Dodt J.
    J. Biol. Chem. 268:16216-16222(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-25.
  2. "Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin."
    van de Locht A., Lamba D., Bauer M., Huber R., Friedrich T., Kroeger B., Hoeffken H.W., Bode W.
    EMBO J. 14:5149-5157(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).

Entry informationi

Entry nameiTHBI_RHOPR
AccessioniPrimary (citable) accession number: Q06684
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 14, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.