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Protein

Thrombin inhibitor rhodniin

Gene
N/A
Organism
Rhodnius prolixus (Triatomid bug)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thrombin-specific inhibitor. Appears to form 1:1 complexes with thrombin. Prevents blood clotting to allow the insect to feed on blood.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei10 – 112Reactive bond

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Protein family/group databases

MEROPSiI01.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombin inhibitor rhodniin
OrganismiRhodnius prolixus (Triatomid bug)
Taxonomic identifieri13249 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraHeteropteraPanheteropteraCimicomorphaReduviidaeTriatominaeRhodnius
Proteomesi
  • UP000015103 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Thrombin inhibitor rhodniinPRO_0000073198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi6 ↔ 31
Disulfide bondi8 ↔ 27
Disulfide bondi16 ↔ 48
Disulfide bondi57 ↔ 84
Disulfide bondi60 ↔ 80
Disulfide bondi69 ↔ 101

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
103
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63Combined sources
Beta strandi7 – 104Combined sources
Beta strandi15 – 173Combined sources
Beta strandi22 – 254Combined sources
Helixi26 – 338Combined sources
Turni34 – 363Combined sources
Beta strandi42 – 465Combined sources
Helixi58 – 603Combined sources
Beta strandi68 – 703Combined sources
Turni71 – 733Combined sources
Beta strandi74 – 785Combined sources
Helixi79 – 857Combined sources
Turni86 – 894Combined sources
Beta strandi95 – 1006Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TBQX-ray3.10R/S1-103[»]
1TBRX-ray2.60R/S1-103[»]
ProteinModelPortaliQ06684.
SMRiQ06684. Positions 1-103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06684.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5050Kazal-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini51 – 10353Kazal-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EGGEPCACPH ALHRVCGSDG ETYSNPCTLN CAKFNGKPEL VKVHDGPCEP
60 70 80 90 100
DEDEDVCQEC DGDEYKPVCG SDDITYDNNC RLECASISSS PGVELKHEGP

CRT
Length:103
Mass (Da):11,079
Last modified:February 1, 1995 - v1
Checksum:iF9588330458836B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22559 mRNA. Translation: CAA80281.1.
PIRiA47337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22559 mRNA. Translation: CAA80281.1.
PIRiA47337.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TBQX-ray3.10R/S1-103[»]
1TBRX-ray2.60R/S1-103[»]
ProteinModelPortaliQ06684.
SMRiQ06684. Positions 1-103.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI01.019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ06684.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHBI_RHOPR
AccessioniPrimary (citable) accession number: Q06684
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 14, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.